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PubMed code 1909177

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM93008
PNG
(Substituted Quinazolin-4(3H)-one, 15)
Show SMILES Nc1ccc(O)c2c1nc[nH]c2=O
Show InChI InChI=1S/C8H7N3O2/c9-4-1-2-5(12)6-7(4)10-3-11-8(6)13/h1-3,12H,9H2,(H,10,11,13)
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1.31E+5n/an/an/an/an/an/an/an/a



Arizona State University



Assay Description
PNPase activity (guanosine to guanine and ribose 1-phosphate) was followed by measuring the decrease in absorbance at 268nm.


Citation and Details
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM93004
PNG
(Substituted Quinazolin-4(3H)-one, 11)
Show SMILES Oc1ccc(O)c2c1nc[nH]c2=O
Show InChI InChI=1S/C8H6N2O3/c11-4-1-2-5(12)7-6(4)8(13)10-3-9-7/h1-3,11-12H,(H,9,10,13)
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1.42E+5n/an/an/an/an/an/an/an/a



Arizona State University



Assay Description
PNPase activity (guanosine to guanine and ribose 1-phosphate) was followed by measuring the decrease in absorbance at 268nm.


Citation and Details
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM93003
PNG
(Substituted Quinazolin-4(3H)-one, 9)
Show SMILES Nc1cccc2nc[nH]c(=O)c12
Show InChI InChI=1S/C8H7N3O/c9-5-2-1-3-6-7(5)8(12)11-4-10-6/h1-4H,9H2,(H,10,11,12)
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3.37E+5n/an/an/an/an/an/an/an/a



Arizona State University



Assay Description
PNPase activity (guanosine to guanine and ribose 1-phosphate) was followed by measuring the decrease in absorbance at 268nm.


Citation and Details
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM93006
PNG
(Substituted Quinazolin-4(3H)-one, 13)
Show SMILES Oc1cccc2nc[nH]c(=O)c12
Show InChI InChI=1S/C8H6N2O2/c11-6-3-1-2-5-7(6)8(12)10-4-9-5/h1-4,11H,(H,9,10,12)
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5.76E+5n/an/an/an/an/an/an/an/a



Arizona State University



Assay Description
PNPase activity (guanosine to guanine and ribose 1-phosphate) was followed by measuring the decrease in absorbance at 268nm.


Citation and Details
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM93007
PNG
(Substituted Quinazolin-4(3H)-one, 14)
Show SMILES Oc1cccc2c1nc[nH]c2=O
Show InChI InChI=1S/C8H6N2O2/c11-6-3-1-2-5-7(6)9-4-10-8(5)12/h1-4,11H,(H,9,10,12)
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5.93E+5n/an/an/an/an/an/an/an/a



Arizona State University



Assay Description
PNPase activity (guanosine to guanine and ribose 1-phosphate) was followed by measuring the decrease in absorbance at 268nm.


Citation and Details
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM93005
PNG
(Substituted Quinazolin-4(3H)-one, 12)
Show SMILES Cc1cc(O)c2nc[nH]c(=O)c2c1
Show InChI InChI=1S/C9H8N2O2/c1-5-2-6-8(7(12)3-5)10-4-11-9(6)13/h2-4,12H,1H3,(H,10,11,13)
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6.18E+5n/an/an/an/an/an/an/an/a



Arizona State University



Assay Description
PNPase activity (guanosine to guanine and ribose 1-phosphate) was followed by measuring the decrease in absorbance at 268nm.


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%