Compile Data Set for Download or QSAR
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Found 179 Enz. Inhib. hit(s) with all data for entry = 50027462
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246181((2-(3,4-dichlorophenoxy)phenyl)-N,N-dimethylmethan...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246186(CHEMBL450714 | N,N-dimethyl-1-(2-(4-(methylthio)ph...)
Affinity DataIC50:  1nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246480(1-(4-chloro-2-(p-tolyloxy)phenyl)-N-methylmethanam...)
Affinity DataIC50:  1.18nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50233471((2-(4-chlorophenoxy)phenyl)-N,N-dimethylmethanamin...)
Affinity DataIC50:  1.68nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246323(1-(2-(3,4-dichlorophenoxy)-5-methylphenyl)-N,N-dim...)
Affinity DataIC50:  2.36nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246185(2-(4-(3,4-dichlorophenoxy)-3-((dimethylamino)methy...)
Affinity DataIC50:  2.43nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246372(4-(3,4-dichlorophenoxy)-3-((methylamino)methyl)ben...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246229(1-(2-(3,4-dichlorophenoxy)phenyl)-N,N-dimethyletha...)
Affinity DataIC50:  3.27nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246182(1-(2-(3,4-dichlorophenoxy)-5-fluorophenyl)-N-methy...)
Affinity DataIC50:  3.28nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246134(1-(4-chloro-2-(3,4-dimethylphenoxy)phenyl)-N-methy...)
Affinity DataIC50:  3.42nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246230(CHEMBL454288 | N,N-dimethyl-1-(2-(p-tolyloxy)pheny...)
Affinity DataIC50:  3.46nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246532(1-(4-chloro-2-(p-tolyloxy)phenyl)-N-methylethanami...)
Affinity DataIC50:  3.54nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246371(1-(2-(3,4-dichlorophenoxy)-4-methoxyphenyl)-N,N-di...)
Affinity DataIC50:  3.61nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246320(1-(2-(3,4-dichlorophenoxy)-5-methoxyphenyl)-N-meth...)
Affinity DataIC50:  3.77nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246376(4-(3,4-dichlorophenoxy)-3-((methylamino)methyl)ben...)
Affinity DataIC50:  3.78nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246184(1-(2-(3,4-dichlorophenoxy)phenyl)-N-methylmethanam...)
Affinity DataIC50:  4.02nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246537(1-(4-chloro-2-(3-chloro-4-methylphenoxy)phenyl)-N-...)
Affinity DataIC50:  4.19nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50245791(1-(4-chloro-2-(4-chloro-3-methylphenoxy)phenyl)-N-...)
Affinity DataIC50:  4.27nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246428(1-(4-chloro-2-(3,4-dichlorophenoxy)-5-fluorophenyl...)
Affinity DataIC50:  4.37nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246478(1-(2-(3,4-dichlorophenoxy)-5-fluoro-4-methoxypheny...)
Affinity DataIC50:  4.51nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246134(1-(4-chloro-2-(3,4-dimethylphenoxy)phenyl)-N-methy...)
Affinity DataIC50:  4.67nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246325(1-(5-bromo-2-(3,4-dichlorophenoxy)phenyl)-N-methyl...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246183(4-(3,4-dichlorophenoxy)-3-((dimethylamino)methyl)a...)
Affinity DataIC50:  4.99nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246324(1-(4-bromo-2-(3,4-dichlorophenoxy)phenyl)-N-methyl...)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246481(1-(2-(4-chloro-3-ethylphenoxy)-5-fluorophenyl)-N-m...)
Affinity DataIC50:  5.53nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246535(1-(5-chloro-2-(3,4-dichlorophenoxy)phenyl)-N-methy...)
Affinity DataIC50:  5.73nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246278(1-(4-chloro-2-(3,4-dichlorophenoxy)phenyl)-N-methy...)
Affinity DataIC50:  6.22nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246531(1-(4-chloro-2-(4-chlorophenoxy)phenyl)-N-methylmet...)
Affinity DataIC50:  6.59nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246533(1-(4-chloro-2-(3,4-dimethylphenoxy)phenyl)-N-methy...)
Affinity DataIC50:  6.82nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246536(1-(5-chloro-2-(4-chlorophenoxy)phenyl)-N-methylmet...)
Affinity DataIC50:  7.49nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246233(1-(2-(3,4-dimethylphenoxy)-5-fluorophenyl)-N-methy...)
Affinity DataIC50:  7.55nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246279(1-(2-(3,4-dichlorophenoxy)-5-fluorophenyl)-N-methy...)
Affinity DataIC50:  8.09nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246429(1-(2-(3,4-dichlorophenoxy)-4-methoxyphenyl)-N-meth...)
Affinity DataIC50:  8.72nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246374(1-(2-(3,4-dichlorophenoxy)-4,5-dimethylphenyl)-N-m...)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50245791(1-(4-chloro-2-(4-chloro-3-methylphenoxy)phenyl)-N-...)
Affinity DataIC50:  9.04nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246537(1-(4-chloro-2-(3-chloro-4-methylphenoxy)phenyl)-N-...)
Affinity DataIC50:  9.11nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246531(1-(4-chloro-2-(4-chlorophenoxy)phenyl)-N-methylmet...)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246373(4-(3,4-dichlorophenoxy)-N-methyl-3-((methylamino)m...)
Affinity DataIC50:  9.35nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246321(1-(2-(4-chlorophenoxy)-5-fluorophenyl)-N-methylmet...)
Affinity DataIC50:  9.47nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50245795(1-(4-chloro-2-(4-fluoro-3-(trifluoromethyl)phenoxy...)
Affinity DataIC50:  9.71nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246534(1-(5-chloro-2-(3,4-dimethylphenoxy)phenyl)-N-methy...)
Affinity DataIC50:  9.81nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246234(1-(2-(3,4-dimethylphenoxy)phenyl)-N-methylmethanam...)
Affinity DataIC50:  12.8nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246235(1-(2-(4-chlorophenoxy)phenyl)-N-methylmethanamine ...)
Affinity DataIC50:  13.9nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246326(1-(2-(3,4-dichlorophenoxy)-4,5-dimethoxyphenyl)-N-...)
Affinity DataIC50:  14.1nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246480(1-(4-chloro-2-(p-tolyloxy)phenyl)-N-methylmethanam...)
Affinity DataIC50:  17nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246231(1-(2-(3,4-dichlorophenoxy)-4-(trifluoromethyl)phen...)
Affinity DataIC50:  17.1nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246430(1-(2-(4-chloro-3-fluorophenoxy)-5-fluorophenyl)-N-...)
Affinity DataIC50:  19.3nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246482(1-(4-chloro-2-(4-chloro-3-ethylphenoxy)phenyl)-N-m...)
Affinity DataIC50:  20.7nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246427(1-(2-(3,4-dichlorophenoxy)-5-(trifluoromethyl)phen...)
Affinity DataIC50:  21.8nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246281(1-(2-(3,4-dichlorophenoxy)phenyl)-N-methylethanami...)
Affinity DataIC50:  23nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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