Affinity Data by PubMed id=1956041

PubMed code 1956041

Found 28 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Aldose reductase (Rattus norvegicus)	BDBM16314 (2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Aldose reductase (Rattus norvegicus)	BDBM50010282 (2,7-difluorospiro[9H-fluorene-9,3'-(tetrahydro-1'H...) Show SMILES Fc1ccc2-c3ccc(F)cc3C3(CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010283 (2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H...) Show SMILES Fc1ccc2-c3ccc(F)cc3C3(NC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010282 (2,7-difluorospiro[9H-fluorene-9,3'-(tetrahydro-1'H...) Show SMILES Fc1ccc2-c3ccc(F)cc3C3(CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010283 (2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H...) Show SMILES Fc1ccc2-c3ccc(F)cc3C3(NC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010281 (2,7-Difluorospiro[9H-fluorene-9,5'-isothiazolidin]...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50009777 ((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010281 (2,7-Difluorospiro[9H-fluorene-9,5'-isothiazolidin]...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM16312 ((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...) Show SMILES Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Aldose reductase (Rattus norvegicus)	BDBM50010286 (2-Chlorospiro[9H-fluorene-9,5'-isothiazolidin]-3'-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010276 (2-Fluorospiro[9H-fluorene-9,5'-isothiazolidin]-3'-...) Show SMILES Fc1ccc2-c3ccccc3C3(CC(=O)NS3(=O)=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	151	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010276 (2-Fluorospiro[9H-fluorene-9,5'-isothiazolidin]-3'-...) Show SMILES Fc1ccc2-c3ccccc3C3(CC(=O)NS3(=O)=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	169	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010286 (2-Chlorospiro[9H-fluorene-9,5'-isothiazolidin]-3'-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	233	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM16314 (2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	950	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Aldose reductase (Rattus norvegicus)	BDBM16312 ((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...) Show SMILES Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Aldose reductase (Rattus norvegicus)	BDBM7460 (2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase from rat kidney				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010278 (CHEMBL325136 \| Spiro[9H-fluorene-9,5'-isothiazolid...) Show SMILES O=C1CC2(c3ccccc3-c3ccccc23)S(=O)(=O)N1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010278 (CHEMBL325136 \| Spiro[9H-fluorene-9,5'-isothiazolid...) Show SMILES O=C1CC2(c3ccccc3-c3ccccc23)S(=O)(=O)N1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010280 (2-Fluorospiro[9H-fluorene-9,4'-isothiazolidin]-3'-...) Show SMILES Fc1ccc2-c3ccccc3C3(CS(=O)(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50009777 ((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010285 (2-Chlorospiro[9H-fluorene-9,4'-isothiazolidin]-3'-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010284 (2,7-DiFluorospiro[9H-fluorene-9,4'-isothiazolidin]...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010277 (CHEMBL110661 \| Spiro[9H-fluorene-9,4'-isothiazolid...) Show SMILES O=C1NS(=O)(=O)CC11c2ccccc2-c2ccccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM7460 (2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against Aldose reductase from rat lens				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010285 (2-Chlorospiro[9H-fluorene-9,4'-isothiazolidin]-3'-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.37E+6	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010284 (2,7-DiFluorospiro[9H-fluorene-9,4'-isothiazolidin]...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.15E+6	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010277 (CHEMBL110661 \| Spiro[9H-fluorene-9,4'-isothiazolid...) Show SMILES O=C1NS(=O)(=O)CC11c2ccccc2-c2ccccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+7	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50010280 (2-Fluorospiro[9H-fluorene-9,4'-isothiazolidin]-3'-...) Show SMILES Fc1ccc2-c3ccccc3C3(CS(=O)(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+7	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Laboratories, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL)				Citation and Details
Alcon Laboratories, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%