Compile Data Set for Download or QSAR
maximum 50k data
Found 29 Enz. Inhib. hit(s) with all data for entry = 50027334
TargetToll-like receptor 4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274760(3-O-DECYL-2-DEOXY-6-O-{2-DEOXY-3-O-[(3R)-3-METHOXY...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetToll-like receptor 4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274760(3-O-DECYL-2-DEOXY-6-O-{2-DEOXY-3-O-[(3R)-3-METHOXY...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at TLR4 in human HL60 cells assessed as inhibition of LPS-induced cytokine productionMore data for this Ligand-Target Pair
TargetToll-like receptor 4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177125(6-(2-Chloro-4-fluoro-phenylsulfamoyl)-cyclohex-1-e...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human TLR4-mediated cytokine production in mouse macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274714(2-(4-(4-methylpiperazin-1-yl)phenyl)-N-(2-morpholi...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human TLR9 expressed in HEK293 cells assessed as blockade of CpG oligonucleotide-induced immune response by NFkappaB luciferas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274715(CHEMBL515364 | N-(2-(dimethylamino)ethyl)-2-(4-(4-...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at human TLR9 expressed in HEK293 cells assessed as blockade of CpG oligonucleotide-induced immune response by NFkappaB luciferas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177145(5-(2-Chloro-4-fluoro-phenylsulfamoyl)-cyclopent-1-...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human TLR4-mediated cytokine production in mouse macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177119(6-(4-Chloro-2-fluoro-phenylsulfamoyl)-cyclohex-1-e...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human TLR4-mediated cytokine production in mouse macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274716(CHEMBL490908 | Dodecanoic acid 3-{(S)-2-hexadecano...)
Affinity DataIC50:  230nMAssay Description:Antagonist activity at human TLR2 expressed in HE293 cells cotransfected with pELAM by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274718(CHEMBL448621 | Phosphoric acid 2-{(2S,3S)-2-[2-(5-...)
Affinity DataIC50:  240nMAssay Description:Antagonist activity at human TLR2 expressed in HE293 cells cotransfected with pELAM by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177129(7-(2-Chloro-4-fluoro-phenylsulfamoyl)-cyclohept-1-...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human TLR4-mediated cytokine production in mouse macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274717(CHEMBL473383 | Phosphoric acid (S)-2-(3-hydroxy-he...)
Affinity DataIC50:  460nMAssay Description:Antagonist activity at human TLR2 expressed in HE293 cells cotransfected with pELAM by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274719(CHEMBL446794 | Dodecanoic acid 1-(2-{(S)-3-[(2-{(2...)
Affinity DataIC50:  900nMAssay Description:Antagonist activity at human TLR2 expressed in HE293 cells cotransfected with pELAM by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274678(CHEMBL485553 | N,N-dimethyl-2-(2-(4-(4-methylpiper...)
Affinity DataIC50:  2.40E+3nMAssay Description:Antagonist activity at human TLR9 expressed in HEK293 cells assessed as blockade of CpG oligonucleotide-induced immune response by NFkappaB luciferas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274720(6-(2-aminophenoxy)benzo[d]isothiazol-3-amine | CHE...)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonist activity at TLR4 in human PBMC cells assessed as suppression of LPS-induced cytokine upregulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50241033(CHEMBL414311 | N-[(1R)-2-{[(2R)-2-{[(1S)-1-{[(1S)-...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of TLR2-mediated IL8 secretion in human THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274677(CHEMBL520189 | N'-(2-Biphenyl-4-yl-quinazolin-4-yl...)
Affinity DataIC50:  5.20E+3nMAssay Description:Antagonist activity at human TLR9 expressed in HEK293 cells assessed as blockade of CpG oligonucleotide-induced immune response by NFkappaB luciferas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274720(6-(2-aminophenoxy)benzo[d]isothiazol-3-amine | CHE...)
Affinity DataIC50:  7.00E+3nMAssay Description:Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177128(2-(2-Chloro-4-fluoro-phenylsulfamoyl)-benzoic acid...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human TLR4-mediated cytokine production in mouse macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274759(6-(4,5-Dihydro-thiazol-2-ylsulfamoyl)-cyclohex-1-e...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human TLR4-mediated cytokine production in mouse macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274598((3-((6-amino-2-(benzylamino)-8-hydroxy-9H-purin-9-...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274598((3-((6-amino-2-(benzylamino)-8-hydroxy-9H-purin-9-...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at TLR7 in human PBMC cells assessed as stimulation of interferon releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274635((3-((6-amino-8-mercapto-2-(2-methoxyethoxy)-9H-pur...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at TLR7 in human PBMC cells assessed as stimulation of interferon releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274635((3-((6-amino-8-mercapto-2-(2-methoxyethoxy)-9H-pur...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274596(6-amino-9-benzyl-N-(2-methoxyethyl)-8-oxo-8,9-dihy...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50241081(9-benzyl-8-hydrazinyl-2-(2-methoxyethoxy)-9H-purin...)
Affinity DataEC50:  790nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50189512(3-(6-amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8...)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274597(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-(thiazo...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50189514(9-benzyl-2-(2-methoxyethoxy)-9H-purine-6,8-diamine...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50189513(9-benzyl-N8-ethyl-2-(2-methoxyethoxy)-9H-purine-6,...)
Affinity DataEC50:  4.40E+3nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed