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PubMed code 18396041

Compile data set for download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50219636
PNG
(CHEMBL400559 | N-(4-(2-chlorophenyl)thiazol-2-yl)-...)
Show SMILES Clc1ccccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H14ClN5OS/c21-16-4-2-1-3-15(16)17-11-28-20(25-17)26-19(27)13-5-7-14(8-6-13)24-18-9-10-22-12-23-18/h1-12H,(H,22,23,24)(H,25,26,27)
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n/an/an/an/a 9.00E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219632
PNG
(CHEMBL393268 | N-(4-(4-chloro-2-fluorophenyl)thiaz...)
Show SMILES Fc1cc(Cl)ccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H13ClFN5OS/c21-13-3-6-15(16(22)9-13)17-10-29-20(26-17)27-19(28)12-1-4-14(5-2-12)25-18-7-8-23-11-24-18/h1-11H,(H,23,24,25)(H,26,27,28)
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n/an/an/an/a 230n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377373
PNG
(CHEMBL261539)
Show SMILES Nc1nc(cs1)-c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C10H6F4N2S/c11-7-2-1-5(10(12,13)14)3-6(7)8-4-17-9(15)16-8/h1-4H,(H2,15,16)
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n/an/an/an/a 5.20E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219646
PNG
(CHEMBL247644 | N-(4-(2,3-difluoro-4-(trifluorometh...)
Show SMILES Fc1c(F)c(ccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1)C(F)(F)F
Show InChI InChI=1S/C21H12F5N5OS/c22-17-13(5-6-14(18(17)23)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 87n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219638
PNG
(CHEMBL247822 | N-(4-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-16-6-3-13(9-15(16)21(23,24)25)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 100n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377378
PNG
(CHEMBL261023)
Show SMILES Nc1nc(cs1)-c1ccccc1F
Show InChI InChI=1S/C9H7FN2S/c10-7-4-2-1-3-6(7)8-5-13-9(11)12-8/h1-5H,(H2,11,12)
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n/an/an/an/a 6.80E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219656
PNG
(CHEMBL247642 | N-(4-(3,4-difluorophenyl)thiazol-2-...)
Show SMILES Fc1ccc(cc1F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H13F2N5OS/c21-15-6-3-13(9-16(15)22)17-10-29-20(26-17)27-19(28)12-1-4-14(5-2-12)25-18-7-8-23-11-24-18/h1-11H,(H,23,24,25)(H,26,27,28)
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n/an/an/an/a 400n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219625
PNG
(CHEMBL247606 | N-(4-(2-fluoro-3-(trifluoromethoxy)...)
Show SMILES Fc1c(OC(F)(F)F)cccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5O2S/c22-18-14(2-1-3-16(18)32-21(23,24)25)15-10-33-20(29-15)30-19(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 32n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219717
PNG
(CHEMBL246618 | N-(4-(3-bromophenyl)thiazol-2-yl)-4...)
Show SMILES Brc1cccc(c1)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H14BrN5OS/c21-15-3-1-2-14(10-15)17-11-28-20(25-17)26-19(27)13-4-6-16(7-5-13)24-18-8-9-22-12-23-18/h1-12H,(H,22,23,24)(H,25,26,27)
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n/an/an/an/a 640n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219658
PNG
(CHEMBL247431 | N-(4-(2,4-difluorophenyl)thiazol-2-...)
Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1
Show InChI InChI=1S/C20H13F2N5OS/c21-13-3-6-15(16(22)9-13)17-10-29-20(26-17)27-19(28)12-1-4-14(5-2-12)25-18-7-8-23-11-24-18/h1-11H,(H,23,24,25)(H,26,27,28)
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n/an/an/an/a 170n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219612
PNG
(CHEMBL249061 | N-(4-(2,3-difluorophenyl)thiazol-2-...)
Show SMILES Fc1cccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c1F
Show InChI InChI=1S/C20H13F2N5OS/c21-15-3-1-2-14(18(15)22)16-10-29-20(26-16)27-19(28)12-4-6-13(7-5-12)25-17-8-9-23-11-24-17/h1-11H,(H,23,24,25)(H,26,27,28)
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n/an/an/an/a 420n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219608
PNG
(CHEMBL249062 | N-(4-(3-chloro-2-fluorophenyl)thiaz...)
Show SMILES Fc1c(Cl)cccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H13ClFN5OS/c21-15-3-1-2-14(18(15)22)16-10-29-20(26-16)27-19(28)12-4-6-13(7-5-12)25-17-8-9-23-11-24-17/h1-11H,(H,23,24,25)(H,26,27,28)
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n/an/an/an/a 610n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219693
PNG
(CHEMBL247013 | N-(4-phenylthiazol-2-yl)-4-(pyrimid...)
Show SMILES O=C(Nc1nc(cs1)-c1ccccc1)c1ccc(Nc2ccncn2)cc1
Show InChI InChI=1S/C20H15N5OS/c26-19(25-20-24-17(12-27-20)14-4-2-1-3-5-14)15-6-8-16(9-7-15)23-18-10-11-21-13-22-18/h1-13H,(H,21,22,23)(H,24,25,26)
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n/an/an/an/a 3.40E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377379
PNG
(CHEMBL409092)
Show SMILES Clc1cccc2-c3nc(NC(=O)c4ccc(Nc5ccncn5)cc4)sc3COc12
Show InChI InChI=1S/C21H14ClN5O2S/c22-15-3-1-2-14-18-16(10-29-19(14)15)30-21(26-18)27-20(28)12-4-6-13(7-5-12)25-17-8-9-23-11-24-17/h1-9,11H,10H2,(H,23,24,25)(H,26,27,28)
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n/an/an/an/a 530n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377381
PNG
(CHEMBL409504)
Show SMILES O=C(Nc1nc-2c(COc3ccccc-23)s1)c1ccc(Nc2ccncn2)cc1
Show InChI InChI=1S/C21H15N5O2S/c27-20(13-5-7-14(8-6-13)24-18-9-10-22-12-23-18)26-21-25-19-15-3-1-2-4-16(15)28-11-17(19)29-21/h1-10,12H,11H2,(H,22,23,24)(H,25,26,27)
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n/an/an/an/a 520n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219607
PNG
(CHEMBL428226 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-18-14(2-1-3-15(18)21(23,24)25)16-10-32-20(29-16)30-19(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 60n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219651
PNG
(4-(pyrimidin-4-ylamino)-N-(4-(3-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1cccc(c1)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H14F3N5OS/c22-21(23,24)15-3-1-2-14(10-15)17-11-31-20(28-17)29-19(30)13-4-6-16(7-5-13)27-18-8-9-25-12-26-18/h1-12H,(H,25,26,27)(H,28,29,30)
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n/an/an/an/a 420n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219616
PNG
(CHEMBL249063 | N-(4-(3-bromo-2-fluorophenyl)thiazo...)
Show SMILES Fc1c(Br)cccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H13BrFN5OS/c21-15-3-1-2-14(18(15)22)16-10-29-20(26-16)27-19(28)12-4-6-13(7-5-12)25-17-8-9-23-11-24-17/h1-11H,(H,23,24,25)(H,26,27,28)
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n/an/an/an/a 100n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377372
PNG
(CHEMBL262855)
Show SMILES Nc1nc(c(F)s1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C10H5F5N2S/c11-6-4(7-8(12)18-9(16)17-7)2-1-3-5(6)10(13,14)15/h1-3H,(H2,16,17)
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n/an/an/an/a 700n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377375
PNG
(CHEMBL263109)
Show SMILES Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C10H6F4N2S/c11-8-5(7-4-17-9(15)16-7)2-1-3-6(8)10(12,13)14/h1-4H,(H2,15,16)
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n/an/an/an/a 57n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219679
PNG
(CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...)
Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H12F5N5OS/c22-14-6-5-13(18(23)17(14)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 33n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219642
PNG
(CHEMBL399136 | N-(4-(4-chlorophenyl)thiazol-2-yl)-...)
Show SMILES Clc1ccc(cc1)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H14ClN5OS/c21-15-5-1-13(2-6-15)17-11-28-20(25-17)26-19(27)14-3-7-16(8-4-14)24-18-9-10-22-12-23-18/h1-12H,(H,22,23,24)(H,25,26,27)
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n/an/an/an/a 570n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219684
PNG
(CHEMBL246617 | N-(4-(3-chlorophenyl)thiazol-2-yl)-...)
Show SMILES Clc1cccc(c1)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H14ClN5OS/c21-15-3-1-2-14(10-15)17-11-28-20(25-17)26-19(27)13-4-6-16(7-5-13)24-18-8-9-22-12-23-18/h1-12H,(H,22,23,24)(H,25,26,27)
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n/an/an/an/a 3.00E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219663
PNG
(CHEMBL248006 | N-(4-(2,6-difluorophenyl)thiazol-2-...)
Show SMILES Fc1cccc(F)c1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H13F2N5OS/c21-14-2-1-3-15(22)18(14)16-10-29-20(26-16)27-19(28)12-4-6-13(7-5-12)25-17-8-9-23-11-24-17/h1-11H,(H,23,24,25)(H,26,27,28)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377374
PNG
(CHEMBL405478)
Show SMILES Nc1nc(cs1)-c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C10H6F4N2S/c11-7-3-5(10(12,13)14)1-2-6(7)8-4-17-9(15)16-8/h1-4H,(H2,15,16)
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n/an/an/an/a 260n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377376
PNG
(CHEMBL408853)
Show SMILES Nc1nc(cs1)-c1cccc(OC(F)(F)F)c1F
Show InChI InChI=1S/C10H6F4N2OS/c11-8-5(6-4-18-9(15)16-6)2-1-3-7(8)17-10(12,13)14/h1-4H,(H2,15,16)
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n/an/an/an/a 32n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219680
PNG
(CHEMBL247643 | N-(4-(3-fluoro-4-(trifluoromethyl)p...)
Show SMILES Fc1cc(ccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-16-9-13(3-6-15(16)21(23,24)25)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 290n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219709
PNG
(CHEMBL245994 | N-(4-(4-fluorophenyl)thiazol-2-yl)-...)
Show SMILES Fc1ccc(cc1)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H14FN5OS/c21-15-5-1-13(2-6-15)17-11-28-20(25-17)26-19(27)14-3-7-16(8-4-14)24-18-9-10-22-12-23-18/h1-12H,(H,22,23,24)(H,25,26,27)
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n/an/an/an/a 2.60E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377370
PNG
(CHEMBL260846)
Show SMILES Nc1nc(cs1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C10H6F4N2S/c11-7-2-1-5(3-6(7)10(12,13)14)8-4-17-9(15)16-8/h1-4H,(H2,15,16)
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n/an/an/an/a 100n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377371
PNG
(CHEMBL405203)
Show SMILES Cc1sc(N)nc1-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C11H8F4N2S/c1-5-9(17-10(16)18-5)6-3-2-4-7(8(6)12)11(13,14)15/h2-4H,1H3,(H2,16,17)
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n/an/an/an/a 540n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377377
PNG
(CHEMBL412807)
Show SMILES Nc1nc(cs1)-c1c(F)cccc1F
Show InChI InChI=1S/C9H6F2N2S/c10-5-2-1-3-6(11)8(5)7-4-14-9(12)13-7/h1-4H,(H2,12,13)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219671
PNG
(4-(pyrimidin-4-ylamino)-N-(6-(trifluoromethyl)-4H-...)
Show SMILES FC(F)(F)c1cccc2-c3nc(NC(=O)c4ccc(Nc5ccncn5)cc4)sc3COc12
Show InChI InChI=1S/C22H14F3N5O2S/c23-22(24,25)15-3-1-2-14-18-16(10-32-19(14)15)33-21(29-18)30-20(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-9,11H,10H2,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 140n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219707
PNG
(CHEMBL428227 | N-(4-(2-fluoro-4-(trifluoromethyl)p...)
Show SMILES Fc1cc(ccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1)C(F)(F)F
Show InChI InChI=1S/C21H13F4N5OS/c22-16-9-13(21(23,24)25)3-6-15(16)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 260n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219665
PNG
(4-(pyrimidin-4-ylamino)-N-(4-(4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H14F3N5OS/c22-21(23,24)15-5-1-13(2-6-15)17-11-31-20(28-17)29-19(30)14-3-7-16(8-4-14)27-18-9-10-25-12-26-18/h1-12H,(H,25,26,27)(H,28,29,30)
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n/an/an/an/a 490n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219708
PNG
(CHEMBL247607 | N-(4-(2,3-dichlorophenyl)thiazol-2-...)
Show SMILES Clc1cccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c1Cl
Show InChI InChI=1S/C20H13Cl2N5OS/c21-15-3-1-2-14(18(15)22)16-10-29-20(26-16)27-19(28)12-4-6-13(7-5-12)25-17-8-9-23-11-24-17/h1-11H,(H,23,24,25)(H,26,27,28)
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n/an/an/an/a 1.30E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219678
PNG
(CHEMBL248035 | N-(4-(2-fluorophenyl)thiazol-2-yl)-...)
Show SMILES Fc1ccccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H14FN5OS/c21-16-4-2-1-3-15(16)17-11-28-20(25-17)26-19(27)13-5-7-14(8-6-13)24-18-9-10-22-12-23-18/h1-12H,(H,22,23,24)(H,25,26,27)
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n/an/an/an/a 6.80E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219712
PNG
(4-(pyrimidin-4-ylamino)-N-(4-(2,3,4-trifluoropheny...)
Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1F
Show InChI InChI=1S/C20H12F3N5OS/c21-14-6-5-13(17(22)18(14)23)15-9-30-20(27-15)28-19(29)11-1-3-12(4-2-11)26-16-7-8-24-10-25-16/h1-10H,(H,24,25,26)(H,27,28,29)
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n/an/an/an/a 84n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219647
PNG
(4-(pyrimidin-4-ylamino)-N-(4-(2-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H14F3N5OS/c22-21(23,24)16-4-2-1-3-15(16)17-11-31-20(28-17)29-19(30)13-5-7-14(8-6-13)27-18-9-10-25-12-26-18/h1-12H,(H,25,26,27)(H,28,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377368
PNG
(CHEMBL258532)
Show SMILES Cc1sc(N)nc1-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C11H8F4N2S/c1-5-9(17-10(16)18-5)6-2-3-8(12)7(4-6)11(13,14)15/h2-4H,1H3,(H2,16,17)
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n/an/an/an/a 180n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377380
PNG
(CHEMBL260089)
Show SMILES Fc1cccc2-c3nc(NC(=O)c4ccc(Nc5ccncn5)cc4)sc3COc12
Show InChI InChI=1S/C21H14FN5O2S/c22-15-3-1-2-14-18-16(10-29-19(14)15)30-21(26-18)27-20(28)12-4-6-13(7-5-12)25-17-8-9-23-11-24-17/h1-9,11H,10H2,(H,23,24,25)(H,26,27,28)
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n/an/an/an/a 1.50E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219631
PNG
(4-(pyrimidin-4-ylamino)-N-(4-(3-(trifluoromethoxy)...)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H14F3N5O2S/c22-21(23,24)31-16-3-1-2-14(10-16)17-11-32-20(28-17)29-19(30)13-4-6-15(7-5-13)27-18-8-9-25-12-26-18/h1-12H,(H,25,26,27)(H,28,29,30)
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n/an/an/an/a 280n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219690
PNG
(CHEMBL398286 | N-(4-(3-fluorophenyl)thiazol-2-yl)-...)
Show SMILES Fc1cccc(c1)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H14FN5OS/c21-15-3-1-2-14(10-15)17-11-28-20(25-17)26-19(27)13-4-6-16(7-5-13)24-18-8-9-22-12-23-18/h1-12H,(H,22,23,24)(H,25,26,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219630
PNG
(CHEMBL247818 | N-(4-(2,4-dichlorophenyl)thiazol-2-...)
Show SMILES Clc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(Cl)c1
Show InChI InChI=1S/C20H13Cl2N5OS/c21-13-3-6-15(16(22)9-13)17-10-29-20(26-17)27-19(28)12-1-4-14(5-2-12)25-18-7-8-23-11-24-18/h1-11H,(H,23,24,25)(H,26,27,28)
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n/an/an/an/a 510n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377369
PNG
(CHEMBL405683)
Show SMILES Nc1nc(c(F)s1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C10H5F5N2S/c11-6-2-1-4(3-5(6)10(13,14)15)7-8(12)18-9(16)17-7/h1-3H,(H2,16,17)
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n/an/an/an/a 89n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
BindingDB Entry DOI: 10.7270/Q2474BRS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%