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PubMed code 19124243

Compile data set for download or QSAR
Found 108 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277407
PNG
(CHEMBL473288 | N-(4-bromophenyl)-4-(pyridin-4-ylme...)
Show SMILES Brc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C16H13BrN4OS/c17-12-1-3-13(4-2-12)20-16(22)15-14(10-23-21-15)19-9-11-5-7-18-8-6-11/h1-8,10,19H,9H2,(H,20,22)
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70n/an/an/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) at IC90 concentration by ATP based competition assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277407
PNG
(CHEMBL473288 | N-(4-bromophenyl)-4-(pyridin-4-ylme...)
Show SMILES Brc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C16H13BrN4OS/c17-12-1-3-13(4-2-12)20-16(22)15-14(10-23-21-15)19-9-11-5-7-18-8-6-11/h1-8,10,19H,9H2,(H,20,22)
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90n/an/an/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) at IC50 concentration by ATP based competition assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277363
PNG
(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)
Show SMILES CC(C)(C)c1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H22N4OS/c1-20(2,3)15-5-4-6-16(11-15)23-19(25)18-17(13-26-24-18)22-12-14-7-9-21-10-8-14/h4-11,13,22H,12H2,1-3H3,(H,23,25)
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120n/an/an/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) at IC90 concentration by ATP based competition assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277281
PNG
(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)12-2-1-3-13(8-12)23-16(25)15-14(10-26-24-15)22-9-11-4-6-21-7-5-11/h1-8,10,22H,9H2,(H,23,25)
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130n/an/an/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) at IC90 concentration by ATP based competition assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277363
PNG
(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)
Show SMILES CC(C)(C)c1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H22N4OS/c1-20(2,3)15-5-4-6-16(11-15)23-19(25)18-17(13-26-24-18)22-12-14-7-9-21-10-8-14/h4-11,13,22H,12H2,1-3H3,(H,23,25)
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130n/an/an/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) at IC50 concentration by ATP based competition assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277281
PNG
(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)12-2-1-3-13(8-12)23-16(25)15-14(10-26-24-15)22-9-11-4-6-21-7-5-11/h1-8,10,22H,9H2,(H,23,25)
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160n/an/an/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) at IC50 concentration by ATP based competition assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM9503
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
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n/an/a 1.20n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced VEGFR2 phosphorylation (unknown origin) expressed in CHO cells in presence of 8 uM ATP by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/a 16n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced VEGFR2 phosphorylation (unknown origin) expressed in CHO cells in presence of 8 uM ATP by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/a 21n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM9503
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
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n/an/a 23n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 8 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277406
PNG
(CHEMBL473287 | N-(3-bromophenyl)-4-(pyridin-4-ylme...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C16H13BrN4OS/c17-12-2-1-3-13(8-12)20-16(22)15-14(10-23-21-15)19-9-11-4-6-18-7-5-11/h1-8,10,19H,9H2,(H,20,22)
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n/an/a 27n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM9503
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
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n/an/a 32n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277361
PNG
(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy...)
Show SMILES FC(F)(F)Oc1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C17H13F3N4O2S/c18-17(19,20)26-13-3-1-2-12(8-13)23-16(25)15-14(10-27-24-15)22-9-11-4-6-21-7-5-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a 33n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277363
PNG
(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)
Show SMILES CC(C)(C)c1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H22N4OS/c1-20(2,3)15-5-4-6-16(11-15)23-19(25)18-17(13-26-24-18)22-12-14-7-9-21-10-8-14/h4-11,13,22H,12H2,1-3H3,(H,23,25)
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n/an/a 35n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277361
PNG
(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy...)
Show SMILES FC(F)(F)Oc1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C17H13F3N4O2S/c18-17(19,20)26-13-3-1-2-12(8-13)23-16(25)15-14(10-27-24-15)22-9-11-4-6-21-7-5-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a 41n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277281
PNG
(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)12-2-1-3-13(8-12)23-16(25)15-14(10-26-24-15)22-9-11-4-6-21-7-5-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a 41n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/a 42n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 8 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277436
PNG
(CHEMBL470441 | N-(4-methyl-3-(trifluoromethyl)phen...)
Show SMILES Cc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1C(F)(F)F
Show InChI InChI=1S/C18H15F3N4OS/c1-11-2-3-13(8-14(11)18(19,20)21)24-17(26)16-15(10-27-25-16)23-9-12-4-6-22-7-5-12/h2-8,10,23H,9H2,1H3,(H,24,26)
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n/an/a 43n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/a 54n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277281
PNG
(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)12-2-1-3-13(8-12)23-16(25)15-14(10-26-24-15)22-9-11-4-6-21-7-5-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a 54n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277406
PNG
(CHEMBL473287 | N-(3-bromophenyl)-4-(pyridin-4-ylme...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C16H13BrN4OS/c17-12-2-1-3-13(8-12)20-16(22)15-14(10-23-21-15)19-9-11-4-6-18-7-5-11/h1-8,10,19H,9H2,(H,20,22)
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n/an/a 55n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277436
PNG
(CHEMBL470441 | N-(4-methyl-3-(trifluoromethyl)phen...)
Show SMILES Cc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1C(F)(F)F
Show InChI InChI=1S/C18H15F3N4OS/c1-11-2-3-13(8-14(11)18(19,20)21)24-17(26)16-15(10-27-25-16)23-9-12-4-6-22-7-5-12/h2-8,10,23H,9H2,1H3,(H,24,26)
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n/an/a 56n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277363
PNG
(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)
Show SMILES CC(C)(C)c1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H22N4OS/c1-20(2,3)15-5-4-6-16(11-15)23-19(25)18-17(13-26-24-18)22-12-14-7-9-21-10-8-14/h4-11,13,22H,12H2,1-3H3,(H,23,25)
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n/an/a 82n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM9503
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
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n/an/a 90n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277064
PNG
(4-(quinolin-4-ylmethylamino)-N-(3-(trifluoromethyl...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2ccnc3ccccc23)c1
Show InChI InChI=1S/C21H15F3N4OS/c22-21(23,24)14-4-3-5-15(10-14)27-20(29)19-18(12-30-28-19)26-11-13-8-9-25-17-7-2-1-6-16(13)17/h1-10,12,26H,11H2,(H,27,29)
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n/an/a 110n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/a 110n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 8 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9503
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
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n/an/a 130n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 8 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/a 140n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277365
PNG
(CHEMBL475709 | N-(4-chlorophenyl)-4-(pyridin-4-ylm...)
Show SMILES Clc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C16H13ClN4OS/c17-12-1-3-13(4-2-12)20-16(22)15-14(10-23-21-15)19-9-11-5-7-18-8-6-11/h1-8,10,19H,9H2,(H,20,22)
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n/an/a 140n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50276992
PNG
(CHEMBL517399 | N-(3-bromophenyl)-4-(quinolin-4-ylm...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCc2ccnc3ccccc23)c1
Show InChI InChI=1S/C20H15BrN4OS/c21-14-4-3-5-15(10-14)24-20(26)19-18(12-27-25-19)23-11-13-8-9-22-17-7-2-1-6-16(13)17/h1-10,12,23H,11H2,(H,24,26)
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n/an/a 150n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9503
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
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n/an/a 170n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277281
PNG
(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)12-2-1-3-13(8-12)23-16(25)15-14(10-26-24-15)22-9-11-4-6-21-7-5-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a 170n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277436
PNG
(CHEMBL470441 | N-(4-methyl-3-(trifluoromethyl)phen...)
Show SMILES Cc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1C(F)(F)F
Show InChI InChI=1S/C18H15F3N4OS/c1-11-2-3-13(8-14(11)18(19,20)21)24-17(26)16-15(10-27-25-16)23-9-12-4-6-22-7-5-12/h2-8,10,23H,9H2,1H3,(H,24,26)
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n/an/a 190n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277320
PNG
(4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)12-1-3-13(4-2-12)23-16(25)15-14(10-26-24-15)22-9-11-5-7-21-8-6-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a 210n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277406
PNG
(CHEMBL473287 | N-(3-bromophenyl)-4-(pyridin-4-ylme...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C16H13BrN4OS/c17-12-2-1-3-13(8-12)20-16(22)15-14(10-23-21-15)19-9-11-4-6-18-7-5-11/h1-8,10,19H,9H2,(H,20,22)
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n/an/a 210n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277407
PNG
(CHEMBL473288 | N-(4-bromophenyl)-4-(pyridin-4-ylme...)
Show SMILES Brc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C16H13BrN4OS/c17-12-1-3-13(4-2-12)20-16(22)15-14(10-23-21-15)19-9-11-5-7-18-8-6-11/h1-8,10,19H,9H2,(H,20,22)
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n/an/a 230n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277433
PNG
(CHEMBL473268 | N-(4-chloro-3-(trifluoromethyl)phen...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2nscc2NCc2ccncc2)ccc1Cl
Show InChI InChI=1S/C17H12ClF3N4OS/c18-13-2-1-11(7-12(13)17(19,20)21)24-16(26)15-14(9-27-25-15)23-8-10-3-5-22-6-4-10/h1-7,9,23H,8H2,(H,24,26)
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n/an/a 230n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277320
PNG
(4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)12-1-3-13(4-2-12)23-16(25)15-14(10-26-24-15)22-9-11-5-7-21-8-6-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a 250n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277365
PNG
(CHEMBL475709 | N-(4-chlorophenyl)-4-(pyridin-4-ylm...)
Show SMILES Clc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C16H13ClN4OS/c17-12-1-3-13(4-2-12)20-16(22)15-14(10-23-21-15)19-9-11-5-7-18-8-6-11/h1-8,10,19H,9H2,(H,20,22)
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n/an/a 250n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277407
PNG
(CHEMBL473288 | N-(4-bromophenyl)-4-(pyridin-4-ylme...)
Show SMILES Brc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C16H13BrN4OS/c17-12-1-3-13(4-2-12)20-16(22)15-14(10-23-21-15)19-9-11-5-7-18-8-6-11/h1-8,10,19H,9H2,(H,20,22)
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n/an/a 260n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277361
PNG
(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy...)
Show SMILES FC(F)(F)Oc1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C17H13F3N4O2S/c18-17(19,20)26-13-3-1-2-12(8-13)23-16(25)15-14(10-27-24-15)22-9-11-4-6-21-7-5-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a 260n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50276992
PNG
(CHEMBL517399 | N-(3-bromophenyl)-4-(quinolin-4-ylm...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCc2ccnc3ccccc23)c1
Show InChI InChI=1S/C20H15BrN4OS/c21-14-4-3-5-15(10-14)24-20(26)19-18(12-27-25-19)23-11-13-8-9-22-17-7-2-1-6-16(13)17/h1-10,12,23H,11H2,(H,24,26)
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n/an/a 270n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277363
PNG
(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)
Show SMILES CC(C)(C)c1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H22N4OS/c1-20(2,3)15-5-4-6-16(11-15)23-19(25)18-17(13-26-24-18)22-12-14-7-9-21-10-8-14/h4-11,13,22H,12H2,1-3H3,(H,23,25)
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n/an/a 310n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50276992
PNG
(CHEMBL517399 | N-(3-bromophenyl)-4-(quinolin-4-ylm...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCc2ccnc3ccccc23)c1
Show InChI InChI=1S/C20H15BrN4OS/c21-14-4-3-5-15(10-14)24-20(26)19-18(12-27-25-19)23-11-13-8-9-22-17-7-2-1-6-16(13)17/h1-10,12,23H,11H2,(H,24,26)
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n/an/a 330n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277364
PNG
(CHEMBL475708 | N-(4-tert-butylphenyl)-4-(pyridin-4...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C20H22N4OS/c1-20(2,3)15-4-6-16(7-5-15)23-19(25)18-17(13-26-24-18)22-12-14-8-10-21-11-9-14/h4-11,13,22H,12H2,1-3H3,(H,23,25)
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n/an/a 360n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277409
PNG
(4-(pyridin-4-ylmethylamino)-N-(quinolin-2-yl)isoth...)
Show SMILES O=C(Nc1ccc2ccccc2n1)c1nscc1NCc1ccncc1
Show InChI InChI=1S/C19H15N5OS/c25-19(23-17-6-5-14-3-1-2-4-15(14)22-17)18-16(12-26-24-18)21-11-13-7-9-20-10-8-13/h1-10,12,21H,11H2,(H,22,23,25)
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n/an/a 380n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277064
PNG
(4-(quinolin-4-ylmethylamino)-N-(3-(trifluoromethyl...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2ccnc3ccccc23)c1
Show InChI InChI=1S/C21H15F3N4OS/c22-21(23,24)14-4-3-5-15(10-14)27-20(29)19-18(12-30-28-19)26-11-13-8-9-25-17-7-2-1-6-16(13)17/h1-10,12,26H,11H2,(H,27,29)
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n/an/a 390n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277365
PNG
(CHEMBL475709 | N-(4-chlorophenyl)-4-(pyridin-4-ylm...)
Show SMILES Clc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C16H13ClN4OS/c17-12-1-3-13(4-2-12)20-16(22)15-14(10-23-21-15)19-9-11-5-7-18-8-6-11/h1-8,10,19H,9H2,(H,20,22)
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n/an/a 420n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277409
PNG
(4-(pyridin-4-ylmethylamino)-N-(quinolin-2-yl)isoth...)
Show SMILES O=C(Nc1ccc2ccccc2n1)c1nscc1NCc1ccncc1
Show InChI InChI=1S/C19H15N5OS/c25-19(23-17-6-5-14-3-1-2-4-15(14)22-17)18-16(12-26-24-18)21-11-13-7-9-20-10-8-13/h1-10,12,21H,11H2,(H,22,23,25)
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n/an/a 440n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277362
PNG
(4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethoxy...)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C17H13F3N4O2S/c18-17(19,20)26-13-3-1-12(2-4-13)23-16(25)15-14(10-27-24-15)22-9-11-5-7-21-8-6-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a 460n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277437
PNG
(CHEMBL512863 | N-(3-methyl-4-(trifluoromethyl)phen...)
Show SMILES Cc1cc(NC(=O)c2nscc2NCc2ccncc2)ccc1C(F)(F)F
Show InChI InChI=1S/C18H15F3N4OS/c1-11-8-13(2-3-14(11)18(19,20)21)24-17(26)16-15(10-27-25-16)23-9-12-4-6-22-7-5-12/h2-8,10,23H,9H2,1H3,(H,24,26)
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n/an/a 490n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277433
PNG
(CHEMBL473268 | N-(4-chloro-3-(trifluoromethyl)phen...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2nscc2NCc2ccncc2)ccc1Cl
Show InChI InChI=1S/C17H12ClF3N4OS/c18-13-2-1-11(7-12(13)17(19,20)21)24-16(26)15-14(9-27-25-15)23-8-10-3-5-22-6-4-10/h1-7,9,23H,8H2,(H,24,26)
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n/an/a 530n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277064
PNG
(4-(quinolin-4-ylmethylamino)-N-(3-(trifluoromethyl...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2ccnc3ccccc23)c1
Show InChI InChI=1S/C21H15F3N4OS/c22-21(23,24)14-4-3-5-15(10-14)27-20(29)19-18(12-30-28-19)26-11-13-8-9-25-17-7-2-1-6-16(13)17/h1-10,12,26H,11H2,(H,27,29)
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n/an/a 580n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277364
PNG
(CHEMBL475708 | N-(4-tert-butylphenyl)-4-(pyridin-4...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C20H22N4OS/c1-20(2,3)15-4-6-16(7-5-15)23-19(25)18-17(13-26-24-18)22-12-14-8-10-21-11-9-14/h4-11,13,22H,12H2,1-3H3,(H,23,25)
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n/an/a 610n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50276964
PNG
(CHEMBL462315 | N-(benzo[d][1,3]dioxol-5-ylmethyl)-...)
Show SMILES O=C(NCc1ccc2OCOc2c1)c1nscc1NCc1ccncc1
Show InChI InChI=1S/C18H16N4O3S/c23-18(21-9-13-1-2-15-16(7-13)25-11-24-15)17-14(10-26-22-17)20-8-12-3-5-19-6-4-12/h1-7,10,20H,8-9,11H2,(H,21,23)
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n/an/a 650n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277437
PNG
(CHEMBL512863 | N-(3-methyl-4-(trifluoromethyl)phen...)
Show SMILES Cc1cc(NC(=O)c2nscc2NCc2ccncc2)ccc1C(F)(F)F
Show InChI InChI=1S/C18H15F3N4OS/c1-11-8-13(2-3-14(11)18(19,20)21)24-17(26)16-15(10-27-25-16)23-9-12-4-6-22-7-5-12/h2-8,10,23H,9H2,1H3,(H,24,26)
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n/an/a 670n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277435
PNG
(CHEMBL470440 | N-(3,4-dichlorophenyl)-4-(pyridin-4...)
Show SMILES Clc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1Cl
Show InChI InChI=1S/C16H12Cl2N4OS/c17-12-2-1-11(7-13(12)18)21-16(23)15-14(9-24-22-15)20-8-10-3-5-19-6-4-10/h1-7,9,20H,8H2,(H,21,23)
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n/an/a 670n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50276964
PNG
(CHEMBL462315 | N-(benzo[d][1,3]dioxol-5-ylmethyl)-...)
Show SMILES O=C(NCc1ccc2OCOc2c1)c1nscc1NCc1ccncc1
Show InChI InChI=1S/C18H16N4O3S/c23-18(21-9-13-1-2-15-16(7-13)25-11-24-15)17-14(10-26-22-17)20-8-12-3-5-19-6-4-12/h1-7,10,20H,8-9,11H2,(H,21,23)
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n/an/a 700n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277437
PNG
(CHEMBL512863 | N-(3-methyl-4-(trifluoromethyl)phen...)
Show SMILES Cc1cc(NC(=O)c2nscc2NCc2ccncc2)ccc1C(F)(F)F
Show InChI InChI=1S/C18H15F3N4OS/c1-11-8-13(2-3-14(11)18(19,20)21)24-17(26)16-15(10-27-25-16)23-9-12-4-6-22-7-5-12/h2-8,10,23H,9H2,1H3,(H,24,26)
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n/an/a 710n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277435
PNG
(CHEMBL470440 | N-(3,4-dichlorophenyl)-4-(pyridin-4...)
Show SMILES Clc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1Cl
Show InChI InChI=1S/C16H12Cl2N4OS/c17-12-2-1-11(7-13(12)18)21-16(23)15-14(9-24-22-15)20-8-10-3-5-19-6-4-10/h1-7,9,20H,8H2,(H,21,23)
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n/an/a 750n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277409
PNG
(4-(pyridin-4-ylmethylamino)-N-(quinolin-2-yl)isoth...)
Show SMILES O=C(Nc1ccc2ccccc2n1)c1nscc1NCc1ccncc1
Show InChI InChI=1S/C19H15N5OS/c25-19(23-17-6-5-14-3-1-2-4-15(14)22-17)18-16(12-26-24-18)21-11-13-7-9-20-10-8-13/h1-10,12,21H,11H2,(H,22,23,25)
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n/an/a 770n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277362
PNG
(4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethoxy...)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C17H13F3N4O2S/c18-17(19,20)26-13-3-1-12(2-4-13)23-16(25)15-14(10-27-24-15)22-9-11-5-7-21-8-6-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a 770n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50276964
PNG
(CHEMBL462315 | N-(benzo[d][1,3]dioxol-5-ylmethyl)-...)
Show SMILES O=C(NCc1ccc2OCOc2c1)c1nscc1NCc1ccncc1
Show InChI InChI=1S/C18H16N4O3S/c23-18(21-9-13-1-2-15-16(7-13)25-11-24-15)17-14(10-26-22-17)20-8-12-3-5-19-6-4-12/h1-7,10,20H,8-9,11H2,(H,21,23)
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n/an/a 790n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277410
PNG
(CHEMBL443921 | N-(3a,7a-dihydro-1H-indazol-5-yl)-4...)
Show SMILES O=C(Nc1ccc2NNCc2c1)c1nscc1NCc1ccncc1
Show InChI InChI=1S/C17H16N6OS/c24-17(21-13-1-2-14-12(7-13)9-20-22-14)16-15(10-25-23-16)19-8-11-3-5-18-6-4-11/h1-7,10,19-20,22H,8-9H2,(H,21,24)
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n/an/a 820n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277434
PNG
(CHEMBL512862 | N-(3-chloro-4-(trifluoromethyl)phen...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1Cl
Show InChI InChI=1S/C17H12ClF3N4OS/c18-13-7-11(1-2-12(13)17(19,20)21)24-16(26)15-14(9-27-25-15)23-8-10-3-5-22-6-4-10/h1-7,9,23H,8H2,(H,24,26)
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n/an/a 890n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277433
PNG
(CHEMBL473268 | N-(4-chloro-3-(trifluoromethyl)phen...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2nscc2NCc2ccncc2)ccc1Cl
Show InChI InChI=1S/C17H12ClF3N4OS/c18-13-2-1-11(7-12(13)17(19,20)21)24-16(26)15-14(9-27-25-15)23-8-10-3-5-22-6-4-10/h1-7,9,23H,8H2,(H,24,26)
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n/an/a 980n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277407
PNG
(CHEMBL473288 | N-(4-bromophenyl)-4-(pyridin-4-ylme...)
Show SMILES Brc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C16H13BrN4OS/c17-12-1-3-13(4-2-12)20-16(22)15-14(10-23-21-15)19-9-11-5-7-18-8-6-11/h1-8,10,19H,9H2,(H,20,22)
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n/an/a 1.04E+3n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277410
PNG
(CHEMBL443921 | N-(3a,7a-dihydro-1H-indazol-5-yl)-4...)
Show SMILES O=C(Nc1ccc2NNCc2c1)c1nscc1NCc1ccncc1
Show InChI InChI=1S/C17H16N6OS/c24-17(21-13-1-2-14-12(7-13)9-20-22-14)16-15(10-25-23-16)19-8-11-3-5-18-6-4-11/h1-7,10,19-20,22H,8-9H2,(H,21,24)
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n/an/a 1.09E+3n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277435
PNG
(CHEMBL470440 | N-(3,4-dichlorophenyl)-4-(pyridin-4...)
Show SMILES Clc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1Cl
Show InChI InChI=1S/C16H12Cl2N4OS/c17-12-2-1-11(7-13(12)18)21-16(23)15-14(9-24-22-15)20-8-10-3-5-19-6-4-10/h1-7,9,20H,8H2,(H,21,23)
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n/an/a 1.11E+3n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277364
PNG
(CHEMBL475708 | N-(4-tert-butylphenyl)-4-(pyridin-4...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C20H22N4OS/c1-20(2,3)15-4-6-16(7-5-15)23-19(25)18-17(13-26-24-18)22-12-14-8-10-21-11-9-14/h4-11,13,22H,12H2,1-3H3,(H,23,25)
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n/an/a 1.15E+3n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277362
PNG
(4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethoxy...)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C17H13F3N4O2S/c18-17(19,20)26-13-3-1-12(2-4-13)23-16(25)15-14(10-27-24-15)22-9-11-5-7-21-8-6-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a 1.23E+3n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277320
PNG
(4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)12-1-3-13(4-2-12)23-16(25)15-14(10-26-24-15)22-9-11-5-7-21-8-6-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a 1.53E+3n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277434
PNG
(CHEMBL512862 | N-(3-chloro-4-(trifluoromethyl)phen...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1Cl
Show InChI InChI=1S/C17H12ClF3N4OS/c18-13-7-11(1-2-12(13)17(19,20)21)24-16(26)15-14(9-27-25-15)23-8-10-3-5-22-6-4-10/h1-7,9,23H,8H2,(H,24,26)
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n/an/a 1.80E+3n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50276963
PNG
(CHEMBL460191 | N-(2-fluoro-4-methylphenyl)-4-(pyri...)
Show SMILES Cc1ccc(NC(=O)c2nscc2NCc2ccncc2)c(F)c1
Show InChI InChI=1S/C17H15FN4OS/c1-11-2-3-14(13(18)8-11)21-17(23)16-15(10-24-22-16)20-9-12-4-6-19-7-5-12/h2-8,10,20H,9H2,1H3,(H,21,23)
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n/an/a 1.89E+3n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50276963
PNG
(CHEMBL460191 | N-(2-fluoro-4-methylphenyl)-4-(pyri...)
Show SMILES Cc1ccc(NC(=O)c2nscc2NCc2ccncc2)c(F)c1
Show InChI InChI=1S/C17H15FN4OS/c1-11-2-3-14(13(18)8-11)21-17(23)16-15(10-24-22-16)20-9-12-4-6-19-7-5-12/h2-8,10,20H,9H2,1H3,(H,21,23)
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n/an/a 1.98E+3n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277434
PNG
(CHEMBL512862 | N-(3-chloro-4-(trifluoromethyl)phen...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1Cl
Show InChI InChI=1S/C17H12ClF3N4OS/c18-13-7-11(1-2-12(13)17(19,20)21)24-16(26)15-14(9-27-25-15)23-8-10-3-5-22-6-4-10/h1-7,9,23H,8H2,(H,24,26)
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n/an/a 2.05E+3n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50276963
PNG
(CHEMBL460191 | N-(2-fluoro-4-methylphenyl)-4-(pyri...)
Show SMILES Cc1ccc(NC(=O)c2nscc2NCc2ccncc2)c(F)c1
Show InChI InChI=1S/C17H15FN4OS/c1-11-2-3-14(13(18)8-11)21-17(23)16-15(10-24-22-16)20-9-12-4-6-19-7-5-12/h2-8,10,20H,9H2,1H3,(H,21,23)
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n/an/a 2.51E+3n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277318
PNG
(4-(pyridin-3-ylmethylamino)-N-(3-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2cccnc2)c1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)12-4-1-5-13(7-12)23-16(25)15-14(10-26-24-15)22-9-11-3-2-6-21-8-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a 4.23E+3n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50276966
PNG
(4-(2-(benzo[d][1,3]dioxol-5-yl)ethylamino)-N-(3-(t...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCCc2ccc3OCOc3c2)c1
Show InChI InChI=1S/C20H16F3N3O3S/c21-20(22,23)13-2-1-3-14(9-13)25-19(27)18-15(10-30-26-18)24-7-6-12-4-5-16-17(8-12)29-11-28-16/h1-5,8-10,24H,6-7,11H2,(H,25,27)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277065
PNG
(CHEMBL512380 | N-(3-bromophenyl)-4-(isoxazol-4-ylm...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCc2cnoc2)c1
Show InChI InChI=1S/C14H11BrN4O2S/c15-10-2-1-3-11(4-10)18-14(20)13-12(8-22-19-13)16-5-9-6-17-21-7-9/h1-4,6-8,16H,5H2,(H,18,20)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277322
PNG
(4-(pyridin-2-ylmethylamino)-N-(4-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2nscc2NCc2ccccn2)cc1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)11-4-6-12(7-5-11)23-16(25)15-14(10-26-24-15)22-9-13-3-1-2-8-21-13/h1-8,10,22H,9H2,(H,23,25)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50276966
PNG
(4-(2-(benzo[d][1,3]dioxol-5-yl)ethylamino)-N-(3-(t...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCCc2ccc3OCOc3c2)c1
Show InChI InChI=1S/C20H16F3N3O3S/c21-20(22,23)13-2-1-3-14(9-13)25-19(27)18-15(10-30-26-18)24-7-6-12-4-5-16-17(8-12)29-11-28-16/h1-5,8-10,24H,6-7,11H2,(H,25,27)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277066
PNG
(CHEMBL458532 | N-(3-bromophenyl)-4-(quinolin-2-ylm...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C20H15BrN4OS/c21-14-5-3-6-15(10-14)24-20(26)19-18(12-27-25-19)22-11-16-9-8-13-4-1-2-7-17(13)23-16/h1-10,12,22H,11H2,(H,24,26)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277322
PNG
(4-(pyridin-2-ylmethylamino)-N-(4-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2nscc2NCc2ccccn2)cc1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)11-4-6-12(7-5-11)23-16(25)15-14(10-26-24-15)22-9-13-3-1-2-8-21-13/h1-8,10,22H,9H2,(H,23,25)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277065
PNG
(CHEMBL512380 | N-(3-bromophenyl)-4-(isoxazol-4-ylm...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCc2cnoc2)c1
Show InChI InChI=1S/C14H11BrN4O2S/c15-10-2-1-3-11(4-10)18-14(20)13-12(8-22-19-13)16-5-9-6-17-21-7-9/h1-4,6-8,16H,5H2,(H,18,20)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50276965
PNG
(4-(3,4-difluorobenzylamino)-N-(3-(trifluoromethyl)...)
Show SMILES Fc1ccc(CNc2csnc2C(=O)Nc2cccc(c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C18H12F5N3OS/c19-13-5-4-10(6-14(13)20)8-24-15-9-28-26-16(15)17(27)25-12-3-1-2-11(7-12)18(21,22)23/h1-7,9,24H,8H2,(H,25,27)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277321
PNG
(4-(pyridin-3-ylmethylamino)-N-(4-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2nscc2NCc2cccnc2)cc1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)12-3-5-13(6-4-12)23-16(25)15-14(10-26-24-15)22-9-11-2-1-7-21-8-11/h1-8,10,22H,9H2,(H,23,25)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50276965
PNG
(4-(3,4-difluorobenzylamino)-N-(3-(trifluoromethyl)...)
Show SMILES Fc1ccc(CNc2csnc2C(=O)Nc2cccc(c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C18H12F5N3OS/c19-13-5-4-10(6-14(13)20)8-24-15-9-28-26-16(15)17(27)25-12-3-1-2-11(7-12)18(21,22)23/h1-7,9,24H,8H2,(H,25,27)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277319
PNG
(4-(pyridin-2-ylmethylamino)-N-(3-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2ccccn2)c1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)11-4-3-6-12(8-11)23-16(25)15-14(10-26-24-15)22-9-13-5-1-2-7-21-13/h1-8,10,22H,9H2,(H,23,25)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277066
PNG
(CHEMBL458532 | N-(3-bromophenyl)-4-(quinolin-2-ylm...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C20H15BrN4OS/c21-14-5-3-6-15(10-14)24-20(26)19-18(12-27-25-19)22-11-16-9-8-13-4-1-2-7-17(13)23-16/h1-10,12,22H,11H2,(H,24,26)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50276967
PNG
(4-(2-(benzo[d][1,3]dioxol-5-yl)ethylamino)-N-(3-br...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCCc2ccc3OCOc3c2)c1
Show InChI InChI=1S/C19H16BrN3O3S/c20-13-2-1-3-14(9-13)22-19(24)18-15(10-27-23-18)21-7-6-12-4-5-16-17(8-12)26-11-25-16/h1-5,8-10,21H,6-7,11H2,(H,22,24)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50276967
PNG
(4-(2-(benzo[d][1,3]dioxol-5-yl)ethylamino)-N-(3-br...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCCc2ccc3OCOc3c2)c1
Show InChI InChI=1S/C19H16BrN3O3S/c20-13-2-1-3-14(9-13)22-19(24)18-15(10-27-23-18)21-7-6-12-4-5-16-17(8-12)26-11-25-16/h1-5,8-10,21H,6-7,11H2,(H,22,24)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277319
PNG
(4-(pyridin-2-ylmethylamino)-N-(3-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2ccccn2)c1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)11-4-3-6-12(8-11)23-16(25)15-14(10-26-24-15)22-9-13-5-1-2-7-21-13/h1-8,10,22H,9H2,(H,23,25)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50276967
PNG
(4-(2-(benzo[d][1,3]dioxol-5-yl)ethylamino)-N-(3-br...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCCc2ccc3OCOc3c2)c1
Show InChI InChI=1S/C19H16BrN3O3S/c20-13-2-1-3-14(9-13)22-19(24)18-15(10-27-23-18)21-7-6-12-4-5-16-17(8-12)26-11-25-16/h1-5,8-10,21H,6-7,11H2,(H,22,24)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277321
PNG
(4-(pyridin-3-ylmethylamino)-N-(4-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2nscc2NCc2cccnc2)cc1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)12-3-5-13(6-4-12)23-16(25)15-14(10-26-24-15)22-9-11-2-1-7-21-8-11/h1-8,10,22H,9H2,(H,23,25)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277321
PNG
(4-(pyridin-3-ylmethylamino)-N-(4-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2nscc2NCc2cccnc2)cc1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)12-3-5-13(6-4-12)23-16(25)15-14(10-26-24-15)22-9-11-2-1-7-21-8-11/h1-8,10,22H,9H2,(H,23,25)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50276965
PNG
(4-(3,4-difluorobenzylamino)-N-(3-(trifluoromethyl)...)
Show SMILES Fc1ccc(CNc2csnc2C(=O)Nc2cccc(c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C18H12F5N3OS/c19-13-5-4-10(6-14(13)20)8-24-15-9-28-26-16(15)17(27)25-12-3-1-2-11(7-12)18(21,22)23/h1-7,9,24H,8H2,(H,25,27)
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deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277065
PNG
(CHEMBL512380 | N-(3-bromophenyl)-4-(isoxazol-4-ylm...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCc2cnoc2)c1
Show InChI InChI=1S/C14H11BrN4O2S/c15-10-2-1-3-11(4-10)18-14(20)13-12(8-22-19-13)16-5-9-6-17-21-7-9/h1-4,6-8,16H,5H2,(H,18,20)
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n/an/a>1.00E+4n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277408
PNG
(CHEMBL509737 | N-(2-bromophenyl)-4-(pyridin-4-ylme...)
Show SMILES Brc1ccccc1NC(=O)c1nscc1NCc1ccncc1
Show InChI InChI=1S/C16H13BrN4OS/c17-12-3-1-2-4-13(12)20-16(22)15-14(10-23-21-15)19-9-11-5-7-18-8-6-11/h1-8,10,19H,9H2,(H,20,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50276966
PNG
(4-(2-(benzo[d][1,3]dioxol-5-yl)ethylamino)-N-(3-(t...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCCc2ccc3OCOc3c2)c1
Show InChI InChI=1S/C20H16F3N3O3S/c21-20(22,23)13-2-1-3-14(9-13)25-19(27)18-15(10-30-26-18)24-7-6-12-4-5-16-17(8-12)29-11-28-16/h1-5,8-10,24H,6-7,11H2,(H,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277408
PNG
(CHEMBL509737 | N-(2-bromophenyl)-4-(pyridin-4-ylme...)
Show SMILES Brc1ccccc1NC(=O)c1nscc1NCc1ccncc1
Show InChI InChI=1S/C16H13BrN4OS/c17-12-3-1-2-4-13(12)20-16(22)15-14(10-23-21-15)19-9-11-5-7-18-8-6-11/h1-8,10,19H,9H2,(H,20,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277408
PNG
(CHEMBL509737 | N-(2-bromophenyl)-4-(pyridin-4-ylme...)
Show SMILES Brc1ccccc1NC(=O)c1nscc1NCc1ccncc1
Show InChI InChI=1S/C16H13BrN4OS/c17-12-3-1-2-4-13(12)20-16(22)15-14(10-23-21-15)19-9-11-5-7-18-8-6-11/h1-8,10,19H,9H2,(H,20,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277319
PNG
(4-(pyridin-2-ylmethylamino)-N-(3-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2ccccn2)c1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)11-4-3-6-12(8-11)23-16(25)15-14(10-26-24-15)22-9-13-5-1-2-7-21-13/h1-8,10,22H,9H2,(H,23,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277066
PNG
(CHEMBL458532 | N-(3-bromophenyl)-4-(quinolin-2-ylm...)
Show SMILES Brc1cccc(NC(=O)c2nscc2NCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C20H15BrN4OS/c21-14-5-3-6-15(10-14)24-20(26)19-18(12-27-25-19)22-11-16-9-8-13-4-1-2-7-17(13)23-16/h1-10,12,22H,11H2,(H,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277410
PNG
(CHEMBL443921 | N-(3a,7a-dihydro-1H-indazol-5-yl)-4...)
Show SMILES O=C(Nc1ccc2NNCc2c1)c1nscc1NCc1ccncc1
Show InChI InChI=1S/C17H16N6OS/c24-17(21-13-1-2-14-12(7-13)9-20-22-14)16-15(10-25-23-16)19-8-11-3-5-18-6-4-11/h1-7,10,19-20,22H,8-9H2,(H,21,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277322
PNG
(4-(pyridin-2-ylmethylamino)-N-(4-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2nscc2NCc2ccccn2)cc1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)11-4-6-12(7-5-11)23-16(25)15-14(10-26-24-15)22-9-13-3-1-2-8-21-13/h1-8,10,22H,9H2,(H,23,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50277318
PNG
(4-(pyridin-3-ylmethylamino)-N-(3-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2cccnc2)c1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)12-4-1-5-13(7-12)23-16(25)15-14(10-26-24-15)22-9-11-3-2-6-21-8-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50277318
PNG
(4-(pyridin-3-ylmethylamino)-N-(3-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2cccnc2)c1
Show InChI InChI=1S/C17H13F3N4OS/c18-17(19,20)12-4-1-5-13(7-12)23-16(25)15-14(10-26-24-15)22-9-11-3-2-6-21-8-11/h1-8,10,22H,9H2,(H,23,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA


Bioorg Med Chem Lett 19: 1195-8 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.078
BindingDB Entry DOI: 10.7270/Q2W66KNK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%