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Found 29 Enz. Inhib. hit(s) with all data for entry = 50028702
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249854(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(N-piperid...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human MDR1 expressed in HEK cells assessed as [3H]vinblastine transport after 2.5 mins by scintillation countMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Mus musculus (Mouse))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249649(CHEMBL490121 | Dimethyl-(8-phenyl-2,3,5,6-tetrahyd...)
Affinity DataIC50:  280nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249854(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(N-piperid...)
Affinity DataIC50:  670nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50423653(CHEMBL2087786)
Affinity DataIC50:  930nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249854(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(N-piperid...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249649(CHEMBL490121 | Dimethyl-(8-phenyl-2,3,5,6-tetrahyd...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Mus musculus (Mouse))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249906(3,6-Bis(N,N-dimethylamino)-9-(2-thienyl-5-carboxam...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249648(CHEMBL523281 | Dimethyl-(8-phenyl-2,3,5,6-tetrahyd...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249649(CHEMBL490121 | Dimethyl-(8-phenyl-2,3,5,6-tetrahyd...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249853(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249855(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(N-piperid...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249730(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(4-N,N-dim...)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249818(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249852(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249852(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50246356(CHEMBL454113 | N-(6-(dimethylamino)-9-phenyl-3H-se...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50246355(CHEMBL510624 | N-(6-(dimethylamino)-9-phenyl-3H-th...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249853(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249858(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(N-morphol...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249856(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(N-piperid...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50338982((R)-5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Mus musculus (Mouse))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249648(CHEMBL523281 | Dimethyl-(8-phenyl-2,3,5,6-tetrahyd...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249818(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249857(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(N-morphol...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Mus musculus (Mouse))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249698(CHEMBL490549 | N-(6-(dimethylamino)-9-(4-(dimethyl...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Mus musculus (Mouse))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249768(CHEMBL493641 | N-(6-(dimethylamino)-9-(4-morpholin...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249749(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(3-N,N-dim...)
Affinity DataIC50:  2.36E+4nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Mus musculus (Mouse))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249818(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Mus musculus (Mouse))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50249817(CHEMBL491928 | N-(9-(5-carboxythiophen-2-yl)-6-(di...)
Affinity DataIC50: >1.20E+5nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed