Found 38 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368060
(CHEMBL1907695)Show SMILES CCCc1cc(OC)c(OC)c(C(=O)NC[C@@H]2CCCN2CC)c1O Show InChI InChI=1S/C19H30N2O4/c1-5-8-13-11-15(24-3)18(25-4)16(17(13)22)19(23)20-12-14-9-7-10-21(14)6-2/h11,14,22H,5-10,12H2,1-4H3,(H,20,23)/t14-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.0230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368067
(CHEMBL1907702)Show InChI InChI=1S/C18H28N2O4/c1-5-12-10-14(23-3)17(24-4)15(16(12)21)18(22)19-11-13-8-7-9-20(13)6-2/h10,13,21H,5-9,11H2,1-4H3,(H,19,22)/t13-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.0330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50007517
((S)-3-bromo-N-((1-ethylpyrrolidin-2-yl)methyl)-2-h...)Show InChI InChI=1S/C16H23BrN2O4/c1-4-19-7-5-6-10(19)9-18-16(21)13-14(20)11(17)8-12(22-2)15(13)23-3/h8,10,20H,4-7,9H2,1-3H3,(H,18,21)/t10-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.0640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368065
(CHEMBL1907692)Show InChI InChI=1S/C16H23ClN2O4/c1-4-19-7-5-6-10(19)9-18-16(21)13-14(20)11(17)8-12(22-2)15(13)23-3/h8,10,20H,4-7,9H2,1-3H3,(H,18,21)/t10-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.0870 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50007518
((S)-3-chloro-5-ethyl-N-((1-ethylpyrrolidin-2-yl)me...)Show InChI InChI=1S/C17H25ClN2O3/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2/h9,12,21H,4-8,10H2,1-3H3,(H,19,22)/t12-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
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AffyNet
| Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM21398
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50007534
(3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...)Show InChI InChI=1S/C15H21BrN2O3/c1-3-18-8-4-5-10(18)9-17-15(20)13-12(21-2)7-6-11(16)14(13)19/h6-7,10,19H,3-5,8-9H2,1-2H3,(H,17,20)/t10-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50010724
(CHEMBL305916 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-6...)Show InChI InChI=1S/C16H24N2O4/c1-4-18-9-5-6-11(18)10-17-16(20)14-12(19)7-8-13(21-2)15(14)22-3/h7-8,11,19H,4-6,9-10H2,1-3H3,(H,17,20)/t11-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
(Rattus norvegicus (rat)) | BDBM50005118
((S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)...)Show InChI InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368062
(CHEMBL1907915)Show InChI InChI=1S/C16H23BrN2O4/c1-4-19-7-5-6-10(19)9-18-16(21)13-14(20)11(17)8-12(22-2)15(13)23-3/h8,10,20H,4-7,9H2,1-3H3,(H,18,21)/t10-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
(Rattus norvegicus (rat)) | BDBM81774
(CAS_15676-16-1 | SULPIRIDE,(+) | Sulpiride-S | Sul...)Show InChI InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/t11-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368073
(CHEMBL1907690)Show InChI InChI=1S/C16H23BrN2O4/c1-4-19-7-5-6-10(19)9-18-16(21)13-14(20)12(22-2)8-11(17)15(13)23-3/h8,10,20H,4-7,9H2,1-3H3,(H,18,21)/t10-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
(Rattus norvegicus (rat)) | BDBM50368067
(CHEMBL1907702)Show InChI InChI=1S/C18H28N2O4/c1-5-12-10-14(23-3)17(24-4)15(16(12)21)18(22)19-11-13-8-7-9-20(13)6-2/h10,13,21H,5-9,11H2,1-4H3,(H,19,22)/t13-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.770 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
(Rattus norvegicus (rat)) | BDBM50007518
((S)-3-chloro-5-ethyl-N-((1-ethylpyrrolidin-2-yl)me...)Show InChI InChI=1S/C17H25ClN2O3/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2/h9,12,21H,4-8,10H2,1-3H3,(H,19,22)/t12-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
(Rattus norvegicus (rat)) | BDBM50007517
((S)-3-bromo-N-((1-ethylpyrrolidin-2-yl)methyl)-2-h...)Show InChI InChI=1S/C16H23BrN2O4/c1-4-19-7-5-6-10(19)9-18-16(21)13-14(20)11(17)8-12(22-2)15(13)23-3/h8,10,20H,4-7,9H2,1-3H3,(H,18,21)/t10-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
(Rattus norvegicus (rat)) | BDBM50368065
(CHEMBL1907692)Show InChI InChI=1S/C16H23ClN2O4/c1-4-19-7-5-6-10(19)9-18-16(21)13-14(20)11(17)8-12(22-2)15(13)23-3/h8,10,20H,4-7,9H2,1-3H3,(H,18,21)/t10-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50010644
((S)-3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,5-...)Show SMILES Cl.CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)cc(O)c1OC Show InChI InChI=1S/C15H21BrN2O4.ClH/c1-3-18-6-4-5-9(18)8-17-15(21)12-13(20)10(16)7-11(19)14(12)22-2;/h7,9,19-20H,3-6,8H2,1-2H3,(H,17,21);1H/t9-;/m0./s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368063
(CHEMBL1907700)Show SMILES COc1cc(Br)c(O)c(C(=O)NC[C@@H]2CCCN2CC=C)c1OC Show InChI InChI=1S/C17H23BrN2O4/c1-4-7-20-8-5-6-11(20)10-19-17(22)14-15(21)12(18)9-13(23-2)16(14)24-3/h4,9,11,21H,1,5-8,10H2,2-3H3,(H,19,22)/t11-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
(Rattus norvegicus (rat)) | BDBM50368060
(CHEMBL1907695)Show SMILES CCCc1cc(OC)c(OC)c(C(=O)NC[C@@H]2CCCN2CC)c1O Show InChI InChI=1S/C19H30N2O4/c1-5-8-13-11-15(24-3)18(25-4)16(17(13)22)19(23)20-12-14-9-7-10-21(14)6-2/h11,14,22H,5-10,12H2,1-4H3,(H,20,23)/t14-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
(Rattus norvegicus (rat)) | BDBM50010724
(CHEMBL305916 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-6...)Show InChI InChI=1S/C16H24N2O4/c1-4-18-9-5-6-11(18)10-17-16(20)14-12(19)7-8-13(21-2)15(14)22-3/h7-8,11,19H,4-6,9-10H2,1-3H3,(H,17,20)/t11-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
(Rattus norvegicus (rat)) | BDBM50007534
(3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...)Show InChI InChI=1S/C15H21BrN2O3/c1-3-18-8-4-5-10(18)9-17-15(20)13-12(21-2)7-6-11(16)14(13)19/h6-7,10,19H,3-5,8-9H2,1-2H3,(H,17,20)/t10-/m0/s1 | Reactome pathway
KEGG
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Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
(Rattus norvegicus (rat)) | BDBM21398
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 | Reactome pathway
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Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368059
(CHEMBL1907697)Show InChI InChI=1S/C18H28N2O4/c1-5-12-10-14(23-3)16(21)15(17(12)24-4)18(22)19-11-13-8-7-9-20(13)6-2/h10,13,21H,5-9,11H2,1-4H3,(H,19,22)/t13-/m0/s1 | Reactome pathway
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Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368070
(CHEMBL1907693)Show InChI InChI=1S/C16H24BrN3O3/c1-4-20-7-5-6-10(20)9-19-16(21)13-14(18)11(17)8-12(22-2)15(13)23-3/h8,10H,4-7,9,18H2,1-3H3,(H,19,21)/t10-/m0/s1 | Reactome pathway
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50005118
((S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)...)Show InChI InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1 | Reactome pathway
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Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50010640
((S)-3-Amino-5-bromo-N-(1-ethyl-pyrrolidin-2-ylmeth...)Show SMILES Cl.CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)cc(N)c1OC Show InChI InChI=1S/C15H22BrN3O3.ClH/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2;/h7,9,20H,3-6,8,17H2,1-2H3,(H,18,21);1H/t9-;/m0./s1 | Reactome pathway
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| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368061
(CHEMBL1907694)Show SMILES COc1cc(Br)c(OC)c(C(=O)NC[C@@H]2CCCN2CC=C)c1O Show InChI InChI=1S/C17H23BrN2O4/c1-4-7-20-8-5-6-11(20)10-19-17(22)14-15(21)13(23-2)9-12(18)16(14)24-3/h4,9,11,21H,1,5-8,10H2,2-3H3,(H,19,22)/t11-/m0/s1 | Reactome pathway
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Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368071
(CHEMBL1907691)Show InChI InChI=1S/C15H22N2O4/c1-3-17-8-4-5-10(17)9-16-15(20)13-11(18)6-7-12(19)14(13)21-2/h6-7,10,18-19H,3-5,8-9H2,1-2H3,(H,16,20)/t10-/m0/s1 | Reactome pathway
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Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
(Rattus norvegicus (rat)) | BDBM50368073
(CHEMBL1907690)Show InChI InChI=1S/C16H23BrN2O4/c1-4-19-7-5-6-10(19)9-18-16(21)13-14(20)12(22-2)8-11(17)15(13)23-3/h8,10,20H,4-7,9H2,1-3H3,(H,18,21)/t10-/m0/s1 | Reactome pathway
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| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368069
(CHEMBL1907698)Show InChI InChI=1S/C16H23ClN2O4/c1-4-19-7-5-6-10(19)9-18-16(21)13-14(20)12(22-2)8-11(17)15(13)23-3/h8,10,20H,4-7,9H2,1-3H3,(H,18,21)/t10-/m0/s1 | Reactome pathway
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| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
(Rattus norvegicus (rat)) | BDBM50368062
(CHEMBL1907915)Show InChI InChI=1S/C16H23BrN2O4/c1-4-19-7-5-6-10(19)9-18-16(21)13-14(20)11(17)8-12(22-2)15(13)23-3/h8,10,20H,4-7,9H2,1-3H3,(H,18,21)/t10-/m1/s1 | Reactome pathway
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| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368068
(CHEMBL1907696)Show InChI InChI=1S/C16H24N2O4/c1-4-18-9-5-6-11(18)10-17-16(20)14-12(21-2)7-8-13(22-3)15(14)19/h7-8,11,19H,4-6,9-10H2,1-3H3,(H,17,20)/t11-/m0/s1 | Reactome pathway
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| n/a | n/a | 205 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM81774
(CAS_15676-16-1 | SULPIRIDE,(+) | Sulpiride-S | Sul...)Show InChI InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/t11-/m0/s1 | Reactome pathway
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| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368064
(CHEMBL1907701)Show InChI InChI=1S/C17H25ClN2O4/c1-5-20-8-6-7-11(20)10-19-17(21)14-15(23-3)12(18)9-13(22-2)16(14)24-4/h9,11H,5-8,10H2,1-4H3,(H,19,21)/t11-/m0/s1 | Reactome pathway
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| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50010655
((S)-3-Ethyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,5,...)Show InChI InChI=1S/C19H30N2O4/c1-6-13-11-15(23-3)18(25-5)16(17(13)24-4)19(22)20-12-14-9-8-10-21(14)7-2/h11,14H,6-10,12H2,1-5H3,(H,20,22) | Reactome pathway
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| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368066
(CHEMBL1907699)Show InChI InChI=1S/C17H25BrN2O4/c1-5-20-8-6-7-11(20)10-19-17(21)14-15(23-3)12(18)9-13(22-2)16(14)24-4/h9,11H,5-8,10H2,1-4H3,(H,19,21)/t11-/m0/s1 | Reactome pathway
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| n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368058
(CHEMBL1907703)Show SMILES CCCc1cc(OC)c(OC)c(C(=O)NC[C@@H]2CCCN2CC)c1OC Show InChI InChI=1S/C20H32N2O4/c1-6-9-14-12-16(24-3)19(26-5)17(18(14)25-4)20(23)21-13-15-10-8-11-22(15)7-2/h12,15H,6-11,13H2,1-5H3,(H,21,23)/t15-/m0/s1 | Reactome pathway
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| n/a | n/a | 2.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50368072
(CHEMBL1907914)Show InChI InChI=1S/C16H23BrN2O4/c1-4-19-7-5-6-10(19)9-18-16(21)13-14(20)12(22-2)8-11(17)15(13)23-3/h8,10,20H,4-7,9H2,1-3H3,(H,18,21)/t10-/m1/s1 | Reactome pathway
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| n/a | n/a | 6.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Astra Research Centre AB
Curated by ChEMBL
| Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes. |
J Med Chem 33: 1155-63 (1990)
Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR |
More data for this
Ligand-Target Pair | |
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