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PubMed code 18513967

Compile data set for download or QSAR
Found 103 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50334048
PNG
((-)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl...)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)18(22)17-13(2)11-21(3,4)24-19(12)17/h5-10,13,23-24H,11H2,1-4H3
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0.300n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50334048
PNG
((-)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl...)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)18(22)17-13(2)11-21(3,4)24-19(12)17/h5-10,13,23-24H,11H2,1-4H3
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0.600n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377346
PNG
(CHEMBL403274)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(F)cc2cc[nH]c12
Show InChI InChI=1S/C21H22ClFN2/c1-11-7-15(16-9-14(23)8-13-5-6-24-20(13)16)18(22)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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0.800n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377350
PNG
(CHEMBL257152)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc(F)c2cc[nH]c12
Show InChI InChI=1S/C21H22ClFN2/c1-11-9-15(13-5-6-16(23)14-7-8-24-20(13)14)18(22)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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1.30n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377349
PNG
(CHEMBL253745)
Show SMILES COc1ccc2cc[nH]c2c1-c1cc(C)c2NC(C)(C)CC(C)c2c1Cl
Show InChI InChI=1S/C22H25ClN2O/c1-12-10-15(18-16(26-5)7-6-14-8-9-24-21(14)18)19(23)17-13(2)11-22(3,4)25-20(12)17/h6-10,13,24-25H,11H2,1-5H3
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1.5n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377338
PNG
(CHEMBL429842)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(F)c(F)c2cc[nH]c12
Show InChI InChI=1S/C21H21ClF2N2/c1-10-7-13(14-8-15(23)18(24)12-5-6-25-20(12)14)17(22)16-11(2)9-21(3,4)26-19(10)16/h5-8,11,25-26H,9H2,1-4H3
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1.80n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377348
PNG
(CHEMBL258193)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(14-6-5-7-17-15(14)8-9-23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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4.40n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM19190
PNG
((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
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5.30n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50334048
PNG
((-)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl...)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)18(22)17-13(2)11-21(3,4)24-19(12)17/h5-10,13,23-24H,11H2,1-4H3
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8.20n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50086551
PNG
(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Show SMILES CC1CC(C)(C)Nc2ccc(cc12)-c1sc(cc1C)C#N
Show InChI InChI=1S/C18H20N2S/c1-11-7-14(10-19)21-17(11)13-5-6-16-15(8-13)12(2)9-18(3,4)20-16/h5-8,12,20H,9H2,1-4H3
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8.30n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377345
PNG
(CHEMBL256787)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2c(C)c[nH]c12
Show InChI InChI=1S/C22H25ClN2/c1-12-9-17(16-8-6-7-15-14(3)11-24-21(15)16)19(23)18-13(2)10-22(4,5)25-20(12)18/h6-9,11,13,24-25H,10H2,1-5H3
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11n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50334048
PNG
((-)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl...)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)18(22)17-13(2)11-21(3,4)24-19(12)17/h5-10,13,23-24H,11H2,1-4H3
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13n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377346
PNG
(CHEMBL403274)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(F)cc2cc[nH]c12
Show InChI InChI=1S/C21H22ClFN2/c1-11-7-15(16-9-14(23)8-13-5-6-24-20(13)16)18(22)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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15n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50334048
PNG
((-)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl...)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)18(22)17-13(2)11-21(3,4)24-19(12)17/h5-10,13,23-24H,11H2,1-4H3
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21n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at mineralocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377345
PNG
(CHEMBL256787)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2c(C)c[nH]c12
Show InChI InChI=1S/C22H25ClN2/c1-12-9-17(16-8-6-7-15-14(3)11-24-21(15)16)19(23)18-13(2)10-22(4,5)25-20(12)18/h6-9,11,13,24-25H,10H2,1-5H3
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22n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377343
PNG
(CHEMBL404496)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3c[nH]c4ccccc34)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(16-11-23-17-8-6-5-7-14(16)17)19(22)18-13(2)10-21(3,4)24-20(12)18/h5-9,11,13,23-24H,10H2,1-4H3
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24n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377341
PNG
(CHEMBL438885)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(Cl)cc2cc[nH]c12
Show InChI InChI=1S/C21H22Cl2N2/c1-11-7-15(16-9-14(22)8-13-5-6-24-20(13)16)18(23)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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24n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50377350
PNG
(CHEMBL257152)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc(F)c2cc[nH]c12
Show InChI InChI=1S/C21H22ClFN2/c1-11-9-15(13-5-6-16(23)14-7-8-24-20(13)14)18(22)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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32n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at mineralocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50086551
PNG
(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Show SMILES CC1CC(C)(C)Nc2ccc(cc12)-c1sc(cc1C)C#N
Show InChI InChI=1S/C18H20N2S/c1-11-7-14(10-19)21-17(11)13-5-6-16-15(8-13)12(2)9-18(3,4)20-16/h5-8,12,20H,9H2,1-4H3
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43n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50377338
PNG
(CHEMBL429842)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(F)c(F)c2cc[nH]c12
Show InChI InChI=1S/C21H21ClF2N2/c1-10-7-13(14-8-15(23)18(24)12-5-6-25-20(12)14)17(22)16-11(2)9-21(3,4)26-19(10)16/h5-8,11,25-26H,9H2,1-4H3
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50n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at androgen receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50334048
PNG
((-)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl...)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)18(22)17-13(2)11-21(3,4)24-19(12)17/h5-10,13,23-24H,11H2,1-4H3
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57n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at androgen receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377350
PNG
(CHEMBL257152)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc(F)c2cc[nH]c12
Show InChI InChI=1S/C21H22ClFN2/c1-11-9-15(13-5-6-16(23)14-7-8-24-20(13)14)18(22)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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75n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377351
PNG
(CHEMBL427899)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2ccn(C)c12
Show InChI InChI=1S/C22H25ClN2/c1-13-11-17(16-8-6-7-15-9-10-25(5)21(15)16)19(23)18-14(2)12-22(3,4)24-20(13)18/h6-11,14,24H,12H2,1-5H3
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79n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377340
PNG
(CHEMBL443847)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc(C)[nH]c12
Show InChI InChI=1S/C22H25ClN2/c1-12-9-17(16-8-6-7-15-10-14(3)24-21(15)16)19(23)18-13(2)11-22(4,5)25-20(12)18/h6-10,13,24-25H,11H2,1-5H3
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90n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377342
PNG
(CHEMBL436848)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3cc4ccccc4[nH]3)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(17-10-14-7-5-6-8-16(14)23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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100n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377347
PNG
(CHEMBL404640)
Show SMILES COc1ccc(-c2cc(C)c3NC(C)(C)CC(C)c3c2Cl)c2[nH]ccc12
Show InChI InChI=1S/C22H25ClN2O/c1-12-10-16(14-6-7-17(26-5)15-8-9-24-21(14)15)19(23)18-13(2)11-22(3,4)25-20(12)18/h6-10,13,24-25H,11H2,1-5H3
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110n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377339
PNG
(CHEMBL404879)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc(Cl)c2cc[nH]c12
Show InChI InChI=1S/C21H22Cl2N2/c1-11-9-15(13-5-6-16(22)14-7-8-24-20(13)14)18(23)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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131n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50377338
PNG
(CHEMBL429842)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(F)c(F)c2cc[nH]c12
Show InChI InChI=1S/C21H21ClF2N2/c1-10-7-13(14-8-15(23)18(24)12-5-6-25-20(12)14)17(22)16-11(2)9-21(3,4)26-19(10)16/h5-8,11,25-26H,9H2,1-4H3
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145n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at mineralocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377338
PNG
(CHEMBL429842)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(F)c(F)c2cc[nH]c12
Show InChI InChI=1S/C21H21ClF2N2/c1-10-7-13(14-8-15(23)18(24)12-5-6-25-20(12)14)17(22)16-11(2)9-21(3,4)26-19(10)16/h5-8,11,25-26H,9H2,1-4H3
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151n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50377349
PNG
(CHEMBL253745)
Show SMILES COc1ccc2cc[nH]c2c1-c1cc(C)c2NC(C)(C)CC(C)c2c1Cl
Show InChI InChI=1S/C22H25ClN2O/c1-12-10-15(18-16(26-5)7-6-14-8-9-24-21(14)18)19(23)17-13(2)11-22(3,4)25-20(12)17/h6-10,13,24-25H,11H2,1-5H3
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155n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at mineralocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377348
PNG
(CHEMBL258193)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(14-6-5-7-17-15(14)8-9-23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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230n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377342
PNG
(CHEMBL436848)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3cc4ccccc4[nH]3)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(17-10-14-7-5-6-8-16(14)23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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370n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377343
PNG
(CHEMBL404496)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3c[nH]c4ccccc34)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(16-11-23-17-8-6-5-7-14(16)17)19(22)18-13(2)10-21(3,4)24-20(12)18/h5-9,11,13,23-24H,10H2,1-4H3
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450n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377344
PNG
(CHEMBL402362)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc2cc[nH]c2c1
Show InChI InChI=1S/C21H23ClN2/c1-12-9-16(15-6-5-14-7-8-23-17(14)10-15)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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460n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377339
PNG
(CHEMBL404879)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc(Cl)c2cc[nH]c12
Show InChI InChI=1S/C21H22Cl2N2/c1-11-9-15(13-5-6-16(22)14-7-8-24-20(13)14)18(23)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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520n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377341
PNG
(CHEMBL438885)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(Cl)cc2cc[nH]c12
Show InChI InChI=1S/C21H22Cl2N2/c1-11-7-15(16-9-14(22)8-13-5-6-24-20(13)16)18(23)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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650n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377351
PNG
(CHEMBL427899)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2ccn(C)c12
Show InChI InChI=1S/C22H25ClN2/c1-13-11-17(16-8-6-7-15-9-10-25(5)21(15)16)19(23)18-14(2)12-22(3,4)24-20(13)18/h6-11,14,24H,12H2,1-5H3
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650n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377342
PNG
(CHEMBL436848)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3cc4ccccc4[nH]3)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(17-10-14-7-5-6-8-16(14)23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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770n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled Dexamethasone from glucocorticoid receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50377350
PNG
(CHEMBL257152)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc(F)c2cc[nH]c12
Show InChI InChI=1S/C21H22ClFN2/c1-11-9-15(13-5-6-16(23)14-7-8-24-20(13)14)18(22)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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780n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at androgen receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM19190
PNG
((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377349
PNG
(CHEMBL253745)
Show SMILES COc1ccc2cc[nH]c2c1-c1cc(C)c2NC(C)(C)CC(C)c2c1Cl
Show InChI InChI=1S/C22H25ClN2O/c1-12-10-15(18-16(26-5)7-6-14-8-9-24-21(14)18)19(23)17-13(2)11-22(3,4)25-20(12)17/h6-10,13,24-25H,11H2,1-5H3
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1.40E+3n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377340
PNG
(CHEMBL443847)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc(C)[nH]c12
Show InChI InChI=1S/C22H25ClN2/c1-12-9-17(16-8-6-7-15-10-14(3)24-21(15)16)19(23)18-13(2)11-22(4,5)25-20(12)18/h6-10,13,24-25H,11H2,1-5H3
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1.40E+3n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50377349
PNG
(CHEMBL253745)
Show SMILES COc1ccc2cc[nH]c2c1-c1cc(C)c2NC(C)(C)CC(C)c2c1Cl
Show InChI InChI=1S/C22H25ClN2O/c1-12-10-15(18-16(26-5)7-6-14-8-9-24-21(14)18)19(23)17-13(2)11-22(3,4)25-20(12)17/h6-10,13,24-25H,11H2,1-5H3
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1.50E+3n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at androgen receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377342
PNG
(CHEMBL436848)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3cc4ccccc4[nH]3)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(17-10-14-7-5-6-8-16(14)23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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1.70E+3n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377344
PNG
(CHEMBL402362)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc2cc[nH]c2c1
Show InChI InChI=1S/C21H23ClN2/c1-12-9-16(15-6-5-14-7-8-23-17(14)10-15)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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2.30E+3n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50377347
PNG
(CHEMBL404640)
Show SMILES COc1ccc(-c2cc(C)c3NC(C)(C)CC(C)c3c2Cl)c2[nH]ccc12
Show InChI InChI=1S/C22H25ClN2O/c1-12-10-16(14-6-7-17(26-5)15-8-9-24-21(14)15)19(23)18-13(2)11-22(3,4)25-20(12)18/h6-10,13,24-25H,11H2,1-5H3
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6.60E+3n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at progesterone receptor


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM19190
PNG
((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
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n/an/a>1n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377348
PNG
(CHEMBL258193)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(14-6-5-7-17-15(14)8-9-23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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n/an/a 1.80n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377346
PNG
(CHEMBL403274)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(F)cc2cc[nH]c12
Show InChI InChI=1S/C21H22ClFN2/c1-11-7-15(16-9-14(23)8-13-5-6-24-20(13)16)18(22)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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n/an/a 3.10n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM19190
PNG
((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
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n/an/a 4.10n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377350
PNG
(CHEMBL257152)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc(F)c2cc[nH]c12
Show InChI InChI=1S/C21H22ClFN2/c1-11-9-15(13-5-6-16(23)14-7-8-24-20(13)14)18(22)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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n/an/a 5n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377345
PNG
(CHEMBL256787)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2c(C)c[nH]c12
Show InChI InChI=1S/C22H25ClN2/c1-12-9-17(16-8-6-7-15-14(3)11-24-21(15)16)19(23)18-13(2)10-22(4,5)25-20(12)18/h6-9,11,13,24-25H,10H2,1-5H3
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n/an/a 5.30n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377343
PNG
(CHEMBL404496)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3c[nH]c4ccccc34)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(16-11-23-17-8-6-5-7-14(16)17)19(22)18-13(2)10-21(3,4)24-20(12)18/h5-9,11,13,23-24H,10H2,1-4H3
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n/an/a 10n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50334048
PNG
((-)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl...)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)18(22)17-13(2)11-21(3,4)24-19(12)17/h5-10,13,23-24H,11H2,1-4H3
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n/an/a 10n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377338
PNG
(CHEMBL429842)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(F)c(F)c2cc[nH]c12
Show InChI InChI=1S/C21H21ClF2N2/c1-10-7-13(14-8-15(23)18(24)12-5-6-25-20(12)14)17(22)16-11(2)9-21(3,4)26-19(10)16/h5-8,11,25-26H,9H2,1-4H3
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n/an/a 11n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377339
PNG
(CHEMBL404879)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc(Cl)c2cc[nH]c12
Show InChI InChI=1S/C21H22Cl2N2/c1-11-9-15(13-5-6-16(22)14-7-8-24-20(13)14)18(23)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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n/an/a 12n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50334048
PNG
((-)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl...)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)18(22)17-13(2)11-21(3,4)24-19(12)17/h5-10,13,23-24H,11H2,1-4H3
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n/an/a 12n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377349
PNG
(CHEMBL253745)
Show SMILES COc1ccc2cc[nH]c2c1-c1cc(C)c2NC(C)(C)CC(C)c2c1Cl
Show InChI InChI=1S/C22H25ClN2O/c1-12-10-15(18-16(26-5)7-6-14-8-9-24-21(14)18)19(23)17-13(2)11-22(3,4)25-20(12)17/h6-10,13,24-25H,11H2,1-5H3
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n/an/a 33n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377341
PNG
(CHEMBL438885)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(Cl)cc2cc[nH]c12
Show InChI InChI=1S/C21H22Cl2N2/c1-11-7-15(16-9-14(22)8-13-5-6-24-20(13)16)18(23)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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n/an/a 53n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377347
PNG
(CHEMBL404640)
Show SMILES COc1ccc(-c2cc(C)c3NC(C)(C)CC(C)c3c2Cl)c2[nH]ccc12
Show InChI InChI=1S/C22H25ClN2O/c1-12-10-16(14-6-7-17(26-5)15-8-9-24-21(14)15)19(23)18-13(2)11-22(3,4)25-20(12)18/h6-10,13,24-25H,11H2,1-5H3
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n/an/a 67n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50086551
PNG
(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Show SMILES CC1CC(C)(C)Nc2ccc(cc12)-c1sc(cc1C)C#N
Show InChI InChI=1S/C18H20N2S/c1-11-7-14(10-19)21-17(11)13-5-6-16-15(8-13)12(2)9-18(3,4)20-16/h5-8,12,20H,9H2,1-4H3
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n/an/a 73n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377351
PNG
(CHEMBL427899)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2ccn(C)c12
Show InChI InChI=1S/C22H25ClN2/c1-13-11-17(16-8-6-7-15-9-10-25(5)21(15)16)19(23)18-14(2)12-22(3,4)24-20(13)18/h6-11,14,24H,12H2,1-5H3
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n/an/a 84n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377338
PNG
(CHEMBL429842)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(F)c(F)c2cc[nH]c12
Show InChI InChI=1S/C21H21ClF2N2/c1-10-7-13(14-8-15(23)18(24)12-5-6-25-20(12)14)17(22)16-11(2)9-21(3,4)26-19(10)16/h5-8,11,25-26H,9H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377344
PNG
(CHEMBL402362)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc2cc[nH]c2c1
Show InChI InChI=1S/C21H23ClN2/c1-12-9-16(15-6-5-14-7-8-23-17(14)10-15)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377351
PNG
(CHEMBL427899)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2ccn(C)c12
Show InChI InChI=1S/C22H25ClN2/c1-13-11-17(16-8-6-7-15-9-10-25(5)21(15)16)19(23)18-14(2)12-22(3,4)24-20(13)18/h6-11,14,24H,12H2,1-5H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377346
PNG
(CHEMBL403274)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(F)cc2cc[nH]c12
Show InChI InChI=1S/C21H22ClFN2/c1-11-7-15(16-9-14(23)8-13-5-6-24-20(13)16)18(22)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377347
PNG
(CHEMBL404640)
Show SMILES COc1ccc(-c2cc(C)c3NC(C)(C)CC(C)c3c2Cl)c2[nH]ccc12
Show InChI InChI=1S/C22H25ClN2O/c1-12-10-16(14-6-7-17(26-5)15-8-9-24-21(14)15)19(23)18-13(2)11-22(3,4)25-20(12)18/h6-10,13,24-25H,11H2,1-5H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377345
PNG
(CHEMBL256787)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2c(C)c[nH]c12
Show InChI InChI=1S/C22H25ClN2/c1-12-9-17(16-8-6-7-15-14(3)11-24-21(15)16)19(23)18-13(2)10-22(4,5)25-20(12)18/h6-9,11,13,24-25H,10H2,1-5H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377350
PNG
(CHEMBL257152)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc(F)c2cc[nH]c12
Show InChI InChI=1S/C21H22ClFN2/c1-11-9-15(13-5-6-16(23)14-7-8-24-20(13)14)18(22)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377344
PNG
(CHEMBL402362)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc2cc[nH]c2c1
Show InChI InChI=1S/C21H23ClN2/c1-12-9-16(15-6-5-14-7-8-23-17(14)10-15)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377342
PNG
(CHEMBL436848)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3cc4ccccc4[nH]3)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(17-10-14-7-5-6-8-16(14)23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377342
PNG
(CHEMBL436848)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3cc4ccccc4[nH]3)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(17-10-14-7-5-6-8-16(14)23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377349
PNG
(CHEMBL253745)
Show SMILES COc1ccc2cc[nH]c2c1-c1cc(C)c2NC(C)(C)CC(C)c2c1Cl
Show InChI InChI=1S/C22H25ClN2O/c1-12-10-15(18-16(26-5)7-6-14-8-9-24-21(14)18)19(23)17-13(2)11-22(3,4)25-20(12)17/h6-10,13,24-25H,11H2,1-5H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377348
PNG
(CHEMBL258193)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(14-6-5-7-17-15(14)8-9-23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377343
PNG
(CHEMBL404496)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3c[nH]c4ccccc34)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(16-11-23-17-8-6-5-7-14(16)17)19(22)18-13(2)10-21(3,4)24-20(12)18/h5-9,11,13,23-24H,10H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377340
PNG
(CHEMBL443847)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc(C)[nH]c12
Show InChI InChI=1S/C22H25ClN2/c1-12-9-17(16-8-6-7-15-10-14(3)24-21(15)16)19(23)18-13(2)11-22(4,5)25-20(12)18/h6-10,13,24-25H,11H2,1-5H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377340
PNG
(CHEMBL443847)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc(C)[nH]c12
Show InChI InChI=1S/C22H25ClN2/c1-12-9-17(16-8-6-7-15-10-14(3)24-21(15)16)19(23)18-13(2)11-22(4,5)25-20(12)18/h6-10,13,24-25H,11H2,1-5H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377342
PNG
(CHEMBL436848)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3cc4ccccc4[nH]3)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(17-10-14-7-5-6-8-16(14)23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50334048
PNG
((-)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl...)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)18(22)17-13(2)11-21(3,4)24-19(12)17/h5-10,13,23-24H,11H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50334048
PNG
((-)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl...)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)18(22)17-13(2)11-21(3,4)24-19(12)17/h5-10,13,23-24H,11H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50086551
PNG
(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Show SMILES CC1CC(C)(C)Nc2ccc(cc12)-c1sc(cc1C)C#N
Show InChI InChI=1S/C18H20N2S/c1-11-7-14(10-19)21-17(11)13-5-6-16-15(8-13)12(2)9-18(3,4)20-16/h5-8,12,20H,9H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377341
PNG
(CHEMBL438885)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(Cl)cc2cc[nH]c12
Show InChI InChI=1S/C21H22Cl2N2/c1-11-7-15(16-9-14(22)8-13-5-6-24-20(13)16)18(23)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377339
PNG
(CHEMBL404879)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc(Cl)c2cc[nH]c12
Show InChI InChI=1S/C21H22Cl2N2/c1-11-9-15(13-5-6-16(22)14-7-8-24-20(13)14)18(23)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377342
PNG
(CHEMBL436848)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3cc4ccccc4[nH]3)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(17-10-14-7-5-6-8-16(14)23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50334048
PNG
((-)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl...)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)18(22)17-13(2)11-21(3,4)24-19(12)17/h5-10,13,23-24H,11H2,1-4H3
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n/an/an/an/a 20n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377350
PNG
(CHEMBL257152)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc(F)c2cc[nH]c12
Show InChI InChI=1S/C21H22ClFN2/c1-11-9-15(13-5-6-16(23)14-7-8-24-20(13)14)18(22)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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n/an/an/an/a 46n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377344
PNG
(CHEMBL402362)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc2cc[nH]c2c1
Show InChI InChI=1S/C21H23ClN2/c1-12-9-16(15-6-5-14-7-8-23-17(14)10-15)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50086551
PNG
(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Show SMILES CC1CC(C)(C)Nc2ccc(cc12)-c1sc(cc1C)C#N
Show InChI InChI=1S/C18H20N2S/c1-11-7-14(10-19)21-17(11)13-5-6-16-15(8-13)12(2)9-18(3,4)20-16/h5-8,12,20H,9H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377342
PNG
(CHEMBL436848)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3cc4ccccc4[nH]3)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(17-10-14-7-5-6-8-16(14)23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377343
PNG
(CHEMBL404496)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3c[nH]c4ccccc34)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(16-11-23-17-8-6-5-7-14(16)17)19(22)18-13(2)10-21(3,4)24-20(12)18/h5-9,11,13,23-24H,10H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377351
PNG
(CHEMBL427899)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2ccn(C)c12
Show InChI InChI=1S/C22H25ClN2/c1-13-11-17(16-8-6-7-15-9-10-25(5)21(15)16)19(23)18-14(2)12-22(3,4)24-20(13)18/h6-11,14,24H,12H2,1-5H3
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n/an/an/an/a 191n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50334048
PNG
((-)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl...)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)18(22)17-13(2)11-21(3,4)24-19(12)17/h5-10,13,23-24H,11H2,1-4H3
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n/an/an/an/a 12n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377348
PNG
(CHEMBL258193)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H23ClN2/c1-12-10-16(14-6-5-7-17-15(14)8-9-23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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n/an/an/an/a 433n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377341
PNG
(CHEMBL438885)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(Cl)cc2cc[nH]c12
Show InChI InChI=1S/C21H22Cl2N2/c1-11-7-15(16-9-14(22)8-13-5-6-24-20(13)16)18(23)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377347
PNG
(CHEMBL404640)
Show SMILES COc1ccc(-c2cc(C)c3NC(C)(C)CC(C)c3c2Cl)c2[nH]ccc12
Show InChI InChI=1S/C22H25ClN2O/c1-12-10-16(14-6-7-17(26-5)15-8-9-24-21(14)15)19(23)18-13(2)11-22(3,4)25-20(12)18/h6-10,13,24-25H,11H2,1-5H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377346
PNG
(CHEMBL403274)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(F)cc2cc[nH]c12
Show InChI InChI=1S/C21H22ClFN2/c1-11-7-15(16-9-14(23)8-13-5-6-24-20(13)16)18(22)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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n/an/an/an/a 9.20n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377349
PNG
(CHEMBL253745)
Show SMILES COc1ccc2cc[nH]c2c1-c1cc(C)c2NC(C)(C)CC(C)c2c1Cl
Show InChI InChI=1S/C22H25ClN2O/c1-12-10-15(18-16(26-5)7-6-14-8-9-24-21(14)18)19(23)17-13(2)11-22(3,4)25-20(12)17/h6-10,13,24-25H,11H2,1-5H3
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n/an/an/an/a 4.80E+4n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377340
PNG
(CHEMBL443847)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc(C)[nH]c12
Show InChI InChI=1S/C22H25ClN2/c1-12-9-17(16-8-6-7-15-10-14(3)24-21(15)16)19(23)18-13(2)11-22(4,5)25-20(12)18/h6-10,13,24-25H,11H2,1-5H3
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n/an/an/an/a 531n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377345
PNG
(CHEMBL256787)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2c(C)c[nH]c12
Show InChI InChI=1S/C22H25ClN2/c1-12-9-17(16-8-6-7-15-14(3)11-24-21(15)16)19(23)18-13(2)10-22(4,5)25-20(12)18/h6-9,11,13,24-25H,10H2,1-5H3
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n/an/an/an/a 7.50E+3n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377339
PNG
(CHEMBL404879)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1ccc(Cl)c2cc[nH]c12
Show InChI InChI=1S/C21H22Cl2N2/c1-11-9-15(13-5-6-16(22)14-7-8-24-20(13)14)18(23)17-12(2)10-21(3,4)25-19(11)17/h5-9,12,24-25H,10H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377338
PNG
(CHEMBL429842)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cc(F)c(F)c2cc[nH]c12
Show InChI InChI=1S/C21H21ClF2N2/c1-10-7-13(14-8-15(23)18(24)12-5-6-25-20(12)14)17(22)16-11(2)9-21(3,4)26-19(10)16/h5-8,11,25-26H,9H2,1-4H3
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n/an/an/an/a 76n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM19190
PNG
((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
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n/an/an/an/a 5.30n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50377342
PNG
(CHEMBL436848)
Show SMILES CC1CC(C)(C)Nc2c(C)cc(-c3cc4ccccc4[nH]3)c(Cl)c12
Show InChI InChI=1S/C21H23ClN2/c1-12-9-15(17-10-14-7-5-6-8-16(14)23-17)19(22)18-13(2)11-21(3,4)24-20(12)18/h5-10,13,23-24H,11H2,1-4H3
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay


Bioorg Med Chem Lett 18: 3504-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.029
BindingDB Entry DOI: 10.7270/Q2CR5V8F
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%