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PubMed code 18394906

Compile data set for download or QSAR
Found 56 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24285
PNG
((3S)-3-amino-5-[(4-phenoxyphenyl)carbamoyl]pentano...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccccc2)cc1)CC(O)=O
Show InChI InChI=1S/C18H20N2O4/c19-13(12-18(22)23)6-11-17(21)20-14-7-9-16(10-8-14)24-15-4-2-1-3-5-15/h1-5,7-10,13H,6,11-12,19H2,(H,20,21)(H,22,23)/t13-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24282
PNG
((2S)-2-amino-N-[4-(4-methylphenoxy)phenyl]pentaned...)
Show SMILES Cc1ccc(Oc2ccc(NC(=O)CC[C@H](N)C(N)=O)cc2)cc1
Show InChI InChI=1S/C18H21N3O3/c1-12-2-6-14(7-3-12)24-15-8-4-13(5-9-15)21-17(22)11-10-16(19)18(20)23/h2-9,16H,10-11,19H2,1H3,(H2,20,23)(H,21,22)/t16-/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24291
PNG
((4S)-4-amino-5-hydroxy-N-(4-phenoxyphenyl)pentanam...)
Show SMILES N[C@H](CO)CCC(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C17H20N2O3/c18-13(12-20)6-11-17(21)19-14-7-9-16(10-8-14)22-15-4-2-1-3-5-15/h1-5,7-10,13,20H,6,11-12,18H2,(H,19,21)/t13-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24277
PNG
((2S)-2-amino-4-{[4-(2-hydroxy-2-phenylethoxy)pheny...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(OCC(O)c2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C19H22N2O5/c20-16(19(24)25)10-11-18(23)21-14-6-8-15(9-7-14)26-12-17(22)13-4-2-1-3-5-13/h1-9,16-17,22H,10-12,20H2,(H,21,23)(H,24,25)/t16-,17?/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24287
PNG
(3-[(2S)-2-amino-N-(4-phenoxyphenyl)pentanediamido]...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccccc2)cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C20H23N3O5/c21-17(20(27)22-13-12-19(25)26)10-11-18(24)23-14-6-8-16(9-7-14)28-15-4-2-1-3-5-15/h1-9,17H,10-13,21H2,(H,22,27)(H,23,24)(H,25,26)/t17-/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24276
PNG
((2S)-2-amino-4-{[4-(2-oxo-2-phenylethoxy)phenyl]ca...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(OCC(=O)c2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C19H20N2O5/c20-16(19(24)25)10-11-18(23)21-14-6-8-15(9-7-14)26-12-17(22)13-4-2-1-3-5-13/h1-9,16H,10-12,20H2,(H,21,23)(H,24,25)/t16-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24270
PNG
((2S)-2-amino-4-[(4-phenoxyphenyl)carbamoyl]butanoi...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C17H18N2O4/c18-15(17(21)22)10-11-16(20)19-12-6-8-14(9-7-12)23-13-4-2-1-3-5-13/h1-9,15H,10-11,18H2,(H,19,20)(H,21,22)/t15-/m0/s1
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n/an/a 19n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24288
PNG
(4-[(2S)-2-amino-N-(4-phenoxyphenyl)pentanediamido]...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccccc2)cc1)C(=O)NCCCC(O)=O
Show InChI InChI=1S/C21H25N3O5/c22-18(21(28)23-14-4-7-20(26)27)12-13-19(25)24-15-8-10-17(11-9-15)29-16-5-2-1-3-6-16/h1-3,5-6,8-11,18H,4,7,12-14,22H2,(H,23,28)(H,24,25)(H,26,27)/t18-/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24289
PNG
((2S)-2-amino-N-(2-hydroxyethyl)-N'-(4-phenoxypheny...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccccc2)cc1)C(=O)NCCO
Show InChI InChI=1S/C19H23N3O4/c20-17(19(25)21-12-13-23)10-11-18(24)22-14-6-8-16(9-7-14)26-15-4-2-1-3-5-15/h1-9,17,23H,10-13,20H2,(H,21,25)(H,22,24)/t17-/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24256
PNG
((2S)-2-amino-4-{[4-(benzyloxy)phenyl]carbamoyl}but...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(OCc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C18H20N2O4/c19-16(18(22)23)10-11-17(21)20-14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16H,10-12,19H2,(H,20,21)(H,22,23)/t16-/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24292
PNG
((4S)-4,5-diamino-N-(4-phenoxyphenyl)pentanamide | ...)
Show SMILES NC[C@@H](N)CCC(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C17H21N3O2/c18-12-13(19)6-11-17(21)20-14-7-9-16(10-8-14)22-15-4-2-1-3-5-15/h1-5,7-10,13H,6,11-12,18-19H2,(H,20,21)/t13-/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24271
PNG
((2S)-2-amino-N-(4-benzylphenyl)pentanediamide | Mo...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Cc2ccccc2)cc1)C(N)=O
Show InChI InChI=1S/C18H21N3O2/c19-16(18(20)23)10-11-17(22)21-15-8-6-14(7-9-15)12-13-4-2-1-3-5-13/h1-9,16H,10-12,19H2,(H2,20,23)(H,21,22)/t16-/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24290
PNG
((2S)-2-amino-N-(2-aminoethyl)-N'-(4-phenoxyphenyl)...)
Show SMILES NCCNC(=O)[C@@H](N)CCC(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C19H24N4O3/c20-12-13-22-19(25)17(21)10-11-18(24)23-14-6-8-16(9-7-14)26-15-4-2-1-3-5-15/h1-9,17H,10-13,20-21H2,(H,22,25)(H,23,24)/t17-/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24286
PNG
(2-[(2S)-2-amino-N-(4-phenoxyphenyl)pentanediamido]...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccccc2)cc1)C(=O)NCC(O)=O
Show InChI InChI=1S/C19H21N3O5/c20-16(19(26)21-12-18(24)25)10-11-17(23)22-13-6-8-15(9-7-13)27-14-4-2-1-3-5-14/h1-9,16H,10-12,20H2,(H,21,26)(H,22,23)(H,24,25)/t16-/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24283
PNG
((2S)-2-amino-4-({4-[4-(1H-pyrrol-1-yl)phenoxy]phen...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccc(cc2)-n2cccc2)cc1)C(O)=O
Show InChI InChI=1S/C21H21N3O4/c22-19(21(26)27)11-12-20(25)23-15-3-7-17(8-4-15)28-18-9-5-16(6-10-18)24-13-1-2-14-24/h1-10,13-14,19H,11-12,22H2,(H,23,25)(H,26,27)/t19-/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24261
PNG
((2S)-2-amino-N-[4-(benzyloxy)phenyl]pentanediamide...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(OCc2ccccc2)cc1)C(N)=O
Show InChI InChI=1S/C18H21N3O3/c19-16(18(20)23)10-11-17(22)21-14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16H,10-12,19H2,(H2,20,23)(H,21,22)/t16-/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24262
PNG
((2S)-2-amino-N-[4-(benzyloxy)phenyl]-N'-hydroxypen...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(OCc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H21N3O4/c19-16(18(23)21-24)10-11-17(22)20-14-6-8-15(9-7-14)25-12-13-4-2-1-3-5-13/h1-9,16,24H,10-12,19H2,(H,20,22)(H,21,23)/t16-/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24284
PNG
((2S)-2-amino-N-{4-[4-(furan-3-yl)phenoxy]phenyl}pe...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccc(cc2)-c2ccoc2)cc1)C(N)=O
Show InChI InChI=1S/C21H21N3O4/c22-19(21(23)26)9-10-20(25)24-16-3-7-18(8-4-16)28-17-5-1-14(2-6-17)15-11-12-27-13-15/h1-8,11-13,19H,9-10,22H2,(H2,23,26)(H,24,25)/t19-/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24275
PNG
((2S)-2-amino-4-{[4-(3-phenylpropoxy)phenyl]carbamo...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(OCCCc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C20H24N2O4/c21-18(20(24)25)12-13-19(23)22-16-8-10-17(11-9-16)26-14-4-7-15-5-2-1-3-6-15/h1-3,5-6,8-11,18H,4,7,12-14,21H2,(H,22,23)(H,24,25)/t18-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24259
PNG
(Modified amino acid analog, 6a | methyl (2S)-2-ami...)
Show SMILES COC(=O)[C@@H](N)CCC(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C19H22N2O4/c1-24-19(23)17(20)11-12-18(22)21-15-7-9-16(10-8-15)25-13-14-5-3-2-4-6-14/h2-10,17H,11-13,20H2,1H3,(H,21,22)/t17-/m0/s1
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n/an/a 39n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24274
PNG
((2S)-2-amino-4-{[4-(2-phenylethoxy)phenyl]carbamoy...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(OCCc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C19H22N2O4/c20-17(19(23)24)10-11-18(22)21-15-6-8-16(9-7-15)25-13-12-14-4-2-1-3-5-14/h1-9,17H,10-13,20H2,(H,21,22)(H,23,24)/t17-/m0/s1
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n/an/a 46n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24260
PNG
(Modified amino acid analog, 6b | tert-butyl (2S)-2...)
Show SMILES CC(C)(C)OC(=O)[C@@H](N)CCC(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C22H28N2O4/c1-22(2,3)28-21(26)19(23)13-14-20(25)24-17-9-11-18(12-10-17)27-15-16-7-5-4-6-8-16/h4-12,19H,13-15,23H2,1-3H3,(H,24,25)/t19-/m0/s1
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n/an/a 60n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24263
PNG
(4-amino-N-[4-(benzyloxy)phenyl]butanamide | Modifi...)
Show SMILES NCCCC(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C17H20N2O2/c18-12-4-7-17(20)19-15-8-10-16(11-9-15)21-13-14-5-2-1-3-6-14/h1-3,5-6,8-11H,4,7,12-13,18H2,(H,19,20)
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n/an/a 61n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24298
PNG
((4S)-4-amino-5-(1,3-dioxo-2,3-dihydro-1H-isoindol-...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccccc2)cc1)CN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C25H23N3O4/c26-17(16-28-24(30)21-8-4-5-9-22(21)25(28)31)10-15-23(29)27-18-11-13-20(14-12-18)32-19-6-2-1-3-7-19/h1-9,11-14,17H,10,15-16,26H2,(H,27,29)/t17-/m0/s1
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n/an/a 85n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24294
PNG
((2S)-2-amino-4-[(4-phenoxyphenyl)carbamoyl]butane-...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccccc2)cc1)CS(O)(=O)=O
Show InChI InChI=1S/C17H20N2O5S/c18-13(12-25(21,22)23)6-11-17(20)19-14-7-9-16(10-8-14)24-15-4-2-1-3-5-15/h1-5,7-10,13H,6,11-12,18H2,(H,19,20)(H,21,22,23)/t13-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24281
PNG
((2S)-2-amino-N-[4-(3-methylphenoxy)phenyl]pentaned...)
Show SMILES Cc1cccc(Oc2ccc(NC(=O)CC[C@H](N)C(N)=O)cc2)c1
Show InChI InChI=1S/C18H21N3O3/c1-12-3-2-4-15(11-12)24-14-7-5-13(6-8-14)21-17(22)10-9-16(19)18(20)23/h2-8,11,16H,9-10,19H2,1H3,(H2,20,23)(H,21,22)/t16-/m0/s1
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n/an/a 150n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24244
PNG
((2S)-2-amino-N-[4-(benzyloxy)phenyl]propanamide | ...)
Show SMILES C[C@H](N)C(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C16H18N2O2/c1-12(17)16(19)18-14-7-9-15(10-8-14)20-11-13-5-3-2-4-6-13/h2-10,12H,11,17H2,1H3,(H,18,19)/t12-/m0/s1
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n/an/a 150n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24272
PNG
((2S)-2-amino-4-{[4-(phenylamino)phenyl]carbamoyl}b...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Nc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C17H19N3O3/c18-15(17(22)23)10-11-16(21)20-14-8-6-13(7-9-14)19-12-4-2-1-3-5-12/h1-9,15,19H,10-11,18H2,(H,20,21)(H,22,23)/t15-/m0/s1
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n/an/a 210n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24243
PNG
(2-amino-N-[4-(benzyloxy)phenyl]acetamide | Amino a...)
Show SMILES NCC(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O2/c16-10-15(18)17-13-6-8-14(9-7-13)19-11-12-4-2-1-3-5-12/h1-9H,10-11,16H2,(H,17,18)
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n/an/a 280n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24296
PNG
((4S)-4-amino-5-[(5-amino-1,3,4-thiadiazol-2-yl)sul...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccccc2)cc1)CSc1nnc(N)s1
Show InChI InChI=1S/C19H21N5O2S2/c20-13(12-27-19-24-23-18(21)28-19)6-11-17(25)22-14-7-9-16(10-8-14)26-15-4-2-1-3-5-15/h1-5,7-10,13H,6,11-12,20H2,(H2,21,23)(H,22,25)/t13-/m0/s1
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n/an/a 350n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24297
PNG
((4S)-4-amino-N-(4-phenoxyphenyl)-5-(1H-pyrrol-1-yl...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccccc2)cc1)Cn1cccc1
Show InChI InChI=1S/C21H23N3O2/c22-17(16-24-14-4-5-15-24)8-13-21(25)23-18-9-11-20(12-10-18)26-19-6-2-1-3-7-19/h1-7,9-12,14-15,17H,8,13,16,22H2,(H,23,25)/t17-/m0/s1
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Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24251
PNG
((4S)-4-amino-4-{[4-(benzyloxy)phenyl]carbamoyl}but...)
Show SMILES N[C@@H](CCC(O)=O)C(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H20N2O4/c19-16(10-11-17(21)22)18(23)20-14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16H,10-12,19H2,(H,20,23)(H,21,22)/t16-/m0/s1
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n/an/a 680n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24268
PNG
(Modified amino acid analog, 8c | methyl (2S)-2-ami...)
Show SMILES COC(=O)[C@@H](N)CCC(=O)Nc1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C19H22N2O4/c1-24-19(23)17(20)10-11-18(22)21-15-8-5-9-16(12-15)25-13-14-6-3-2-4-7-14/h2-9,12,17H,10-11,13,20H2,1H3,(H,21,22)/t17-/m0/s1
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n/an/a 730n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24295
PNG
((4S)-4-amino-N-(4-phenoxyphenyl)-4-(4H-1,2,4-triaz...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccccc2)cc1)c1nnc[nH]1
Show InChI InChI=1S/C18H19N5O2/c19-16(18-20-12-21-23-18)10-11-17(24)22-13-6-8-15(9-7-13)25-14-4-2-1-3-5-14/h1-9,12,16H,10-11,19H2,(H,22,24)(H,20,21,23)/t16-/m0/s1
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n/an/a 740n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24255
PNG
((2S)-2-amino-3-{[4-(benzyloxy)phenyl]carbamoyl}pro...)
Show SMILES N[C@@H](CC(=O)Nc1ccc(OCc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C17H18N2O4/c18-15(17(21)22)10-16(20)19-13-6-8-14(9-7-13)23-11-12-4-2-1-3-5-12/h1-9,15H,10-11,18H2,(H,19,20)(H,21,22)/t15-/m0/s1
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n/an/a 1.10E+3n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24257
PNG
((2R)-2-amino-4-{[4-(benzyloxy)phenyl]carbamoyl}but...)
Show SMILES N[C@H](CCC(=O)Nc1ccc(OCc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C18H20N2O4/c19-16(18(22)23)10-11-17(21)20-14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16H,10-12,19H2,(H,20,21)(H,22,23)/t16-/m1/s1
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n/an/a 1.60E+3n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24245
PNG
((2S,3S)-2-amino-N-[4-(benzyloxy)phenyl]-3-methylpe...)
Show SMILES CC[C@H](C)[C@H](N)C(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C19H24N2O2/c1-3-14(2)18(20)19(22)21-16-9-11-17(12-10-16)23-13-15-7-5-4-6-8-15/h4-12,14,18H,3,13,20H2,1-2H3,(H,21,22)/t14-,18-/m0/s1
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n/an/a>2.00E+3n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24248
PNG
((2S)-2-amino-N-[4-(benzyloxy)phenyl]pentanediamide...)
Show SMILES N[C@@H](CCC(N)=O)C(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H21N3O3/c19-16(10-11-17(20)22)18(23)21-14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16H,10-12,19H2,(H2,20,22)(H,21,23)/t16-/m0/s1
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n/an/a>2.00E+3n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24247
PNG
((2S)-N-[4-(benzyloxy)phenyl]pyrrolidine-2-carboxam...)
Show SMILES O=C(Nc1ccc(OCc2ccccc2)cc1)[C@@H]1CCCN1
Show InChI InChI=1S/C18H20N2O2/c21-18(17-7-4-12-19-17)20-15-8-10-16(11-9-15)22-13-14-5-2-1-3-6-14/h1-3,5-6,8-11,17,19H,4,7,12-13H2,(H,20,21)/t17-/m0/s1
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n/an/a>2.00E+3n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24246
PNG
((2S)-2-amino-N-[4-(benzyloxy)phenyl]-3-phenylpropa...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C22H22N2O2/c23-21(15-17-7-3-1-4-8-17)22(25)24-19-11-13-20(14-12-19)26-16-18-9-5-2-6-10-18/h1-14,21H,15-16,23H2,(H,24,25)/t21-/m0/s1
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n/an/a>2.00E+3n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24269
PNG
((2S)-2-amino-N-(6-phenoxypyridin-3-yl)pentanediami...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccccc2)nc1)C(N)=O
Show InChI InChI=1S/C16H18N4O3/c17-13(16(18)22)7-8-14(21)20-11-6-9-15(19-10-11)23-12-4-2-1-3-5-12/h1-6,9-10,13H,7-8,17H2,(H2,18,22)(H,20,21)/t13-/m0/s1
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n/an/a 2.60E+3n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24280
PNG
((2S)-2-amino-N-[4-(2-methylphenoxy)phenyl]pentaned...)
Show SMILES Cc1ccccc1Oc1ccc(NC(=O)CC[C@H](N)C(N)=O)cc1
Show InChI InChI=1S/C18H21N3O3/c1-12-4-2-3-5-16(12)24-14-8-6-13(7-9-14)21-17(22)11-10-15(19)18(20)23/h2-9,15H,10-11,19H2,1H3,(H2,20,23)(H,21,22)/t15-/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24252
PNG
((3S)-3-amino-3-{[4-(benzyloxy)phenyl]carbamoyl}pro...)
Show SMILES N[C@@H](CC(O)=O)C(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C17H18N2O4/c18-15(10-16(20)21)17(22)19-13-6-8-14(9-7-13)23-11-12-4-2-1-3-5-12/h1-9,15H,10-11,18H2,(H,19,22)(H,20,21)/t15-/m0/s1
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n/an/a 5.40E+3n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24293
PNG
((4S)-4-amino-5-methoxy-N-(4-phenoxyphenyl)pentanam...)
Show SMILES COC[C@@H](N)CCC(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C18H22N2O3/c1-22-13-14(19)7-12-18(21)20-15-8-10-17(11-9-15)23-16-5-3-2-4-6-16/h2-6,8-11,14H,7,12-13,19H2,1H3,(H,20,21)/t14-/m0/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24250
PNG
((2S)-2,6-diamino-N-[4-(benzyloxy)phenyl]hexanamide...)
Show SMILES NCCCC[C@H](N)C(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C19H25N3O2/c20-13-5-4-8-18(21)19(23)22-16-9-11-17(12-10-16)24-14-15-6-2-1-3-7-15/h1-3,6-7,9-12,18H,4-5,8,13-14,20-21H2,(H,22,23)/t18-/m0/s1
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n/an/a 5.80E+3n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24253
PNG
((4R)-4-amino-4-{[4-(benzyloxy)phenyl]carbamoyl}but...)
Show SMILES N[C@H](CCC(O)=O)C(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H20N2O4/c19-16(10-11-17(21)22)18(23)20-14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16H,10-12,19H2,(H,20,23)(H,21,22)/t16-/m1/s1
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n/an/a 7.20E+3n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24273
PNG
(Modified amino acid analog, 8h | methyl (2S)-2-ami...)
Show SMILES COC(=O)[C@@H](N)CCC(=O)Nc1ccc(cc1)N(C)c1ccccc1
Show InChI InChI=1S/C19H23N3O3/c1-22(15-6-4-3-5-7-15)16-10-8-14(9-11-16)21-18(23)13-12-17(20)19(24)25-2/h3-11,17H,12-13,20H2,1-2H3,(H,21,23)/t17-/m0/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24254
PNG
((3R)-3-amino-3-{[4-(benzyloxy)phenyl]carbamoyl}pro...)
Show SMILES N[C@H](CC(O)=O)C(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C17H18N2O4/c18-15(10-16(20)21)17(22)19-13-6-8-14(9-7-13)23-11-12-4-2-1-3-5-12/h1-9,15H,10-11,18H2,(H,19,22)(H,20,21)/t15-/m1/s1
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n/an/a 9.30E+3n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24265
PNG
(Modified amino acid analog, 7c | N-[4-(benzyloxy)p...)
Show SMILES CN(C)CCCC(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C19H24N2O2/c1-21(2)14-6-9-19(22)20-17-10-12-18(13-11-17)23-15-16-7-4-3-5-8-16/h3-5,7-8,10-13H,6,9,14-15H2,1-2H3,(H,20,22)
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n/an/a 9.40E+3n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24267
PNG
((2S)-2-amino-N-[4-(1H-pyrrol-1-yl)phenyl]pentanedi...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(cc1)-n1cccc1)C(N)=O
Show InChI InChI=1S/C15H18N4O2/c16-13(15(17)21)7-8-14(20)18-11-3-5-12(6-4-11)19-9-1-2-10-19/h1-6,9-10,13H,7-8,16H2,(H2,17,21)(H,18,20)/t13-/m0/s1
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n/an/a 9.70E+3n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24249
PNG
((2S)-2-amino-N-[4-(benzyloxy)phenyl]-3-(1H-imidazo...)
Show SMILES N[C@@H](Cc1cnc[nH]1)C(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C19H20N4O2/c20-18(10-16-11-21-13-22-16)19(24)23-15-6-8-17(9-7-15)25-12-14-4-2-1-3-5-14/h1-9,11,13,18H,10,12,20H2,(H,21,22)(H,23,24)/t18-/m0/s1
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n/an/a 1.00E+4n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24264
PNG
(Modified amino acid analog, 7b | N-[4-(benzyloxy)p...)
Show SMILES CNCCCC(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H22N2O2/c1-19-13-5-8-18(21)20-16-9-11-17(12-10-16)22-14-15-6-3-2-4-7-15/h2-4,6-7,9-12,19H,5,8,13-14H2,1H3,(H,20,21)
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n/an/a 1.10E+4n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24279
PNG
((2S)-2-amino-N-[4-(cyclohexyloxy)phenyl]pentanedia...)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(OC2CCCCC2)cc1)C(N)=O
Show InChI InChI=1S/C17H25N3O3/c18-15(17(19)22)10-11-16(21)20-12-6-8-14(9-7-12)23-13-4-2-1-3-5-13/h6-9,13,15H,1-5,10-11,18H2,(H2,19,22)(H,20,21)/t15-/m0/s1
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n/an/a>1.80E+4n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24266
PNG
((2S)-2-amino-N-phenylpentanediamide | Modified ami...)
Show SMILES N[C@@H](CCC(=O)Nc1ccccc1)C(N)=O
Show InChI InChI=1S/C11H15N3O2/c12-9(11(13)16)6-7-10(15)14-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H2,13,16)(H,14,15)/t9-/m0/s1
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n/an/a>1.80E+4n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24258
PNG
(4-{[4-(benzyloxy)phenyl]carbamoyl}butanoic acid | ...)
Show SMILES OC(=O)CCCC(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H19NO4/c20-17(7-4-8-18(21)22)19-15-9-11-16(12-10-15)23-13-14-5-2-1-3-6-14/h1-3,5-6,9-12H,4,7-8,13H2,(H,19,20)(H,21,22)
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n/an/a>1.80E+4n/an/an/an/a7.522



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24278
PNG
(Modified amino acid analog, 9a | methyl (2S)-2-ami...)
Show SMILES COC(=O)[C@@H](N)CCC(=O)Nc1ccc(OC)cc1
Show InChI InChI=1S/C13H18N2O4/c1-18-10-5-3-9(4-6-10)15-12(16)8-7-11(14)13(17)19-2/h3-6,11H,7-8,14H2,1-2H3,(H,15,16)/t11-/m0/s1
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n/an/a>1.80E+4n/an/an/an/an/an/a



Berlex Biosciences



Assay Description
Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...


Bioorg Med Chem 16: 4963-83 (2008)


Article DOI: 10.1016/j.bmc.2008.03.042
BindingDB Entry DOI: 10.7270/Q2BP013C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%