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PubMed code 18324764

Compile data set for download or QSAR
Found 151 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8349
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 13 | CHEMB...)
Show SMILES Oc1ccc(cc1)-c1nc2[nH]nc(NC(=O)C3CC3)c2cc1Br
Show InChI InChI=1S/C16H13BrN4O2/c17-12-7-11-14(18-13(12)8-3-5-10(22)6-4-8)20-21-15(11)19-16(23)9-1-2-9/h3-7,9,22H,1-2H2,(H2,18,19,20,21,23)
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n/an/a 0.800n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8359
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 23 | N-[5-...)
Show SMILES CN1CCC(CC1)C(=O)Nc1n[nH]c2nc(c(Br)cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C19H20BrN5O2/c1-25-8-6-12(7-9-25)19(27)22-18-14-10-15(20)16(21-17(14)23-24-18)11-2-4-13(26)5-3-11/h2-5,10,12,26H,6-9H2,1H3,(H2,21,22,23,24,27)
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n/an/a 1n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8350
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 14 | N-[5-...)
Show SMILES Oc1ccc(cc1)-c1nc2[nH]nc(NC(=O)C3CC3)c2cc1Cl
Show InChI InChI=1S/C16H13ClN4O2/c17-12-7-11-14(18-13(12)8-3-5-10(22)6-4-8)20-21-15(11)19-16(23)9-1-2-9/h3-7,9,22H,1-2H2,(H2,18,19,20,21,23)
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n/an/a 1n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8357
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 21 | CHEMB...)
Show SMILES CCN1CCN(CCCC(=O)Nc2n[nH]c3nc(c(Br)cc23)-c2ccc(O)cc2)CC1
Show InChI InChI=1S/C22H27BrN6O2/c1-2-28-10-12-29(13-11-28)9-3-4-19(31)24-21-17-14-18(23)20(25-22(17)27-26-21)15-5-7-16(30)8-6-15/h5-8,14,30H,2-4,9-13H2,1H3,(H2,24,25,26,27,31)
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n/an/a 4n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8364
PNG
(CHEMBL260416 | N-[6-(3-bromo-4-hydroxyphenyl)-1H-p...)
Show SMILES Oc1ccc(cc1Br)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C16H13BrN4O2/c17-11-7-9(3-6-13(11)22)12-5-4-10-14(18-12)20-21-15(10)19-16(23)8-1-2-8/h3-8,22H,1-2H2,(H2,18,19,20,21,23)
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n/an/a 5n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8332
PNG
(4-(morpholin-4-yl)-N-{5-phenyl-1H-pyrazolo[3,4-c]p...)
Show SMILES O=C(CCCN1CCOCC1)Nc1n[nH]c2nnc(cc12)-c1ccccc1
Show InChI InChI=1S/C19H22N6O2/c26-17(7-4-8-25-9-11-27-12-10-25)20-18-15-13-16(14-5-2-1-3-6-14)21-23-19(15)24-22-18/h1-3,5-6,13H,4,7-12H2,(H2,20,22,23,24,26)
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n/an/a 5n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8310
PNG
(N-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl}cyclope...)
Show SMILES O=C(Nc1n[nH]c2ncc(cc12)-c1ccccc1)C1CCCC1
Show InChI InChI=1S/C18H18N4O/c23-18(13-8-4-5-9-13)20-17-15-10-14(11-19-16(15)21-22-17)12-6-2-1-3-7-12/h1-3,6-7,10-11,13H,4-5,8-9H2,(H2,19,20,21,22,23)
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n/an/a 5n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8334
PNG
(5-(4-ethylpiperazin-1-yl)-N-{5-phenyl-1H-pyrazolo[...)
Show SMILES CCN1CCN(CCCCC(=O)Nc2n[nH]c3nnc(cc23)-c2ccccc2)CC1
Show InChI InChI=1S/C22H29N7O/c1-2-28-12-14-29(15-13-28)11-7-6-10-20(30)23-21-18-16-19(17-8-4-3-5-9-17)24-26-22(18)27-25-21/h3-5,8-9,16H,2,6-7,10-15H2,1H3,(H2,23,25,26,27,30)
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n/an/a 5n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8351
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 15 | N-[6-...)
Show SMILES Cc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccc(O)cc1
Show InChI InChI=1S/C17H16N4O2/c1-9-8-13-15(18-14(9)10-4-6-12(22)7-5-10)20-21-16(13)19-17(23)11-2-3-11/h4-8,11,22H,2-3H2,1H3,(H2,18,19,20,21,23)
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n/an/a 6n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8317
PNG
(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-b]pyridi...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncc(cc12)-c1cccc(F)c1F
Show InChI InChI=1S/C16H14F2N4O/c1-2-4-13(23)20-16-11-7-9(8-19-15(11)21-22-16)10-5-3-6-12(17)14(10)18/h3,5-8H,2,4H2,1H3,(H2,19,20,21,22,23)
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n/an/a 7n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8329
PNG
(N-{5-phenyl-1H-pyrazolo[3,4-c]pyridin-3-yl}butanam...)
Show SMILES CCCC(=O)Nc1n[nH]c2cnc(cc12)-c1ccccc1
Show InChI InChI=1S/C16H16N4O/c1-2-6-15(21)18-16-12-9-13(11-7-4-3-5-8-11)17-10-14(12)19-20-16/h3-5,7-10H,2,6H2,1H3,(H2,18,19,20,21)
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n/an/a 7n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8392
PNG
(CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...)
Show SMILES Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccco1
Show InChI InChI=1S/C14H11BrN4O2/c15-9-6-8-12(16-11(9)10-2-1-5-21-10)18-19-13(8)17-14(20)7-3-4-7/h1-2,5-7H,3-4H2,(H2,16,17,18,19,20)
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n/an/a 7n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8390
PNG
(CHEMBL407980 | N-[5-bromo-6-(thiophen-2-yl)-1H-pyr...)
Show SMILES Brc1cc2c(NC(=O)C3CCCC3)n[nH]c2nc1-c1cccs1
Show InChI InChI=1S/C16H15BrN4OS/c17-11-8-10-14(18-13(11)12-6-3-7-23-12)20-21-15(10)19-16(22)9-4-1-2-5-9/h3,6-9H,1-2,4-5H2,(H2,18,19,20,21,22)
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n/an/a 7n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8331
PNG
(4-(4-ethylpiperazin-1-yl)-N-{5-phenyl-1H-pyrazolo[...)
Show SMILES CCN1CCN(CCCC(=O)Nc2n[nH]c3nnc(cc23)-c2ccccc2)CC1
Show InChI InChI=1S/C21H27N7O/c1-2-27-11-13-28(14-12-27)10-6-9-19(29)22-20-17-15-18(16-7-4-3-5-8-16)23-25-21(17)26-24-20/h3-5,7-8,15H,2,6,9-14H2,1H3,(H2,22,24,25,26,29)
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n/an/a 7n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8365
PNG
(N-[6-(3-chloro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]...)
Show SMILES Oc1ccc(cc1Cl)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C16H13ClN4O2/c17-11-7-9(3-6-13(11)22)12-5-4-10-14(18-12)20-21-15(10)19-16(23)8-1-2-8/h3-8,22H,1-2H2,(H2,18,19,20,21,23)
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n/an/a 7n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8341
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 5 | N-[6-(...)
Show SMILES Oc1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C16H14N4O2/c21-11-5-3-9(4-6-11)13-8-7-12-14(17-13)19-20-15(12)18-16(22)10-1-2-10/h3-8,10,21H,1-2H2,(H2,17,18,19,20,22)
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n/an/a 8n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8343
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 7 | N-[6-(...)
Show SMILES Oc1ccc(cc1O)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C16H14N4O3/c21-12-6-3-9(7-13(12)22)11-5-4-10-14(17-11)19-20-15(10)18-16(23)8-1-2-8/h3-8,21-22H,1-2H2,(H2,17,18,19,20,23)
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n/an/a 8n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8333
PNG
(1-methyl-N-{5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3...)
Show SMILES CN1CCC(CC1)C(=O)Nc1n[nH]c2nnc(cc12)-c1ccccc1
Show InChI InChI=1S/C18H20N6O/c1-24-9-7-13(8-10-24)18(25)19-16-14-11-15(12-5-3-2-4-6-12)20-22-17(14)23-21-16/h2-6,11,13H,7-10H2,1H3,(H2,19,21,22,23,25)
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n/an/a 9n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8328
PNG
(N-{5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl}-4-(p...)
Show SMILES O=C(CCCN1CCCC1)Nc1n[nH]c2nnc(cc12)-c1ccccc1
Show InChI InChI=1S/C19H22N6O/c26-17(9-6-12-25-10-4-5-11-25)20-18-15-13-16(14-7-2-1-3-8-14)21-23-19(15)24-22-18/h1-3,7-8,13H,4-6,9-12H2,(H2,20,22,23,24,26)
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n/an/a 11n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8319
PNG
(N-[5-(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncc(cc12)-c1cccnc1
Show InChI InChI=1S/C15H15N5O/c1-2-4-13(21)18-15-12-7-11(9-17-14(12)19-20-15)10-5-3-6-16-8-10/h3,5-9H,2,4H2,1H3,(H2,17,18,19,20,21)
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n/an/a 11n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8358
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 22 | N-[6-...)
Show SMILES CN1CCC(CC1)C(=O)Nc1n[nH]c2nc(ccc12)-c1ccc(O)cc1
Show InChI InChI=1S/C19H21N5O2/c1-24-10-8-13(9-11-24)19(26)21-18-15-6-7-16(20-17(15)22-23-18)12-2-4-14(25)5-3-12/h2-7,13,25H,8-11H2,1H3,(H2,20,21,22,23,26)
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n/an/a 12n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8344
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 8 | CHEMBL...)
Show SMILES Oc1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C16H14N4O2/c21-11-3-1-2-10(8-11)13-7-6-12-14(17-13)19-20-15(12)18-16(22)9-4-5-9/h1-3,6-9,21H,4-5H2,(H2,17,18,19,20,22)
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n/an/a 12n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8396
PNG
(1-benzyl-N-[5-bromo-6-(furan-2-yl)-1H-pyrazolo[3,4...)
Show SMILES Brc1cc2c(NC(=O)C3CCN(Cc4ccccc4)C3)n[nH]c2nc1-c1ccco1
Show InChI InChI=1S/C22H20BrN5O2/c23-17-11-16-20(24-19(17)18-7-4-10-30-18)26-27-21(16)25-22(29)15-8-9-28(13-15)12-14-5-2-1-3-6-14/h1-7,10-11,15H,8-9,12-13H2,(H2,24,25,26,27,29)
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n/an/a 14n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8370
PNG
(N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...)
Show SMILES Oc1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
Show InChI InChI=1S/C17H15N3O2/c21-13-6-3-10(4-7-13)12-5-8-14-15(9-12)19-20-16(14)18-17(22)11-1-2-11/h3-9,11,21H,1-2H2,(H2,18,19,20,22)
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n/an/a 15n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8394
PNG
(CHEMBL406644 | N-[5-bromo-6-(1,3-thiazol-2-yl)-1H-...)
Show SMILES Brc1cc2c(NC(=O)C3CCCC3)n[nH]c2nc1-c1nccs1
Show InChI InChI=1S/C15H14BrN5OS/c16-10-7-9-12(18-11(10)15-17-5-6-23-15)20-21-13(9)19-14(22)8-3-1-2-4-8/h5-8H,1-4H2,(H2,18,19,20,21,22)
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n/an/a 16n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8315
PNG
(N-[5-(2-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncc(cc12)-c1ccccc1F
Show InChI InChI=1S/C16H15FN4O/c1-2-5-14(22)19-16-12-8-10(9-18-15(12)20-21-16)11-6-3-4-7-13(11)17/h3-4,6-9H,2,5H2,1H3,(H2,18,19,20,21,22)
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n/an/a 18n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373090
PNG
(CHEMBL260680)
Show SMILES CN1CCC(CC(=O)Nc2n[nH]c3nc(-c4cccs4)c(Br)cc23)CC1
Show InChI InChI=1S/C18H20BrN5OS/c1-24-6-4-11(5-7-24)9-15(25)20-17-12-10-13(19)16(14-3-2-8-26-14)21-18(12)23-22-17/h2-3,8,10-11H,4-7,9H2,1H3,(H2,20,21,22,23,25)
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n/an/a 18n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8309
PNG
(2-methyl-N-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-y...)
Show SMILES CC(C)C(=O)Nc1n[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C16H16N4O/c1-10(2)16(21)18-15-13-8-12(9-17-14(13)19-20-15)11-6-4-3-5-7-11/h3-10H,1-2H3,(H2,17,18,19,20,21)
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n/an/a 19n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8255
PNG
(3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(3-nitro...)
Show SMILES Oc1c(Cl)cc(NC2=C(C(=O)NC2=O)c2cccc(c2)N(=O)=O)cc1Cl
Show InChI InChI=1S/C16H9Cl2N3O5/c17-10-5-8(6-11(18)14(10)22)19-13-12(15(23)20-16(13)24)7-2-1-3-9(4-7)21(25)26/h1-6,22H,(H2,19,20,23,24)
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n/an/a 20n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8316
PNG
(N-[5-(3-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C16H15FN4O/c1-2-4-14(22)19-16-13-8-11(9-18-15(13)20-21-16)10-5-3-6-12(17)7-10/h3,5-9H,2,4H2,1H3,(H2,18,19,20,21,22)
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n/an/a 20n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8360
PNG
(4-(4-ethylpiperazin-1-yl)-N-[6-(3-hydroxyphenyl)-1...)
Show SMILES CCN1CCN(CCCC(=O)Nc2n[nH]c3nc(ccc23)-c2cccc(O)c2)CC1
Show InChI InChI=1S/C22H28N6O2/c1-2-27-11-13-28(14-12-27)10-4-7-20(30)24-22-18-8-9-19(23-21(18)25-26-22)16-5-3-6-17(29)15-16/h3,5-6,8-9,15,29H,2,4,7,10-14H2,1H3,(H2,23,24,25,26,30)
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n/an/a 21n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8327
PNG
(4-(dimethylamino)-N-{5-phenyl-1H-pyrazolo[3,4-c]py...)
Show SMILES CN(C)CCCC(=O)Nc1n[nH]c2nnc(cc12)-c1ccccc1
Show InChI InChI=1S/C17H20N6O/c1-23(2)10-6-9-15(24)18-16-13-11-14(12-7-4-3-5-8-12)19-21-17(13)22-20-16/h3-5,7-8,11H,6,9-10H2,1-2H3,(H2,18,20,21,22,24)
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n/an/a 22n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8348
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 12 | CHEMB...)
Show SMILES Oc1ccc(cc1)-c1nc2[nH]nc(NC(=O)C3CC3)c2cc1-c1ccccc1
Show InChI InChI=1S/C22H18N4O2/c27-16-10-8-14(9-11-16)19-17(13-4-2-1-3-5-13)12-18-20(23-19)25-26-21(18)24-22(28)15-6-7-15/h1-5,8-12,15,27H,6-7H2,(H2,23,24,25,26,28)
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n/an/a 24n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373079
PNG
(CHEMBL156379)
Show SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2cccc(c2)[N+]([O-])=O)ccc1Cl
Show InChI InChI=1S/C17H10ClN3O6/c18-12-5-4-9(7-11(12)17(24)25)19-14-13(15(22)20-16(14)23)8-2-1-3-10(6-8)21(26)27/h1-7H,(H,24,25)(H2,19,20,22,23)
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n/an/a 26n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8318
PNG
(N-[5-(2-chlorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncc(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C16H15ClN4O/c1-2-5-14(22)19-16-12-8-10(9-18-15(12)20-21-16)11-6-3-4-7-13(11)17/h3-4,6-9H,2,5H2,1H3,(H2,18,19,20,21,22)
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n/an/a 27n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373086
PNG
(CHEMBL160586)
Show SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2ccccc2[N+]([O-])=O)ccc1Cl
Show InChI InChI=1S/C17H10ClN3O6/c18-11-6-5-8(7-10(11)17(24)25)19-14-13(15(22)20-16(14)23)9-3-1-2-4-12(9)21(26)27/h1-7H,(H,24,25)(H2,19,20,22,23)
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n/an/a 28n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8386
PNG
(CHEMBL260243 | N-[6-(furan-3-yl)-1H-indazol-3-yl]c...)
Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccoc1)C1CC1
Show InChI InChI=1S/C15H13N3O2/c19-15(9-1-2-9)16-14-12-4-3-10(7-13(12)17-18-14)11-5-6-20-8-11/h3-9H,1-2H2,(H2,16,17,18,19)
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n/an/a 35n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8346
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 10 | N-[6-...)
Show SMILES Oc1ccccc1-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C16H14N4O2/c21-13-4-2-1-3-10(13)12-8-7-11-14(17-12)19-20-15(11)18-16(22)9-5-6-9/h1-4,7-9,21H,5-6H2,(H2,17,18,19,20,22)
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n/an/a 36n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8389
PNG
(CHEMBL260231 | N-[5-bromo-6-(thiophen-2-yl)-1H-pyr...)
Show SMILES Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1cccs1
Show InChI InChI=1S/C14H11BrN4OS/c15-9-6-8-12(16-11(9)10-2-1-5-21-10)18-19-13(8)17-14(20)7-3-4-7/h1-2,5-7H,3-4H2,(H2,16,17,18,19,20)
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n/an/a 39n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8371
PNG
(CHEMBL261659 | N-[6-(1H-indol-5-yl)-1H-indazol-3-y...)
Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccc2[nH]ccc2c1)C1CC1
Show InChI InChI=1S/C19H16N4O/c24-19(11-1-2-11)21-18-15-5-3-13(10-17(15)22-23-18)12-4-6-16-14(9-12)7-8-20-16/h3-11,20H,1-2H2,(H2,21,22,23,24)
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n/an/a 42n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8307
PNG
(N-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl}propana...)
Show SMILES CCC(=O)Nc1n[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C15H14N4O/c1-2-13(20)17-15-12-8-11(9-16-14(12)18-19-15)10-6-4-3-5-7-10/h3-9H,2H2,1H3,(H2,16,17,18,19,20)
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n/an/a 43n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373088
PNG
(CHEMBL158885)
Show SMILES Oc1c(Cl)cc(NC2=C(C(=O)NC2=O)c2ccccc2[N+]([O-])=O)cc1Cl
Show InChI InChI=1S/C16H9Cl2N3O5/c17-9-5-7(6-10(18)14(9)22)19-13-12(15(23)20-16(13)24)8-3-1-2-4-11(8)21(25)26/h1-6,22H,(H2,19,20,23,24)
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n/an/a 52n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8308
PNG
(N-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl}butanam...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C16H16N4O/c1-2-6-14(21)18-16-13-9-12(10-17-15(13)19-20-16)11-7-4-3-5-8-11/h3-5,7-10H,2,6H2,1H3,(H2,17,18,19,20,21)
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n/an/a 56n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8253
PNG
(3-(3-chlorophenyl)-4-[(3,5-dichloro-4-hydroxypheny...)
Show SMILES Oc1c(Cl)cc(NC2=C(C(=O)NC2=O)c2cccc(Cl)c2)cc1Cl
Show InChI InChI=1S/C16H9Cl3N2O3/c17-8-3-1-2-7(4-8)12-13(16(24)21-15(12)23)20-9-5-10(18)14(22)11(19)6-9/h1-6,22H,(H2,20,21,23,24)
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n/an/a 58n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373081
PNG
(CHEMBL345348)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2cccc(c2)[N+]([O-])=O)cc1Cl
Show InChI InChI=1S/C16H10ClN3O5/c17-11-7-9(4-5-12(11)21)18-14-13(15(22)19-16(14)23)8-2-1-3-10(6-8)20(24)25/h1-7,21H,(H2,18,19,22,23)
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n/an/a 59n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373084
PNG
(CHEMBL345801)
Show SMILES [O-][N+](=O)c1cccc(c1)C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O
Show InChI InChI=1S/C16H10ClN3O4/c17-10-4-2-5-11(8-10)18-14-13(15(21)19-16(14)22)9-3-1-6-12(7-9)20(23)24/h1-8H,(H2,18,19,21,22)
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n/an/a 70n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373077
PNG
(CHEMBL347681)
Show SMILES Oc1c(Cl)cc(NC2=C(C(=O)NC2=O)c2ccc(cc2)[N+]([O-])=O)cc1Cl
Show InChI InChI=1S/C16H9Cl2N3O5/c17-10-5-8(6-11(18)14(10)22)19-13-12(15(23)20-16(13)24)7-1-3-9(4-2-7)21(25)26/h1-6,22H,(H2,19,20,23,24)
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n/an/a 71n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8267
PNG
(2-chloro-5-{[4-(2-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Show SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)ccc1Cl
Show InChI InChI=1S/C17H10Cl2N2O4/c18-11-4-2-1-3-9(11)13-14(16(23)21-15(13)22)20-8-5-6-12(19)10(7-8)17(24)25/h1-7H,(H,24,25)(H2,20,21,22,23)
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n/an/a 74n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8353
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 17 | CHEMB...)
Show SMILES Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccccc1
Show InChI InChI=1S/C16H13BrN4O/c17-12-8-11-14(18-13(12)9-4-2-1-3-5-9)20-21-15(11)19-16(22)10-6-7-10/h1-5,8,10H,6-7H2,(H2,18,19,20,21,22)
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n/an/a 75n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8269
PNG
(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Show SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2cccc(Cl)c2)ccc1Cl
Show InChI InChI=1S/C17H10Cl2N2O4/c18-9-3-1-2-8(6-9)13-14(16(23)21-15(13)22)20-10-4-5-12(19)11(7-10)17(24)25/h1-7H,(H,24,25)(H2,20,21,22,23)
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n/an/a 76n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373080
PNG
(CHEMBL159149)
Show SMILES OC(=O)c1cccc(NC2=C(C(=O)NC2=O)c2cccc(c2)[N+]([O-])=O)c1
Show InChI InChI=1S/C17H11N3O6/c21-15-13(9-3-2-6-12(8-9)20(25)26)14(16(22)19-15)18-11-5-1-4-10(7-11)17(23)24/h1-8H,(H,23,24)(H2,18,19,21,22)
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n/an/a 79n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8251
PNG
(3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(2-metho...)
Show SMILES COc1ccccc1C1=C(Nc2cc(Cl)c(O)c(Cl)c2)C(=O)NC1=O
Show InChI InChI=1S/C17H12Cl2N2O4/c1-25-12-5-3-2-4-9(12)13-14(17(24)21-16(13)23)20-8-6-10(18)15(22)11(19)7-8/h2-7,22H,1H3,(H2,20,21,23,24)
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n/an/a 82n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8257
PNG
(3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(4-metho...)
Show SMILES COc1ccc(cc1)C1=C(Nc2cc(Cl)c(O)c(Cl)c2)C(=O)NC1=O
Show InChI InChI=1S/C17H12Cl2N2O4/c1-25-10-4-2-8(3-5-10)13-14(17(24)21-16(13)23)20-9-6-11(18)15(22)12(19)7-9/h2-7,22H,1H3,(H2,20,21,23,24)
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n/an/a 83n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8270
PNG
(2-chloro-5-{[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dih...)
Show SMILES COc1cccc(c1)C1=C(Nc2ccc(Cl)c(c2)C(O)=O)C(=O)NC1=O
Show InChI InChI=1S/C18H13ClN2O5/c1-26-11-4-2-3-9(7-11)14-15(17(23)21-16(14)22)20-10-5-6-13(19)12(8-10)18(24)25/h2-8H,1H3,(H,24,25)(H2,20,21,22,23)
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n/an/a 85n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8355
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 19 | N-{5-...)
Show SMILES O=C(Nc1n[nH]c2nc(-c3ccccc3)c(cc12)C#N)C1CC1
Show InChI InChI=1S/C17H13N5O/c18-9-12-8-13-15(19-14(12)10-4-2-1-3-5-10)21-22-16(13)20-17(23)11-6-7-11/h1-5,8,11H,6-7H2,(H2,19,20,21,22,23)
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n/an/a 87n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8256
PNG
(3-(4-chlorophenyl)-4-[(3,5-dichloro-4-hydroxypheny...)
Show SMILES Oc1c(Cl)cc(NC2=C(C(=O)NC2=O)c2ccc(Cl)cc2)cc1Cl
Show InChI InChI=1S/C16H9Cl3N2O3/c17-8-3-1-7(2-4-8)12-13(16(24)21-15(12)23)20-9-5-10(18)14(22)11(19)6-9/h1-6,22H,(H2,20,21,23,24)
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n/an/a 91n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8250
PNG
(3-(2-chlorophenyl)-4-[(3,5-dichloro-4-hydroxypheny...)
Show SMILES Oc1c(Cl)cc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)cc1Cl
Show InChI InChI=1S/C16H9Cl3N2O3/c17-9-4-2-1-3-8(9)12-13(16(24)21-15(12)23)20-7-5-10(18)14(22)11(19)6-7/h1-6,22H,(H2,20,21,23,24)
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n/an/a 93n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8246
PNG
(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2cccc(Cl)c2)cc1Cl
Show InChI InChI=1S/C16H10Cl2N2O3/c17-9-3-1-2-8(6-9)13-14(16(23)20-15(13)22)19-10-4-5-12(21)11(18)7-10/h1-7,21H,(H2,19,20,22,23)
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n/an/a 94n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8393
PNG
(CHEMBL261690 | N-[5-bromo-6-(1,3-thiazol-2-yl)-1H-...)
Show SMILES Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1nccs1
Show InChI InChI=1S/C13H10BrN5OS/c14-8-5-7-10(16-9(8)13-15-3-4-21-13)18-19-11(7)17-12(20)6-1-2-6/h3-6H,1-2H2,(H2,16,17,18,19,20)
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n/an/a 99n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8324
PNG
(N-(5-phenyl-1H-indazol-3-yl)butanamide | indazole ...)
Show SMILES CCCC(=O)Nc1n[nH]c2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C17H17N3O/c1-2-6-16(21)18-17-14-11-13(9-10-15(14)19-20-17)12-7-4-3-5-8-12/h3-5,7-11H,2,6H2,1H3,(H2,18,19,20,21)
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n/an/a 99n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50130725
PNG
(3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phen...)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2[N+]([O-])=O)cc1Cl
Show InChI InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)
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n/an/a 104n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373089
PNG
(CHEMBL346066)
Show SMILES [O-][N+](=O)c1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O
Show InChI InChI=1S/C16H10ClN3O4/c17-9-4-3-5-10(8-9)18-14-13(15(21)19-16(14)22)11-6-1-2-7-12(11)20(23)24/h1-8H,(H2,18,19,21,22)
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PubMed
n/an/a 104n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8272
PNG
(2-chloro-5-{[4-(4-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Show SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2ccc(Cl)cc2)ccc1Cl
Show InChI InChI=1S/C17H10Cl2N2O4/c18-9-3-1-8(2-4-9)13-14(16(23)21-15(13)22)20-10-5-6-12(19)11(7-10)17(24)25/h1-7H,(H,24,25)(H2,20,21,22,23)
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n/an/a 109n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8275
PNG
(3-(2-methoxyphenyl)-4-{[4-(methylsulfanyl)phenyl]a...)
Show SMILES COc1ccccc1C1=C(Nc2ccc(SC)cc2)C(=O)NC1=O
Show InChI InChI=1S/C18H16N2O3S/c1-23-14-6-4-3-5-13(14)15-16(18(22)20-17(15)21)19-11-7-9-12(24-2)10-8-11/h3-10H,1-2H3,(H2,19,20,21,22)
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n/an/a 110n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8226
PNG
(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Show SMILES COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O
Show InChI InChI=1S/C17H13ClN2O3/c1-23-13-8-3-2-7-12(13)14-15(17(22)20-16(14)21)19-11-6-4-5-10(18)9-11/h2-9H,1H3,(H2,19,20,21,22)
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n/an/a 114n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373082
PNG
(CHEMBL155680)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2cccc(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C16H11N3O5/c20-12-6-4-10(5-7-12)17-14-13(15(21)18-16(14)22)9-2-1-3-11(8-9)19(23)24/h1-8,20H,(H2,17,18,21,22)
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n/an/a 123n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8345
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 9 | N-[6-(...)
Show SMILES COc1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C17H16N4O2/c1-23-12-4-2-3-11(9-12)14-8-7-13-15(18-14)20-21-16(13)19-17(22)10-5-6-10/h2-4,7-10H,5-6H2,1H3,(H2,18,19,20,21,22)
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n/an/a 125n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373074
PNG
(CHEMBL158719)
Show SMILES [O-][N+](=O)c1ccccc1C1=C(N2CCc3ccccc23)C(=O)NC1=O
Show InChI InChI=1S/C18H13N3O4/c22-17-15(12-6-2-4-8-14(12)21(24)25)16(18(23)19-17)20-10-9-11-5-1-3-7-13(11)20/h1-8H,9-10H2,(H,19,22,23)
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n/an/a 131n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8261
PNG
(3-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-py...)
Show SMILES OC(=O)c1cccc(NC2=C(C(=O)NC2=O)c2cccc(Cl)c2)c1
Show InChI InChI=1S/C17H11ClN2O4/c18-11-5-1-3-9(7-11)13-14(16(22)20-15(13)21)19-12-6-2-4-10(8-12)17(23)24/h1-8H,(H,23,24)(H2,19,20,21,22)
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n/an/a 134n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8260
PNG
(3-{[4-(2-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-py...)
Show SMILES OC(=O)c1cccc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)c1
Show InChI InChI=1S/C17H11ClN2O4/c18-12-7-2-1-6-11(12)13-14(16(22)20-15(13)21)19-10-5-3-4-9(8-10)17(23)24/h1-8H,(H,23,24)(H2,19,20,21,22)
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n/an/a 136n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8244
PNG
(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-methoxyph...)
Show SMILES COc1ccccc1C1=C(Nc2ccc(O)c(Cl)c2)C(=O)NC1=O
Show InChI InChI=1S/C17H13ClN2O4/c1-24-13-5-3-2-4-10(13)14-15(17(23)20-16(14)22)19-9-6-7-12(21)11(18)8-9/h2-8,21H,1H3,(H2,19,20,22,23)
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n/an/a 139n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373085
PNG
(CHEMBL346371)
Show SMILES [O-][N+](=O)c1cccc(c1)C1=C(Nc2ccccc2)C(=O)NC1=O
Show InChI InChI=1S/C16H11N3O4/c20-15-13(10-5-4-8-12(9-10)19(22)23)14(16(21)18-15)17-11-6-2-1-3-7-11/h1-9H,(H2,17,18,20,21)
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n/an/a 141n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8391
PNG
(CHEMBL101804 | N-[6-(furan-2-yl)-1H-pyrazolo[3,4-b...)
Show SMILES O=C(Nc1n[nH]c2nc(ccc12)-c1ccco1)C1CC1
Show InChI InChI=1S/C14H12N4O2/c19-14(8-3-4-8)16-13-9-5-6-10(11-2-1-7-20-11)15-12(9)17-18-13/h1-2,5-8H,3-4H2,(H2,15,16,17,18,19)
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n/an/a 141n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8254
PNG
(3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(3-metho...)
Show SMILES COc1cccc(c1)C1=C(Nc2cc(Cl)c(O)c(Cl)c2)C(=O)NC1=O
Show InChI InChI=1S/C17H12Cl2N2O4/c1-25-10-4-2-3-8(5-10)13-14(17(24)21-16(13)23)20-9-6-11(18)15(22)12(19)7-9/h2-7,22H,1H3,(H2,20,21,23,24)
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n/an/a 142n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8266
PNG
(2-chloro-5-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyr...)
Show SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2ccccc2)ccc1Cl
Show InChI InChI=1S/C17H11ClN2O4/c18-12-7-6-10(8-11(12)17(23)24)19-14-13(15(21)20-16(14)22)9-4-2-1-3-5-9/h1-8H,(H,23,24)(H2,19,20,21,22)
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n/an/a 143n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8249
PNG
(3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-phenyl-2...)
Show SMILES Oc1c(Cl)cc(NC2=C(C(=O)NC2=O)c2ccccc2)cc1Cl
Show InChI InChI=1S/C16H10Cl2N2O3/c17-10-6-9(7-11(18)14(10)21)19-13-12(15(22)20-16(13)23)8-4-2-1-3-5-8/h1-7,21H,(H2,19,20,22,23)
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n/an/a 149n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8243
PNG
(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-chlorophe...)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)cc1Cl
Show InChI InChI=1S/C16H10Cl2N2O3/c17-10-4-2-1-3-9(10)13-14(16(23)20-15(13)22)19-8-5-6-12(21)11(18)7-8/h1-7,21H,(H2,19,20,22,23)
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n/an/a 152n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373078
PNG
(CHEMBL346996)
Show SMILES CSc1ccc(NC2=C(C(=O)NC2=O)c2cccc(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C17H13N3O4S/c1-25-13-7-5-11(6-8-13)18-15-14(16(21)19-17(15)22)10-3-2-4-12(9-10)20(23)24/h2-9H,1H3,(H2,18,19,21,22)
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n/an/a 152n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8231
PNG
(3-[(3-chlorophenyl)amino]-4-(4-methoxyphenyl)-2,5-...)
Show SMILES COc1ccc(cc1)C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O
Show InChI InChI=1S/C17H13ClN2O3/c1-23-13-7-5-10(6-8-13)14-15(17(22)20-16(14)21)19-12-4-2-3-11(18)9-12/h2-9H,1H3,(H2,19,20,21,22)
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n/an/a 156n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373073
PNG
(CHEMBL156153)
Show SMILES [O-][N+](=O)c1cccc(c1)C1=C(N2CCc3ccccc23)C(=O)NC1=O
Show InChI InChI=1S/C18H13N3O4/c22-17-15(12-5-3-6-13(10-12)21(24)25)16(18(23)19-17)20-9-8-11-4-1-2-7-14(11)20/h1-7,10H,8-9H2,(H,19,22,23)
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n/an/a 161n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8274
PNG
(3-(2-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Show SMILES CSc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)cc1
Show InChI InChI=1S/C17H13ClN2O2S/c1-23-11-8-6-10(7-9-11)19-15-14(16(21)20-17(15)22)12-4-2-3-5-13(12)18/h2-9H,1H3,(H2,19,20,21,22)
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n/an/a 161n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8322
PNG
(N-[5-(naphthalen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncc(cc12)-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H18N4O/c1-2-5-18(25)22-20-17-11-16(12-21-19(17)23-24-20)15-9-8-13-6-3-4-7-14(13)10-15/h3-4,6-12H,2,5H2,1H3,(H2,21,22,23,24,25)
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n/an/a 169n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8248
PNG
(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(4-chlorophe...)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2ccc(Cl)cc2)cc1Cl
Show InChI InChI=1S/C16H10Cl2N2O3/c17-9-3-1-8(2-4-9)13-14(16(23)20-15(13)22)19-10-5-6-12(21)11(18)7-10/h1-7,21H,(H2,19,20,22,23)
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n/an/a 173n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8264
PNG
(3-{[4-(4-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-py...)
Show SMILES OC(=O)c1cccc(NC2=C(C(=O)NC2=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C17H11ClN2O4/c18-11-6-4-9(5-7-11)13-14(16(22)20-15(13)21)19-12-3-1-2-10(8-12)17(23)24/h1-8H,(H,23,24)(H2,19,20,21,22)
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n/an/a 186n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8287
PNG
(3-(2,3-dihydro-1H-indol-1-yl)-4-(2-methoxyphenyl)-...)
Show SMILES COc1ccccc1C1=C(N2CCc3ccccc23)C(=O)NC1=O
Show InChI InChI=1S/C19H16N2O3/c1-24-15-9-5-3-7-13(15)16-17(19(23)20-18(16)22)21-11-10-12-6-2-4-8-14(12)21/h2-9H,10-11H2,1H3,(H,20,22,23)
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n/an/a 187n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8225
PNG
(3-(2-chlorophenyl)-4-[(3-chlorophenyl)amino]-2,5-d...)
Show SMILES Clc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)c1
Show InChI InChI=1S/C16H10Cl2N2O2/c17-9-4-3-5-10(8-9)19-14-13(15(21)20-16(14)22)11-6-1-2-7-12(11)18/h1-8H,(H2,19,20,21,22)
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n/an/a 195n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8262
PNG
(3-{[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-p...)
Show SMILES COc1cccc(c1)C1=C(Nc2cccc(c2)C(O)=O)C(=O)NC1=O
Show InChI InChI=1S/C18H14N2O5/c1-25-13-7-3-4-10(9-13)14-15(17(22)20-16(14)21)19-12-6-2-5-11(8-12)18(23)24/h2-9H,1H3,(H,23,24)(H2,19,20,21,22)
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n/an/a 195n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8277
PNG
(3-(3-methoxyphenyl)-4-{[4-(methylsulfanyl)phenyl]a...)
Show SMILES COc1cccc(c1)C1=C(Nc2ccc(SC)cc2)C(=O)NC1=O
Show InChI InChI=1S/C18H16N2O3S/c1-23-13-5-3-4-11(10-13)15-16(18(22)20-17(15)21)19-12-6-8-14(24-2)9-7-12/h3-10H,1-2H3,(H2,19,20,21,22)
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n/an/a 203n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8265
PNG
(3-{[4-(4-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-p...)
Show SMILES COc1ccc(cc1)C1=C(Nc2cccc(c2)C(O)=O)C(=O)NC1=O
Show InChI InChI=1S/C18H14N2O5/c1-25-13-7-5-10(6-8-13)14-15(17(22)20-16(14)21)19-12-4-2-3-11(9-12)18(23)24/h2-9H,1H3,(H,23,24)(H2,19,20,21,22)
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n/an/a 214n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8387
PNG
(CHEMBL318522 | N-[6-(thiophen-2-yl)-1H-indazol-3-y...)
Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1cccs1)C1CC1
Show InChI InChI=1S/C15H13N3OS/c19-15(9-3-4-9)16-14-11-6-5-10(8-12(11)17-18-14)13-2-1-7-20-13/h1-2,5-9H,3-4H2,(H2,16,17,18,19)
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n/an/a 215n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8219
PNG
(3-(2-chlorophenyl)-4-(phenylamino)-2,5-dihydro-1H-...)
Show SMILES Clc1ccccc1C1=C(Nc2ccccc2)C(=O)NC1=O
Show InChI InChI=1S/C16H11ClN2O2/c17-12-9-5-4-8-11(12)13-14(16(21)19-15(13)20)18-10-6-2-1-3-7-10/h1-9H,(H2,18,19,20,21)
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n/an/a 216n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8220
PNG
(3-(2-methoxyphenyl)-4-(phenylamino)-2,5-dihydro-1H...)
Show SMILES COc1ccccc1C1=C(Nc2ccccc2)C(=O)NC1=O
Show InChI InChI=1S/C17H14N2O3/c1-22-13-10-6-5-9-12(13)14-15(17(21)19-16(14)20)18-11-7-3-2-4-8-11/h2-10H,1H3,(H2,18,19,20,21)
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n/an/a 216n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8354
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 18 | N-{5-...)
Show SMILES Clc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccccc1
Show InChI InChI=1S/C16H13ClN4O/c17-12-8-11-14(18-13(12)9-4-2-1-3-5-9)20-21-15(11)19-16(22)10-6-7-10/h1-5,8,10H,6-7H2,(H2,18,19,20,21,22)
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n/an/a 234n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373083
PNG
(CHEMBL158559)
Show SMILES Oc1cccc(NC2=C(C(=O)NC2=O)c2cccc(c2)[N+]([O-])=O)c1
Show InChI InChI=1S/C16H11N3O5/c20-12-6-2-4-10(8-12)17-14-13(15(21)18-16(14)22)9-3-1-5-11(7-9)19(23)24/h1-8,20H,(H2,17,18,21,22)
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n/an/a 236n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8323
PNG
(N-[5-(naphthalen-1-yl)-1H-pyrazolo[3,4-b]pyridin-3...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncc(cc12)-c1cccc2ccccc12
Show InChI InChI=1S/C20H18N4O/c1-2-6-18(25)22-20-17-11-14(12-21-19(17)23-24-20)16-10-5-8-13-7-3-4-9-15(13)16/h3-5,7-12H,2,6H2,1H3,(H2,21,22,23,24,25)
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n/an/a 241n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8280
PNG
(3-(4-methoxyphenyl)-4-{[4-(methylsulfanyl)phenyl]a...)
Show SMILES COc1ccc(cc1)C1=C(Nc2ccc(SC)cc2)C(=O)NC1=O
Show InChI InChI=1S/C18H16N2O3S/c1-23-13-7-3-11(4-8-13)15-16(18(22)20-17(15)21)19-12-5-9-14(24-2)10-6-12/h3-10H,1-2H3,(H2,19,20,21,22)
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n/an/a 243n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM7463
PNG
(4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine |...)
Show SMILES Nc1n[nH]c2nnc(-c3ccccc3)c(-c3ccccc3)c12
Show InChI InChI=1S/C17H13N5/c18-16-14-13(11-7-3-1-4-8-11)15(12-9-5-2-6-10-12)19-21-17(14)22-20-16/h1-10H,(H3,18,20,21,22)
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n/an/a 250n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373087
PNG
(CHEMBL155931)
Show SMILES Oc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2[N+]([O-])=O)c1
Show InChI InChI=1S/C16H11N3O5/c20-10-5-3-4-9(8-10)17-14-13(15(21)18-16(14)22)11-6-1-2-7-12(11)19(23)24/h1-8,20H,(H2,17,18,21,22)
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n/an/a 251n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8228
PNG
(3-[(3-chlorophenyl)amino]-4-(3-methoxyphenyl)-2,5-...)
Show SMILES COc1cccc(c1)C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O
Show InChI InChI=1S/C17H13ClN2O3/c1-23-13-7-2-4-10(8-13)14-15(17(22)20-16(14)21)19-12-6-3-5-11(18)9-12/h2-9H,1H3,(H2,19,20,21,22)
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n/an/a 257n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8234
PNG
(3-[(3-hydroxyphenyl)amino]-4-(2-methoxyphenyl)-2,5...)
Show SMILES COc1ccccc1C1=C(Nc2cccc(O)c2)C(=O)NC1=O
Show InChI InChI=1S/C17H14N2O4/c1-23-13-8-3-2-7-12(13)14-15(17(22)19-16(14)21)18-10-5-4-6-11(20)9-10/h2-9,20H,1H3,(H2,18,19,21,22)
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n/an/a 259n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8259
PNG
(3-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-3-yl)...)
Show SMILES OC(=O)c1cccc(NC2=C(C(=O)NC2=O)c2ccccc2)c1
Show InChI InChI=1S/C17H12N2O4/c20-15-13(10-5-2-1-3-6-10)14(16(21)19-15)18-12-8-4-7-11(9-12)17(22)23/h1-9H,(H,22,23)(H2,18,19,20,21)
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n/an/a 291n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8306
PNG
(N-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl}acetami...)
Show SMILES CC(=O)Nc1n[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C14H12N4O/c1-9(19)16-14-12-7-11(8-15-13(12)17-18-14)10-5-3-2-4-6-10/h2-8H,1H3,(H2,15,16,17,18,19)
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n/an/a 291n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8224
PNG
(3-[(3-chlorophenyl)amino]-4-phenyl-2,5-dihydro-1H-...)
Show SMILES Clc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2)c1
Show InChI InChI=1S/C16H11ClN2O2/c17-11-7-4-8-12(9-11)18-14-13(15(20)19-16(14)21)10-5-2-1-3-6-10/h1-9H,(H2,18,19,20,21)
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n/an/a 301n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8242
PNG
(3-(4-chlorophenyl)-4-[(4-hydroxyphenyl)amino]-2,5-...)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C16H11ClN2O3/c17-10-3-1-9(2-4-10)13-14(16(22)19-15(13)21)18-11-5-7-12(20)8-6-11/h1-8,20H,(H2,18,19,21,22)
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n/an/a 317n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8384
PNG
(CHEMBL260929 | N-[6-(1H-pyrrol-2-yl)-1H-indazol-3-...)
Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccc[nH]1)C1CC1
Show InChI InChI=1S/C15H14N4O/c20-15(9-3-4-9)17-14-11-6-5-10(8-13(11)18-19-14)12-2-1-7-16-12/h1-2,5-9,16H,3-4H2,(H2,17,18,19,20)
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n/an/a 320n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8388
PNG
(CHEMBL260928 | N-[6-(thiophen-3-yl)-1H-indazol-3-y...)
Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccsc1)C1CC1
Show InChI InChI=1S/C15H13N3OS/c19-15(9-1-2-9)16-14-12-4-3-10(7-13(12)17-18-14)11-5-6-20-8-11/h3-9H,1-2H2,(H2,16,17,18,19)
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n/an/a 329n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8286
PNG
(3-(2-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-2...)
Show SMILES Clc1ccccc1C1=C(N2CCc3ccccc23)C(=O)NC1=O
Show InChI InChI=1S/C18H13ClN2O2/c19-13-7-3-2-6-12(13)15-16(18(23)20-17(15)22)21-10-9-11-5-1-4-8-14(11)21/h1-8H,9-10H2,(H,20,22,23)
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n/an/a 337n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8313
PNG
(N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncc(cc12)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C16H23BN4O3/c1-6-7-12(22)19-14-11-8-10(9-18-13(11)20-21-14)17-23-15(2,3)16(4,5)24-17/h8-9H,6-7H2,1-5H3,(H2,18,19,20,21,22)
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n/an/a 356n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8233
PNG
(3-(2-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-2,5-...)
Show SMILES Oc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)c1
Show InChI InChI=1S/C16H11ClN2O3/c17-12-7-2-1-6-11(12)13-14(16(22)19-15(13)21)18-9-4-3-5-10(20)8-9/h1-8,20H,(H2,18,19,21,22)
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n/an/a 374n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8356
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 20 | N-{5-...)
Show SMILES CN1CCC(CC1)C(=O)Nc1n[nH]c2nc(c(Br)cc12)-c1ccccc1
Show InChI InChI=1S/C19H20BrN5O/c1-25-9-7-13(8-10-25)19(26)22-18-14-11-15(20)16(21-17(14)23-24-18)12-5-3-2-4-6-12/h2-6,11,13H,7-10H2,1H3,(H2,21,22,23,24,26)
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n/an/a 383n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8223
PNG
(3-(4-methoxyphenyl)-4-(phenylamino)-2,5-dihydro-1H...)
Show SMILES COc1ccc(cc1)C1=C(Nc2ccccc2)C(=O)NC1=O
Show InChI InChI=1S/C17H14N2O3/c1-22-13-9-7-11(8-10-13)14-15(17(21)19-16(14)20)18-12-5-3-2-4-6-12/h2-10H,1H3,(H2,18,19,20,21)
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n/an/a 390n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373076
PNG
(CHEMBL158835)
Show SMILES CSc1ccc(NC2=C(C(=O)NC2=O)c2ccc(cc2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C17H13N3O4S/c1-25-13-8-4-11(5-9-13)18-15-14(16(21)19-17(15)22)10-2-6-12(7-3-10)20(23)24/h2-9H,1H3,(H2,18,19,21,22)
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n/an/a 392n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8273
PNG
(3-{[4-(methylsulfanyl)phenyl]amino}-4-phenyl-2,5-d...)
Show SMILES CSc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2)cc1
Show InChI InChI=1S/C17H14N2O2S/c1-22-13-9-7-12(8-10-13)18-15-14(16(20)19-17(15)21)11-5-3-2-4-6-11/h2-10H,1H3,(H2,18,19,20,21)
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n/an/a 404n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8239
PNG
(3-(4-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-2,5-...)
Show SMILES Oc1cccc(NC2=C(C(=O)NC2=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C16H11ClN2O3/c17-10-6-4-9(5-7-10)13-14(16(22)19-15(13)21)18-11-2-1-3-12(20)8-11/h1-8,20H,(H2,18,19,21,22)
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n/an/a 407n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8352
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 16 | N-{5,...)
Show SMILES O=C(Nc1n[nH]c2nc(-c3ccccc3)c(cc12)-c1ccccc1)C1CC1
Show InChI InChI=1S/C22H18N4O/c27-22(16-11-12-16)24-21-18-13-17(14-7-3-1-4-8-14)19(23-20(18)25-26-21)15-9-5-2-6-10-15/h1-10,13,16H,11-12H2,(H2,23,24,25,26,27)
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n/an/a 415n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8340
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 4 | N-{6-p...)
Show SMILES O=C(Nc1n[nH]c2nc(ccc12)-c1ccccc1)C1CC1
Show InChI InChI=1S/C16H14N4O/c21-16(11-6-7-11)18-15-12-8-9-13(17-14(12)19-20-15)10-4-2-1-3-5-10/h1-5,8-9,11H,6-7H2,(H2,17,18,19,20,21)
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n/an/a 425n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8300
PNG
(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amine | pyraz...)
Show SMILES Nc1n[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C12H10N4/c13-11-10-6-9(7-14-12(10)16-15-11)8-4-2-1-3-5-8/h1-7H,(H3,13,14,15,16)
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n/an/a 430n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8320
PNG
(N-[5-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncc(cc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5O/c1-2-3-13(21)18-15-12-8-11(9-17-14(12)19-20-15)10-4-6-16-7-5-10/h4-9H,2-3H2,1H3,(H2,17,18,19,20,21)
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n/an/a 443n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8230
PNG
(3-(4-chlorophenyl)-4-[(3-chlorophenyl)amino]-2,5-d...)
Show SMILES Clc1ccc(cc1)C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O
Show InChI InChI=1S/C16H10Cl2N2O2/c17-10-6-4-9(5-7-10)13-14(16(22)20-15(13)21)19-12-3-1-2-11(18)8-12/h1-8H,(H2,19,20,21,22)
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n/an/a 447n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8289
PNG
(3-(3-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-2...)
Show SMILES Clc1cccc(c1)C1=C(N2CCc3ccccc23)C(=O)NC1=O
Show InChI InChI=1S/C18H13ClN2O2/c19-13-6-3-5-12(10-13)15-16(18(23)20-17(15)22)21-9-8-11-4-1-2-7-14(11)21/h1-7,10H,8-9H2,(H,20,22,23)
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n/an/a 460n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8237
PNG
(3-[(3-hydroxyphenyl)amino]-4-(3-methoxyphenyl)-2,5...)
Show SMILES COc1cccc(c1)C1=C(Nc2cccc(O)c2)C(=O)NC1=O
Show InChI InChI=1S/C17H14N2O4/c1-23-13-7-2-4-10(8-13)14-15(17(22)19-16(14)21)18-11-5-3-6-12(20)9-11/h2-9,20H,1H3,(H2,18,19,21,22)
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n/an/a 472n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8374
PNG
(CHEMBL407113 | N-[6-(3-sulfamoylphenyl)-1H-indazol...)
Show SMILES NS(=O)(=O)c1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
Show InChI InChI=1S/C17H16N4O3S/c18-25(23,24)13-3-1-2-11(8-13)12-6-7-14-15(9-12)20-21-16(14)19-17(22)10-4-5-10/h1-3,6-10H,4-5H2,(H2,18,23,24)(H2,19,20,21,22)
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n/an/a 481n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8240
PNG
(3-[(3-hydroxyphenyl)amino]-4-(4-methoxyphenyl)-2,5...)
Show SMILES COc1ccc(cc1)C1=C(Nc2cccc(O)c2)C(=O)NC1=O
Show InChI InChI=1S/C17H14N2O4/c1-23-13-7-5-10(6-8-13)14-15(17(22)19-16(14)21)18-11-3-2-4-12(20)9-11/h2-9,20H,1H3,(H2,18,19,21,22)
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n/an/a 481n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8369
PNG
(CHEMBL405021 | N-(6-phenyl-1H-indazol-3-yl)cyclopr...)
Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccccc1)C1CC1
Show InChI InChI=1S/C17H15N3O/c21-17(12-6-7-12)18-16-14-9-8-13(10-15(14)19-20-16)11-4-2-1-3-5-11/h1-5,8-10,12H,6-7H2,(H2,18,19,20,21)
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n/an/a 498n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8222
PNG
(3-(4-chlorophenyl)-4-(phenylamino)-2,5-dihydro-1H-...)
Show SMILES Clc1ccc(cc1)C1=C(Nc2ccccc2)C(=O)NC1=O
Show InChI InChI=1S/C16H11ClN2O2/c17-11-8-6-10(7-9-11)13-14(16(21)19-15(13)20)18-12-4-2-1-3-5-12/h1-9H,(H2,18,19,20,21)
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n/an/a 514n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8279
PNG
(3-(4-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Show SMILES CSc1ccc(NC2=C(C(=O)NC2=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C17H13ClN2O2S/c1-23-13-8-6-12(7-9-13)19-15-14(16(21)20-17(15)22)10-2-4-11(18)5-3-10/h2-9H,1H3,(H2,19,20,21,22)
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n/an/a 529n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM7476
PNG
(3-Amino-5-phenyl-1H-pyrazolo[3,4-c]pyridazine | 5-...)
Show SMILES Nc1n[nH]c2nnc(cc12)-c1ccccc1
Show InChI InChI=1S/C11H9N5/c12-10-8-6-9(7-4-2-1-3-5-7)13-15-11(8)16-14-10/h1-6H,(H3,12,14,15,16)
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n/an/a 530n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8276
PNG
(3-(3-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Show SMILES CSc1ccc(NC2=C(C(=O)NC2=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C17H13ClN2O2S/c1-23-13-7-5-12(6-8-13)19-15-14(16(21)20-17(15)22)10-3-2-4-11(18)9-10/h2-9H,1H3,(H2,19,20,21,22)
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n/an/a 532n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8218
PNG
(3-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2,...)
Show SMILES O=C1NC(=O)C(=C1Nc1ccccc1)c1ccccc1
Show InChI InChI=1S/C16H12N2O2/c19-15-13(11-7-3-1-4-8-11)14(16(20)18-15)17-12-9-5-2-6-10-12/h1-10H,(H2,17,18,19,20)
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n/an/a 590n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8326
PNG
(N-{4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl}b...)
Show SMILES CCCC(=O)Nc1n[nH]c2nnc(-c3ccccc3)c(-c3ccccc3)c12
Show InChI InChI=1S/C21H19N5O/c1-2-9-16(27)22-20-18-17(14-10-5-3-6-11-14)19(15-12-7-4-8-13-15)23-25-21(18)26-24-20/h3-8,10-13H,2,9H2,1H3,(H2,22,24,25,26,27)
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n/an/a 691n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8292
PNG
(3-(2,3-dihydro-1H-indol-1-yl)-4-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)C1=C(N2CCc3ccccc23)C(=O)NC1=O
Show InChI InChI=1S/C19H16N2O3/c1-24-14-8-6-13(7-9-14)16-17(19(23)20-18(16)22)21-11-10-12-4-2-3-5-15(12)21/h2-9H,10-11H2,1H3,(H,20,22,23)
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n/an/a 694n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8232
PNG
(3-[(3-hydroxyphenyl)amino]-4-phenyl-2,5-dihydro-1H...)
Show SMILES Oc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2)c1
Show InChI InChI=1S/C16H12N2O3/c19-12-8-4-7-11(9-12)17-14-13(15(20)18-16(14)21)10-5-2-1-3-6-10/h1-9,19H,(H2,17,18,20,21)
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n/an/a 704n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8382
PNG
(CHEMBL261660 | N-[6-(3-fluorophenyl)-1H-indazol-3-...)
Show SMILES Fc1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
Show InChI InChI=1S/C17H14FN3O/c18-13-3-1-2-11(8-13)12-6-7-14-15(9-12)20-21-16(14)19-17(22)10-4-5-10/h1-3,6-10H,4-5H2,(H2,19,20,21,22)
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n/an/a 828n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8321
PNG
(N-[5-(4-phenylphenyl)-1H-pyrazolo[3,4-b]pyridin-3-...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncc(cc12)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H20N4O/c1-2-6-20(27)24-22-19-13-18(14-23-21(19)25-26-22)17-11-9-16(10-12-17)15-7-4-3-5-8-15/h3-5,7-14H,2,6H2,1H3,(H2,23,24,25,26,27)
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n/an/a 851n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8379
PNG
(N-[6-(2,5-difluorophenyl)-1H-indazol-3-yl]cyclopro...)
Show SMILES Fc1ccc(F)c(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
Show InChI InChI=1S/C17H13F2N3O/c18-11-4-6-14(19)13(8-11)10-3-5-12-15(7-10)21-22-16(12)20-17(23)9-1-2-9/h3-9H,1-2H2,(H2,20,21,22,23)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8302
PNG
(5-phenyl-1H-pyrazolo[3,4-c]pyridin-3-amine | pyraz...)
Show SMILES Nc1n[nH]c2cnc(cc12)-c1ccccc1
Show InChI InChI=1S/C12H10N4/c13-12-9-6-10(8-4-2-1-3-5-8)14-7-11(9)15-16-12/h1-7H,(H3,13,15,16)
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n/an/a 1.26E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50373075
PNG
(CHEMBL156801)
Show SMILES CN(C1=C(C(=O)NC1=O)c1cccc(c1)[N+]([O-])=O)c1ccccc1
Show InChI InChI=1S/C17H13N3O4/c1-19(12-7-3-2-4-8-12)15-14(16(21)18-17(15)22)11-6-5-9-13(10-11)20(23)24/h2-10H,1H3,(H,18,21,22)
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8291
PNG
(3-(4-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-2...)
Show SMILES Clc1ccc(cc1)C1=C(N2CCc3ccccc23)C(=O)NC1=O
Show InChI InChI=1S/C18H13ClN2O2/c19-13-7-5-12(6-8-13)15-16(18(23)20-17(15)22)21-10-9-11-3-1-2-4-14(11)21/h1-8H,9-10H2,(H,20,22,23)
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n/an/a 1.41E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8236
PNG
(3-(3-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-2,5-...)
Show SMILES Oc1cccc(NC2=C(C(=O)NC2=O)c2cccc(Cl)c2)c1
Show InChI InChI=1S/C16H11ClN2O3/c17-10-4-1-3-9(7-10)13-14(16(22)19-15(13)21)18-11-5-2-6-12(20)8-11/h1-8,20H,(H2,18,19,21,22)
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n/an/a 1.48E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8347
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 11 | N-[6-...)
Show SMILES COc1ccccc1-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C17H16N4O2/c1-23-14-5-3-2-4-11(14)13-9-8-12-15(18-13)20-21-16(12)19-17(22)10-6-7-10/h2-5,8-10H,6-7H2,1H3,(H2,18,19,20,21,22)
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n/an/a 1.59E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8285
PNG
(3-(4-chlorophenyl)-4-[methyl(phenyl)amino]-2,5-dih...)
Show SMILES CN(C1=C(C(=O)NC1=O)c1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1S/C17H13ClN2O2/c1-20(13-5-3-2-4-6-13)15-14(16(21)19-17(15)22)11-7-9-12(18)10-8-11/h2-10H,1H3,(H,19,21,22)
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n/an/a 2.29E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8314
PNG
(N-{1H-pyrazolo[3,4-b]pyridin-3-yl}butanamide | pyr...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncccc12
Show InChI InChI=1S/C10H12N4O/c1-2-4-8(15)12-10-7-5-3-6-11-9(7)13-14-10/h3,5-6H,2,4H2,1H3,(H2,11,12,13,14,15)
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n/an/a 2.34E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8282
PNG
(3-[methyl(phenyl)amino]-4-phenyl-2,5-dihydro-1H-py...)
Show SMILES CN(C1=C(C(=O)NC1=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H14N2O2/c1-19(13-10-6-3-7-11-13)15-14(16(20)18-17(15)21)12-8-4-2-5-9-12/h2-11H,1H3,(H,18,20,21)
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n/an/a 2.61E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8325
PNG
(N-{5-phenyl-1H-pyrazolo[4,3-d]pyrimidin-3-yl}butan...)
Show SMILES CCCC(=O)Nc1[nH]nc2cnc(nc12)-c1ccccc1
Show InChI InChI=1S/C15H15N5O/c1-2-6-12(21)17-15-13-11(19-20-15)9-16-14(18-13)10-7-4-3-5-8-10/h3-5,7-9H,2,6H2,1H3,(H2,17,19,20,21)
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8311
PNG
(3-ethyl-1-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl...)
Show SMILES CCNC(=O)Nc1n[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C15H15N5O/c1-2-16-15(21)18-14-12-8-11(9-17-13(12)19-20-14)10-6-4-3-5-7-10/h3-9H,2H2,1H3,(H3,16,17,18,19,20,21)
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n/an/a 2.81E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8312
PNG
(N-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl}methane...)
Show SMILES CS(=O)(=O)Nc1n[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C13H12N4O2S/c1-20(18,19)17-13-11-7-10(8-14-12(11)15-16-13)9-5-3-2-4-6-9/h2-8H,1H3,(H2,14,15,16,17)
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n/an/a 3.57E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8304
PNG
(5-phenylpyrido[3,2-d][1,2]oxazol-3-amine | isoxazo...)
Show SMILES Nc1noc2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C12H9N3O/c13-11-10-6-9(7-14-12(10)16-15-11)8-4-2-1-3-5-8/h1-7H,(H2,13,15)
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8301
PNG
(4-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amine | pyraz...)
Show SMILES Nc1n[nH]c2nccc(-c3ccccc3)c12
Show InChI InChI=1S/C12H10N4/c13-11-10-9(8-4-2-1-3-5-8)6-7-14-12(10)16-15-11/h1-7H,(H3,13,14,15,16)
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8305
PNG
(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine | pyrrol...)
Show SMILES Nc1c[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C13H11N3/c14-12-8-16-13-11(12)6-10(7-15-13)9-4-2-1-3-5-9/h1-8H,14H2,(H,15,16)
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8342
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 6 | N-[6-(...)
Show SMILES COc1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C17H16N4O2/c1-23-12-6-4-10(5-7-12)14-9-8-13-15(18-14)20-21-16(13)19-17(22)11-2-3-11/h4-9,11H,2-3H2,1H3,(H2,18,19,20,21,22)
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8303
PNG
(1-methyl-5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amin...)
Show SMILES Cn1nc(N)c2cc(cnc12)-c1ccccc1
Show InChI InChI=1S/C13H12N4/c1-17-13-11(12(14)16-17)7-10(8-15-13)9-5-3-2-4-6-9/h2-8H,1H3,(H2,14,16)
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%