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PubMed code 1908521

Compile data set for download or QSAR
Found 106 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010044
PNG
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24FN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
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 0.260n/an/an/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
Binding constant against 5-hydroxytryptamine 2 receptor (in vivo)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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 0.690n/an/an/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
Binding constant against 5-hydroxytryptamine 2 receptor (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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 6n/an/an/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
Binding constant against histamine H1 receptor (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))		BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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 22n/an/an/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
Binding constant against dopamine receptor D2 (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50010044
PNG
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24FN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
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 25n/an/an/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
Binding constant against histamine H1 receptor (in vivo)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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 29n/an/an/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
Binding constant against Alpha-1 adrenergic receptor (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010044
PNG
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24FN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
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 38n/an/an/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
Binding constant against Alpha-1 adrenergic receptor (in vivo)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))		BDBM50010044
PNG
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24FN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
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 70n/an/an/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
Binding constant against 5-hydroxytryptamine 1A receptor (in vivo)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))		BDBM50010044
PNG
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24FN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
Binding constant against dopamine receptor D2 (in vivo)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))		BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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 1.00E+3n/an/an/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
Binding constant against 5-hydroxytryptamine 1A receptor (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010041
PNG
(CHEMBL84087 | {1-[3-(1,1-Dioxo-1H-1lambda*6*-napht...)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C25H25FN2O3S/c26-21-10-8-19(9-11-21)25(29)20-12-16-27(17-13-20)14-3-15-28-22-6-1-4-18-5-2-7-23(24(18)22)32(28,30)31/h1-2,4-11,20H,3,12-17H2
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n/an/a 0.100n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010048
PNG
(2-[3-(4-Phenyl-piperidin-1-yl)-propyl]-2H-naphtho[...)
Show SMILES O=S1(=O)N(CCCN2CCC(CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C24H26N2O2S/c27-29(28)23-12-5-10-21-9-4-11-22(24(21)23)26(29)16-6-15-25-17-13-20(14-18-25)19-7-2-1-3-8-19/h1-5,7-12,20H,6,13-18H2
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n/an/a 0.200n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010049
PNG
(4-{4-[3-(1,1-Dioxo-1H-1lambda*6*-naphtho[1,8-cd]is...)
Show SMILES Oc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H25N3O3S/c27-20-10-8-19(9-11-20)25-16-14-24(15-17-25)12-3-13-26-21-6-1-4-18-5-2-7-22(23(18)21)30(26,28)29/h1-2,4-11,27H,3,12-17H2
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n/an/a 0.300n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010038
PNG
(2-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2nsc3ccccc23)c2cccc3cccc1c23
Show InChI InChI=1S/C24H24N4O2S2/c29-32(30)22-11-4-7-18-6-3-9-20(23(18)22)28(32)13-5-12-26-14-16-27(17-15-26)24-19-8-1-2-10-21(19)31-25-24/h1-4,6-11H,5,12-17H2
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n/an/a 0.400n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
Binding constant against dopamine receptor D2 (in vivo)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010044
PNG
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24FN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
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n/an/a 0.5n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010040
PNG
(2-[3-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-propyl...)
Show SMILES O=S1(=O)N(CCCN2CCC(=CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C24H24N2O2S/c27-29(28)23-12-5-10-21-9-4-11-22(24(21)23)26(29)16-6-15-25-17-13-20(14-18-25)19-7-2-1-3-8-19/h1-5,7-13H,6,14-18H2
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n/an/a 1n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50229423
PNG
(CHEMBL82229)
Show SMILES Fc1ccc(cc1)N1CCN(CCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C22H22FN3O2S/c23-18-7-9-19(10-8-18)25-14-11-24(12-15-25)13-16-26-20-5-1-3-17-4-2-6-21(22(17)20)29(26,27)28/h1-10H,11-16H2
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n/an/a 1n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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n/an/a 1.70n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010052
PNG
(2-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]...)
Show SMILES O=S1(=O)N(CCCCN2CCC(=CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C25H26N2O2S/c28-30(29)24-13-7-11-22-10-6-12-23(25(22)24)27(30)17-5-4-16-26-18-14-21(15-19-26)20-8-2-1-3-9-20/h1-3,6-14H,4-5,15-19H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010033
PNG
(2-[3-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-prop...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2noc3ccccc23)c2cccc3cccc1c23
Show InChI InChI=1S/C24H24N4O3S/c29-32(30)22-11-4-7-18-6-3-9-20(23(18)22)28(32)13-5-12-26-14-16-27(17-15-26)24-19-8-1-2-10-21(19)31-25-24/h1-4,6-11H,5,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010057
PNG
(2-[3-(4-Phenyl-piperazin-1-yl)-propyl]-2H-naphtho[...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C23H25N3O2S/c27-29(28)22-12-5-8-19-7-4-11-21(23(19)22)26(29)14-6-13-24-15-17-25(18-16-24)20-9-2-1-3-10-20/h1-5,7-12H,6,13-18H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010047
PNG
(2-{3-[4-(2-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Fc1ccccc1N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24FN3O2S/c24-19-8-1-2-9-20(19)26-16-14-25(15-17-26)12-5-13-27-21-10-3-6-18-7-4-11-22(23(18)21)30(27,28)29/h1-4,6-11H,5,12-17H2
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n/an/a 3n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010061
PNG
(2-{4-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-butyl}-2...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C24H26FN3O2S/c25-20-9-11-21(12-10-20)27-17-15-26(16-18-27)13-1-2-14-28-22-7-3-5-19-6-4-8-23(24(19)22)31(28,29)30/h3-12H,1-2,13-18H2
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n/an/a 3.70n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010034
PNG
(2-[3-(4-p-Tolyl-piperazin-1-yl)-propyl]-2H-naphtho...)
Show SMILES Cc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C24H27N3O2S/c1-19-9-11-21(12-10-19)26-17-15-25(16-18-26)13-4-14-27-22-7-2-5-20-6-3-8-23(24(20)22)30(27,28)29/h2-3,5-12H,4,13-18H2,1H3
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010042
PNG
(2-{3-[4-(4-Chloro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24ClN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010037
PNG
(CHEMBL79598 | N-Naphthalen-1-yl-N-[3-(4-phenyl-3,6...)
Show SMILES CS(=O)(=O)N(CCCN1CCC(=CC1)c1ccccc1)c1cccc2ccccc12
Show InChI InChI=1S/C25H28N2O2S/c1-30(28,29)27(25-14-7-12-23-11-5-6-13-24(23)25)18-8-17-26-19-15-22(16-20-26)21-9-3-2-4-10-21/h2-7,9-15H,8,16-20H2,1H3
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010055
PNG
(2-[3-(4-Pyridin-2-yl-piperazin-1-yl)-propyl]-2H-na...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2ccccn2)c2cccc3cccc1c23
Show InChI InChI=1S/C22H24N4O2S/c27-29(28)20-9-4-7-18-6-3-8-19(22(18)20)26(29)13-5-12-24-14-16-25(17-15-24)21-10-1-2-11-23-21/h1-4,6-11H,5,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010043
PNG
(2-[2-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-ethyl]...)
Show SMILES O=S1(=O)N(CCN2CCC(=CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C23H22N2O2S/c26-28(27)22-11-5-9-20-8-4-10-21(23(20)22)25(28)17-16-24-14-12-19(13-15-24)18-6-2-1-3-7-18/h1-12H,13-17H2
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n/an/a 6.30n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010054
PNG
(1-{1-[3-(1,1-Dioxo-1H-1lambda*6*-naphtho[1,8-cd]is...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C25H26N4O3S/c30-25-26-20-8-1-2-9-21(20)29(25)19-12-16-27(17-13-19)14-5-15-28-22-10-3-6-18-7-4-11-23(24(18)22)33(28,31)32/h1-4,6-11,19H,5,12-17H2,(H,26,30)
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010045
PNG
(2-{3-[4-(4-Bromo-phenyl)-piperazin-1-yl]-propyl}-2...)
Show SMILES Brc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24BrN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010052
PNG
(2-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]...)
Show SMILES O=S1(=O)N(CCCCN2CCC(=CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C25H26N2O2S/c28-30(29)24-13-7-11-22-10-6-12-23(25(22)24)27(30)17-5-4-16-26-18-14-21(15-19-26)20-8-2-1-3-9-20/h1-3,6-14H,4-5,15-19H2
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n/an/a 7.80n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010041
PNG
(CHEMBL84087 | {1-[3-(1,1-Dioxo-1H-1lambda*6*-napht...)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C25H25FN2O3S/c26-21-10-8-19(9-11-21)25(29)20-12-16-27(17-13-20)14-3-15-28-22-6-1-4-18-5-2-7-23(24(18)22)32(28,30)31/h1-2,4-11,20H,3,12-17H2
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n/an/a 7.90n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010032
PNG
(1-[3-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-propyl...)
Show SMILES O=C1N(CCCN2CCC(=CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C25H24N2O/c28-25-22-11-4-9-21-10-5-12-23(24(21)22)27(25)16-6-15-26-17-13-20(14-18-26)19-7-2-1-3-8-19/h1-5,7-13H,6,14-18H2
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n/an/a 9.80n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010050
PNG
(CHEMBL309660 | N-Phenyl-N-[3-(4-phenyl-3,6-dihydro...)
Show SMILES O=S(=O)(N(CCCN1CCC(=CC1)c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H28N2O2S/c29-31(30,26-15-8-3-9-16-26)28(25-13-6-2-7-14-25)20-10-19-27-21-17-24(18-22-27)23-11-4-1-5-12-23/h1-9,11-17H,10,18-22H2
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n/an/a 10n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010054
PNG
(1-{1-[3-(1,1-Dioxo-1H-1lambda*6*-naphtho[1,8-cd]is...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C25H26N4O3S/c30-25-26-20-8-1-2-9-21(20)29(25)19-12-16-27(17-13-19)14-5-15-28-22-10-3-6-18-7-4-11-23(24(18)22)33(28,31)32/h1-4,6-11,19H,5,12-17H2,(H,26,30)
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010036
PNG
(10-[3-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-propy...)
Show SMILES O=S1(=O)N(CCCN2CCC(=CC2)c2ccccc2)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C26H26N2O2S/c29-31(30)26-14-7-5-12-24(26)23-11-4-6-13-25(23)28(31)18-8-17-27-19-15-22(16-20-27)21-9-2-1-3-10-21/h1-7,9-15H,8,16-20H2
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n/an/a 10n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010036
PNG
(10-[3-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-propy...)
Show SMILES O=S1(=O)N(CCCN2CCC(=CC2)c2ccccc2)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C26H26N2O2S/c29-31(30)26-14-7-5-12-24(26)23-11-4-6-13-25(23)28(31)18-8-17-27-19-15-22(16-20-27)21-9-2-1-3-10-21/h1-7,9-15H,8,16-20H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010031
PNG
(2-(3-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidi...)
Show SMILES Fc1ccc(cc1)C(=C1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C31H28F2N2O2S/c32-26-12-8-23(9-13-26)30(24-10-14-27(33)15-11-24)25-16-20-34(21-17-25)18-3-19-35-28-6-1-4-22-5-2-7-29(31(22)28)38(35,36)37/h1-2,4-15H,3,16-21H2
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n/an/a 11n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010061
PNG
(2-{4-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-butyl}-2...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C24H26FN3O2S/c25-20-9-11-21(12-10-20)27-17-15-26(16-18-27)13-1-2-14-28-22-7-3-5-19-6-4-8-23(24(19)22)31(28,29)30/h3-12H,1-2,13-18H2
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n/an/a 11n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit 3[H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010039
PNG
(2-{3-[4-(3-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Fc1cccc(c1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24FN3O2S/c24-19-7-3-8-20(17-19)26-15-13-25(14-16-26)11-4-12-27-21-9-1-5-18-6-2-10-22(23(18)21)30(27,28)29/h1-3,5-10,17H,4,11-16H2
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n/an/a 18n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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n/an/a 23n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010051
PNG
(2-{3-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C24H27N3O3S/c1-30-21-11-9-20(10-12-21)26-17-15-25(16-18-26)13-4-14-27-22-7-2-5-19-6-3-8-23(24(19)22)31(27,28)29/h2-3,5-12H,4,13-18H2,1H3
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n/an/a 25n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010053
PNG
(2-{3-[4-(4-Nitro-phenyl)-piperazin-1-yl]-propyl}-2...)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24N4O4S/c28-27(29)20-10-8-19(9-11-20)25-16-14-24(15-17-25)12-3-13-26-21-6-1-4-18-5-2-7-22(23(18)21)32(26,30)31/h1-2,4-11H,3,12-17H2
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n/an/a 25n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010048
PNG
(2-[3-(4-Phenyl-piperidin-1-yl)-propyl]-2H-naphtho[...)
Show SMILES O=S1(=O)N(CCCN2CCC(CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C24H26N2O2S/c27-29(28)23-12-5-10-21-9-4-11-22(24(21)23)26(29)16-6-15-25-17-13-20(14-18-25)19-7-2-1-3-8-19/h1-5,7-12,20H,6,13-18H2
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n/an/a 27n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010060
PNG
(2-[3-(4-Pyrimidin-2-yl-piperazin-1-yl)-propyl]-2H-...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2ncccn2)c2cccc3cccc1c23
Show InChI InChI=1S/C21H23N5O2S/c27-29(28)19-8-2-6-17-5-1-7-18(20(17)19)26(29)12-4-11-24-13-15-25(16-14-24)21-22-9-3-10-23-21/h1-3,5-10H,4,11-16H2
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n/an/a 32n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010050
PNG
(CHEMBL309660 | N-Phenyl-N-[3-(4-phenyl-3,6-dihydro...)
Show SMILES O=S(=O)(N(CCCN1CCC(=CC1)c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H28N2O2S/c29-31(30,26-15-8-3-9-16-26)28(25-13-6-2-7-14-25)20-10-19-27-21-17-24(18-22-27)23-11-4-1-5-12-23/h1-9,11-17H,10,18-22H2
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n/an/a 35n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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n/an/a 37n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010041
PNG
(CHEMBL84087 | {1-[3-(1,1-Dioxo-1H-1lambda*6*-napht...)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C25H25FN2O3S/c26-21-10-8-19(9-11-21)25(29)20-12-16-27(17-13-20)14-3-15-28-22-6-1-4-18-5-2-7-23(24(18)22)32(28,30)31/h1-2,4-11,20H,3,12-17H2
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n/an/a 41n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010054
PNG
(1-{1-[3-(1,1-Dioxo-1H-1lambda*6*-naphtho[1,8-cd]is...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C25H26N4O3S/c30-25-26-20-8-1-2-9-21(20)29(25)19-12-16-27(17-13-19)14-5-15-28-22-10-3-6-18-7-4-11-23(24(18)22)33(28,31)32/h1-4,6-11,19H,5,12-17H2,(H,26,30)
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n/an/a 46n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010031
PNG
(2-(3-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidi...)
Show SMILES Fc1ccc(cc1)C(=C1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C31H28F2N2O2S/c32-26-12-8-23(9-13-26)30(24-10-14-27(33)15-11-24)25-16-20-34(21-17-25)18-3-19-35-28-6-1-4-22-5-2-7-29(31(22)28)38(35,36)37/h1-2,4-15H,3,16-21H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010047
PNG
(2-{3-[4-(2-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Fc1ccccc1N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24FN3O2S/c24-19-8-1-2-9-20(19)26-16-14-25(15-17-26)12-5-13-27-21-10-3-6-18-7-4-11-22(23(18)21)30(27,28)29/h1-4,6-11H,5,12-17H2
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n/an/a 52n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010052
PNG
(2-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]...)
Show SMILES O=S1(=O)N(CCCCN2CCC(=CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C25H26N2O2S/c28-30(29)24-13-7-11-22-10-6-12-23(25(22)24)27(30)17-5-4-16-26-18-14-21(15-19-26)20-8-2-1-3-9-20/h1-3,6-14H,4-5,15-19H2
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n/an/a 55n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50229423
PNG
(CHEMBL82229)
Show SMILES Fc1ccc(cc1)N1CCN(CCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C22H22FN3O2S/c23-18-7-9-19(10-8-18)25-14-11-24(12-15-25)13-16-26-20-5-1-3-17-4-2-6-21(22(17)20)29(26,27)28/h1-10H,11-16H2
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n/an/a 64n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010037
PNG
(CHEMBL79598 | N-Naphthalen-1-yl-N-[3-(4-phenyl-3,6...)
Show SMILES CS(=O)(=O)N(CCCN1CCC(=CC1)c1ccccc1)c1cccc2ccccc12
Show InChI InChI=1S/C25H28N2O2S/c1-30(28,29)27(25-14-7-12-23-11-5-6-13-24(23)25)18-8-17-26-19-15-22(16-20-26)21-9-3-2-4-10-21/h2-7,9-15H,8,16-20H2,1H3
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n/an/a 75n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010038
PNG
(2-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2nsc3ccccc23)c2cccc3cccc1c23
Show InChI InChI=1S/C24H24N4O2S2/c29-32(30)22-11-4-7-18-6-3-9-20(23(18)22)28(32)13-5-12-26-14-16-27(17-15-26)24-19-8-1-2-10-21(19)31-25-24/h1-4,6-11H,5,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010050
PNG
(CHEMBL309660 | N-Phenyl-N-[3-(4-phenyl-3,6-dihydro...)
Show SMILES O=S(=O)(N(CCCN1CCC(=CC1)c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H28N2O2S/c29-31(30,26-15-8-3-9-16-26)28(25-13-6-2-7-14-25)20-10-19-27-21-17-24(18-22-27)23-11-4-1-5-12-23/h1-9,11-17H,10,18-22H2
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n/an/a 80n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010043
PNG
(2-[2-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-ethyl]...)
Show SMILES O=S1(=O)N(CCN2CCC(=CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C23H22N2O2S/c26-28(27)22-11-5-9-20-8-4-10-21(23(20)22)25(28)17-16-24-14-12-19(13-15-24)18-6-2-1-3-7-18/h1-12H,13-17H2
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n/an/a 98n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010032
PNG
(1-[3-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-propyl...)
Show SMILES O=C1N(CCCN2CCC(=CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C25H24N2O/c28-25-22-11-4-9-21-10-5-12-23(24(21)22)27(25)16-6-15-26-17-13-20(14-18-26)19-7-2-1-3-8-19/h1-5,7-13H,6,14-18H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50229428
PNG
(CHEMBL310902)
Show SMILES CN(CCCN1CCC(=CC1)c1ccccc1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C25H28N2O2S/c1-26(30(28,29)25-14-7-12-23-11-5-6-13-24(23)25)17-8-18-27-19-15-22(16-20-27)21-9-3-2-4-10-21/h2-7,9-15H,8,16-20H2,1H3
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n/an/a>100n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010043
PNG
(2-[2-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-ethyl]...)
Show SMILES O=S1(=O)N(CCN2CCC(=CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C23H22N2O2S/c26-28(27)22-11-5-9-20-8-4-10-21(23(20)22)25(28)17-16-24-14-12-19(13-15-24)18-6-2-1-3-7-18/h1-12H,13-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010044
PNG
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24FN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
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n/an/a 103n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010049
PNG
(4-{4-[3-(1,1-Dioxo-1H-1lambda*6*-naphtho[1,8-cd]is...)
Show SMILES Oc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H25N3O3S/c27-20-10-8-19(9-11-20)25-16-14-24(15-17-25)12-3-13-26-21-6-1-4-18-5-2-7-22(23(18)21)30(26,28)29/h1-2,4-11,27H,3,12-17H2
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n/an/a 110n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010036
PNG
(10-[3-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-propy...)
Show SMILES O=S1(=O)N(CCCN2CCC(=CC2)c2ccccc2)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C26H26N2O2S/c29-31(30)26-14-7-5-12-24(26)23-11-4-6-13-25(23)28(31)18-8-17-27-19-15-22(16-20-27)21-9-2-1-3-10-21/h1-7,9-15H,8,16-20H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010057
PNG
(2-[3-(4-Phenyl-piperazin-1-yl)-propyl]-2H-naphtho[...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C23H25N3O2S/c27-29(28)22-12-5-8-19-7-4-11-21(23(19)22)26(29)14-6-13-24-15-17-25(18-16-24)20-9-2-1-3-10-20/h1-5,7-12H,6,13-18H2
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n/an/a 141n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010033
PNG
(2-[3-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-prop...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2noc3ccccc23)c2cccc3cccc1c23
Show InChI InChI=1S/C24H24N4O3S/c29-32(30)22-11-4-7-18-6-3-9-20(23(18)22)28(32)13-5-12-26-14-16-27(17-15-26)24-19-8-1-2-10-21(19)31-25-24/h1-4,6-11H,5,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010059
PNG
(2-{3-[4-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazo...)
Show SMILES O=S1(=O)N=C(N2CCN(CCCN3c4cccc5cccc(c45)S3(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C24H24N4O4S2/c29-33(30)21-10-2-1-8-19(21)24(25-33)27-16-14-26(15-17-27)12-5-13-28-20-9-3-6-18-7-4-11-22(23(18)20)34(28,31)32/h1-4,6-11H,5,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010040
PNG
(2-[3-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-propyl...)
Show SMILES O=S1(=O)N(CCCN2CCC(=CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C24H24N2O2S/c27-29(28)23-12-5-10-21-9-4-11-22(24(21)23)26(29)16-6-15-25-17-13-20(14-18-25)19-7-2-1-3-8-19/h1-5,7-13H,6,14-18H2
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n/an/a 192n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010030
PNG
(4-{4-[3-(1,1-Dioxo-1H-1lambda*6*-naphtho[1,8-cd]is...)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C26H29N3O4S/c1-2-33-26(30)21-10-12-22(13-11-21)28-18-16-27(17-19-28)14-5-15-29-23-8-3-6-20-7-4-9-24(25(20)23)34(29,31)32/h3-4,6-13H,2,5,14-19H2,1H3
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010059
PNG
(2-{3-[4-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazo...)
Show SMILES O=S1(=O)N=C(N2CCN(CCCN3c4cccc5cccc(c45)S3(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C24H24N4O4S2/c29-33(30)21-10-2-1-8-19(21)24(25-33)27-16-14-26(15-17-27)12-5-13-28-20-9-3-6-18-7-4-11-22(23(18)20)34(28,31)32/h1-4,6-11H,5,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010055
PNG
(2-[3-(4-Pyridin-2-yl-piperazin-1-yl)-propyl]-2H-na...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2ccccn2)c2cccc3cccc1c23
Show InChI InChI=1S/C22H24N4O2S/c27-29(28)20-9-4-7-18-6-3-8-19(22(18)20)26(29)13-5-12-24-14-16-25(17-15-24)21-10-1-2-11-23-21/h1-4,6-11H,5,12-17H2
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n/an/a 269n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010035
PNG
(2-{3-[4-(4-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C24H24F3N3O2S/c25-24(26,27)19-8-10-20(11-9-19)29-16-14-28(15-17-29)12-3-13-30-21-6-1-4-18-5-2-7-22(23(18)21)33(30,31)32/h1-2,4-11H,3,12-17H2
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n/an/a 275n/an/an/an/an/an/a



Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010037
PNG
(CHEMBL79598 | N-Naphthalen-1-yl-N-[3-(4-phenyl-3,6...)
Show SMILES CS(=O)(=O)N(CCCN1CCC(=CC1)c1ccccc1)c1cccc2ccccc12
Show InChI InChI=1S/C25H28N2O2S/c1-30(28,29)27(25-14-7-12-23-11-5-6-13-24(23)25)18-8-17-26-19-15-22(16-20-26)21-9-3-2-4-10-21/h2-7,9-15H,8,16-20H2,1H3
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010061
PNG
(2-{4-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-butyl}-2...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C24H26FN3O2S/c25-20-9-11-21(12-10-20)27-17-15-26(16-18-27)13-1-2-14-28-22-7-3-5-19-6-4-8-23(24(19)22)31(28,29)30/h3-12H,1-2,13-18H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010048
PNG
(2-[3-(4-Phenyl-piperidin-1-yl)-propyl]-2H-naphtho[...)
Show SMILES O=S1(=O)N(CCCN2CCC(CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C24H26N2O2S/c27-29(28)23-12-5-10-21-9-4-11-22(24(21)23)26(29)16-6-15-25-17-13-20(14-18-25)19-7-2-1-3-8-19/h1-5,7-12,20H,6,13-18H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010038
PNG
(2-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2nsc3ccccc23)c2cccc3cccc1c23
Show InChI InChI=1S/C24H24N4O2S2/c29-32(30)22-11-4-7-18-6-3-9-20(23(18)22)28(32)13-5-12-26-14-16-27(17-15-26)24-19-8-1-2-10-21(19)31-25-24/h1-4,6-11H,5,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010049
PNG
(4-{4-[3-(1,1-Dioxo-1H-1lambda*6*-naphtho[1,8-cd]is...)
Show SMILES Oc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H25N3O3S/c27-20-10-8-19(9-11-20)25-16-14-24(15-17-25)12-3-13-26-21-6-1-4-18-5-2-7-22(23(18)21)30(26,28)29/h1-2,4-11,27H,3,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)		BDBM50010046
PNG
(2-[3-(4-Benzothiazol-2-yl-piperazin-1-yl)-propyl]-...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2nc3ccccc3s2)c2cccc3cccc1c23
Show InChI InChI=1S/C24H24N4O2S2/c29-32(30)22-11-4-7-18-6-3-9-20(23(18)22)28(32)13-5-12-26-14-16-27(17-15-26)24-25-19-8-1-2-10-21(19)31-24/h1-4,6-11H,5,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010032
PNG
(1-[3-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-propyl...)
Show SMILES O=C1N(CCCN2CCC(=CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C25H24N2O/c28-25-22-11-4-9-21-10-5-12-23(24(21)22)27(25)16-6-15-26-17-13-20(14-18-26)19-7-2-1-3-8-19/h1-5,7-13H,6,14-18H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010031
PNG
(2-(3-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidi...)
Show SMILES Fc1ccc(cc1)C(=C1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C31H28F2N2O2S/c32-26-12-8-23(9-13-26)30(24-10-14-27(33)15-11-24)25-16-20-34(21-17-25)18-3-19-35-28-6-1-4-22-5-2-7-29(31(22)28)38(35,36)37/h1-2,4-15H,3,16-21H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010039
PNG
(2-{3-[4-(3-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Fc1cccc(c1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24FN3O2S/c24-19-7-3-8-20(17-19)26-15-13-25(14-16-26)11-4-12-27-21-9-1-5-18-6-2-10-22(23(18)21)30(27,28)29/h1-3,5-10,17H,4,11-16H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010034
PNG
(2-[3-(4-p-Tolyl-piperazin-1-yl)-propyl]-2H-naphtho...)
Show SMILES Cc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C24H27N3O2S/c1-19-9-11-21(12-10-19)26-17-15-25(16-18-26)13-4-14-27-22-7-2-5-20-6-3-8-23(24(20)22)30(27,28)29/h2-3,5-12H,4,13-18H2,1H3
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010033
PNG
(2-[3-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-prop...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2noc3ccccc23)c2cccc3cccc1c23
Show InChI InChI=1S/C24H24N4O3S/c29-32(30)22-11-4-7-18-6-3-9-20(23(18)22)28(32)13-5-12-26-14-16-27(17-15-26)24-19-8-1-2-10-21(19)31-25-24/h1-4,6-11H,5,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010042
PNG
(2-{3-[4-(4-Chloro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24ClN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010042
PNG
(2-{3-[4-(4-Chloro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24ClN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010044
PNG
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24FN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010051
PNG
(2-{3-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C24H27N3O3S/c1-30-21-11-9-20(10-12-21)26-17-15-25(16-18-26)13-4-14-27-22-7-2-5-19-6-3-8-23(24(19)22)31(27,28)29/h2-3,5-12H,4,13-18H2,1H3
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010030
PNG
(4-{4-[3-(1,1-Dioxo-1H-1lambda*6*-naphtho[1,8-cd]is...)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C26H29N3O4S/c1-2-33-26(30)21-10-12-22(13-11-21)28-18-16-27(17-19-28)14-5-15-29-23-8-3-6-20-7-4-9-24(25(20)23)34(29,31)32/h3-4,6-13H,2,5,14-19H2,1H3
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010053
PNG
(2-{3-[4-(4-Nitro-phenyl)-piperazin-1-yl]-propyl}-2...)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24N4O4S/c28-27(29)20-10-8-19(9-11-20)25-16-14-24(15-17-25)12-3-13-26-21-6-1-4-18-5-2-7-22(23(18)21)32(26,30)31/h1-2,4-11H,3,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010047
PNG
(2-{3-[4-(2-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Fc1ccccc1N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24FN3O2S/c24-19-8-1-2-9-20(19)26-16-14-25(15-17-26)12-5-13-27-21-10-3-6-18-7-4-11-22(23(18)21)30(27,28)29/h1-4,6-11H,5,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010059
PNG
(2-{3-[4-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazo...)
Show SMILES O=S1(=O)N=C(N2CCN(CCCN3c4cccc5cccc(c45)S3(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C24H24N4O4S2/c29-33(30)21-10-2-1-8-19(21)24(25-33)27-16-14-26(15-17-27)12-5-13-28-20-9-3-6-18-7-4-11-22(23(18)20)34(28,31)32/h1-4,6-11H,5,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010040
PNG
(2-[3-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-propyl...)
Show SMILES O=S1(=O)N(CCCN2CCC(=CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C24H24N2O2S/c27-29(28)23-12-5-10-21-9-4-11-22(24(21)23)26(29)16-6-15-25-17-13-20(14-18-25)19-7-2-1-3-8-19/h1-5,7-13H,6,14-18H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010035
PNG
(2-{3-[4-(4-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C24H24F3N3O2S/c25-24(26,27)19-8-10-20(11-9-19)29-16-14-28(15-17-29)12-3-13-30-21-6-1-4-18-5-2-7-22(23(18)21)33(30,31)32/h1-2,4-11H,3,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010060
PNG
(2-[3-(4-Pyrimidin-2-yl-piperazin-1-yl)-propyl]-2H-...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2ncccn2)c2cccc3cccc1c23
Show InChI InChI=1S/C21H23N5O2S/c27-29(28)19-8-2-6-17-5-1-7-18(20(17)19)26(29)12-4-11-24-13-15-25(16-14-24)21-22-9-3-10-23-21/h1-3,5-10H,4,11-16H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010035
PNG
(2-{3-[4-(4-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C24H24F3N3O2S/c25-24(26,27)19-8-10-20(11-9-19)29-16-14-28(15-17-29)12-3-13-30-21-6-1-4-18-5-2-7-22(23(18)21)33(30,31)32/h1-2,4-11H,3,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010046
PNG
(2-[3-(4-Benzothiazol-2-yl-piperazin-1-yl)-propyl]-...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2nc3ccccc3s2)c2cccc3cccc1c23
Show InChI InChI=1S/C24H24N4O2S2/c29-32(30)22-11-4-7-18-6-3-9-20(23(18)22)28(32)13-5-12-26-14-16-27(17-15-26)24-25-19-8-1-2-10-21(19)31-24/h1-4,6-11H,5,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010045
PNG
(2-{3-[4-(4-Bromo-phenyl)-piperazin-1-yl]-propyl}-2...)
Show SMILES Brc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24BrN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010039
PNG
(2-{3-[4-(3-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Fc1cccc(c1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24FN3O2S/c24-19-7-3-8-20(17-19)26-15-13-25(14-16-26)11-4-12-27-21-9-1-5-18-6-2-10-22(23(18)21)30(27,28)29/h1-3,5-10,17H,4,11-16H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010030
PNG
(4-{4-[3-(1,1-Dioxo-1H-1lambda*6*-naphtho[1,8-cd]is...)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C26H29N3O4S/c1-2-33-26(30)21-10-12-22(13-11-21)28-18-16-27(17-19-28)14-5-15-29-23-8-3-6-20-7-4-9-24(25(20)23)34(29,31)32/h3-4,6-13H,2,5,14-19H2,1H3
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010060
PNG
(2-[3-(4-Pyrimidin-2-yl-piperazin-1-yl)-propyl]-2H-...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2ncccn2)c2cccc3cccc1c23
Show InChI InChI=1S/C21H23N5O2S/c27-29(28)19-8-2-6-17-5-1-7-18(20(17)19)26(29)12-4-11-24-13-15-25(16-14-24)21-22-9-3-10-23-21/h1-3,5-10H,4,11-16H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010051
PNG
(2-{3-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C24H27N3O3S/c1-30-21-11-9-20(10-12-21)26-17-15-25(16-18-26)13-4-14-27-22-7-2-5-19-6-3-8-23(24(19)22)31(27,28)29/h2-3,5-12H,4,13-18H2,1H3
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010046
PNG
(2-[3-(4-Benzothiazol-2-yl-piperazin-1-yl)-propyl]-...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2nc3ccccc3s2)c2cccc3cccc1c23
Show InChI InChI=1S/C24H24N4O2S2/c29-32(30)22-11-4-7-18-6-3-9-20(23(18)22)28(32)13-5-12-26-14-16-27(17-15-26)24-25-19-8-1-2-10-21(19)31-24/h1-4,6-11H,5,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010057
PNG
(2-[3-(4-Phenyl-piperazin-1-yl)-propyl]-2H-naphtho[...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2ccccc2)c2cccc3cccc1c23
Show InChI InChI=1S/C23H25N3O2S/c27-29(28)22-12-5-8-19-7-4-11-21(23(19)22)26(29)14-6-13-24-15-17-25(18-16-24)20-9-2-1-3-10-20/h1-5,7-12H,6,13-18H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010034
PNG
(2-[3-(4-p-Tolyl-piperazin-1-yl)-propyl]-2H-naphtho...)
Show SMILES Cc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C24H27N3O2S/c1-19-9-11-21(12-10-19)26-17-15-25(16-18-26)13-4-14-27-22-7-2-5-20-6-3-8-23(24(20)22)30(27,28)29/h2-3,5-12H,4,13-18H2,1H3
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010053
PNG
(2-{3-[4-(4-Nitro-phenyl)-piperazin-1-yl]-propyl}-2...)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24N4O4S/c28-27(29)20-10-8-19(9-11-20)25-16-14-24(15-17-25)12-3-13-26-21-6-1-4-18-5-2-7-22(23(18)21)32(26,30)31/h1-2,4-11H,3,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50010045
PNG
(2-{3-[4-(4-Bromo-phenyl)-piperazin-1-yl]-propyl}-2...)
Show SMILES Brc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
Show InChI InChI=1S/C23H24BrN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50010055
PNG
(2-[3-(4-Pyridin-2-yl-piperazin-1-yl)-propyl]-2H-na...)
Show SMILES O=S1(=O)N(CCCN2CCN(CC2)c2ccccn2)c2cccc3cccc1c23
Show InChI InChI=1S/C22H24N4O2S/c27-29(28)20-9-4-7-18-6-3-8-19(22(18)20)26(29)13-5-12-24-14-16-25(17-15-24)21-10-1-2-11-23-21/h1-4,6-11H,5,12-17H2
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Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)

J Med Chem 34: 2477-83 (1991)


Article DOI: 10.1021/jm00112a025
BindingDB Entry DOI: 10.7270/Q2R78FT1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%