Affinity Data by PubMed id=1849996

PubMed code 1849996

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
GABA-B receptor 1/2 (Rattus norvegicus (Rat))	BDBM24182 (4-amino-3-(4-chlorophenyl)butanoic acid \| Baclofen...) Show SMILES NCC(CC(O)=O)c1ccc(Cl)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptor				J Med Chem 34: 1307-13 (1991) Article DOI: 10.1021/jm00108a011 BindingDB Entry DOI: 10.7270/Q27D2VRW
Centre de Neurochimie du CNRS Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GABA-B receptor 1/2 (Rattus norvegicus (Rat))	BDBM50009131 (4-Amino-3-(2,4-dichloro-phenyl)-butyric acid; hydr...) Show SMILES NCC(CC(O)=O)c1ccc(Cl)cc1Cl Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptor				J Med Chem 34: 1307-13 (1991) Article DOI: 10.1021/jm00108a011 BindingDB Entry DOI: 10.7270/Q27D2VRW
Centre de Neurochimie du CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
GABA-B receptor 1/2 (Rattus norvegicus (Rat))	BDBM50009132 ((1-Aminomethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)...) Show SMILES NCC1(CC(O)=O)CCCc2ccccc12 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptor				J Med Chem 34: 1307-13 (1991) Article DOI: 10.1021/jm00108a011 BindingDB Entry DOI: 10.7270/Q27D2VRW
Centre de Neurochimie du CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
GABA-B receptor 1/2 (Rattus norvegicus (Rat))	BDBM50009134 ((1-Aminomethyl-indan-1-yl)-acetic acid; hydrochlor...) Show SMILES NCC1(CC(O)=O)CCc2ccccc12 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptor				J Med Chem 34: 1307-13 (1991) Article DOI: 10.1021/jm00108a011 BindingDB Entry DOI: 10.7270/Q27D2VRW
Centre de Neurochimie du CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
GABA-B receptor 1/2 (Rattus norvegicus (Rat))	BDBM50009136 ((7-Aminomethyl-bicyclo[4.2.0]octa-1(6),2,4-trien-7...) Show SMILES NCC1(CC(O)=O)Cc2ccccc12 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptor				J Med Chem 34: 1307-13 (1991) Article DOI: 10.1021/jm00108a011 BindingDB Entry DOI: 10.7270/Q27D2VRW
Centre de Neurochimie du CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
GABA-B receptor 1/2 (Rattus norvegicus (Rat))	BDBM50009135 ((1-Aminomethyl-5-chloro-indan-1-yl)-acetic acid; h...) Show SMILES NCC1(CC(O)=O)CCc2cc(Cl)ccc12 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptor				J Med Chem 34: 1307-13 (1991) Article DOI: 10.1021/jm00108a011 BindingDB Entry DOI: 10.7270/Q27D2VRW
Centre de Neurochimie du CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
GABA-B receptor 1/2 (Rattus norvegicus (Rat))	BDBM50009133 (4-Amino-3-(2,6-dichloro-phenyl)-butyric acid; hydr...) Show SMILES NCC(CC(O)=O)c1c(Cl)cccc1Cl Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptor				J Med Chem 34: 1307-13 (1991) Article DOI: 10.1021/jm00108a011 BindingDB Entry DOI: 10.7270/Q27D2VRW
Centre de Neurochimie du CNRS Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%