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PubMed code 18318463

Compile data set for download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50375821
PNG
(TANAPROGET)
Show SMILES Cn1c(ccc1-c1ccc2NC(=S)OC(C)(C)c2c1)C#N
Show InChI InChI=1S/C16H15N3OS/c1-16(2)12-8-10(4-6-13(12)18-15(21)20-16)14-7-5-11(9-17)19(14)3/h4-8H,1-3H3,(H,18,21)
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n/an/a 0.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human GR ligand binding domain expressed in african green monkey COS7 cells in presence of Dexamethasone by Gal4 hybrid assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50375823
PNG
(CHEMBL407847)
Show SMILES Cn1c(ccc1-c1cc2c(NC(=O)C22CCCC2)c(F)c1)C#N
Show InChI InChI=1S/C18H16FN3O/c1-22-12(10-20)4-5-15(22)11-8-13-16(14(19)9-11)21-17(23)18(13)6-2-3-7-18/h4-5,8-9H,2-3,6-7H2,1H3,(H,21,23)
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n/an/a 3.20n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144435
PNG
(1-methyl-5-[2'-oxospiro[cyclohexane-1,3'-(2',3'-di...)
Show SMILES Cn1c(ccc1-c1ccc2NC(=O)C3(CCCCC3)c2c1)C#N
Show InChI InChI=1S/C19H19N3O/c1-22-14(12-20)6-8-17(22)13-5-7-16-15(11-13)19(18(23)21-16)9-3-2-4-10-19/h5-8,11H,2-4,9-10H2,1H3,(H,21,23)
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n/an/a 3.30n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375817
PNG
(CHEMBL272663)
Show SMILES CCC1(CC)C(=O)Nc2ccc(cc12)-c1ccc(C#N)n1C
Show InChI InChI=1S/C18H19N3O/c1-4-18(5-2)14-10-12(6-8-15(14)20-17(18)22)16-9-7-13(11-19)21(16)3/h6-10H,4-5H2,1-3H3,(H,20,22)
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375822
PNG
(CHEMBL408648)
Show SMILES Cn1c(ccc1-c1cc2c(NC(=O)C22CCCCC2)c(F)c1)C#N
Show InChI InChI=1S/C19H18FN3O/c1-23-13(11-21)5-6-16(23)12-9-14-17(15(20)10-12)22-18(24)19(14)7-3-2-4-8-19/h5-6,9-10H,2-4,7-8H2,1H3,(H,22,24)
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Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375827
PNG
(CHEMBL407848 | WAY-255348)
Show SMILES Cn1c(ccc1-c1cc2c(NC(=O)C2(C)C)c(F)c1)C#N
Show InChI InChI=1S/C16H14FN3O/c1-16(2)11-6-9(7-12(17)14(11)19-15(16)21)13-5-4-10(8-18)20(13)3/h4-7H,1-3H3,(H,19,21)
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Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375831
PNG
(CHEMBL429572)
Show SMILES Cn1c(ccc1-c1cc2c(N(CC=C)C(=O)C2(C)C)c(F)c1)C#N
Show InChI InChI=1S/C19H18FN3O/c1-5-8-23-17-14(19(2,3)18(23)24)9-12(10-15(17)20)16-7-6-13(11-21)22(16)4/h5-7,9-10H,1,8H2,2-4H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375824
PNG
(CHEMBL429928)
Show SMILES CCC1(CC)C(=O)Nc2c1cc(cc2F)-c1ccc(C#N)n1C
Show InChI InChI=1S/C18H18FN3O/c1-4-18(5-2)13-8-11(9-14(19)16(13)21-17(18)23)15-7-6-12(10-20)22(15)3/h6-9H,4-5H2,1-3H3,(H,21,23)
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144438
PNG
(5-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Show SMILES Cn1c(ccc1-c1ccc2NC(=O)OC(C)(C)c2c1)C#N
Show InChI InChI=1S/C16H15N3O2/c1-16(2)12-8-10(4-6-13(12)18-15(20)21-16)14-7-5-11(9-17)19(14)3/h4-8H,1-3H3,(H,18,20)
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Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375827
PNG
(CHEMBL407848 | WAY-255348)
Show SMILES Cn1c(ccc1-c1cc2c(NC(=O)C2(C)C)c(F)c1)C#N
Show InChI InChI=1S/C16H14FN3O/c1-16(2)11-6-9(7-12(17)14(11)19-15(16)21)13-5-4-10(8-18)20(13)3/h4-7H,1-3H3,(H,19,21)
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n/an/a 5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375826
PNG
(CHEMBL270714)
Show SMILES Cn1c(ccc1-c1ccc2NC(=O)C(C)(C)c2c1F)C#N
Show InChI InChI=1S/C16H14FN3O/c1-16(2)13-11(19-15(16)21)6-5-10(14(13)17)12-7-4-9(8-18)20(12)3/h4-7H,1-3H3,(H,19,21)
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Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375826
PNG
(CHEMBL270714)
Show SMILES Cn1c(ccc1-c1ccc2NC(=O)C(C)(C)c2c1F)C#N
Show InChI InChI=1S/C16H14FN3O/c1-16(2)13-11(19-15(16)21)6-5-10(14(13)17)12-7-4-9(8-18)20(12)3/h4-7H,1-3H3,(H,19,21)
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50375423
PNG
(ASOPRISNIL)
Show SMILES COC[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(CN=O)cc1)OC
Show InChI InChI=1S/C28H35NO4/c1-27-15-24(19-6-4-18(5-7-19)16-29-31)26-22-11-9-21(30)14-20(22)8-10-23(26)25(27)12-13-28(27,33-3)17-32-2/h4-7,14,23-25H,8-13,15-17H2,1-3H3/t23-,24+,25-,27-,28+/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human AR ligand binding domain expressed in african green monkey COS7 cells in presence of 5-alpha-dihydrotestosterone by Gal4...


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 6.90n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human AR ligand binding domain expressed in african green monkey COS7 cells in presence of 5-alpha-dihydrotestosterone by Gal4...


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375816
PNG
(CHEMBL407622)
Show SMILES Cn1c(ccc1-c1ccc2NC(=O)C3(CCCC3)c2c1)C#N
Show InChI InChI=1S/C18H17N3O/c1-21-13(11-19)5-7-16(21)12-4-6-15-14(10-12)18(17(22)20-15)8-2-3-9-18/h4-7,10H,2-3,8-9H2,1H3,(H,20,22)
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Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375818
PNG
(CHEMBL270908)
Show SMILES Cn1c(ccc1-c1ccc2NC(=O)C(C)(C)c2c1)C#N
Show InChI InChI=1S/C16H15N3O/c1-16(2)12-8-10(4-6-13(12)18-15(16)20)14-7-5-11(9-17)19(14)3/h4-8H,1-3H3,(H,18,20)
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375834
PNG
(CHEMBL271804)
Show SMILES CC(C)N1C(=O)C(C)(C)c2cc(cc(F)c12)-c1ccc(C#N)n1C
Show InChI InChI=1S/C19H20FN3O/c1-11(2)23-17-14(19(3,4)18(23)24)8-12(9-15(17)20)16-7-6-13(10-21)22(16)5/h6-9,11H,1-5H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375823
PNG
(CHEMBL407847)
Show SMILES Cn1c(ccc1-c1cc2c(NC(=O)C22CCCC2)c(F)c1)C#N
Show InChI InChI=1S/C18H16FN3O/c1-22-12(10-20)4-5-15(22)11-8-13-16(14(19)9-11)21-17(23)18(13)6-2-3-7-18/h4-5,8-9H,2-3,6-7H2,1H3,(H,21,23)
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n/an/a 14.7n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375836
PNG
(CHEMBL271552)
Show SMILES CN1C(=O)C(C)(C)c2cc(cc(F)c12)-c1ccc(C#N)n1C
Show InChI InChI=1S/C17H16FN3O/c1-17(2)12-7-10(14-6-5-11(9-19)20(14)3)8-13(18)15(12)21(4)16(17)22/h5-8H,1-4H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50121163
PNG
(3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indo...)
Show SMILES O=C1Nc2ccc(cc2C11CCCCC1)-c1cccc(c1)C#N
Show InChI InChI=1S/C20H18N2O/c21-13-14-5-4-6-15(11-14)16-7-8-18-17(12-16)20(19(23)22-18)9-2-1-3-10-20/h4-8,11-12H,1-3,9-10H2,(H,22,23)
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375819
PNG
(CHEMBL270052)
Show SMILES Cn1c(ccc1-c1ccc2NC(=O)Cc2c1)C#N
Show InChI InChI=1S/C14H11N3O/c1-17-11(8-15)3-5-13(17)9-2-4-12-10(6-9)7-14(18)16-12/h2-6H,7H2,1H3,(H,16,18)
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375825
PNG
(CHEMBL406235)
Show SMILES Cn1c(ccc1-c1cc2c(NC(=O)C2(C)C)cc1F)C#N
Show InChI InChI=1S/C16H14FN3O/c1-16(2)11-6-10(12(17)7-13(11)19-15(16)21)14-5-4-9(8-18)20(14)3/h4-7H,1-3H3,(H,19,21)
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n/an/a 20.3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375818
PNG
(CHEMBL270908)
Show SMILES Cn1c(ccc1-c1ccc2NC(=O)C(C)(C)c2c1)C#N
Show InChI InChI=1S/C16H15N3O/c1-16(2)12-8-10(4-6-13(12)18-15(16)20)14-7-5-11(9-17)19(14)3/h4-8H,1-3H3,(H,18,20)
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Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375839
PNG
(CHEMBL271149)
Show SMILES Cn1c(ccc1-c1cc2c(N(C3CCCC3)C(=O)C2(C)C)c(F)c1)C#N
Show InChI InChI=1S/C21H22FN3O/c1-21(2)16-10-13(18-9-8-15(12-23)24(18)3)11-17(22)19(16)25(20(21)26)14-6-4-5-7-14/h8-11,14H,4-7H2,1-3H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50121163
PNG
(3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indo...)
Show SMILES O=C1Nc2ccc(cc2C11CCCCC1)-c1cccc(c1)C#N
Show InChI InChI=1S/C20H18N2O/c21-13-14-5-4-6-15(11-14)16-7-8-18-17(12-16)20(19(23)22-18)9-2-1-3-10-20/h4-8,11-12H,1-3,9-10H2,(H,22,23)
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Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50121164
PNG
(3-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-b...)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H14N2O/c1-17(2)14-9-13(6-7-15(14)19-16(17)20)12-5-3-4-11(8-12)10-18/h3-9H,1-2H3,(H,19,20)
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375835
PNG
(CHEMBL437801)
Show SMILES CCCN1C(=O)C(C)(C)c2cc(cc(F)c12)-c1ccc(C#N)n1C
Show InChI InChI=1S/C19H20FN3O/c1-5-8-23-17-14(19(2,3)18(23)24)9-12(10-15(17)20)16-7-6-13(11-21)22(16)4/h6-7,9-10H,5,8H2,1-4H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375840
PNG
(CHEMBL405428)
Show SMILES CCN1C(=O)C(C)(C)c2cc(cc(F)c12)-c1ccc(C#N)n1C
Show InChI InChI=1S/C18H18FN3O/c1-5-22-16-13(18(2,3)17(22)23)8-11(9-14(16)19)15-7-6-12(10-20)21(15)4/h6-9H,5H2,1-4H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375816
PNG
(CHEMBL407622)
Show SMILES Cn1c(ccc1-c1ccc2NC(=O)C3(CCCC3)c2c1)C#N
Show InChI InChI=1S/C18H17N3O/c1-21-13(11-19)5-7-16(21)12-4-6-15-14(10-12)18(17(22)20-15)8-2-3-9-18/h4-7,10H,2-3,8-9H2,1H3,(H,20,22)
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375833
PNG
(CHEMBL437622)
Show SMILES CC(C)CN1C(=O)C(C)(C)c2cc(cc(F)c12)-c1ccc(C#N)n1C
Show InChI InChI=1S/C20H22FN3O/c1-12(2)11-24-18-15(20(3,4)19(24)25)8-13(9-16(18)21)17-7-6-14(10-22)23(17)5/h6-9,12H,11H2,1-5H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375830
PNG
(CHEMBL271175)
Show SMILES Cn1c(ccc1-c1cc2c(N(CC#C)C(=O)C2(C)C)c(F)c1)C#N
Show InChI InChI=1S/C19H16FN3O/c1-5-8-23-17-14(19(2,3)18(23)24)9-12(10-15(17)20)16-7-6-13(11-21)22(16)4/h1,6-7,9-10H,8H2,2-4H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375817
PNG
(CHEMBL272663)
Show SMILES CCC1(CC)C(=O)Nc2ccc(cc12)-c1ccc(C#N)n1C
Show InChI InChI=1S/C18H19N3O/c1-4-18(5-2)14-10-12(6-8-15(14)20-17(18)22)16-9-7-13(11-19)21(16)3/h6-10H,4-5H2,1-3H3,(H,20,22)
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Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375828
PNG
(CHEMBL271336)
Show SMILES CC(=O)OCN1C(=O)C(C)(C)c2cc(cc(F)c12)-c1ccc(C#N)n1C
Show InChI InChI=1S/C19H18FN3O3/c1-11(24)26-10-23-17-14(19(2,3)18(23)25)7-12(8-15(17)20)16-6-5-13(9-21)22(16)4/h5-8H,10H2,1-4H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375819
PNG
(CHEMBL270052)
Show SMILES Cn1c(ccc1-c1ccc2NC(=O)Cc2c1)C#N
Show InChI InChI=1S/C14H11N3O/c1-17-11(8-15)3-5-13(17)9-2-4-12-10(6-9)7-14(18)16-12/h2-6H,7H2,1H3,(H,16,18)
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Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50375423
PNG
(ASOPRISNIL)
Show SMILES COC[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(CN=O)cc1)OC
Show InChI InChI=1S/C28H35NO4/c1-27-15-24(19-6-4-18(5-7-19)16-29-31)26-22-11-9-21(30)14-20(22)8-10-23(26)25(27)12-13-28(27,33-3)17-32-2/h4-7,14,23-25H,8-13,15-17H2,1-3H3/t23-,24+,25-,27-,28+/m0/s1
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n/an/a 85n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human GR ligand binding domain expressed in african green monkey COS7 cells in presence of Dexamethasone by Gal4 hybrid assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375838
PNG
(CHEMBL271835)
Show SMILES Cn1c(ccc1-c1cc2c(N(Cc3ccccc3)C(=O)C2(C)C)c(F)c1)C#N
Show InChI InChI=1S/C23H20FN3O/c1-23(2)18-11-16(20-10-9-17(13-25)26(20)3)12-19(24)21(18)27(22(23)28)14-15-7-5-4-6-8-15/h4-12H,14H2,1-3H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375832
PNG
(CHEMBL408696)
Show SMILES Cn1c(ccc1-c1cc2c(N(C3CCCCC3)C(=O)C2(C)C)c(F)c1)C#N
Show InChI InChI=1S/C22H24FN3O/c1-22(2)17-11-14(19-10-9-16(13-24)25(19)3)12-18(23)20(17)26(21(22)27)15-7-5-4-6-8-15/h9-12,15H,4-8H2,1-3H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50375827
PNG
(CHEMBL407848 | WAY-255348)
Show SMILES Cn1c(ccc1-c1cc2c(NC(=O)C2(C)C)c(F)c1)C#N
Show InChI InChI=1S/C16H14FN3O/c1-16(2)11-6-9(7-12(17)14(11)19-15(16)21)13-5-4-10(8-18)20(13)3/h4-7H,1-3H3,(H,19,21)
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human AR ligand binding domain expressed in african green monkey COS7 cells in presence of 5-alpha-dihydrotestosterone by Gal4...


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375820
PNG
(CHEMBL270909)
Show SMILES O=C1Cc2cc(ccc2N1)-c1ccc([nH]1)C#N
Show InChI InChI=1S/C13H9N3O/c14-7-10-2-4-11(15-10)8-1-3-12-9(5-8)6-13(17)16-12/h1-5,15H,6H2,(H,16,17)
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n/an/a 300n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375829
PNG
(CHEMBL409147)
Show SMILES Cn1c(ccc1-c1cc2c(N(CCc3ccccc3)C(=O)C2(C)C)c(F)c1)C#N
Show InChI InChI=1S/C24H22FN3O/c1-24(2)19-13-17(21-10-9-18(15-26)27(21)3)14-20(25)22(19)28(23(24)29)12-11-16-7-5-4-6-8-16/h4-10,13-14H,11-12H2,1-3H3
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n/an/a 351n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50375423
PNG
(ASOPRISNIL)
Show SMILES COC[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(CN=O)cc1)OC
Show InChI InChI=1S/C28H35NO4/c1-27-15-24(19-6-4-18(5-7-19)16-29-31)26-22-11-9-21(30)14-20(22)8-10-23(26)25(27)12-13-28(27,33-3)17-32-2/h4-7,14,23-25H,8-13,15-17H2,1-3H3/t23-,24+,25-,27-,28+/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human MR ligand binding domain expressed in african green monkey COS7 cells in presence of aldosterone by Gal4 hybrid assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50375423
PNG
(ASOPRISNIL)
Show SMILES COC[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(CN=O)cc1)OC
Show InChI InChI=1S/C28H35NO4/c1-27-15-24(19-6-4-18(5-7-19)16-29-31)26-22-11-9-21(30)14-20(22)8-10-23(26)25(27)12-13-28(27,33-3)17-32-2/h4-7,14,23-25H,8-13,15-17H2,1-3H3/t23-,24+,25-,27-,28+/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human ER ligand binding domain expressed in african green monkey COS7 cells in presence of 17-beta-estradiol by Gal4 hybrid as...


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50375827
PNG
(CHEMBL407848 | WAY-255348)
Show SMILES Cn1c(ccc1-c1cc2c(NC(=O)C2(C)C)c(F)c1)C#N
Show InChI InChI=1S/C16H14FN3O/c1-16(2)11-6-9(7-12(17)14(11)19-15(16)21)13-5-4-10(8-18)20(13)3/h4-7H,1-3H3,(H,19,21)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human MR ligand binding domain expressed in african green monkey COS7 cells in presence of aldosterone by Gal4 hybrid assay


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144438
PNG
(5-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Show SMILES Cn1c(ccc1-c1ccc2NC(=O)OC(C)(C)c2c1)C#N
Show InChI InChI=1S/C16H15N3O2/c1-16(2)12-8-10(4-6-13(12)18-15(20)21-16)14-7-5-11(9-17)19(14)3/h4-8H,1-3H3,(H,18,20)
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n/an/an/an/a 1.10n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human PR expressed in human T47D cells assessed as stimulation of alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375837
PNG
(CHEMBL270976)
Show SMILES S=C1Nc2ccc(cc2C11CCCCC1)-c1cccc(c1)C#N
Show InChI InChI=1S/C20H18N2S/c21-13-14-5-4-6-15(11-14)16-7-8-18-17(12-16)20(19(23)22-18)9-2-1-3-10-20/h4-8,11-12H,1-3,9-10H2,(H,22,23)
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n/an/an/an/a 2n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human PR expressed in human T47D cells assessed as stimulation of alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375823
PNG
(CHEMBL407847)
Show SMILES Cn1c(ccc1-c1cc2c(NC(=O)C22CCCC2)c(F)c1)C#N
Show InChI InChI=1S/C18H16FN3O/c1-22-12(10-20)4-5-15(22)11-8-13-16(14(19)9-11)21-17(23)18(13)6-2-3-7-18/h4-5,8-9H,2-3,6-7H2,1H3,(H,21,23)
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n/an/an/an/a 3.00E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human PR expressed in human T47D cells assessed as stimulation of alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375816
PNG
(CHEMBL407622)
Show SMILES Cn1c(ccc1-c1ccc2NC(=O)C3(CCCC3)c2c1)C#N
Show InChI InChI=1S/C18H17N3O/c1-21-13(11-19)5-7-16(21)12-4-6-15-14(10-12)18(17(22)20-15)8-2-3-9-18/h4-7,10H,2-3,8-9H2,1H3,(H,20,22)
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n/an/an/an/a 300n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human PR expressed in human T47D cells assessed as stimulation of alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375821
PNG
(TANAPROGET)
Show SMILES Cn1c(ccc1-c1ccc2NC(=S)OC(C)(C)c2c1)C#N
Show InChI InChI=1S/C16H15N3OS/c1-16(2)12-8-10(4-6-13(12)18-15(21)20-16)14-7-5-11(9-17)19(14)3/h4-8H,1-3H3,(H,18,21)
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n/an/an/an/a 0.150n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human PR expressed in human T47D cells assessed as stimulation of alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50375822
PNG
(CHEMBL408648)
Show SMILES Cn1c(ccc1-c1cc2c(NC(=O)C22CCCCC2)c(F)c1)C#N
Show InChI InChI=1S/C19H18FN3O/c1-23-13(11-21)5-6-16(23)12-9-14-17(15(20)10-12)22-18(24)19(14)7-3-2-4-8-19/h5-6,9-10H,2-4,7-8H2,1H3,(H,22,24)
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n/an/an/an/a 1.30n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human PR expressed in human T47D cells assessed as stimulation of alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144435
PNG
(1-methyl-5-[2'-oxospiro[cyclohexane-1,3'-(2',3'-di...)
Show SMILES Cn1c(ccc1-c1ccc2NC(=O)C3(CCCCC3)c2c1)C#N
Show InChI InChI=1S/C19H19N3O/c1-22-14(12-20)6-8-17(22)13-5-7-16-15(11-13)19(18(23)21-16)9-3-2-4-10-19/h5-8,11H,2-4,9-10H2,1H3,(H,21,23)
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n/an/an/an/a 2.30n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human PR expressed in human T47D cells assessed as stimulation of alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%