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PubMed code 18557606

Compile data set for download or QSAR
Found 64 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243417
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(ccn3c2N)-c2cnn(C)c2)c1
Show InChI InChI=1S/C25H23N7O/c1-16-4-3-5-20(12-16)30-25(33)29-19-8-6-17(7-9-19)22-14-27-24-21(10-11-32(24)23(22)26)18-13-28-31(2)15-18/h3-15H,26H2,1-2H3,(H2,29,30,33)
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n/an/a 0.700n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243360
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)-c2cnn(C)c2)c1
Show InChI InChI=1S/C24H22N8O/c1-15-4-3-5-19(10-15)30-24(33)29-18-8-6-16(7-9-18)20-12-26-23-21(13-28-32(23)22(20)25)17-11-27-31(2)14-17/h3-14H,25H2,1-2H3,(H2,29,30,33)
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n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50243417
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(ccn3c2N)-c2cnn(C)c2)c1
Show InChI InChI=1S/C25H23N7O/c1-16-4-3-5-20(12-16)30-25(33)29-19-8-6-17(7-9-19)22-14-27-24-21(10-11-32(24)23(22)26)18-13-28-31(2)15-18/h3-15H,26H2,1-2H3,(H2,29,30,33)
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n/an/a 3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt1 (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243417
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(ccn3c2N)-c2cnn(C)c2)c1
Show InChI InChI=1S/C25H23N7O/c1-16-4-3-5-20(12-16)30-25(33)29-19-8-6-17(7-9-19)22-14-27-24-21(10-11-32(24)23(22)26)18-13-28-31(2)15-18/h3-15H,26H2,1-2H3,(H2,29,30,33)
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n/an/a 3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243418
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cn1cc(cn1)-c1ccn2c(N)c(cnc12)-c1ccc(NC(=O)Nc2cccc(Cl)c2)cc1
Show InChI InChI=1S/C24H20ClN7O/c1-31-14-16(12-28-31)20-9-10-32-22(26)21(13-27-23(20)32)15-5-7-18(8-6-15)29-24(33)30-19-4-2-3-17(25)11-19/h2-14H,26H2,1H3,(H2,29,30,33)
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n/an/a 4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50243417
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(ccn3c2N)-c2cnn(C)c2)c1
Show InChI InChI=1S/C25H23N7O/c1-16-4-3-5-20(12-16)30-25(33)29-19-8-6-17(7-9-19)22-14-27-24-21(10-11-32(24)23(22)26)18-13-28-31(2)15-18/h3-15H,26H2,1-2H3,(H2,29,30,33)
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n/an/a 4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CSF1R (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243360
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)-c2cnn(C)c2)c1
Show InChI InChI=1S/C24H22N8O/c1-15-4-3-5-19(10-15)30-24(33)29-18-8-6-16(7-9-18)20-12-26-23-21(13-28-32(23)22(20)25)17-11-27-31(2)14-17/h3-14H,25H2,1-2H3,(H2,29,30,33)
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n/an/a 4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50243417
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(ccn3c2N)-c2cnn(C)c2)c1
Show InChI InChI=1S/C25H23N7O/c1-16-4-3-5-20(12-16)30-25(33)29-19-8-6-17(7-9-19)22-14-27-24-21(10-11-32(24)23(22)26)18-13-28-31(2)15-18/h3-15H,26H2,1-2H3,(H2,29,30,33)
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n/an/a 5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt3 (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242918
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cn1cc(cn1)-c1ccn2c(N)c(cnc12)-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C25H19F4N7O/c1-35-13-15(11-32-35)18-8-9-36-22(30)19(12-31-23(18)36)14-2-5-17(6-3-14)33-24(37)34-21-10-16(25(27,28)29)4-7-20(21)26/h2-13H,30H2,1H3,(H2,33,34,37)
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n/an/a 5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242919
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cn1cc(cn1)-c1ccn2c(N)c(cnc12)-c1ccc(NC(=O)Nc2ccc(F)c(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H19F4N7O/c1-35-13-15(11-32-35)18-8-9-36-22(30)19(12-31-23(18)36)14-2-4-16(5-3-14)33-24(37)34-17-6-7-21(26)20(10-17)25(27,28)29/h2-13H,30H2,1H3,(H2,33,34,37)
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n/an/a 6n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243359
PNG
(1-[4-(7-Amino-3-pyridin-3-yl-pyrazolo[1,5-a]pyrimi...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)-c2cccnc2)c1
Show InChI InChI=1S/C25H21N7O/c1-16-4-2-6-20(12-16)31-25(33)30-19-9-7-17(8-10-19)21-14-28-24-22(15-29-32(24)23(21)26)18-5-3-11-27-13-18/h2-15H,26H2,1H3,(H2,30,31,33)
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n/an/a 7n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243418
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cn1cc(cn1)-c1ccn2c(N)c(cnc12)-c1ccc(NC(=O)Nc2cccc(Cl)c2)cc1
Show InChI InChI=1S/C24H20ClN7O/c1-31-14-16(12-28-31)20-9-10-32-22(26)21(13-27-23(20)32)15-5-7-18(8-6-15)29-24(33)30-19-4-2-3-17(25)11-19/h2-14H,26H2,1H3,(H2,29,30,33)
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n/an/a 8n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243363
PNG
(1-(4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)...)
Show SMILES Nc1c(cnc2ccnn12)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H15F3N6O/c21-20(22,23)13-2-1-3-15(10-13)28-19(30)27-14-6-4-12(5-7-14)16-11-25-17-8-9-26-29(17)18(16)24/h1-11H,24H2,(H2,27,28,30)
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n/an/a 9n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243359
PNG
(1-[4-(7-Amino-3-pyridin-3-yl-pyrazolo[1,5-a]pyrimi...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)-c2cccnc2)c1
Show InChI InChI=1S/C25H21N7O/c1-16-4-2-6-20(12-16)31-25(33)30-19-9-7-17(8-10-19)21-14-28-24-22(15-29-32(24)23(21)26)18-5-3-11-27-13-18/h2-15H,26H2,1H3,(H2,30,31,33)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50243417
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(ccn3c2N)-c2cnn(C)c2)c1
Show InChI InChI=1S/C25H23N7O/c1-16-4-3-5-20(12-16)30-25(33)29-19-8-6-17(7-9-19)22-14-27-24-21(10-11-32(24)23(22)26)18-13-28-31(2)15-18/h3-15H,26H2,1-2H3,(H2,29,30,33)
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n/an/a 9n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242920
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cn1cc(cn1)-c1ccn2c(N)c(cnc12)-c1ccc(NC(=O)Nc2cccc(F)c2)cc1
Show InChI InChI=1S/C24H20FN7O/c1-31-14-16(12-28-31)20-9-10-32-22(26)21(13-27-23(20)32)15-5-7-18(8-6-15)29-24(33)30-19-4-2-3-17(25)11-19/h2-14H,26H2,1H3,(H2,29,30,33)
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n/an/a 10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243327
PNG
(1-[4-(7-Amino-3-thiophen-3-yl-pyrazolo[1,5-a]pyrim...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)-c2ccsc2)c1
Show InChI InChI=1S/C24H20N6OS/c1-15-3-2-4-19(11-15)29-24(31)28-18-7-5-16(6-8-18)20-12-26-23-21(17-9-10-32-14-17)13-27-30(23)22(20)25/h2-14H,25H2,1H3,(H2,28,29,31)
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n/an/a 11n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243366
PNG
(1-(4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)...)
Show SMILES Nc1c(cnc2ccnn12)-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C20H14F4N6O/c21-15-6-3-12(20(22,23)24)9-16(15)29-19(31)28-13-4-1-11(2-5-13)14-10-26-17-7-8-27-30(17)18(14)25/h1-10H,25H2,(H2,28,29,31)
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n/an/a 14n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243326
PNG
(1-[4-(7-Amino-3-thiophen-2-yl-pyrazolo[1,5-a]pyrim...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)-c2cccs2)c1
Show InChI InChI=1S/C24H20N6OS/c1-15-4-2-5-18(12-15)29-24(31)28-17-9-7-16(8-10-17)19-13-26-23-20(21-6-3-11-32-21)14-27-30(23)22(19)25/h2-14H,25H2,1H3,(H2,28,29,31)
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n/an/a 15n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243328
PNG
(1-[4-(7-Amino-3-cyclopropyl-pyrazolo[1,5-a]pyrimid...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)C2CC2)c1
Show InChI InChI=1S/C23H22N6O/c1-14-3-2-4-18(11-14)28-23(30)27-17-9-7-15(8-10-17)19-12-25-22-20(16-5-6-16)13-26-29(22)21(19)24/h2-4,7-13,16H,5-6,24H2,1H3,(H2,27,28,30)
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n/an/a 16n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242997
PNG
(1-[4-(7-Amino-3-phenyl-pyrazolo[1,5-a]pyrimidin-6-...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)-c2ccccc2)c1
Show InChI InChI=1S/C26H22N6O/c1-17-6-5-9-21(14-17)31-26(33)30-20-12-10-19(11-13-20)22-15-28-25-23(16-29-32(25)24(22)27)18-7-3-2-4-8-18/h2-16H,27H2,1H3,(H2,30,31,33)
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n/an/a 17n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243329
PNG
(1-[4-(7-Amino-3-benzo[1,3]dioxol-5-yl-pyrazolo[1,5...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)-c2ccc3OCOc3c2)c1
Show InChI InChI=1S/C27H22N6O3/c1-16-3-2-4-20(11-16)32-27(34)31-19-8-5-17(6-9-19)21-13-29-26-22(14-30-33(26)25(21)28)18-7-10-23-24(12-18)36-15-35-23/h2-14H,15,28H2,1H3,(H2,31,32,34)
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n/an/a 17n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243329
PNG
(1-[4-(7-Amino-3-benzo[1,3]dioxol-5-yl-pyrazolo[1,5...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)-c2ccc3OCOc3c2)c1
Show InChI InChI=1S/C27H22N6O3/c1-16-3-2-4-20(11-16)32-27(34)31-19-8-5-17(6-9-19)21-13-29-26-22(14-30-33(26)25(21)28)18-7-10-23-24(12-18)36-15-35-23/h2-14H,15,28H2,1H3,(H2,31,32,34)
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n/an/a 21n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242997
PNG
(1-[4-(7-Amino-3-phenyl-pyrazolo[1,5-a]pyrimidin-6-...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)-c2ccccc2)c1
Show InChI InChI=1S/C26H22N6O/c1-17-6-5-9-21(14-17)31-26(33)30-20-12-10-19(11-13-20)22-15-28-25-23(16-29-32(25)24(22)27)18-7-3-2-4-8-18/h2-16H,27H2,1H3,(H2,30,31,33)
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n/an/a 22n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243327
PNG
(1-[4-(7-Amino-3-thiophen-3-yl-pyrazolo[1,5-a]pyrim...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)-c2ccsc2)c1
Show InChI InChI=1S/C24H20N6OS/c1-15-3-2-4-19(11-15)29-24(31)28-18-7-5-16(6-8-18)20-12-26-23-21(17-9-10-32-14-17)13-27-30(23)22(20)25/h2-14H,25H2,1H3,(H2,28,29,31)
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n/an/a 22n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243362
PNG
(7-Amino-6-[4-(3-m-tolylureido)phenyl]pyrazolo[1,5-...)
Show SMILES CCOC(=O)c1cnn2c(N)c(cnc12)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C23H22N6O3/c1-3-32-22(30)19-13-26-29-20(24)18(12-25-21(19)29)15-7-9-16(10-8-15)27-23(31)28-17-6-4-5-14(2)11-17/h4-13H,3,24H2,1-2H3,(H2,27,28,31)
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n/an/a 25n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242918
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cn1cc(cn1)-c1ccn2c(N)c(cnc12)-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C25H19F4N7O/c1-35-13-15(11-32-35)18-8-9-36-22(30)19(12-31-23(18)36)14-2-5-17(6-3-14)33-24(37)34-21-10-16(25(27,28)29)4-7-20(21)26/h2-13H,30H2,1H3,(H2,33,34,37)
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n/an/a 28n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 28n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242920
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cn1cc(cn1)-c1ccn2c(N)c(cnc12)-c1ccc(NC(=O)Nc2cccc(F)c2)cc1
Show InChI InChI=1S/C24H20FN7O/c1-31-14-16(12-28-31)20-9-10-32-22(26)21(13-27-23(20)32)15-5-7-18(8-6-15)29-24(33)30-19-4-2-3-17(25)11-19/h2-14H,26H2,1H3,(H2,29,30,33)
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n/an/a 29n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243328
PNG
(1-[4-(7-Amino-3-cyclopropyl-pyrazolo[1,5-a]pyrimid...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)C2CC2)c1
Show InChI InChI=1S/C23H22N6O/c1-14-3-2-4-18(11-14)28-23(30)27-17-9-7-15(8-10-17)19-12-25-22-20(16-5-6-16)13-26-29(22)21(19)24/h2-4,7-13,16H,5-6,24H2,1H3,(H2,27,28,30)
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n/an/a 33n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243363
PNG
(1-(4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)...)
Show SMILES Nc1c(cnc2ccnn12)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H15F3N6O/c21-20(22,23)13-2-1-3-15(10-13)28-19(30)27-14-6-4-12(5-7-14)16-11-25-17-8-9-26-29(17)18(16)24/h1-11H,24H2,(H2,27,28,30)
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n/an/a 35n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243000
PNG
(1-[4-(7-Amino-5-methylpyrazolo[1,5-a]pyrimidin-6-y...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(C)nc3ccnn3c2N)c1
Show InChI InChI=1S/C21H20N6O/c1-13-4-3-5-17(12-13)26-21(28)25-16-8-6-15(7-9-16)19-14(2)24-18-10-11-23-27(18)20(19)22/h3-12H,22H2,1-2H3,(H2,25,26,28)
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n/an/a 39n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243364
PNG
(1-(4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)...)
Show SMILES Nc1c(cnc2ccnn12)-c1ccc(NC(=O)Nc2cccc(Cl)c2)cc1
Show InChI InChI=1S/C19H15ClN6O/c20-13-2-1-3-15(10-13)25-19(27)24-14-6-4-12(5-7-14)16-11-22-17-8-9-23-26(17)18(16)21/h1-11H,21H2,(H2,24,25,27)
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n/an/a 44n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242910
PNG
(1-[4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3ccnn3c2N)c1
Show InChI InChI=1S/C20H18N6O/c1-13-3-2-4-16(11-13)25-20(27)24-15-7-5-14(6-8-15)17-12-22-18-9-10-23-26(18)19(17)21/h2-12H,21H2,1H3,(H2,24,25,27)
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n/an/a 47n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243326
PNG
(1-[4-(7-Amino-3-thiophen-2-yl-pyrazolo[1,5-a]pyrim...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)-c2cccs2)c1
Show InChI InChI=1S/C24H20N6OS/c1-15-4-2-5-18(12-15)29-24(31)28-17-9-7-16(8-10-17)19-13-26-23-20(21-6-3-11-32-21)14-27-30(23)22(19)25/h2-14H,25H2,1H3,(H2,28,29,31)
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n/an/a 49n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242919
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cn1cc(cn1)-c1ccn2c(N)c(cnc12)-c1ccc(NC(=O)Nc2ccc(F)c(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H19F4N7O/c1-35-13-15(11-32-35)18-8-9-36-22(30)19(12-31-23(18)36)14-2-4-16(5-3-14)33-24(37)34-17-6-7-21(26)20(10-17)25(27,28)29/h2-13H,30H2,1H3,(H2,33,34,37)
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n/an/a 55n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242910
PNG
(1-[4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3ccnn3c2N)c1
Show InChI InChI=1S/C20H18N6O/c1-13-3-2-4-16(11-13)25-20(27)24-15-7-5-14(6-8-15)17-12-22-18-9-10-23-26(18)19(17)21/h2-12H,21H2,1H3,(H2,24,25,27)
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n/an/a 70n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243366
PNG
(1-(4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)...)
Show SMILES Nc1c(cnc2ccnn12)-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C20H14F4N6O/c21-15-6-3-12(20(22,23)24)9-16(15)29-19(31)28-13-4-1-11(2-5-13)14-10-26-17-7-8-27-30(17)18(14)25/h1-10H,25H2,(H2,28,29,31)
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n/an/a 70n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243324
PNG
(1-(4-(7-Amino-3-bromopyrazolo[1,5-a]pyrimidin-6-yl...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(Br)cnn3c2N)c1
Show InChI InChI=1S/C20H17BrN6O/c1-12-3-2-4-15(9-12)26-20(28)25-14-7-5-13(6-8-14)16-10-23-19-17(21)11-24-27(19)18(16)22/h2-11H,22H2,1H3,(H2,25,26,28)
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n/an/a 72n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243365
PNG
(1-(4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cnc3ccnn3c2N)c1
Show InChI InChI=1S/C20H17FN6O/c1-12-2-7-16(21)17(10-12)26-20(28)25-14-5-3-13(4-6-14)15-11-23-18-8-9-24-27(18)19(15)22/h2-11H,22H2,1H3,(H2,25,26,28)
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n/an/a 74n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243324
PNG
(1-(4-(7-Amino-3-bromopyrazolo[1,5-a]pyrimidin-6-yl...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(Br)cnn3c2N)c1
Show InChI InChI=1S/C20H17BrN6O/c1-12-3-2-4-15(9-12)26-20(28)25-14-7-5-13(6-8-14)16-10-23-19-17(21)11-24-27(19)18(16)22/h2-11H,22H2,1H3,(H2,25,26,28)
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n/an/a 86n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242915
PNG
(7-Amino-6-[4-(3-m-tolylureido)phenyl]pyrazolo[1,5-...)
Show SMILES CNC(=O)c1cnn2c(N)c(cnc12)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C22H21N7O2/c1-13-4-3-5-16(10-13)28-22(31)27-15-8-6-14(7-9-15)17-11-25-20-18(21(30)24-2)12-26-29(20)19(17)23/h3-12H,23H2,1-2H3,(H,24,30)(H2,27,28,31)
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n/an/a 100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243320
PNG
(1-(4-(5-aminoquinoxalin-6-yl)phenyl)-3-m-tolylurea...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc3nccnc3c2N)c1
Show InChI InChI=1S/C22H19N5O/c1-14-3-2-4-17(13-14)27-22(28)26-16-7-5-15(6-8-16)18-9-10-19-21(20(18)23)25-12-11-24-19/h2-13H,23H2,1H3,(H2,26,27,28)
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n/an/a 168n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM5432
PNG
(6-(4-methoxyphenyl)-3-(thiophen-3-yl)pyrazolo[1,5-...)
Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1
Show InChI InChI=1S/C17H13N3OS/c1-21-15-4-2-12(3-5-15)14-8-18-17-16(9-19-20(17)10-14)13-6-7-22-11-13/h2-11H,1H3
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n/an/a 185n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243362
PNG
(7-Amino-6-[4-(3-m-tolylureido)phenyl]pyrazolo[1,5-...)
Show SMILES CCOC(=O)c1cnn2c(N)c(cnc12)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C23H22N6O3/c1-3-32-22(30)19-13-26-29-20(24)18(12-25-21(19)29)15-7-9-16(10-8-15)27-23(31)28-17-6-4-5-14(2)11-17/h4-13H,3,24H2,1-2H3,(H2,27,28,31)
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n/an/a 220n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243000
PNG
(1-[4-(7-Amino-5-methylpyrazolo[1,5-a]pyrimidin-6-y...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(C)nc3ccnn3c2N)c1
Show InChI InChI=1S/C21H20N6O/c1-13-4-3-5-17(12-13)26-21(28)25-16-8-6-15(7-9-16)19-14(2)24-18-10-11-23-27(18)20(19)22/h3-12H,22H2,1-2H3,(H2,25,26,28)
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n/an/a 250n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243001
PNG
(7-Amino-6-[4-(3-m-tolyl-ureido)-phenyl]-pyrazolo[1...)
Show SMILES CCN(CC)CCNC(=O)c1cnn2c(N)c(cnc12)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C27H32N8O2/c1-4-34(5-2)14-13-29-26(36)23-17-31-35-24(28)22(16-30-25(23)35)19-9-11-20(12-10-19)32-27(37)33-21-8-6-7-18(3)15-21/h6-12,15-17H,4-5,13-14,28H2,1-3H3,(H,29,36)(H2,32,33,37)
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n/an/a 500n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242916
PNG
(1-(4-(7-amino-3-(4-methylpiperazine-1-carbonyl)pyr...)
Show SMILES CN1CCN(CC1)C(=O)c1cnn2c(N)c(cnc12)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C26H28N8O2/c1-17-4-3-5-20(14-17)31-26(36)30-19-8-6-18(7-9-19)21-15-28-24-22(16-29-34(24)23(21)27)25(35)33-12-10-32(2)11-13-33/h3-9,14-16H,10-13,27H2,1-2H3,(H2,30,31,36)
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n/an/a 790n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243003
PNG
(1-(4-(7-Amino-3-bromopyrazolo[1,5-a]pyrimidin-6-yl...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(Br)cnn3c2N)cc1
Show InChI InChI=1S/C20H17BrN6O/c1-12-2-6-14(7-3-12)25-20(28)26-15-8-4-13(5-9-15)16-10-23-19-17(21)11-24-27(19)18(16)22/h2-11H,22H2,1H3,(H2,25,26,28)
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n/an/a 810n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243361
PNG
(1-[4-(7-Amino-3-cyano-pyrazolo[1,5-a]pyrimidin-6-y...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)C#N)c1
Show InChI InChI=1S/C21H17N7O/c1-13-3-2-4-17(9-13)27-21(29)26-16-7-5-14(6-8-16)18-12-24-20-15(10-22)11-25-28(20)19(18)23/h2-9,11-12H,23H2,1H3,(H2,26,27,29)
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n/an/a 930n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243004
PNG
(1-(4-(7-Amino-3-bromopyrazolo[1,5-a]pyrimidin-6-yl...)
Show SMILES Nc1c(cnc2c(Br)cnn12)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C19H15BrN6O/c20-16-11-23-26-17(21)15(10-22-18(16)26)12-6-8-14(9-7-12)25-19(27)24-13-4-2-1-3-5-13/h1-11H,21H2,(H2,24,25,27)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242914
PNG
(7-Amino-6-[4-(3-m-tolylureido)phenyl]pyrazolo[1,5-...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)C(O)=O)c1
Show InChI InChI=1S/C21H18N6O3/c1-12-3-2-4-15(9-12)26-21(30)25-14-7-5-13(6-8-14)16-10-23-19-17(20(28)29)11-24-27(19)18(16)22/h2-11H,22H2,1H3,(H,28,29)(H2,25,26,30)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242998
PNG
(1-[4-(7-Amino-2-methyl-pyrazolo[1,5-a]pyrimidin-6-...)
Show SMILES Cc1cc2ncc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)c(N)n2n1
Show InChI InChI=1S/C21H20N6O/c1-13-4-3-5-17(10-13)25-21(28)24-16-8-6-15(7-9-16)18-12-23-19-11-14(2)26-27(19)20(18)22/h3-12H,22H2,1-2H3,(H2,24,25,28)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243416
PNG
(6-(4-methoxyphenyl)-3-(thiophen-3-yl)pyrazolo[1,5-...)
Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1N)-c1ccsc1
Show InChI InChI=1S/C17H14N4OS/c1-22-13-4-2-11(3-5-13)14-8-19-17-15(12-6-7-23-10-12)9-20-21(17)16(14)18/h2-10H,18H2,1H3
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n/an/a 6.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242911
PNG
(1-[3-(7-Amino-pyrazolo[1,5-a]pyrimidin-6-yl)-pheny...)
Show SMILES Cc1cccc(NC(=O)Nc2cccc(c2)-c2cnc3ccnn3c2N)c1
Show InChI InChI=1S/C20H18N6O/c1-13-4-2-6-15(10-13)24-20(27)25-16-7-3-5-14(11-16)17-12-22-18-8-9-23-26(18)19(17)21/h2-12H,21H2,1H3,(H2,24,25,27)
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n/an/a 6.60E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242912
PNG
(1-[4-(7-Amino-pyrazolo[1,5-a]pyrimidin-6-yl)-pheny...)
Show SMILES Cc1cccc(NC(=S)Nc2ccc(cc2)-c2cnc3ccnn3c2N)c1
Show InChI InChI=1S/C20H18N6S/c1-13-3-2-4-16(11-13)25-20(27)24-15-7-5-14(6-8-15)17-12-22-18-9-10-23-26(18)19(17)21/h2-12H,21H2,1H3,(H2,24,25,27)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243367
PNG
(3-bromo-6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidi...)
Show SMILES COc1ccc(cc1)-c1cnc2c(Br)cnn2c1
Show InChI InChI=1S/C13H10BrN3O/c1-18-11-4-2-9(3-5-11)10-6-15-13-12(14)7-16-17(13)8-10/h2-8H,1H3
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n/an/a>1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242999
PNG
(1-[4-(7-Amino-2-phenyl-pyrazolo[1,5-a]pyrimidin-6-...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3cc(nn3c2N)-c2ccccc2)c1
Show InChI InChI=1S/C26H22N6O/c1-17-6-5-9-21(14-17)30-26(33)29-20-12-10-18(11-13-20)22-16-28-24-15-23(31-32(24)25(22)27)19-7-3-2-4-8-19/h2-16H,27H2,1H3,(H2,29,30,33)
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n/an/a>1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243321
PNG
(3-Bromo-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine |...)
Show SMILES Nc1c(cnc2c(Br)cnn12)-c1ccccc1
Show InChI InChI=1S/C12H9BrN4/c13-10-7-16-17-11(14)9(6-15-12(10)17)8-4-2-1-3-5-8/h1-7H,14H2
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n/an/a>1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243323
PNG
(6-(4-Aminophenyl)-3-bromopyrazolo[1,5-a]pyrimidin-...)
Show SMILES Nc1ccc(cc1)-c1cnc2c(Br)cnn2c1N
Show InChI InChI=1S/C12H10BrN5/c13-10-6-17-18-11(15)9(5-16-12(10)18)7-1-3-8(14)4-2-7/h1-6H,14-15H2
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n/an/a>1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243325
PNG
(CHEMBL510071 | N-(4-(7-Amino-3-bromopyrazolo[1,5-a...)
Show SMILES Nc1c(cnc2c(Br)cnn12)-c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C19H14BrN5O/c20-16-11-23-25-17(21)15(10-22-18(16)25)12-6-8-14(9-7-12)24-19(26)13-4-2-1-3-5-13/h1-11H,21H2,(H,24,26)
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n/an/a>1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50242909
PNG
(1-[4-(3-Bromopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(Br)cnn3c2)c1
Show InChI InChI=1S/C20H16BrN5O/c1-13-3-2-4-17(9-13)25-20(27)24-16-7-5-14(6-8-16)15-10-22-19-18(21)11-23-26(19)12-15/h2-12H,1H3,(H2,24,25,27)
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n/an/a>1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243002
PNG
(1-(4-(7-Amino-3-bromopyrazolo[1,5-a]pyrimidin-6-yl...)
Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1cnc2c(Br)cnn2c1N
Show InChI InChI=1S/C20H17BrN6O/c1-12-4-2-3-5-17(12)26-20(28)25-14-8-6-13(7-9-14)15-10-23-19-16(21)11-24-27(19)18(15)22/h2-11H,22H2,1H3,(H2,25,26,28)
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n/an/a>1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243322
PNG
(3-bromo-6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidi...)
Show SMILES COc1ccc(cc1)-c1cnc2c(Br)cnn2c1N
Show InChI InChI=1S/C13H11BrN4O/c1-19-9-4-2-8(3-5-9)10-6-16-13-11(14)7-17-18(13)12(10)15/h2-7H,15H2,1H3
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n/an/a>1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%