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PubMed code 19552436

Compile data set for download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293912
PNG
((R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4...)
Show SMILES COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O
Show InChI InChI=1S/C19H24ClN3O3/c1-11-8-16(26-4)12(2)7-14(11)21-18-19(24)23(9-17(20)22-18)15(10-25-3)13-5-6-13/h7-9,13,15H,5-6,10H2,1-4H3,(H,21,22)/t15-/m0/s1
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n/an/a 0.260n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293941
PNG
((R)-5-Chloro-1-(1-cyclopropylethyl)-3-(4-methoxy-2...)
Show SMILES COc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C
Show InChI InChI=1S/C18H22ClN3O2/c1-10-8-15(24-4)11(2)7-14(10)20-17-18(23)22(9-16(19)21-17)12(3)13-5-6-13/h7-9,12-13H,5-6H2,1-4H3,(H,20,21)/t12-/m1/s1
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n/an/a 0.420n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293916
PNG
((R)-5-Chloro-1-(1-cyclopropylpropyl)-3-(2,6-dichlo...)
Show SMILES CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC)cc2Cl)c1=O
Show InChI InChI=1S/C17H18Cl3N3O2/c1-3-13(9-4-5-9)23-8-14(20)21-16(17(23)24)22-15-11(18)6-10(25-2)7-12(15)19/h6-9,13H,3-5H2,1-2H3,(H,21,22)/t13-/m1/s1
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n/an/a 0.440n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293935
PNG
((R)-5-Chloro-1-(1-cyclopropylethyl)-3-[2,6-dichlor...)
Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O
Show InChI InChI=1S/C16H14Cl3F2N3O2/c1-7(8-2-3-8)24-6-12(19)22-14(15(24)25)23-13-10(17)4-9(5-11(13)18)26-16(20)21/h4-8,16H,2-3H2,1H3,(H,22,23)/t7-/m1/s1
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n/an/a 0.460n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293914
PNG
((R)-5-chloro-1-(1-cyclopropylpropyl)-3-(2,4-dichlo...)
Show SMILES CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(Cl)cc2Cl)c1=O
Show InChI InChI=1S/C17H18Cl3N3O/c1-3-13(10-4-5-10)23-8-14(20)21-16(17(23)24)22-15-9(2)6-11(18)7-12(15)19/h6-8,10,13H,3-5H2,1-2H3,(H,21,22)/t13-/m1/s1
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n/an/a 0.530n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing hormone receptor 2


(Sus scrofa)
BDBM50158983
PNG
(CHEMBL439883 | E G P P I S I D L S L E L L R K M I...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C202H345N55O64S/c1-29-103(20)156(250-178(298)125(62-71-153(276)277)236-195(315)157(104(21)30-2)251-179(299)126(72-81-322-28)234-169(289)114(49-37-41-76-206)222-170(290)115(50-42-77-216-201(212)213)226-180(300)127(82-96(6)7)240-183(303)130(85-99(12)13)239-177(297)123(60-69-151(272)273)233-181(301)128(83-97(8)9)244-191(311)138(94-258)248-186(306)133(88-102(18)19)243-189(309)136(91-154(278)279)247-196(316)158(105(22)31-3)252-192(312)139(95-259)249-197(317)159(106(23)32-4)253-193(313)140-52-44-80-257(140)199(319)141-53-45-79-256(141)148(267)93-218-164(284)117-57-66-147(266)221-117)194(314)235-124(61-70-152(274)275)176(296)225-112(47-35-39-74-204)167(287)230-120(56-65-144(209)263)173(293)232-122(59-68-150(270)271)175(295)224-113(48-36-40-75-205)168(288)231-121(58-67-149(268)269)174(294)223-111(46-34-38-73-203)166(286)229-119(55-64-143(208)262)172(292)228-118(54-63-142(207)261)165(285)220-108(25)162(282)219-109(26)163(283)237-134(89-145(210)264)188(308)245-135(90-146(211)265)187(307)227-116(51-43-78-217-202(214)215)171(291)238-129(84-98(10)11)182(302)241-131(86-100(14)15)184(304)242-132(87-101(16)17)185(305)246-137(92-155(280)281)190(310)255-161(110(27)260)198(318)254-160(200(320)321)107(24)33-5/h96-141,156-161,258-260H,29-95,203-206H2,1-28H3,(H2,207,261)(H2,208,262)(H2,209,263)(H2,210,264)(H2,211,265)(H,218,284)(H,219,282)(H,220,285)(H,221,266)(H,222,290)(H,223,294)(H,224,295)(H,225,296)(H,226,300)(H,227,307)(H,228,292)(H,229,286)(H,230,287)(H,231,288)(H,232,293)(H,233,301)(H,234,289)(H,235,314)(H,236,315)(H,237,283)(H,238,291)(H,239,297)(H,240,303)(H,241,302)(H,242,304)(H,243,309)(H,244,311)(H,245,308)(H,246,305)(H,247,316)(H,248,306)(H,249,317)(H,250,298)(H,251,299)(H,252,312)(H,253,313)(H,254,318)(H,255,310)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,212,213,216)(H4,214,215,217)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-/m0/s1
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n/an/a 0.580n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]sauvagine from CRF2 receptor in pig choroid plexus by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293913
PNG
((R)-5-Chloro-1-(1-cyclopropylpropyl)-3-(2,4,6-trim...)
Show SMILES CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O
Show InChI InChI=1S/C19H24ClN3O/c1-5-15(14-6-7-14)23-10-16(20)21-18(19(23)24)22-17-12(3)8-11(2)9-13(17)4/h8-10,14-15H,5-7H2,1-4H3,(H,21,22)/t15-/m1/s1
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n/an/a 0.630n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293930
PNG
((R)-5-Chloro-1-(1-cyclopropylethyl)-3-(2,4,6-trich...)
Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1=O
Show InChI InChI=1S/C15H13Cl4N3O/c1-7(8-2-3-8)22-6-12(19)20-14(15(22)23)21-13-10(17)4-9(16)5-11(13)18/h4-8H,2-3H2,1H3,(H,20,21)/t7-/m1/s1
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n/an/a 0.910n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293929
PNG
((R)-5-Chloro-3-(2-chloro-4,6-dimethylphenylamino)-...)
Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(C)cc2Cl)c1=O
Show InChI InChI=1S/C17H19Cl2N3O/c1-9-6-10(2)15(13(18)7-9)21-16-17(23)22(8-14(19)20-16)11(3)12-4-5-12/h6-8,11-12H,4-5H2,1-3H3,(H,20,21)/t11-/m1/s1
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n/an/a 0.980n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293910
PNG
((S)-5-chloro-1-(1-cyclopropylethyl)-3-(2,6-dichlor...)
Show SMILES C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O
Show InChI InChI=1S/C16H14Cl3F2N3O2/c1-7(8-2-3-8)24-6-12(19)22-14(15(24)25)23-13-10(17)4-9(5-11(13)18)26-16(20)21/h4-8,16H,2-3H2,1H3,(H,22,23)/t7-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293927
PNG
((R)-5-Chloro-1-(1-cyclopropylethyl)-3-(2,6-dichlor...)
Show SMILES COc1cc(Cl)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(Cl)c1
Show InChI InChI=1S/C16H16Cl3N3O2/c1-8(9-3-4-9)22-7-13(19)20-15(16(22)23)21-14-11(17)5-10(24-2)6-12(14)18/h5-9H,3-4H2,1-2H3,(H,20,21)/t8-/m1/s1
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n/an/a 1.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293942
PNG
((R)-5-Chloro-1-(1-cyclopropylethyl)-3-(4-ethoxy-2,...)
Show SMILES CCOc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C
Show InChI InChI=1S/C19H24ClN3O2/c1-5-25-16-9-11(2)15(8-12(16)3)21-18-19(24)23(10-17(20)22-18)13(4)14-6-7-14/h8-10,13-14H,5-7H2,1-4H3,(H,21,22)/t13-/m1/s1
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Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50084875
PNG
(8-(2,4-dichlorophenyl)-N-(1,3-dimethoxypropan-2-yl...)
Show SMILES COCC(COC)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H21Cl2N5O2/c1-10-16(14-6-5-12(19)7-15(14)20)17-21-11(2)22-18(25(17)24-10)23-13(8-26-3)9-27-4/h5-7,13H,8-9H2,1-4H3,(H,21,22,23)
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Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293937
PNG
((R)-5-Chloro-1-(1-cyclopropylethyl)-3-(2,4-dichlor...)
Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(Cl)cc2Cl)c1=O
Show InChI InChI=1S/C16H16Cl3N3O/c1-8-5-11(17)6-12(18)14(8)21-15-16(23)22(7-13(19)20-15)9(2)10-3-4-10/h5-7,9-10H,3-4H2,1-2H3,(H,20,21)/t9-/m1/s1
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Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293915
PNG
((R)-3,5-Dichloro-4-[6-chloro-4-(1-cyclopropylpropy...)
Show SMILES CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)C#N)c1=O
Show InChI InChI=1S/C17H15Cl3N4O/c1-2-13(10-3-4-10)24-8-14(20)22-16(17(24)25)23-15-11(18)5-9(7-21)6-12(15)19/h5-6,8,10,13H,2-4H2,1H3,(H,22,23)/t13-/m1/s1
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Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293922
PNG
((R)-5-Chloro-1-(1-cyclopropylpropyl)-3-(2,6-dichlo...)
Show SMILES CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C17H15Cl3F3N3O/c1-2-12(8-3-4-8)26-7-13(20)24-15(16(26)27)25-14-10(18)5-9(6-11(14)19)17(21,22)23/h5-8,12H,2-4H2,1H3,(H,24,25)/t12-/m1/s1
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n/an/a 1.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293925
PNG
((R)-5-Chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-[2...)
Show SMILES COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C17H15Cl3F3N3O2/c1-28-7-12(8-2-3-8)26-6-13(20)24-15(16(26)27)25-14-10(18)4-9(5-11(14)19)17(21,22)23/h4-6,8,12H,2-3,7H2,1H3,(H,24,25)/t12-/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293920
PNG
((R)-3,5-Dichloro-4-{6-chloro-4-[1-(methoxymethyl)p...)
Show SMILES CC[C@H](COC)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)C#N)c1=O
Show InChI InChI=1S/C16H15Cl3N4O2/c1-3-10(8-25-2)23-7-13(19)21-15(16(23)24)22-14-11(17)4-9(6-20)5-12(14)18/h4-5,7,10H,3,8H2,1-2H3,(H,21,22)/t10-/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293928
PNG
((R)-5-Chloro-1-(1-cyclopropylethyl)-3-(2,4,6-trime...)
Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O
Show InChI InChI=1S/C18H22ClN3O/c1-10-7-11(2)16(12(3)8-10)21-17-18(23)22(9-15(19)20-17)13(4)14-5-6-14/h7-9,13-14H,5-6H2,1-4H3,(H,20,21)/t13-/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293917
PNG
((R)-5-Chloro-1-(1-cyclopropylpropyl)-3-(2,6-dichlo...)
Show SMILES CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)(F)F)cc2Cl)c1=O
Show InChI InChI=1S/C17H15Cl3F3N3O2/c1-2-12(8-3-4-8)26-7-13(20)24-15(16(26)27)25-14-10(18)5-9(6-11(14)19)28-17(21,22)23/h5-8,12H,2-4H2,1H3,(H,24,25)/t12-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293918
PNG
((R)-5-Chloro-3-[2,6-dichloro-4-(trifluoromethyl)ph...)
Show SMILES CC[C@H](COC)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C16H15Cl3F3N3O2/c1-3-9(7-27-2)25-6-12(19)23-14(15(25)26)24-13-10(17)4-8(5-11(13)18)16(20,21)22/h4-6,9H,3,7H2,1-2H3,(H,23,24)/t9-/m1/s1
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n/an/a 2.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293931
PNG
((R)-3,5-dichloro-4-(6-chloro-4-(1-cyclopropylethyl...)
Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)C#N)c1=O
Show InChI InChI=1S/C16H13Cl3N4O/c1-8(10-2-3-10)23-7-13(19)21-15(16(23)24)22-14-11(17)4-9(6-20)5-12(14)18/h4-5,7-8,10H,2-3H2,1H3,(H,21,22)/t8-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293932
PNG
((R)-3-Chloro-4-[6-chloro-4-(1-cyclopropylethyl)-3-...)
Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(cc2Cl)C#N)c1=O
Show InChI InChI=1S/C17H16Cl2N4O/c1-9-5-11(7-20)6-13(18)15(9)22-16-17(24)23(8-14(19)21-16)10(2)12-3-4-12/h5-6,8,10,12H,3-4H2,1-2H3,(H,21,22)/t10-/m1/s1
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n/an/a 2.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293947
PNG
((R)-3-(4-Chloro-2,6-dimethylphenylamino)-1-(1-cycl...)
Show SMILES C[C@H](C1CC1)n1cc(C)nc(Nc2c(C)cc(Cl)cc2C)c1=O
Show InChI InChI=1S/C18H22ClN3O/c1-10-7-15(19)8-11(2)16(10)21-17-18(23)22(9-12(3)20-17)13(4)14-5-6-14/h7-9,13-14H,5-6H2,1-4H3,(H,20,21)/t13-/m1/s1
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n/an/a 3.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293923
PNG
(5-Chloro-3-[2,6-dichloro-4-(trifluoromethyl)phenyl...)
Show SMILES CCCC(CCC)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C18H19Cl3F3N3O/c1-3-5-11(6-4-2)27-9-14(21)25-16(17(27)28)26-15-12(19)7-10(8-13(15)20)18(22,23)24/h7-9,11H,3-6H2,1-2H3,(H,25,26)
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n/an/a 3.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293924
PNG
((R)-5-Chloro-1-(1-cyclopropylethyl)-3-[2,6-dichlor...)
Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C16H13Cl3F3N3O/c1-7(8-2-3-8)25-6-12(19)23-14(15(25)26)24-13-10(17)4-9(5-11(13)18)16(20,21)22/h4-8H,2-3H2,1H3,(H,23,24)/t7-/m1/s1
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n/an/a 4.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293949
PNG
((R)-4-(1-Cyclopropylethyl)-6-[2,6-dichloro-4-(difl...)
Show SMILES C[C@H](C1CC1)n1cc(nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O)C#N
Show InChI InChI=1S/C17H14Cl2F2N4O2/c1-8(9-2-3-9)25-7-10(6-22)23-15(16(25)26)24-14-12(18)4-11(5-13(14)19)27-17(20)21/h4-5,7-9,17H,2-3H2,1H3,(H,23,24)/t8-/m1/s1
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n/an/a 4.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293940
PNG
((R)-5-Chloro-1-(1-cyclopropylethyl)-3-(2,4,5-trime...)
Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(C)cc2C)c1=O
Show InChI InChI=1S/C18H22ClN3O/c1-10-7-12(3)15(8-11(10)2)20-17-18(23)22(9-16(19)21-17)13(4)14-5-6-14/h7-9,13-14H,5-6H2,1-4H3,(H,20,21)/t13-/m1/s1
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n/an/a 4.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50293910
PNG
((S)-5-chloro-1-(1-cyclopropylethyl)-3-(2,6-dichlor...)
Show SMILES C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O
Show InChI InChI=1S/C16H14Cl3F2N3O2/c1-7(8-2-3-8)24-6-12(19)22-14(15(24)25)23-13-10(17)4-9(5-11(13)18)26-16(20)21/h4-8,16H,2-3H2,1H3,(H,22,23)/t7-/m0/s1
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n/an/a 4.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CRF1 receptor in human Y-79 cells assessed as inhibition of CRF-induced cAMP production after 30 mins by HTRF analysis


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293933
PNG
((R)-5-Chloro-1-(1-cyclopropylethyl)-3-[2,6-dichlor...)
Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)(F)F)cc2Cl)c1=O
Show InChI InChI=1S/C16H13Cl3F3N3O2/c1-7(8-2-3-8)25-6-12(19)23-14(15(25)26)24-13-10(17)4-9(5-11(13)18)27-16(20,21)22/h4-8H,2-3H2,1H3,(H,23,24)/t7-/m1/s1
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n/an/a 6.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293948
PNG
((R)-4-(1-Cyclopropylethyl)-6-(2,6-dichloro-4-(trif...)
Show SMILES C[C@H](C1CC1)n1cc(nc(Nc2c(Cl)cc(cc2Cl)C(F)(F)F)c1=O)C#N
Show InChI InChI=1S/C17H13Cl2F3N4O/c1-8(9-2-3-9)26-7-11(6-23)24-15(16(26)27)25-14-12(18)4-10(5-13(14)19)17(20,21)22/h4-5,7-9H,2-3H2,1H3,(H,24,25)/t8-/m1/s1
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n/an/a 7.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293934
PNG
((S)-5-Chloro-1-(1-cyclopropylethyl)-3-[2,6-dichlor...)
Show SMILES C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C16H13Cl3F3N3O/c1-7(8-2-3-8)25-6-12(19)23-14(15(25)26)24-13-10(17)4-9(5-11(13)18)16(20,21)22/h4-8H,2-3H2,1H3,(H,23,24)/t7-/m0/s1
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n/an/a 7.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293944
PNG
((R)-5-Chloro-3-(2-chloro-5-fluoro-4-methoxyphenyla...)
Show SMILES COc1cc(Cl)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1F
Show InChI InChI=1S/C16H16Cl2FN3O2/c1-8(9-3-4-9)22-7-14(18)21-15(16(22)23)20-12-6-11(19)13(24-2)5-10(12)17/h5-9H,3-4H2,1-2H3,(H,20,21)/t8-/m1/s1
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n/an/a 8.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293926
PNG
(5-Chloro-3-[2,6-dichloro-4-(trifluoromethyl)phenyl...)
Show SMILES COCC(COC)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C16H15Cl3F3N3O3/c1-27-6-9(7-28-2)25-5-12(19)23-14(15(25)26)24-13-10(17)3-8(4-11(13)18)16(20,21)22/h3-5,9H,6-7H2,1-2H3,(H,23,24)
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n/an/a 8.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293919
PNG
((R)-5-Chloro-3-[2,6-dichloro-4-(trifluoromethyl)ph...)
Show SMILES COC[C@@H](C)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C15H13Cl3F3N3O2/c1-7(6-26-2)24-5-11(18)22-13(14(24)25)23-12-9(16)3-8(4-10(12)17)15(19,20)21/h3-5,7H,6H2,1-2H3,(H,22,23)/t7-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293943
PNG
((R)-5-Chloro-1-(1-cyclopropylethyl)-3-(4,5-dimetho...)
Show SMILES COc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1OC
Show InChI InChI=1S/C18H22ClN3O3/c1-10-7-14(24-3)15(25-4)8-13(10)20-17-18(23)22(9-16(19)21-17)11(2)12-5-6-12/h7-9,11-12H,5-6H2,1-4H3,(H,20,21)/t11-/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293921
PNG
((R)-3,5-Dichloro-4-[6-chloro-4-(2-methoxy-1-methyl...)
Show SMILES COC[C@@H](C)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)C#N)c1=O
Show InChI InChI=1S/C15H13Cl3N4O2/c1-8(7-24-2)22-6-12(18)20-14(15(22)23)21-13-10(16)3-9(5-19)4-11(13)17/h3-4,6,8H,7H2,1-2H3,(H,20,21)/t8-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293938
PNG
((R)-3,5-Dichloro-2-[6-chloro-4-(1-cyclopropylethyl...)
Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(Cl)cc2C#N)c1=O
Show InChI InChI=1S/C16H13Cl3N4O/c1-8(9-2-3-9)23-7-13(19)21-15(16(23)24)22-14-10(6-20)4-11(17)5-12(14)18/h4-5,7-9H,2-3H2,1H3,(H,21,22)/t8-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293945
PNG
((R)-4-Chloro-5-[6-chloro-4-(1-cyclopropylethyl)-3-...)
Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C#N)c(C)cc2Cl)c1=O
Show InChI InChI=1S/C17H16Cl2N4O/c1-9-5-13(18)14(6-12(9)7-20)21-16-17(24)23(8-15(19)22-16)10(2)11-3-4-11/h5-6,8,10-11H,3-4H2,1-2H3,(H,21,22)/t10-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293939
PNG
((R)-5-Chloro-3-(4-chloro-2-methoxy-5-methylphenyla...)
Show SMILES COc1cc(Cl)c(C)cc1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O
Show InChI InChI=1S/C17H19Cl2N3O2/c1-9-6-13(14(24-3)7-12(9)18)20-16-17(23)22(8-15(19)21-16)10(2)11-4-5-11/h6-8,10-11H,4-5H2,1-3H3,(H,20,21)/t10-/m1/s1
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n/an/a 36n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293936
PNG
((R)-5-Chloro-1-(1-cyclopropylethyl)-3-(2,6-dichlor...)
Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(cc2Cl)S(C)(=O)=O)c1=O
Show InChI InChI=1S/C16H16Cl3N3O3S/c1-8(9-3-4-9)22-7-13(19)20-15(16(22)23)21-14-11(17)5-10(6-12(14)18)26(2,24)25/h5-9H,3-4H2,1-2H3,(H,20,21)/t8-/m1/s1
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n/an/a 63n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50293946
PNG
((R)-5-Chloro-3-(6-chloro-2,3-dihydrobenzofuran-5-y...)
Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2cc3COCc3cc2Cl)c1=O
Show InChI InChI=1S/C17H17Cl2N3O2/c1-9(10-2-3-10)22-6-15(19)21-16(17(22)23)20-14-5-12-8-24-7-11(12)4-13(14)18/h4-6,9-10H,2-3,7-8H2,1H3,(H,20,21)/t9-/m1/s1
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n/an/a 120n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing hormone receptor 2


(Sus scrofa)
BDBM50293910
PNG
((S)-5-chloro-1-(1-cyclopropylethyl)-3-(2,6-dichlor...)
Show SMILES C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O
Show InChI InChI=1S/C16H14Cl3F2N3O2/c1-7(8-2-3-8)24-6-12(19)22-14(15(24)25)23-13-10(17)4-9(5-11(13)18)26-16(20)21/h4-8,16H,2-3H2,1H3,(H,22,23)/t7-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]sauvagine from CRF2 receptor in pig choroid plexus by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%