BindingDB logo
myBDB logout

PubMed code 19155177

Compile data set for download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM85093
PNG
(CAS_3853 | CHEMBL267014 | CHEMBL555670 | L 745,870...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2c[nH]c3ncccc23)CC1
Show InChI InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.430n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.10n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.60n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
5.10n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
5.30n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
5.5n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50277041
PNG
(2-{(1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl}-5-(4-chl...)
Show SMILES Clc1ccc(cc1)N1CC2CC1CN2Cc1c[nH]c2ncccc12
Show InChI InChI=1S/C19H19ClN4/c20-14-3-5-15(6-4-14)24-12-16-8-17(24)11-23(16)10-13-9-22-19-18(13)2-1-7-21-19/h1-7,9,16-17H,8,10-12H2,(H,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
11n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
11n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50050467
PNG
(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)
Show SMILES OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
11.2n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
12.7n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50155520
PNG
(4-[4-(4-Chloro-phenyl)-piperazin-1-yl]-1-(4-fluoro...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN(CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H22ClFN2O/c21-17-5-9-19(10-6-17)24-14-12-23(13-15-24)11-1-2-20(25)16-3-7-18(22)8-4-16/h3-10H,1-2,11-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
17n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50277002
PNG
(8-(2-(1H-indol-3-yl)ethyl)-3-(4-chlorophenyl)-8-az...)
Show SMILES OC1(CC2CCC(C1)N2CCc1c[nH]c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClN2O/c24-18-7-5-17(6-8-18)23(27)13-19-9-10-20(14-23)26(19)12-11-16-15-25-22-4-2-1-3-21(16)22/h1-8,15,19-20,25,27H,9-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
18n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50277005
PNG
(3-{[4-(4-Chlorophenyl)-1,4-diazepan-1-yl]methyl}-1...)
Show SMILES Clc1ccc(cc1)N1CCCN(Cc2c[nH]c3ncccc23)CC1
Show InChI InChI=1S/C19H21ClN4/c20-16-4-6-17(7-5-16)24-10-2-9-23(11-12-24)14-15-13-22-19-18(15)3-1-8-21-19/h1,3-8,13H,2,9-12,14H2,(H,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
18.6n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50253549
PNG
(3-(4-Chlorophenyl)-8-(1H-indol-3-ylmethyl)-8-azabi...)
Show SMILES OC1(CC2CCC(C1)N2Cc1c[nH]c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H23ClN2O/c23-17-7-5-16(6-8-17)22(26)11-18-9-10-19(12-22)25(18)14-15-13-24-21-4-2-1-3-20(15)21/h1-8,13,18-19,24,26H,9-12,14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
25n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
33n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50277002
PNG
(8-(2-(1H-indol-3-yl)ethyl)-3-(4-chlorophenyl)-8-az...)
Show SMILES OC1(CC2CCC(C1)N2CCc1c[nH]c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClN2O/c24-18-7-5-17(6-8-18)23(27)13-19-9-10-20(14-23)26(19)12-11-16-15-25-22-4-2-1-3-21(16)22/h1-8,15,19-20,25,27H,9-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
53n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50276975
PNG
(3-{(4-(Pyrimidin-2-yl)piperazin-1-yl)methyl}-1H-py...)
Show SMILES C(N1CCN(CC1)c1ncccn1)c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H18N6/c1-3-14-13(11-20-15(14)17-4-1)12-21-7-9-22(10-8-21)16-18-5-2-6-19-16/h1-6,11H,7-10,12H2,(H,17,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
56n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50277041
PNG
(2-{(1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl}-5-(4-chl...)
Show SMILES Clc1ccc(cc1)N1CC2CC1CN2Cc1c[nH]c2ncccc12
Show InChI InChI=1S/C19H19ClN4/c20-14-3-5-15(6-4-14)24-12-16-8-17(24)11-23(16)10-13-9-22-19-18(13)2-1-7-21-19/h1-7,9,16-17H,8,10-12H2,(H,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
62n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50277041
PNG
(2-{(1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl}-5-(4-chl...)
Show SMILES Clc1ccc(cc1)N1CC2CC1CN2Cc1c[nH]c2ncccc12
Show InChI InChI=1S/C19H19ClN4/c20-14-3-5-15(6-4-14)24-12-16-8-17(24)11-23(16)10-13-9-22-19-18(13)2-1-7-21-19/h1-7,9,16-17H,8,10-12H2,(H,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
69n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50277038
PNG
(3-(4-Chlorophenyl)-8-(1H-pyrrolo[2,3-b]pyridin-3-y...)
Show SMILES OC1(CC2CCC(C1)N2Cc1c[nH]c2ncccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClN3O/c22-16-5-3-15(4-6-16)21(26)10-17-7-8-18(11-21)25(17)13-14-12-24-20-19(14)2-1-9-23-20/h1-6,9,12,17-18,26H,7-8,10-11,13H2,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
128n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50253549
PNG
(3-(4-Chlorophenyl)-8-(1H-indol-3-ylmethyl)-8-azabi...)
Show SMILES OC1(CC2CCC(C1)N2Cc1c[nH]c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H23ClN2O/c23-17-7-5-16(6-8-17)22(26)11-18-9-10-19(12-22)25(18)14-15-13-24-21-4-2-1-3-20(15)21/h1-8,13,18-19,24,26H,9-12,14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
160n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50277040
PNG
(4-(6-(4-chlorophenyl)-2,6-diazabicyclo[2.2.1]hepta...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CC2CC1N(C2)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClFN2O/c22-17-5-9-19(10-6-17)25-14-15-12-21(25)24(13-15)11-1-2-20(26)16-3-7-18(23)8-4-16/h3-10,15,21H,1-2,11-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
170n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50277037
PNG
(3-(4-Chlorophenyl)-8-(4-fluorobenzyl)-8-azabicyclo...)
Show SMILES OC1(CC2CCC(C1)N2Cc1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO/c21-16-5-3-15(4-6-16)20(24)11-18-9-10-19(12-20)23(18)13-14-1-7-17(22)8-2-14/h1-8,18-19,24H,9-13H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
172n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50262930
PNG
(4-(3-(4-chlorophenyl)-3,9-diazabicyclo[4.2.1]nonan...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1C2CCC1CN(CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H26ClFN2O/c24-18-5-9-20(10-6-18)26-15-13-21-11-12-22(16-26)27(21)14-1-2-23(28)17-3-7-19(25)8-4-17/h3-10,21-22H,1-2,11-16H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
195n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human 5HT2A receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50185474
PNG
((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-7-5-16(6-8-17)20(25)11-13-23(14-20)12-1-2-19(24)15-3-9-18(22)10-4-15/h3-10,25H,1-2,11-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
200n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50277040
PNG
(4-(6-(4-chlorophenyl)-2,6-diazabicyclo[2.2.1]hepta...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CC2CC1N(C2)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClFN2O/c22-17-5-9-19(10-6-17)25-14-15-12-21(25)24(13-15)11-1-2-20(26)16-3-7-18(23)8-4-16/h3-10,15,21H,1-2,11-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
220n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50155520
PNG
(4-[4-(4-Chloro-phenyl)-piperazin-1-yl]-1-(4-fluoro...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN(CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H22ClFN2O/c21-17-5-9-19(10-6-17)24-14-12-23(13-15-24)11-1-2-20(25)16-3-7-18(22)8-4-16/h3-10H,1-2,11-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
254n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50277002
PNG
(8-(2-(1H-indol-3-yl)ethyl)-3-(4-chlorophenyl)-8-az...)
Show SMILES OC1(CC2CCC(C1)N2CCc1c[nH]c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClN2O/c24-18-7-5-17(6-8-18)23(27)13-19-9-10-20(14-23)26(19)12-11-16-15-25-22-4-2-1-3-21(16)22/h1-8,15,19-20,25,27H,9-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
278n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50277039
PNG
(9-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-3-(4-chl...)
Show SMILES Clc1ccc(cc1)N1CCC2CCC(C1)N2Cc1c[nH]c2ncccc12
Show InChI InChI=1S/C21H23ClN4/c22-16-3-5-17(6-4-16)25-11-9-18-7-8-19(14-25)26(18)13-15-12-24-21-20(15)2-1-10-23-21/h1-6,10,12,18-19H,7-9,11,13-14H2,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
336n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50277005
PNG
(3-{[4-(4-Chlorophenyl)-1,4-diazepan-1-yl]methyl}-1...)
Show SMILES Clc1ccc(cc1)N1CCCN(Cc2c[nH]c3ncccc23)CC1
Show InChI InChI=1S/C19H21ClN4/c20-16-4-6-17(7-5-16)24-10-2-9-23(11-12-24)14-15-13-22-19-18(15)3-1-8-21-19/h1,3-8,13H,2,9-12,14H2,(H,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
370n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50277040
PNG
(4-(6-(4-chlorophenyl)-2,6-diazabicyclo[2.2.1]hepta...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CC2CC1N(C2)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClFN2O/c22-17-5-9-19(10-6-17)25-14-15-12-21(25)24(13-15)11-1-2-20(26)16-3-7-18(23)8-4-16/h3-10,15,21H,1-2,11-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
513n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50277039
PNG
(9-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-3-(4-chl...)
Show SMILES Clc1ccc(cc1)N1CCC2CCC(C1)N2Cc1c[nH]c2ncccc12
Show InChI InChI=1S/C21H23ClN4/c22-16-3-5-17(6-4-16)25-11-9-18-7-8-19(14-25)26(18)13-15-12-24-21-20(15)2-1-10-23-21/h1-6,10,12,18-19H,7-9,11,13-14H2,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
584n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50277038
PNG
(3-(4-Chlorophenyl)-8-(1H-pyrrolo[2,3-b]pyridin-3-y...)
Show SMILES OC1(CC2CCC(C1)N2Cc1c[nH]c2ncccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClN3O/c22-16-5-3-15(4-6-16)21(26)10-17-7-8-18(11-21)25(17)13-14-12-24-20-19(14)2-1-9-23-20/h1-6,9,12,17-18,26H,7-8,10-11,13H2,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
588n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50277036
PNG
(2-[3-(4-Chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1...)
Show SMILES OC1(CC2CCC(C1)N2CC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClFNO2/c22-16-5-3-15(4-6-16)21(26)11-18-9-10-19(12-21)24(18)13-20(25)14-1-7-17(23)8-2-14/h1-8,18-19,26H,9-13H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
789n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50277003
PNG
(3-(4-Chlorophenyl)-1-(1H-indol-3-ylmethyl)pyrrolid...)
Show SMILES OC1(CCN(Cc2c[nH]c3ccccc23)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H19ClN2O/c20-16-7-5-15(6-8-16)19(23)9-10-22(13-19)12-14-11-21-18-4-2-1-3-17(14)18/h1-8,11,21,23H,9-10,12-13H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
817n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM85093
PNG
(CAS_3853 | CHEMBL267014 | CHEMBL555670 | L 745,870...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2c[nH]c3ncccc23)CC1
Show InChI InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
960n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50277005
PNG
(3-{[4-(4-Chlorophenyl)-1,4-diazepan-1-yl]methyl}-1...)
Show SMILES Clc1ccc(cc1)N1CCCN(Cc2c[nH]c3ncccc23)CC1
Show InChI InChI=1S/C19H21ClN4/c20-16-4-6-17(7-5-16)24-10-2-9-23(11-12-24)14-15-13-22-19-18(15)3-1-8-21-19/h1,3-8,13H,2,9-12,14H2,(H,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
970n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50277037
PNG
(3-(4-Chlorophenyl)-8-(4-fluorobenzyl)-8-azabicyclo...)
Show SMILES OC1(CC2CCC(C1)N2Cc1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO/c21-16-5-3-15(4-6-16)20(24)11-18-9-10-19(12-20)23(18)13-14-1-7-17(22)8-2-14/h1-8,18-19,24H,9-13H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.02E+3n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50277037
PNG
(3-(4-Chlorophenyl)-8-(4-fluorobenzyl)-8-azabicyclo...)
Show SMILES OC1(CC2CCC(C1)N2Cc1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClFNO/c21-16-5-3-15(4-6-16)20(24)11-18-9-10-19(12-20)23(18)13-14-1-7-17(22)8-2-14/h1-8,18-19,24H,9-13H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.05E+3n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50276975
PNG
(3-{(4-(Pyrimidin-2-yl)piperazin-1-yl)methyl}-1H-py...)
Show SMILES C(N1CCN(CC1)c1ncccn1)c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H18N6/c1-3-14-13(11-20-15(14)17-4-1)12-21-7-9-22(10-8-21)16-18-5-2-6-19-16/h1-6,11H,7-10,12H2,(H,17,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.17E+3n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50277042
PNG
(3-(4-Chlorophenyl)-1-(1H-pyrrolo[2,3-b]pyridin-3-y...)
Show SMILES OC1(CCN(Cc2c[nH]c3ncccc23)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H18ClN3O/c19-15-5-3-14(4-6-15)18(23)7-9-22(12-18)11-13-10-21-17-16(13)2-1-8-20-17/h1-6,8,10,23H,7,9,11-12H2,(H,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.21E+3n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50277036
PNG
(2-[3-(4-Chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1...)
Show SMILES OC1(CC2CCC(C1)N2CC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClFNO2/c22-16-5-3-15(4-6-16)21(26)11-18-9-10-19(12-21)24(18)13-20(25)14-1-7-17(23)8-2-14/h1-8,18-19,26H,9-13H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.23E+3n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50276975
PNG
(3-{(4-(Pyrimidin-2-yl)piperazin-1-yl)methyl}-1H-py...)
Show SMILES C(N1CCN(CC1)c1ncccn1)c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H18N6/c1-3-14-13(11-20-15(14)17-4-1)12-21-7-9-22(10-8-21)16-18-5-2-6-19-16/h1-6,11H,7-10,12H2,(H,17,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.50E+3n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50050467
PNG
(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)
Show SMILES OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.52E+3n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50262930
PNG
(4-(3-(4-chlorophenyl)-3,9-diazabicyclo[4.2.1]nonan...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1C2CCC1CN(CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H26ClFN2O/c24-18-5-9-20(10-6-18)26-15-13-21-11-12-22(16-26)27(21)14-1-2-23(28)17-3-7-19(25)8-4-17/h3-10,21-22H,1-2,11-16H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.33E+3n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]8OH-DPAT from human 5HT1A receptor receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50277003
PNG
(3-(4-Chlorophenyl)-1-(1H-indol-3-ylmethyl)pyrrolid...)
Show SMILES OC1(CCN(Cc2c[nH]c3ccccc23)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H19ClN2O/c20-16-7-5-15(6-8-16)19(23)9-10-22(13-19)12-14-11-21-18-4-2-1-3-17(14)18/h1-8,11,21,23H,9-10,12-13H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.87E+3n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50253549
PNG
(3-(4-Chlorophenyl)-8-(1H-indol-3-ylmethyl)-8-azabi...)
Show SMILES OC1(CC2CCC(C1)N2Cc1c[nH]c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H23ClN2O/c23-17-7-5-16(6-8-17)22(26)11-18-9-10-19(12-22)25(18)14-15-13-24-21-4-2-1-3-20(15)21/h1-8,13,18-19,24,26H,9-12,14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.01E+3n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50277004
PNG
(3-(4-Chlorophenyl)-1-[2-(1H-indol-3-yl)ethyl]pyrro...)
Show SMILES OC1(CCN(CCc2c[nH]c3ccccc23)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)10-12-23(14-20)11-9-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.07E+3n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50262930
PNG
(4-(3-(4-chlorophenyl)-3,9-diazabicyclo[4.2.1]nonan...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1C2CCC1CN(CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H26ClFN2O/c24-18-5-9-20(10-6-18)26-15-13-21-11-12-22(16-26)27(21)14-1-2-23(28)17-3-7-19(25)8-4-17/h3-10,21-22H,1-2,11-16H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.51E+3n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human 5HT2C receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50277038
PNG
(3-(4-Chlorophenyl)-8-(1H-pyrrolo[2,3-b]pyridin-3-y...)
Show SMILES OC1(CC2CCC(C1)N2Cc1c[nH]c2ncccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClN3O/c22-16-5-3-15(4-6-16)21(26)10-17-7-8-18(11-21)25(17)13-14-12-24-20-19(14)2-1-9-23-20/h1-6,9,12,17-18,26H,7-8,10-11,13H2,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
7.87E+3n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50277039
PNG
(9-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-3-(4-chl...)
Show SMILES Clc1ccc(cc1)N1CCC2CCC(C1)N2Cc1c[nH]c2ncccc12
Show InChI InChI=1S/C21H23ClN4/c22-16-3-5-17(6-4-16)25-11-9-18-7-8-19(14-25)26(18)13-15-12-24-21-20(15)2-1-10-23-21/h1-6,10,12,18-19H,7-9,11,13-14H2,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50277036
PNG
(2-[3-(4-Chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1...)
Show SMILES OC1(CC2CCC(C1)N2CC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClFNO2/c22-16-5-3-15(4-6-16)21(26)11-18-9-10-19(12-21)24(18)13-20(25)14-1-7-17(23)8-2-14/h1-8,18-19,26H,9-13H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Florida A&M University

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting


Bioorg Med Chem 17: 1716-23 (2009)


Article DOI: 10.1016/j.bmc.2008.12.054
BindingDB Entry DOI: 10.7270/Q2NG4QGT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%