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PubMed code 1875352

Compile data set for download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate-NMDA


(RAT)
BDBM50009591
PNG
(1-(2-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Show SMILES CC1CCCCC1(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-10-6-7-13-18(16,17-11-4-2-5-12-17)19-14-8-3-9-15-19/h2,4-5,11-12,16H,3,6-10,13-15H2,1H3
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PC sid
UniChem

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PubMed
11n/an/an/an/an/an/an/an/a



Istituto Superiore di Sanità

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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KEGG
PC cid
PC sid
PDB
UniChem

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PubMed
53n/an/an/an/an/an/an/an/a



Istituto Superiore di Sanità

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50009592
PNG
(CHEMBL424610 | cis-1-(4-Methyl-1-phenyl-cyclohexyl...)
Show SMILES CC1CCC(CC1)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-10-12-18(13-11-16,17-8-4-2-5-9-17)19-14-6-3-7-15-19/h2,4-5,8-9,16H,3,6-7,10-15H2,1H3
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PubMed
166n/an/an/an/an/an/an/an/a



Istituto Superiore di Sanità

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50009592
PNG
(CHEMBL424610 | cis-1-(4-Methyl-1-phenyl-cyclohexyl...)
Show SMILES CC1CCC(CC1)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-10-12-18(13-11-16,17-8-4-2-5-9-17)19-14-6-3-7-15-19/h2,4-5,8-9,16H,3,6-7,10-15H2,1H3
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PubMed
617n/an/an/an/an/an/an/an/a



Istituto Superiore di Sanità

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50009590
PNG
(CHEMBL86824 | cis-C-(2-Methyl-1-piperidin-1-yl-cyc...)
Show SMILES CC1CCCCC1(N1CCCCC1)C(=N)c1ccccc1
Show InChI InChI=1S/C19H28N2/c1-16-10-6-7-13-19(16,21-14-8-3-9-15-21)18(20)17-11-4-2-5-12-17/h2,4-5,11-12,16,20H,3,6-10,13-15H2,1H3
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PubMed
4.70E+3n/an/an/an/an/an/an/an/a



Istituto Superiore di Sanità

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50009590
PNG
(CHEMBL86824 | cis-C-(2-Methyl-1-piperidin-1-yl-cyc...)
Show SMILES CC1CCCCC1(N1CCCCC1)C(=N)c1ccccc1
Show InChI InChI=1S/C19H28N2/c1-16-10-6-7-13-19(16,21-14-8-3-9-15-21)18(20)17-11-4-2-5-12-17/h2,4-5,11-12,16,20H,3,6-10,13-15H2,1H3
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PubMed
4.70E+3n/an/an/an/an/an/an/an/a



Istituto Superiore di Sanità

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50009591
PNG
(1-(2-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Show SMILES CC1CCCCC1(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-10-6-7-13-18(16,17-11-4-2-5-12-17)19-14-8-3-9-15-19/h2,4-5,11-12,16H,3,6-10,13-15H2,1H3
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PubMed
7.40E+3n/an/an/an/an/an/an/an/a



Istituto Superiore di Sanità

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50009593
PNG
(C-Phenyl-C-(1-piperidin-1-yl-cyclohexyl)-methylene...)
Show SMILES N=C(c1ccccc1)C1(CCCCC1)N1CCCCC1
Show InChI InChI=1S/C18H26N2/c19-17(16-10-4-1-5-11-16)18(12-6-2-7-13-18)20-14-8-3-9-15-20/h1,4-5,10-11,19H,2-3,6-9,12-15H2
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PubMed
3.10E+4n/an/an/an/an/an/an/an/a



Istituto Superiore di Sanità

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%