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PubMed code 18343109

Compile data set for download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375196
PNG
(CHEMBL402531)
Show SMILES CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1cccs1
Show InChI InChI=1S/C27H22N4O2S/c1-3-31-20-9-6-14(26(32)21-5-4-10-34-21)11-16(20)23-17-12-28-27(33)24(17)22-15(25(23)31)7-8-19-18(22)13-30(2)29-19/h4-6,9-11,13H,3,7-8,12H2,1-2H3,(H,28,33)
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n/an/a 1n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375205
PNG
(CHEMBL428876)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4[nH]c32)C(=O)c2cccs2)n1
Show InChI InChI=1S/C25H18N4O2S/c1-29-11-16-18(28-29)7-5-13-20(16)22-15(10-26-25(22)31)21-14-9-12(4-6-17(14)27-23(13)21)24(30)19-3-2-8-32-19/h2-4,6,8-9,11,27H,5,7,10H2,1H3,(H,26,31)
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n/an/a 2n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375207
PNG
(CHEMBL255405)
Show SMILES CCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(C)=O
Show InChI InChI=1S/C25H24N4O2/c1-4-9-29-20-8-5-14(13(2)30)10-16(20)22-17-11-26-25(31)23(17)21-15(24(22)29)6-7-19-18(21)12-28(3)27-19/h5,8,10,12H,4,6-7,9,11H2,1-3H3,(H,26,31)
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n/an/a 3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375189
PNG
(CHEMBL410100)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1ccco1
Show InChI InChI=1S/C29H26N4O3/c1-15(2)13-33-22-9-6-16(28(34)23-5-4-10-36-23)11-18(22)25-19-12-30-29(35)26(19)24-17(27(25)33)7-8-21-20(24)14-32(3)31-21/h4-6,9-11,14-15H,7-8,12-13H2,1-3H3,(H,30,35)
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375195
PNG
(CHEMBL255959)
Show SMILES CCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1cccs1
Show InChI InChI=1S/C28H24N4O2S/c1-3-10-32-21-9-6-15(27(33)22-5-4-11-35-22)12-17(21)24-18-13-29-28(34)25(18)23-16(26(24)32)7-8-20-19(23)14-31(2)30-20/h4-6,9,11-12,14H,3,7-8,10,13H2,1-2H3,(H,29,34)
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n/an/a 5n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375191
PNG
(CHEMBL401881)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1sccc1C
Show InChI InChI=1S/C30H28N4O2S/c1-15(2)13-34-23-8-5-17(28(35)29-16(3)9-10-37-29)11-19(23)25-20-12-31-30(36)26(20)24-18(27(25)34)6-7-22-21(24)14-33(4)32-22/h5,8-11,14-15H,6-7,12-13H2,1-4H3,(H,31,36)
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n/an/a 5n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375204
PNG
(CHEMBL444105)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1cccs1
Show InChI InChI=1S/C29H26N4O2S/c1-15(2)13-33-22-9-6-16(28(34)23-5-4-10-36-23)11-18(22)25-19-12-30-29(35)26(19)24-17(27(25)33)7-8-21-20(24)14-32(3)31-21/h4-6,9-11,14-15H,7-8,12-13H2,1-3H3,(H,30,35)
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n/an/a 6n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375193
PNG
(CHEMBL269924)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1sccc1Cl
Show InChI InChI=1S/C29H25ClN4O2S/c1-14(2)12-34-22-7-4-15(27(35)28-20(30)8-9-37-28)10-17(22)24-18-11-31-29(36)25(18)23-16(26(24)34)5-6-21-19(23)13-33(3)32-21/h4,7-10,13-14H,5-6,11-12H2,1-3H3,(H,31,36)
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n/an/a 7n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375202
PNG
(CHEMBL411520)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1ccoc1
Show InChI InChI=1S/C29H26N4O3/c1-15(2)12-33-23-7-4-16(28(34)17-8-9-36-14-17)10-19(23)25-20-11-30-29(35)26(20)24-18(27(25)33)5-6-22-21(24)13-32(3)31-22/h4,7-10,13-15H,5-6,11-12H2,1-3H3,(H,30,35)
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n/an/a 8n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375199
PNG
(CHEMBL271301)
Show SMILES CC(=O)c1ccc2n(C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C23H20N4O2/c1-11(28)12-4-7-18-14(8-12)20-15-9-24-23(29)21(15)19-13(22(20)27(18)3)5-6-17-16(19)10-26(2)25-17/h4,7-8,10H,5-6,9H2,1-3H3,(H,24,29)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50375193
PNG
(CHEMBL269924)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1sccc1Cl
Show InChI InChI=1S/C29H25ClN4O2S/c1-14(2)12-34-22-7-4-15(27(35)28-20(30)8-9-37-28)10-17(22)24-18-11-31-29(36)25(18)23-16(26(24)34)5-6-21-19(23)13-33(3)32-21/h4,7-10,13-14H,5-6,11-12H2,1-3H3,(H,31,36)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse VEGFR2 autophosphorylation in NIH3T3 cell


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50375204
PNG
(CHEMBL444105)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1cccs1
Show InChI InChI=1S/C29H26N4O2S/c1-15(2)13-33-22-9-6-16(28(34)23-5-4-10-36-23)11-18(22)25-19-12-30-29(35)26(19)24-17(27(25)33)7-8-21-20(24)14-32(3)31-21/h4-6,9-11,14-15H,7-8,12-13H2,1-3H3,(H,30,35)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse VEGFR2 autophosphorylation in NIH3T3 cell


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375191
PNG
(CHEMBL401881)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1sccc1C
Show InChI InChI=1S/C30H28N4O2S/c1-15(2)13-34-23-8-5-17(28(35)29-16(3)9-10-37-29)11-19(23)25-20-12-31-30(36)26(20)24-18(27(25)34)6-7-22-21(24)14-33(4)32-22/h5,8-11,14-15H,6-7,12-13H2,1-4H3,(H,31,36)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375203
PNG
(CHEMBL271861)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1cc(C)cs1
Show InChI InChI=1S/C30H28N4O2S/c1-15(2)12-34-23-8-5-17(29(35)24-9-16(3)14-37-24)10-19(23)26-20-11-31-30(36)27(20)25-18(28(26)34)6-7-22-21(25)13-33(4)32-22/h5,8-10,13-15H,6-7,11-12H2,1-4H3,(H,31,36)
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n/an/a 11n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375210
PNG
(CHEMBL406909)
Show SMILES CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(C)=O
Show InChI InChI=1S/C24H22N4O2/c1-4-28-19-8-5-13(12(2)29)9-15(19)21-16-10-25-24(30)22(16)20-14(23(21)28)6-7-18-17(20)11-27(3)26-18/h5,8-9,11H,4,6-7,10H2,1-3H3,(H,25,30)
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n/an/a 13n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375190
PNG
(CHEMBL271849)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1ccsc1
Show InChI InChI=1S/C29H26N4O2S/c1-15(2)12-33-23-7-4-16(28(34)17-8-9-36-14-17)10-19(23)25-20-11-30-29(35)26(20)24-18(27(25)33)5-6-22-21(24)13-32(3)31-22/h4,7-10,13-15H,5-6,11-12H2,1-3H3,(H,30,35)
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n/an/a 13n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375193
PNG
(CHEMBL269924)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1sccc1Cl
Show InChI InChI=1S/C29H25ClN4O2S/c1-14(2)12-34-22-7-4-15(27(35)28-20(30)8-9-37-28)10-17(22)24-18-11-31-29(36)25(18)23-16(26(24)34)5-6-21-19(23)13-33(3)32-21/h4,7-10,13-14H,5-6,11-12H2,1-3H3,(H,31,36)
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n/an/a 13n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375192
PNG
(CHEMBL403158)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1sccc1Br
Show InChI InChI=1S/C29H25BrN4O2S/c1-14(2)12-34-22-7-4-15(27(35)28-20(30)8-9-37-28)10-17(22)24-18-11-31-29(36)25(18)23-16(26(24)34)5-6-21-19(23)13-33(3)32-21/h4,7-10,13-14H,5-6,11-12H2,1-3H3,(H,31,36)
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n/an/a 15n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375209
PNG
(CHEMBL270828)
Show SMILES CCn1c2ccccc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C22H20N4O/c1-3-26-17-7-5-4-6-12(17)19-14-10-23-22(27)20(14)18-13(21(19)26)8-9-16-15(18)11-25(2)24-16/h4-7,11H,3,8-10H2,1-2H3,(H,23,27)
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n/an/a 15n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375194
PNG
(CHEMBL402182)
Show SMILES CC(C)n1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1cccs1
Show InChI InChI=1S/C28H24N4O2S/c1-14(2)32-21-9-6-15(27(33)22-5-4-10-35-22)11-17(21)24-18-12-29-28(34)25(18)23-16(26(24)32)7-8-20-19(23)13-31(3)30-20/h4-6,9-11,13-14H,7-8,12H2,1-3H3,(H,29,34)
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n/an/a 15n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136024
PNG
(3-(9-isopropoxymethyl-5-oxo-6,7,12,13-tetrahydro-5...)
Show SMILES CC(C)OCc1ccc2n(CCCOC(=O)CN(C)C)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C32H35N3O4/c1-19(2)39-18-20-10-11-26-23(14-20)29-25-16-33-32(37)30(25)28-22-9-6-5-8-21(22)15-24(28)31(29)35(26)12-7-13-38-27(36)17-34(3)4/h5-6,8-11,14,19H,7,12-13,15-18H2,1-4H3,(H,33,37)
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n/an/a 16n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50236255
PNG
(19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4ccccc4[nH]c32)n1
Show InChI InChI=1S/C20H16N4O/c1-24-9-13-15(23-24)7-6-11-16(13)18-12(8-21-20(18)25)17-10-4-2-3-5-14(10)22-19(11)17/h2-5,9,22H,6-8H2,1H3,(H,21,25)
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n/an/a 16n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375201
PNG
(CHEMBL271042)
Show SMILES CCCn1c2ccccc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C23H22N4O/c1-3-10-27-18-7-5-4-6-13(18)20-15-11-24-23(28)21(15)19-14(22(20)27)8-9-17-16(19)12-26(2)25-17/h4-7,12H,3,8-11H2,1-2H3,(H,24,28)
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n/an/a 16n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375200
PNG
(CHEMBL270827)
Show SMILES CC(C)Cn1c2ccccc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C24H24N4O/c1-13(2)11-28-19-7-5-4-6-14(19)21-16-10-25-24(29)22(16)20-15(23(21)28)8-9-18-17(20)12-27(3)26-18/h4-7,12-13H,8-11H2,1-3H3,(H,25,29)
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n/an/a 17n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375204
PNG
(CHEMBL444105)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1cccs1
Show InChI InChI=1S/C29H26N4O2S/c1-15(2)13-33-22-9-6-16(28(34)23-5-4-10-36-23)11-18(22)25-19-12-30-29(35)26(19)24-17(27(25)33)7-8-21-20(24)14-32(3)31-21/h4-6,9-11,14-15H,7-8,12-13H2,1-3H3,(H,30,35)
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n/an/a 20n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375197
PNG
(CHEMBL401900)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(C)=O
Show InChI InChI=1S/C26H26N4O2/c1-13(2)11-30-21-8-5-15(14(3)31)9-17(21)23-18-10-27-26(32)24(18)22-16(25(23)30)6-7-20-19(22)12-29(4)28-20/h5,8-9,12-13H,6-7,10-11H2,1-4H3,(H,27,32)
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n/an/a 21n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375194
PNG
(CHEMBL402182)
Show SMILES CC(C)n1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1cccs1
Show InChI InChI=1S/C28H24N4O2S/c1-14(2)32-21-9-6-15(27(33)22-5-4-10-35-22)11-17(21)24-18-12-29-28(34)25(18)23-16(26(24)32)7-8-20-19(23)13-31(3)30-20/h4-6,9-11,13-14H,7-8,12H2,1-3H3,(H,29,34)
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n/an/a 24n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375192
PNG
(CHEMBL403158)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1sccc1Br
Show InChI InChI=1S/C29H25BrN4O2S/c1-14(2)12-34-22-7-4-15(27(35)28-20(30)8-9-37-28)10-17(22)24-18-11-31-29(36)25(18)23-16(26(24)34)5-6-21-19(23)13-33(3)32-21/h4,7-10,13-14H,5-6,11-12H2,1-3H3,(H,31,36)
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n/an/a 25n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375206
PNG
(CHEMBL255406)
Show SMILES CCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(C)=O
Show InChI InChI=1S/C26H26N4O2/c1-4-5-10-30-21-9-6-15(14(2)31)11-17(21)23-18-12-27-26(32)24(18)22-16(25(23)30)7-8-20-19(22)13-29(3)28-20/h6,9,11,13H,4-5,7-8,10,12H2,1-3H3,(H,27,32)
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n/an/a 26n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375195
PNG
(CHEMBL255959)
Show SMILES CCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1cccs1
Show InChI InChI=1S/C28H24N4O2S/c1-3-10-32-21-9-6-15(27(33)22-5-4-11-35-22)12-17(21)24-18-13-29-28(34)25(18)23-16(26(24)32)7-8-20-19(23)14-31(2)30-20/h4-6,9,11-12,14H,3,7-8,10,13H2,1-2H3,(H,29,34)
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n/an/a 26n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375208
PNG
(CHEMBL404497)
Show SMILES CC(=O)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C22H18N4O2/c1-10(27)11-3-5-16-13(7-11)19-14-8-23-22(28)20(14)18-12(21(19)24-16)4-6-17-15(18)9-26(2)25-17/h3,5,7,9,24H,4,6,8H2,1-2H3,(H,23,28)
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n/an/a 35n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375203
PNG
(CHEMBL271861)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1cc(C)cs1
Show InChI InChI=1S/C30H28N4O2S/c1-15(2)12-34-23-8-5-17(29(35)24-9-16(3)14-37-24)10-19(23)26-20-11-31-30(36)27(20)25-18(28(26)34)6-7-22-21(25)13-33(4)32-22/h5,8-10,13-15H,6-7,11-12H2,1-4H3,(H,31,36)
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n/an/a 43n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375196
PNG
(CHEMBL402531)
Show SMILES CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1cccs1
Show InChI InChI=1S/C27H22N4O2S/c1-3-31-20-9-6-14(26(32)21-5-4-10-34-21)11-16(20)23-17-12-28-27(33)24(17)22-15(25(23)31)7-8-19-18(22)13-30(2)29-19/h4-6,9-11,13H,3,7-8,12H2,1-2H3,(H,28,33)
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n/an/a 43n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50375203
PNG
(CHEMBL271861)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1cc(C)cs1
Show InChI InChI=1S/C30H28N4O2S/c1-15(2)12-34-23-8-5-17(29(35)24-9-16(3)14-37-24)10-19(23)26-20-11-31-30(36)27(20)25-18(28(26)34)6-7-22-21(25)13-33(4)32-22/h5,8-10,13-15H,6-7,11-12H2,1-4H3,(H,31,36)
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n/an/a>50n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse VEGFR2 autophosphorylation in NIH3T3 cell


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375202
PNG
(CHEMBL411520)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1ccoc1
Show InChI InChI=1S/C29H26N4O3/c1-15(2)12-33-23-7-4-16(28(34)17-8-9-36-14-17)10-19(23)25-20-11-30-29(35)26(20)24-18(27(25)33)5-6-22-21(24)13-32(3)31-22/h4,7-10,13-15H,5-6,11-12H2,1-3H3,(H,30,35)
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n/an/a 58n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375190
PNG
(CHEMBL271849)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1ccsc1
Show InChI InChI=1S/C29H26N4O2S/c1-15(2)12-33-23-7-4-16(28(34)17-8-9-36-14-17)10-19(23)25-20-11-30-29(35)26(20)24-18(27(25)33)5-6-22-21(24)13-32(3)31-22/h4,7-10,13-15H,5-6,11-12H2,1-3H3,(H,30,35)
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n/an/a 63n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375189
PNG
(CHEMBL410100)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1ccco1
Show InChI InChI=1S/C29H26N4O3/c1-15(2)13-33-22-9-6-16(28(34)23-5-4-10-36-23)11-18(22)25-19-12-30-29(35)26(19)24-17(27(25)33)7-8-21-20(24)14-32(3)31-21/h4-6,9-11,14-15H,7-8,12-13H2,1-3H3,(H,30,35)
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n/an/a 72n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50375198
PNG
(CHEMBL255404)
Show SMILES CC(C)n1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(C)=O
Show InChI InChI=1S/C25H24N4O2/c1-12(2)29-20-8-5-14(13(3)30)9-16(20)22-17-10-26-25(31)23(17)21-15(24(22)29)6-7-19-18(21)11-28(4)27-19/h5,8-9,11-12H,6-7,10H2,1-4H3,(H,26,31)
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n/an/a 75n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375197
PNG
(CHEMBL401900)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(C)=O
Show InChI InChI=1S/C26H26N4O2/c1-13(2)11-30-21-8-5-15(14(3)31)9-17(21)23-18-10-27-26(32)24(18)22-16(25(23)30)6-7-20-19(22)12-29(4)28-20/h5,8-9,12-13H,6-7,10-11H2,1-4H3,(H,27,32)
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n/an/a 83n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375201
PNG
(CHEMBL271042)
Show SMILES CCCn1c2ccccc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C23H22N4O/c1-3-10-27-18-7-5-4-6-13(18)20-15-11-24-23(28)21(15)19-14(22(20)27)8-9-17-16(19)12-26(2)25-17/h4-7,12H,3,8-11H2,1-2H3,(H,24,28)
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n/an/a 136n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375205
PNG
(CHEMBL428876)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4[nH]c32)C(=O)c2cccs2)n1
Show InChI InChI=1S/C25H18N4O2S/c1-29-11-16-18(28-29)7-5-13-20(16)22-15(10-26-25(22)31)21-14-9-12(4-6-17(14)27-23(13)21)24(30)19-3-2-8-32-19/h2-4,6,8-9,11,27H,5,7,10H2,1H3,(H,26,31)
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n/an/a 136n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375207
PNG
(CHEMBL255405)
Show SMILES CCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(C)=O
Show InChI InChI=1S/C25H24N4O2/c1-4-9-29-20-8-5-14(13(2)30)10-16(20)22-17-11-26-25(31)23(17)21-15(24(22)29)6-7-19-18(21)12-28(3)27-19/h5,8,10,12H,4,6-7,9,11H2,1-3H3,(H,26,31)
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n/an/a 272n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375206
PNG
(CHEMBL255406)
Show SMILES CCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(C)=O
Show InChI InChI=1S/C26H26N4O2/c1-4-5-10-30-21-9-6-15(14(2)31)11-17(21)23-18-12-27-26(32)24(18)22-16(25(23)30)7-8-20-19(22)13-29(3)28-20/h6,9,11,13H,4-5,7-8,10,12H2,1-3H3,(H,27,32)
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n/an/a 300n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375200
PNG
(CHEMBL270827)
Show SMILES CC(C)Cn1c2ccccc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C24H24N4O/c1-13(2)11-28-19-7-5-4-6-14(19)21-16-10-25-24(29)22(16)20-15(23(21)28)8-9-18-17(20)12-27(3)26-18/h4-7,12-13H,8-11H2,1-3H3,(H,25,29)
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n/an/a 372n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375198
PNG
(CHEMBL255404)
Show SMILES CC(C)n1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(C)=O
Show InChI InChI=1S/C25H24N4O2/c1-12(2)29-20-8-5-14(13(3)30)9-16(20)22-17-10-26-25(31)23(17)21-15(24(22)29)6-7-19-18(21)11-28(4)27-19/h5,8-9,11-12H,6-7,10H2,1-4H3,(H,26,31)
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n/an/a 726n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375210
PNG
(CHEMBL406909)
Show SMILES CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(C)=O
Show InChI InChI=1S/C24H22N4O2/c1-4-28-19-8-5-13(12(2)29)9-15(19)21-16-10-25-24(30)22(16)20-14(23(21)28)6-7-18-17(20)11-27(3)26-18/h5,8-9,11H,4,6-7,10H2,1-3H3,(H,25,30)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375208
PNG
(CHEMBL404497)
Show SMILES CC(=O)c1ccc2[nH]c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C22H18N4O2/c1-10(27)11-3-5-16-13(7-11)19-14-8-23-22(28)20(14)18-12(21(19)24-16)4-6-17-15(18)9-26(2)25-17/h3,5,7,9,24H,4,6,8H2,1-2H3,(H,23,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375209
PNG
(CHEMBL270828)
Show SMILES CCn1c2ccccc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12
Show InChI InChI=1S/C22H20N4O/c1-3-26-17-7-5-4-6-12(17)19-14-10-23-22(27)20(14)18-13(21(19)26)8-9-16-15(18)11-25(2)24-16/h4-7,11H,3,8-10H2,1-2H3,(H,23,27)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50236255
PNG
(19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4ccccc4[nH]c32)n1
Show InChI InChI=1S/C20H16N4O/c1-24-9-13-15(23-24)7-6-11-16(13)18-12(8-21-20(18)25)17-10-4-2-3-5-14(10)22-19(11)17/h2-5,9,22H,6-8H2,1H3,(H,21,25)
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n/an/a 1.36E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50136024
PNG
(3-(9-isopropoxymethyl-5-oxo-6,7,12,13-tetrahydro-5...)
Show SMILES CC(C)OCc1ccc2n(CCCOC(=O)CN(C)C)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C32H35N3O4/c1-19(2)39-18-20-10-11-26-23(14-20)29-25-16-33-32(37)30(25)28-22-9-6-5-8-21(22)15-24(28)31(29)35(26)12-7-13-38-27(36)17-34(3)4/h5-6,8-11,14,19H,7,12-13,15-18H2,1-4H3,(H,33,37)
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n/an/a 1.36E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50375199
PNG
(CHEMBL271301)
Show SMILES CC(=O)c1ccc2n(C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C23H20N4O2/c1-11(28)12-4-7-18-14(8-12)20-15-9-24-23(29)21(15)19-13(22(20)27(18)3)5-6-17-16(19)10-26(2)25-17/h4,7-8,10H,5-6,9H2,1-3H3,(H,24,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of TIE2


Bioorg Med Chem Lett 18: 2368-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.069
BindingDB Entry DOI: 10.7270/Q2ZG6T3P
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%