Affinity Data by PubMed id=1875344

PubMed code 1875344

Found 9 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50009407 (But-3-enoic acid 8-[2-(4-hydroxy-6-oxo-tetrahydro-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against rat liver HMG-CoA reductase enzyme				J Med Chem 34: 2474-7 (1991) Article DOI: 10.1021/jm00112a024 BindingDB Entry DOI: 10.7270/Q29S1Q0D
					More data for this Ligand-Target Pair
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50009411 (6-{2-[8-(4-Fluoro-benzyloxy)-2,6-dimethyl-1,2,6,7,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against rat liver HMG-CoA reductase enzyme				J Med Chem 34: 2474-7 (1991) Article DOI: 10.1021/jm00112a024 BindingDB Entry DOI: 10.7270/Q29S1Q0D
					More data for this Ligand-Target Pair
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50009413 (CHEMBL3085466 \| Phenyl-acetic acid 8-[2-(4-hydroxy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against rat liver HMG-CoA reductase enzyme				J Med Chem 34: 2474-7 (1991) Article DOI: 10.1021/jm00112a024 BindingDB Entry DOI: 10.7270/Q29S1Q0D
					More data for this Ligand-Target Pair
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50009414 (6-[2-(8-Benzyloxy-2,6-dimethyl-1,2,6,7,8,8a-hexahy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against rat liver HMG-CoA reductase enzyme				J Med Chem 34: 2474-7 (1991) Article DOI: 10.1021/jm00112a024 BindingDB Entry DOI: 10.7270/Q29S1Q0D
					More data for this Ligand-Target Pair
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50009409 (6-{2-[8-(4-Chloro-benzyloxy)-2,6-dimethyl-1,2,6,7,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against rat liver HMG-CoA reductase enzyme				J Med Chem 34: 2474-7 (1991) Article DOI: 10.1021/jm00112a024 BindingDB Entry DOI: 10.7270/Q29S1Q0D
					More data for this Ligand-Target Pair
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50009408 (Acetic acid 8-[2-(4-hydroxy-6-oxo-tetrahydro-pyran...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	269	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against rat liver HMG-CoA reductase enzyme				J Med Chem 34: 2474-7 (1991) Article DOI: 10.1021/jm00112a024 BindingDB Entry DOI: 10.7270/Q29S1Q0D
					More data for this Ligand-Target Pair
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50009415 (6-{2-[2,6-Dimethyl-8-(2-methyl-allyloxy)-1,2,6,7,8...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against rat liver HMG-CoA reductase enzyme				J Med Chem 34: 2474-7 (1991) Article DOI: 10.1021/jm00112a024 BindingDB Entry DOI: 10.7270/Q29S1Q0D
					More data for this Ligand-Target Pair
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50009410 (6-[2-(8-Allyloxy-2,6-dimethyl-1,2,6,7,8,8a-hexahyd...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against rat liver HMG-CoA reductase enzyme				J Med Chem 34: 2474-7 (1991) Article DOI: 10.1021/jm00112a024 BindingDB Entry DOI: 10.7270/Q29S1Q0D
					More data for this Ligand-Target Pair
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50009412 (4-Hydroxy-6-[2-(8-methoxy-2,6-dimethyl-1,2,6,7,8,8...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against rat liver HMG-CoA reductase enzyme				J Med Chem 34: 2474-7 (1991) Article DOI: 10.1021/jm00112a024 BindingDB Entry DOI: 10.7270/Q29S1Q0D
					More data for this Ligand-Target Pair

* indicates data uncertainty>20%