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PubMed code 18541424

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50243848
PNG
(1-(2-Benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(...)
Show SMILES NS(=O)(=O)c1ccccc1C#Cc1ccc(=O)n(O)c1
Show InChI InChI=1S/C13H10N2O4S/c14-20(18,19)12-4-2-1-3-11(12)7-5-10-6-8-13(16)15(17)9-10/h1-4,6,8-9,17H,(H2,14,18,19)
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PC sid
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Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



University of Alberta

Curated by ChEMBL


Assay Description
Inhibition of lipoxygenase-5 in human ED273b-BT cells assessed as amount of cysteinyl leukotriene secreted after 24 hrs by immunoassay


Bioorg Med Chem Lett 18: 4195-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.071
BindingDB Entry DOI: 10.7270/Q2SF2VZW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50243739
PNG
(1-(3-Benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(...)
Show SMILES NS(=O)(=O)c1cccc(c1)C#Cc1ccc(=O)n(O)c1
Show InChI InChI=1S/C13H10N2O4S/c14-20(18,19)12-3-1-2-10(8-12)4-5-11-6-7-13(16)15(17)9-11/h1-3,6-9,17H,(H2,14,18,19)
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Article
PubMed
n/an/a 1.50E+4n/an/an/an/an/an/a



University of Alberta

Curated by ChEMBL


Assay Description
Inhibition of lipoxygenase-5 in human ED273b-BT cells assessed as amount of cysteinyl leukotriene secreted after 24 hrs by immunoassay


Bioorg Med Chem Lett 18: 4195-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.071
BindingDB Entry DOI: 10.7270/Q2SF2VZW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM32020
PNG
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Show SMILES CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1
Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
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Article
PubMed
n/an/a 3.50E+4n/an/an/an/an/an/a



University of Alberta

Curated by ChEMBL


Assay Description
Inhibition of lipoxygenase-5 in human ED273b-BT cells assessed as amount of cysteinyl leukotriene secreted after 24 hrs by immunoassay


Bioorg Med Chem Lett 18: 4195-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.071
BindingDB Entry DOI: 10.7270/Q2SF2VZW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50243740
PNG
(1-(4-Benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C#Cc1ccc(=O)n(O)c1
Show InChI InChI=1S/C13H10N2O4S/c14-20(18,19)12-6-3-10(4-7-12)1-2-11-5-8-13(16)15(17)9-11/h3-9,17H,(H2,14,18,19)
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Article
PubMed
n/an/a 6.80E+4n/an/an/an/an/an/a



University of Alberta

Curated by ChEMBL


Assay Description
Inhibition of lipoxygenase-5 in human ED273b-BT cells assessed as amount of cysteinyl leukotriene secreted after 24 hrs by immunoassay


Bioorg Med Chem Lett 18: 4195-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.071
BindingDB Entry DOI: 10.7270/Q2SF2VZW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%