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PubMed code 1975275

Compile data set for download or QSAR
Found 113 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sigma


(HUMAN)
BDBM50010779
PNG
(CHEMBL310003 | N-Bicyclo[2.2.1]hept-2-yl-N'-(2-iod...)
Show SMILES NC(Nc1ccccc1I)=NC1CC2CCC1C2
Show InChI InChI=1S/C14H18IN3/c15-11-3-1-2-4-12(11)17-14(16)18-13-8-9-5-6-10(13)7-9/h1-4,9-10,13H,5-8H2,(H3,16,17,18)
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PubMed
n/an/a 4n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010759
PNG
(CHEMBL553896 | N-Adamantan-1-yl-N'-(2-iodo-phenyl)...)
Show SMILES NC(NC12CC3CC(CC(C3)C1)C2)=Nc1ccccc1I
Show InChI InChI=1S/C17H22IN3/c18-14-3-1-2-4-15(14)20-16(19)21-17-8-11-5-12(9-17)7-13(6-11)10-17/h1-4,11-13H,5-10H2,(H3,19,20,21)
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n/an/a 5n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010779
PNG
(CHEMBL310003 | N-Bicyclo[2.2.1]hept-2-yl-N'-(2-iod...)
Show SMILES NC(Nc1ccccc1I)=NC1CC2CCC1C2
Show InChI InChI=1S/C14H18IN3/c15-11-3-1-2-4-12(11)17-14(16)18-13-8-9-5-6-10(13)7-9/h1-4,9-10,13H,5-8H2,(H3,16,17,18)
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n/an/a 5n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010782
PNG
(CHEMBL553347 | N-Adamantan-2-yl-N'-(2-iodo-phenyl)...)
Show SMILES NC(Nc1ccccc1I)=NC1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C17H22IN3/c18-14-3-1-2-4-15(14)20-17(19)21-16-12-6-10-5-11(8-12)9-13(16)7-10/h1-4,10-13,16H,5-9H2,(H3,19,20,21)
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n/an/a 5.20n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010795
PNG
(CHEMBL81461 | N-Adamantan-2-yl-N'-o-tolyl-guanidin...)
Show SMILES Cc1ccccc1NC(N)=NC1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C18H25N3/c1-11-4-2-3-5-16(11)20-18(19)21-17-14-7-12-6-13(9-14)10-15(17)8-12/h2-5,12-15,17H,6-10H2,1H3,(H3,19,20,21)
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n/an/a 6n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010759
PNG
(CHEMBL553896 | N-Adamantan-1-yl-N'-(2-iodo-phenyl)...)
Show SMILES NC(NC12CC3CC(CC(C3)C1)C2)=Nc1ccccc1I
Show InChI InChI=1S/C17H22IN3/c18-14-3-1-2-4-15(14)20-16(19)21-17-8-11-5-12(9-17)7-13(6-11)10-17/h1-4,11-13H,5-10H2,(H3,19,20,21)
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n/an/a 6n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010742
PNG
(CHEMBL81773 | N-Bicyclo[2.2.1]hept-2-yl-N'-o-tolyl...)
Show SMILES Cc1ccccc1NC(N)=NC1CC2CCC1C2
Show InChI InChI=1S/C15H21N3/c1-10-4-2-3-5-13(10)17-15(16)18-14-9-11-6-7-12(14)8-11/h2-5,11-12,14H,6-9H2,1H3,(H3,16,17,18)
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n/an/a 6n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010742
PNG
(CHEMBL81773 | N-Bicyclo[2.2.1]hept-2-yl-N'-o-tolyl...)
Show SMILES Cc1ccccc1NC(N)=NC1CC2CCC1C2
Show InChI InChI=1S/C15H21N3/c1-10-4-2-3-5-13(10)17-15(16)18-14-9-11-6-7-12(14)8-11/h2-5,11-12,14H,6-9H2,1H3,(H3,16,17,18)
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PubMed
n/an/a 7.70n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010756
PNG
(CHEMBL81835 | N-Adamantan-1-yl-N'-o-tolyl-guanidin...)
Show SMILES Cc1ccccc1N=C(N)NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C18H25N3/c1-12-4-2-3-5-16(12)20-17(19)21-18-9-13-6-14(10-18)8-15(7-13)11-18/h2-5,13-15H,6-11H2,1H3,(H3,19,20,21)
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n/an/a 8n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010764
PNG
(CHEMBL543597 | N-Adamantan-1-yl-N'-cyclohexyl-guan...)
Show SMILES NC(NC1CCCCC1)=NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C17H29N3/c18-16(19-15-4-2-1-3-5-15)20-17-9-12-6-13(10-17)8-14(7-12)11-17/h12-15H,1-11H2,(H3,18,19,20)
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n/an/a 8n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010756
PNG
(CHEMBL81835 | N-Adamantan-1-yl-N'-o-tolyl-guanidin...)
Show SMILES Cc1ccccc1N=C(N)NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C18H25N3/c1-12-4-2-3-5-16(12)20-17(19)21-18-9-13-6-14(10-18)8-15(7-13)11-18/h2-5,13-15H,6-11H2,1H3,(H3,19,20,21)
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n/an/a 8n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010747
PNG
(CHEMBL543201 | CHEMBL78777 | N,N'-Bis-(3-ethyl-phe...)
Show SMILES CCc1cccc(NC(N)=Nc2cccc(CC)c2)c1
Show InChI InChI=1S/C17H21N3/c1-3-13-7-5-9-15(11-13)19-17(18)20-16-10-6-8-14(4-2)12-16/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
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n/an/a 8.30n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010747
PNG
(CHEMBL543201 | CHEMBL78777 | N,N'-Bis-(3-ethyl-phe...)
Show SMILES CCc1cccc(NC(N)=Nc2cccc(CC)c2)c1
Show InChI InChI=1S/C17H21N3/c1-3-13-7-5-9-15(11-13)19-17(18)20-16-10-6-8-14(4-2)12-16/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
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n/an/a 8.30n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010768
PNG
(CHEMBL553535 | N,N'-Di-adamantan-1-yl-guanidine; h...)
Show SMILES NC(NC12CC3CC(CC(C3)C1)C2)=NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C21H33N3/c22-19(23-20-7-13-1-14(8-20)3-15(2-13)9-20)24-21-10-16-4-17(11-21)6-18(5-16)12-21/h13-18H,1-12H2,(H3,22,23,24)
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n/an/a 11n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010766
PNG
(CHEMBL79164 | N-Cyclohexyl-N'-o-tolyl-guanidine)
Show SMILES Cc1ccccc1N=C(N)NC1CCCCC1
Show InChI InChI=1S/C14H21N3/c1-11-7-5-6-10-13(11)17-14(15)16-12-8-3-2-4-9-12/h5-7,10,12H,2-4,8-9H2,1H3,(H3,15,16,17)
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n/an/a 12n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010764
PNG
(CHEMBL543597 | N-Adamantan-1-yl-N'-cyclohexyl-guan...)
Show SMILES NC(NC1CCCCC1)=NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C17H29N3/c18-16(19-15-4-2-1-3-5-15)20-17-9-12-6-13(10-17)8-14(7-12)11-17/h12-15H,1-11H2,(H3,18,19,20)
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n/an/a 13n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010760
PNG
(CHEMBL310170 | N,N'-Bis-(2-ethyl-phenyl)-guanidine)
Show SMILES CCc1ccccc1NC(N)=Nc1ccccc1CC
Show InChI InChI=1S/C17H21N3/c1-3-13-9-5-7-11-15(13)19-17(18)20-16-12-8-6-10-14(16)4-2/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
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n/an/a 14n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010760
PNG
(CHEMBL310170 | N,N'-Bis-(2-ethyl-phenyl)-guanidine)
Show SMILES CCc1ccccc1NC(N)=Nc1ccccc1CC
Show InChI InChI=1S/C17H21N3/c1-3-13-9-5-7-11-15(13)19-17(18)20-16-12-8-6-10-14(16)4-2/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
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n/an/a 14n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010758
PNG
(CHEMBL312600 | N,N'-Bis-(2-iodo-phenyl)-guanidine)
Show SMILES NC(Nc1ccccc1I)=Nc1ccccc1I
Show InChI InChI=1S/C13H11I2N3/c14-9-5-1-3-7-11(9)17-13(16)18-12-8-4-2-6-10(12)15/h1-8H,(H3,16,17,18)
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n/an/a 14n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010766
PNG
(CHEMBL79164 | N-Cyclohexyl-N'-o-tolyl-guanidine)
Show SMILES Cc1ccccc1N=C(N)NC1CCCCC1
Show InChI InChI=1S/C14H21N3/c1-11-7-5-6-10-13(11)17-14(15)16-12-8-3-2-4-9-12/h5-7,10,12H,2-4,8-9H2,1H3,(H3,15,16,17)
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n/an/a 15n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010748
PNG
(CHEMBL540291 | N-(3,5-Dimethyl-adamantan-1-yl)-N'-...)
Show SMILES Cc1ccccc1N=C(N)NC12CC3CC(C)(CC(C)(C3)C1)C2
Show InChI InChI=1S/C20H29N3/c1-14-6-4-5-7-16(14)22-17(21)23-20-10-15-8-18(2,12-20)11-19(3,9-15)13-20/h4-7,15H,8-13H2,1-3H3,(H3,21,22,23)
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n/an/a 15n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010781
PNG
(CHEMBL545011 | N,N'-Bis-bicyclo[2.2.1]hept-2-yl-gu...)
Show SMILES NC(NC1CC2CCC1C2)=NC1CC2CCC1C2
Show InChI InChI=1S/C15H25N3/c16-15(17-13-7-9-1-3-11(13)5-9)18-14-8-10-2-4-12(14)6-10/h9-14H,1-8H2,(H3,16,17,18)
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n/an/a 16n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010753
PNG
(CHEMBL553074 | N-(3,5-Dimethyl-adamantan-1-yl)-N'-...)
Show SMILES CC12CC3CC(C)(C1)CC(C3)(C2)NC(N)=Nc1ccccc1I
Show InChI InChI=1S/C19H26IN3/c1-17-7-13-8-18(2,10-17)12-19(9-13,11-17)23-16(21)22-15-6-4-3-5-14(15)20/h3-6,13H,7-12H2,1-2H3,(H3,21,22,23)
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n/an/a 16n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010758
PNG
(CHEMBL312600 | N,N'-Bis-(2-iodo-phenyl)-guanidine)
Show SMILES NC(Nc1ccccc1I)=Nc1ccccc1I
Show InChI InChI=1S/C13H11I2N3/c14-9-5-1-3-7-11(9)17-13(16)18-12-8-4-2-6-10(12)15/h1-8H,(H3,16,17,18)
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n/an/a 16n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010768
PNG
(CHEMBL553535 | N,N'-Di-adamantan-1-yl-guanidine; h...)
Show SMILES NC(NC12CC3CC(CC(C3)C1)C2)=NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C21H33N3/c22-19(23-20-7-13-1-14(8-20)3-15(2-13)9-20)24-21-10-16-4-17(11-21)6-18(5-16)12-21/h13-18H,1-12H2,(H3,22,23,24)
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n/an/a 16n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010735
PNG
(CHEMBL553817 | N-(2-Iodo-phenyl)-N'-(1,7,7-trimeth...)
Show SMILES CC1(C)C2CCC1(C)C(C2)N=C(N)Nc1ccccc1I
Show InChI InChI=1S/C17H24IN3/c1-16(2)11-8-9-17(16,3)14(10-11)21-15(19)20-13-7-5-4-6-12(13)18/h4-7,11,14H,8-10H2,1-3H3,(H3,19,20,21)
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n/an/a 18n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010765
PNG
(CHEMBL78488 | N-Adamantan-1-yl-N'-(2-nitro-phenyl)...)
Show SMILES N\C([N-]C12CC3CC(CC(C3)C1)C2)=[NH+]/c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C17H21N4O2/c18-16(19-14-3-1-2-4-15(14)21(22)23)20-17-8-11-5-12(9-17)7-13(6-11)10-17/h1-4,11-13H,5-10H2,(H2-,18,19,20)/q-1/p+1
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n/an/a 20n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010762
PNG
(CHEMBL556021 | N-tert-Butyl-N'-(2-iodo-phenyl)-gua...)
Show SMILES CC(C)(C)NC(N)=Nc1ccccc1I
Show InChI InChI=1S/C11H16IN3/c1-11(2,3)15-10(13)14-9-7-5-4-6-8(9)12/h4-7H,1-3H3,(H3,13,14,15)
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n/an/a 21n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010746
PNG
(CHEMBL79186 | N-(2-Iodo-phenyl)-N'-o-tolyl-guanidi...)
Show SMILES Cc1ccccc1N=C(N)Nc1ccccc1I
Show InChI InChI=1S/C14H14IN3/c1-10-6-2-4-8-12(10)17-14(16)18-13-9-5-3-7-11(13)15/h2-9H,1H3,(H3,16,17,18)
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n/an/a 21n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010802
PNG
(CHEMBL554972 | N,N'-Bis-bicyclo[2.2.1]hept-2-yl-gu...)
Show SMILES NC(NC1CC2CCC1C2)=NC1CC2CCC1C2
Show InChI InChI=1S/C15H25N3/c16-15(17-13-7-9-1-3-11(13)5-9)18-14-8-10-2-4-12(14)6-10/h9-14H,1-8H2,(H3,16,17,18)
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n/an/a 22n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010746
PNG
(CHEMBL79186 | N-(2-Iodo-phenyl)-N'-o-tolyl-guanidi...)
Show SMILES Cc1ccccc1N=C(N)Nc1ccccc1I
Show InChI InChI=1S/C14H14IN3/c1-10-6-2-4-8-12(10)17-14(16)18-13-9-5-3-7-11(13)15/h2-9H,1H3,(H3,16,17,18)
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n/an/a 23n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010801
PNG
(CHEMBL79665 | N-o-Tolyl-N'-(1,7,7-trimethyl-bicycl...)
Show SMILES Cc1ccccc1NC(N)=NC1CC2CCC1(C)C2(C)C
Show InChI InChI=1S/C18H27N3/c1-12-7-5-6-8-14(12)20-16(19)21-15-11-13-9-10-18(15,4)17(13,2)3/h5-8,13,15H,9-11H2,1-4H3,(H3,19,20,21)
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n/an/a 25n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010765
PNG
(CHEMBL78488 | N-Adamantan-1-yl-N'-(2-nitro-phenyl)...)
Show SMILES N\C([N-]C12CC3CC(CC(C3)C1)C2)=[NH+]/c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C17H21N4O2/c18-16(19-14-3-1-2-4-15(14)21(22)23)20-17-8-11-5-12(9-17)7-13(6-11)10-17/h1-4,11-13H,5-10H2,(H2-,18,19,20)/q-1/p+1
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n/an/a 30n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010774
PNG
(CHEMBL539782 | CHEMBL83430 | N,N'-Dibenzyl-guanidi...)
Show SMILES N=C(NCc1ccccc1)NCc1ccccc1
Show InChI InChI=1S/C15H17N3/c16-15(17-11-13-7-3-1-4-8-13)18-12-14-9-5-2-6-10-14/h1-10H,11-12H2,(H3,16,17,18)
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n/an/a 33n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010739
PNG
(CHEMBL79437 | N,N'-Bis-(3-propyl-phenyl)-guanidine)
Show SMILES CCCc1cccc(NC(N)=Nc2cccc(CCC)c2)c1
Show InChI InChI=1S/C19H25N3/c1-3-7-15-9-5-11-17(13-15)21-19(20)22-18-12-6-10-16(14-18)8-4-2/h5-6,9-14H,3-4,7-8H2,1-2H3,(H3,20,21,22)
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n/an/a 36n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010799
PNG
(CHEMBL81824 | N-(2-Methyl-4-nitro-phenyl)-N'-o-tol...)
Show SMILES Cc1ccccc1[N-]C(N)=[NH+]c1ccc(cc1C)[N+]([O-])=O
Show InChI InChI=1S/C15H15N4O2/c1-10-5-3-4-6-13(10)17-15(16)18-14-8-7-12(19(20)21)9-11(14)2/h3-9H,1-2H3,(H2-,16,17,18)/q-1/p+1
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n/an/a 37n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010800
PNG
(CHEMBL79436 | N,N'-Bis-(4-bromo-2-methyl-phenyl)-g...)
Show SMILES Cc1cc(Br)ccc1NC(N)=Nc1ccc(Br)cc1C
Show InChI InChI=1S/C15H15Br2N3/c1-9-7-11(16)3-5-13(9)19-15(18)20-14-6-4-12(17)8-10(14)2/h3-8H,1-2H3,(H3,18,19,20)
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n/an/a 37n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010800
PNG
(CHEMBL79436 | N,N'-Bis-(4-bromo-2-methyl-phenyl)-g...)
Show SMILES Cc1cc(Br)ccc1NC(N)=Nc1ccc(Br)cc1C
Show InChI InChI=1S/C15H15Br2N3/c1-9-7-11(16)3-5-13(9)19-15(18)20-14-6-4-12(17)8-10(14)2/h3-8H,1-2H3,(H3,18,19,20)
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n/an/a 37n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM81982
PNG
(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)
Show SMILES Cc1ccccc1NC(N)=Nc1ccccc1C
Show InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
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n/an/a 38n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM81982
PNG
(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)
Show SMILES Cc1ccccc1NC(N)=Nc1ccccc1C
Show InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
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n/an/a 38n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010799
PNG
(CHEMBL81824 | N-(2-Methyl-4-nitro-phenyl)-N'-o-tol...)
Show SMILES Cc1ccccc1[N-]C(N)=[NH+]c1ccc(cc1C)[N+]([O-])=O
Show InChI InChI=1S/C15H15N4O2/c1-10-5-3-4-6-13(10)17-15(16)18-14-8-7-12(19(20)21)9-11(14)2/h3-9H,1-2H3,(H2-,16,17,18)/q-1/p+1
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n/an/a 39n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010790
PNG
(CHEMBL78637 | N-(2,6-Dimethyl-phenyl)-N'-o-tolyl-g...)
Show SMILES Cc1ccccc1NC(N)=Nc1c(C)cccc1C
Show InChI InChI=1S/C16H19N3/c1-11-7-4-5-10-14(11)18-16(17)19-15-12(2)8-6-9-13(15)3/h4-10H,1-3H3,(H3,17,18,19)
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n/an/a 42n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to sigma receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010738
PNG
(CHEMBL81867 | N,N'-Dicyclohexyl-guanidine)
Show SMILES NC(NC1CCCCC1)=NC1CCCCC1
Show InChI InChI=1S/C13H25N3/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h11-12H,1-10H2,(H3,14,15,16)
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n/an/a 48n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010791
PNG
(CHEMBL309603 | N,N'-Di-m-tolyl-guanidine)
Show SMILES Cc1cccc(NC(N)=Nc2cccc(C)c2)c1
Show InChI InChI=1S/C15H17N3/c1-11-5-3-7-13(9-11)17-15(16)18-14-8-4-6-12(2)10-14/h3-10H,1-2H3,(H3,16,17,18)
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n/an/a 59n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010806
PNG
(CHEMBL78306 | N,N'-Bis-(5,6,7,8-tetrahydro-naphtha...)
Show SMILES NC(Nc1cccc2CCCCc12)=Nc1cccc2CCCCc12
Show InChI InChI=1S/C21H25N3/c22-21(23-19-13-5-9-15-7-1-3-11-17(15)19)24-20-14-6-10-16-8-2-4-12-18(16)20/h5-6,9-10,13-14H,1-4,7-8,11-12H2,(H3,22,23,24)
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n/an/a 59n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010755
PNG
(CHEMBL280243 | N,N'-Bis-(2-isopropyl-phenyl)-guani...)
Show SMILES CC(C)c1ccccc1NC(N)=Nc1ccccc1C(C)C
Show InChI InChI=1S/C19H25N3/c1-13(2)15-9-5-7-11-17(15)21-19(20)22-18-12-8-6-10-16(18)14(3)4/h5-14H,1-4H3,(H3,20,21,22)
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n/an/a 65n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010794
PNG
(CHEMBL312318 | N,N'-Bis-(2,6-dimethyl-phenyl)-guan...)
Show SMILES Cc1cccc(C)c1NC(N)=Nc1c(C)cccc1C
Show InChI InChI=1S/C17H21N3/c1-11-7-5-8-12(2)15(11)19-17(18)20-16-13(3)9-6-10-14(16)4/h5-10H,1-4H3,(H3,18,19,20)
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n/an/a 66n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to sigma receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010790
PNG
(CHEMBL78637 | N-(2,6-Dimethyl-phenyl)-N'-o-tolyl-g...)
Show SMILES Cc1ccccc1NC(N)=Nc1c(C)cccc1C
Show InChI InChI=1S/C16H19N3/c1-11-7-4-5-10-14(11)18-16(17)19-15-12(2)8-6-9-13(15)3/h4-10H,1-3H3,(H3,17,18,19)
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n/an/a 70n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010738
PNG
(CHEMBL81867 | N,N'-Dicyclohexyl-guanidine)
Show SMILES NC(NC1CCCCC1)=NC1CCCCC1
Show InChI InChI=1S/C13H25N3/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h11-12H,1-10H2,(H3,14,15,16)
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n/an/a 71n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010789
PNG
(CHEMBL82078 | N,N'-Bis-(3-isopropyl-phenyl)-guanid...)
Show SMILES CC(C)c1cccc(NC(N)=Nc2cccc(c2)C(C)C)c1
Show InChI InChI=1S/C19H25N3/c1-13(2)15-7-5-9-17(11-15)21-19(20)22-18-10-6-8-16(12-18)14(3)4/h5-14H,1-4H3,(H3,20,21,22)
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n/an/a 77n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010791
PNG
(CHEMBL309603 | N,N'-Di-m-tolyl-guanidine)
Show SMILES Cc1cccc(NC(N)=Nc2cccc(C)c2)c1
Show InChI InChI=1S/C15H17N3/c1-11-5-3-7-13(9-11)17-15(16)18-14-8-4-6-12(2)10-14/h3-10H,1-2H3,(H3,16,17,18)
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n/an/a 84n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010794
PNG
(CHEMBL312318 | N,N'-Bis-(2,6-dimethyl-phenyl)-guan...)
Show SMILES Cc1cccc(C)c1NC(N)=Nc1c(C)cccc1C
Show InChI InChI=1S/C17H21N3/c1-11-7-5-8-12(2)15(11)19-17(18)20-16-13(3)9-6-10-14(16)4/h5-10H,1-4H3,(H3,18,19,20)
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n/an/a 90n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010774
PNG
(CHEMBL539782 | CHEMBL83430 | N,N'-Dibenzyl-guanidi...)
Show SMILES N=C(NCc1ccccc1)NCc1ccccc1
Show InChI InChI=1S/C15H17N3/c16-15(17-11-13-7-3-1-4-8-13)18-12-14-9-5-2-6-10-14/h1-10H,11-12H2,(H3,16,17,18)
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n/an/a 90n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010763
PNG
(CHEMBL543355 | N-Adamantan-1-yl-N'-(2-phenethyl-ph...)
Show SMILES NC(NC12CC3CC(CC(C3)C1)C2)=Nc1ccccc1CCc1ccccc1
Show InChI InChI=1S/C25H31N3/c26-24(28-25-15-19-12-20(16-25)14-21(13-19)17-25)27-23-9-5-4-8-22(23)11-10-18-6-2-1-3-7-18/h1-9,19-21H,10-17H2,(H3,26,27,28)
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n/an/a 112n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010803
PNG
(CHEMBL81735 | N-(2-Nitro-phenyl)-N'-o-tolyl-guanid...)
Show SMILES Cc1ccccc1[N-]C(N)=[NH+]c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C14H13N4O2/c1-10-6-2-3-7-11(10)16-14(15)17-12-8-4-5-9-13(12)18(19)20/h2-9H,1H3,(H2-,15,16,17)/q-1/p+1
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n/an/a 113n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010767
PNG
(CHEMBL312588 | N-(3-Hydroxy-phenyl)-N'-(2-methyl-4...)
Show SMILES Cc1cc(ccc1[N-]C(N)=[NH+]c1cccc(O)c1)[N+]([O-])=O
Show InChI InChI=1S/C14H13N4O3/c1-9-7-11(18(20)21)5-6-13(9)17-14(15)16-10-3-2-4-12(19)8-10/h2-8H,1H3,(H3-,15,16,17,19)/q-1/p+1
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n/an/a 118n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010767
PNG
(CHEMBL312588 | N-(3-Hydroxy-phenyl)-N'-(2-methyl-4...)
Show SMILES Cc1cc(ccc1[N-]C(N)=[NH+]c1cccc(O)c1)[N+]([O-])=O
Show InChI InChI=1S/C14H13N4O3/c1-9-7-11(18(20)21)5-6-13(9)17-14(15)16-10-3-2-4-12(19)8-10/h2-8H,1H3,(H3-,15,16,17,19)/q-1/p+1
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n/an/a 118n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010750
PNG
(CHEMBL545007 | N-Adamantan-1-yl-N'-(2-phenyl-cyclo...)
Show SMILES NC(NC12CC3CC(CC(C3)C1)C2)=NC1C[C@H]1c1ccccc1
Show InChI InChI=1S/C20H27N3/c21-19(22-18-9-17(18)16-4-2-1-3-5-16)23-20-10-13-6-14(11-20)8-15(7-13)12-20/h1-5,13-15,17-18H,6-12H2,(H3,21,22,23)/t13?,14?,15?,17-,18?,20?/m0/s1
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n/an/a 120n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010810
PNG
(CHEMBL79509 | N,N'-Di-naphthalen-1-yl-guanidine)
Show SMILES NC(Nc1cccc2ccccc12)=Nc1cccc2ccccc12
Show InChI InChI=1S/C21H17N3/c22-21(23-19-13-5-9-15-7-1-3-11-17(15)19)24-20-14-6-10-16-8-2-4-12-18(16)20/h1-14H,(H3,22,23,24)
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n/an/a 133n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010798
PNG
(CHEMBL79145 | N,N'-dicyclohexyl-N''-hydroxyguanidi...)
Show SMILES ONC(NC1CCCCC1)=NC1CCCCC1
Show InChI InChI=1S/C13H25N3O/c17-16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h11-12,17H,1-10H2,(H2,14,15,16)
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n/an/a 140n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010771
PNG
(CHEMBL543121 | N,N'-Dicyclohexyl-N''-methyl-guanid...)
Show SMILES CNC(NC1CCCCC1)=NC1CCCCC1
Show InChI InChI=1S/C14H27N3/c1-15-14(16-12-8-4-2-5-9-12)17-13-10-6-3-7-11-13/h12-13H,2-11H2,1H3,(H2,15,16,17)
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n/an/a 145n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to sigma receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010807
PNG
(CHEMBL536782 | N-(3-Hydroxy-phenyl)-N'-o-tolyl-gua...)
Show SMILES Cc1ccccc1N=C(N)Nc1cccc(O)c1
Show InChI InChI=1S/C14H15N3O/c1-10-5-2-3-8-13(10)17-14(15)16-11-6-4-7-12(18)9-11/h2-9,18H,1H3,(H3,15,16,17)
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n/an/a 155n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010778
PNG
(CHEMBL312806 | N,N'-Dicyclohexyl-N''-cyclopropyl-g...)
Show SMILES C1CC1N=C(NC1CCCCC1)NC1CCCCC1
Show InChI InChI=1S/C16H29N3/c1-3-7-13(8-4-1)17-16(19-15-11-12-15)18-14-9-5-2-6-10-14/h13-15H,1-12H2,(H2,17,18,19)
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n/an/a 163n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to sigma receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010797
PNG
(CHEMBL81678 | N,N'-Bis-(3-iodo-phenyl)-guanidine)
Show SMILES NC(Nc1cccc(I)c1)=Nc1cccc(I)c1
Show InChI InChI=1S/C13H11I2N3/c14-9-3-1-5-11(7-9)17-13(16)18-12-6-2-4-10(15)8-12/h1-8H,(H3,16,17,18)
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n/an/a 173n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010785
PNG
(CHEMBL543839 | N,N'-Di-adamantan-2-yl-guanidine; h...)
Show SMILES NC(NC1C2CC3CC(C2)CC1C3)=NC1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C21H33N3/c22-21(23-19-15-3-11-1-12(5-15)6-16(19)4-11)24-20-17-7-13-2-14(9-17)10-18(20)8-13/h11-20H,1-10H2,(H3,22,23,24)
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n/an/a 203n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010807
PNG
(CHEMBL536782 | N-(3-Hydroxy-phenyl)-N'-o-tolyl-gua...)
Show SMILES Cc1ccccc1N=C(N)Nc1cccc(O)c1
Show InChI InChI=1S/C14H15N3O/c1-10-5-2-3-8-13(10)17-14(15)16-11-6-4-7-12(18)9-11/h2-9,18H,1H3,(H3,15,16,17)
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n/an/a 207n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010796
PNG
(CHEMBL81539 | N,N'-Bis-(2-trifluoromethyl-phenyl)-...)
Show SMILES NC(Nc1ccccc1C(F)(F)F)=Nc1ccccc1C(F)(F)F
Show InChI InChI=1S/C15H11F6N3/c16-14(17,18)9-5-1-3-7-11(9)23-13(22)24-12-8-4-2-6-10(12)15(19,20)21/h1-8H,(H3,22,23,24)
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n/an/a 215n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010775
PNG
(CHEMBL543596 | N-(4-Amino-2-methyl-phenyl)-N'-o-to...)
Show SMILES Cc1ccccc1NC(N)=Nc1ccc(N)cc1C
Show InChI InChI=1S/C15H18N4/c1-10-5-3-4-6-13(10)18-15(17)19-14-8-7-12(16)9-11(14)2/h3-9H,16H2,1-2H3,(H3,17,18,19)
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n/an/a 220n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010771
PNG
(CHEMBL543121 | N,N'-Dicyclohexyl-N''-methyl-guanid...)
Show SMILES CNC(NC1CCCCC1)=NC1CCCCC1
Show InChI InChI=1S/C14H27N3/c1-15-14(16-12-8-4-2-5-9-12)17-13-10-6-3-7-11-13/h12-13H,2-11H2,1H3,(H2,15,16,17)
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n/an/a 237n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010752
PNG
(CHEMBL543120 | N,N'-Dicyclohexyl-N''-octyl-guanidi...)
Show SMILES CCCCCCCCNC(NC1CCCCC1)=NC1CCCCC1
Show InChI InChI=1S/C21H41N3/c1-2-3-4-5-6-13-18-22-21(23-19-14-9-7-10-15-19)24-20-16-11-8-12-17-20/h19-20H,2-18H2,1H3,(H2,22,23,24)
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n/an/a 237n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010752
PNG
(CHEMBL543120 | N,N'-Dicyclohexyl-N''-octyl-guanidi...)
Show SMILES CCCCCCCCNC(NC1CCCCC1)=NC1CCCCC1
Show InChI InChI=1S/C21H41N3/c1-2-3-4-5-6-13-18-22-21(23-19-14-9-7-10-15-19)24-20-16-11-8-12-17-20/h19-20H,2-18H2,1H3,(H2,22,23,24)
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n/an/a 238n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010773
PNG
(CHEMBL556617 | N-Adamantan-1-yl-N'-[2-(2-pentafluo...)
Show SMILES NC(NC12CC3CC(CC(C3)C1)C2)=Nc1ccccc1C=Cc1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C25H24F5N3/c26-19-17(20(27)22(29)23(30)21(19)28)6-5-16-3-1-2-4-18(16)32-24(31)33-25-10-13-7-14(11-25)9-15(8-13)12-25/h1-6,13-15H,7-12H2,(H3,31,32,33)
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n/an/a 245n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010736
PNG
(CHEMBL78083 | N,N'-Bis-(4-ethyl-phenyl)-guanidine)
Show SMILES CCc1ccc(NC(N)=Nc2ccc(CC)cc2)cc1
Show InChI InChI=1S/C17H21N3/c1-3-13-5-9-15(10-6-13)19-17(18)20-16-11-7-14(4-2)8-12-16/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
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n/an/a 245n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010761
PNG
(CHEMBL553536 | N-(17-Acetyl-10,13-dimethyl-2,3,4,7...)
Show SMILES CC(=O)[C@H]1CCC2C3CC=C4CC(CC[C@]4(C)C3CC[C@]12C)NC(N)=Nc1ccccc1C
Show InChI InChI=1S/C29H41N3O/c1-18-7-5-6-8-26(18)32-27(30)31-21-13-15-28(3)20(17-21)9-10-22-24-12-11-23(19(2)33)29(24,4)16-14-25(22)28/h5-9,21-25H,10-17H2,1-4H3,(H3,30,31,32)/t21?,22?,23-,24?,25?,28+,29-/m1/s1
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n/an/a 250n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010754
PNG
(CHEMBL81626 | N,N'-Bis-(4-isopropyl-phenyl)-guanid...)
Show SMILES CC(C)c1ccc(NC(N)=Nc2ccc(cc2)C(C)C)cc1
Show InChI InChI=1S/C19H25N3/c1-13(2)15-5-9-17(10-6-15)21-19(20)22-18-11-7-16(8-12-18)14(3)4/h5-14H,1-4H3,(H3,20,21,22)
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n/an/a 270n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010798
PNG
(CHEMBL79145 | N,N'-dicyclohexyl-N''-hydroxyguanidi...)
Show SMILES ONC(NC1CCCCC1)=NC1CCCCC1
Show InChI InChI=1S/C13H25N3O/c17-16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h11-12,17H,1-10H2,(H2,14,15,16)
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n/an/a 271n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010775
PNG
(CHEMBL543596 | N-(4-Amino-2-methyl-phenyl)-N'-o-to...)
Show SMILES Cc1ccccc1NC(N)=Nc1ccc(N)cc1C
Show InChI InChI=1S/C15H18N4/c1-10-5-3-4-6-13(10)18-15(17)19-14-8-7-12(16)9-11(14)2/h3-9H,16H2,1-2H3,(H3,17,18,19)
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n/an/a 280n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010793
PNG
(CHEMBL415077 | N-Adamantan-1-yl-N'-biphenyl-2-yl-g...)
Show SMILES NC(NC12CC3CC(CC(C3)C1)C2)=Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C23H27N3/c24-22(26-23-13-16-10-17(14-23)12-18(11-16)15-23)25-21-9-5-4-8-20(21)19-6-2-1-3-7-19/h1-9,16-18H,10-15H2,(H3,24,25,26)
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n/an/a 300n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010804
PNG
(1,3-Diphenyl-imidazolidin-2-ylideneamine | CHEMBL5...)
Show SMILES N=C1N(CCN1c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15N3/c16-15-17(13-7-3-1-4-8-13)11-12-18(15)14-9-5-2-6-10-14/h1-10,16H,11-12H2
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n/an/a 340n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010776
PNG
(CHEMBL539360 | N-Adamantan-1-yl-N'-(2-styryl-pheny...)
Show SMILES NC(NC12CC3CC(CC(C3)C1)C2)=Nc1ccccc1C=Cc1ccccc1
Show InChI InChI=1S/C25H29N3/c26-24(28-25-15-19-12-20(16-25)14-21(13-19)17-25)27-23-9-5-4-8-22(23)11-10-18-6-2-1-3-7-18/h1-11,19-21H,12-17H2,(H3,26,27,28)
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n/an/a 345n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010784
PNG
(CHEMBL81070 | N,N'-Bis-(4-bromo-phenyl)-guanidine)
Show SMILES NC(Nc1ccc(Br)cc1)=Nc1ccc(Br)cc1
Show InChI InChI=1S/C13H11Br2N3/c14-9-1-5-11(6-2-9)17-13(16)18-12-7-3-10(15)4-8-12/h1-8H,(H3,16,17,18)
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n/an/a 350n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010786
PNG
(CHEMBL78411 | N,N'-Bis-(2-tert-butyl-phenyl)-guani...)
Show SMILES CC(C)(C)c1ccccc1NC(N)=Nc1ccccc1C(C)(C)C
Show InChI InChI=1S/C21H29N3/c1-20(2,3)15-11-7-9-13-17(15)23-19(22)24-18-14-10-8-12-16(18)21(4,5)6/h7-14H,1-6H3,(H3,22,23,24)
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n/an/a 356n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010780
PNG
(CHEMBL543602 | N-Adamantan-2-yl-N'-(2-styryl-pheny...)
Show SMILES NC(Nc1ccccc1C=Cc1ccccc1)=NC1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C25H29N3/c26-25(28-24-21-13-18-12-19(15-21)16-22(24)14-18)27-23-9-5-4-8-20(23)11-10-17-6-2-1-3-7-17/h1-11,18-19,21-22,24H,12-16H2,(H3,26,27,28)
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n/an/a 370n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010769
PNG
(CHEMBL556117 | CHEMBL77675 | N,N'-Diphenyl-guanidi...)
Show SMILES NC(Nc1ccccc1)=Nc1ccccc1
Show InChI InChI=1S/C13H13N3/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H,(H3,14,15,16)
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n/an/a 397n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010769
PNG
(CHEMBL556117 | CHEMBL77675 | N,N'-Diphenyl-guanidi...)
Show SMILES NC(Nc1ccccc1)=Nc1ccccc1
Show InChI InChI=1S/C13H13N3/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H,(H3,14,15,16)
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n/an/a 400n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010744
PNG
(CHEMBL78585 | N-(2-Amino-phenyl)-N'-o-tolyl-guanid...)
Show SMILES Cc1ccccc1N=C(N)Nc1ccccc1N
Show InChI InChI=1S/C14H16N4/c1-10-6-2-4-8-12(10)17-14(16)18-13-9-5-3-7-11(13)15/h2-9H,15H2,1H3,(H3,16,17,18)
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n/an/a 440n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010744
PNG
(CHEMBL78585 | N-(2-Amino-phenyl)-N'-o-tolyl-guanid...)
Show SMILES Cc1ccccc1N=C(N)Nc1ccccc1N
Show InChI InChI=1S/C14H16N4/c1-10-6-2-4-8-12(10)17-14(16)18-13-9-5-3-7-11(13)15/h2-9H,15H2,1H3,(H3,16,17,18)
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n/an/a 463n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010778
PNG
(CHEMBL312806 | N,N'-Dicyclohexyl-N''-cyclopropyl-g...)
Show SMILES C1CC1N=C(NC1CCCCC1)NC1CCCCC1
Show InChI InChI=1S/C16H29N3/c1-3-7-13(8-4-1)17-16(19-15-11-12-15)18-14-9-5-2-6-10-14/h13-15H,1-12H2,(H2,17,18,19)
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n/an/a 513n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010743
PNG
(N,N'-Di-p-tolyl-guanidine)
Show SMILES Cc1ccc(NC(N)=Nc2ccc(C)cc2)cc1
Show InChI InChI=1S/C15H17N3/c1-11-3-7-13(8-4-11)17-15(16)18-14-9-5-12(2)6-10-14/h3-10H,1-2H3,(H3,16,17,18)
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n/an/a 535n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010784
PNG
(CHEMBL81070 | N,N'-Bis-(4-bromo-phenyl)-guanidine)
Show SMILES NC(Nc1ccc(Br)cc1)=Nc1ccc(Br)cc1
Show InChI InChI=1S/C13H11Br2N3/c14-9-1-5-11(6-2-9)17-13(16)18-12-7-3-10(15)4-8-12/h1-8H,(H3,16,17,18)
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n/an/a 540n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010749
PNG
(CHEMBL80081 | N,N'-Dibutyl-guanidine (C6H3N3O7))
Show SMILES CCCCNC(=N)NCCCC
Show InChI InChI=1S/C9H21N3/c1-3-5-7-11-9(10)12-8-6-4-2/h3-8H2,1-2H3,(H3,10,11,12)
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n/an/a 750n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010783
PNG
(CHEMBL541828 | N,N'-Bis-(2-methyl-4-nitro-phenyl)-...)
Show SMILES Cc1cc(ccc1N\C([NH-])=[NH+]/c1ccc(cc1C)[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C15H14N5O4/c1-9-7-11(19(21)22)3-5-13(9)17-15(16)18-14-6-4-12(20(23)24)8-10(14)2/h3-8H,1-2H3,(H2-,16,17,18)/q-1/p+1
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n/an/a 760n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010783
PNG
(CHEMBL541828 | N,N'-Bis-(2-methyl-4-nitro-phenyl)-...)
Show SMILES Cc1cc(ccc1N\C([NH-])=[NH+]/c1ccc(cc1C)[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C15H14N5O4/c1-9-7-11(19(21)22)3-5-13(9)17-15(16)18-14-6-4-12(20(23)24)8-10(14)2/h3-8H,1-2H3,(H2-,16,17,18)/q-1/p+1
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n/an/a 760n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010796
PNG
(CHEMBL81539 | N,N'-Bis-(2-trifluoromethyl-phenyl)-...)
Show SMILES NC(Nc1ccccc1C(F)(F)F)=Nc1ccccc1C(F)(F)F
Show InChI InChI=1S/C15H11F6N3/c16-14(17,18)9-5-1-3-7-11(9)23-13(22)24-12-8-4-2-6-10(12)15(19,20)21/h1-8H,(H3,22,23,24)
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n/an/a 766n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010749
PNG
(CHEMBL80081 | N,N'-Dibutyl-guanidine (C6H3N3O7))
Show SMILES CCCCNC(=N)NCCCC
Show InChI InChI=1S/C9H21N3/c1-3-5-7-11-9(10)12-8-6-4-2/h3-8H2,1-2H3,(H3,10,11,12)
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n/an/a 800n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010740
PNG
(CHEMBL82247 | N-(2-Styryl-phenyl)-N'-o-tolyl-guani...)
Show SMILES Cc1ccccc1N=C(N)Nc1ccccc1C=Cc1ccccc1
Show InChI InChI=1S/C22H21N3/c1-17-9-5-7-13-20(17)24-22(23)25-21-14-8-6-12-19(21)16-15-18-10-3-2-4-11-18/h2-16H,1H3,(H3,23,24,25)
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n/an/a 920n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010787
PNG
(CHEMBL82246 | N-Biphenyl-2-yl-N'-naphthalen-1-yl-g...)
Show SMILES NC(Nc1cccc2ccccc12)=Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C23H19N3/c24-23(26-22-16-8-12-18-11-4-5-13-20(18)22)25-21-15-7-6-14-19(21)17-9-2-1-3-10-17/h1-16H,(H3,24,25,26)
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n/an/a 935n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010757
PNG
(CHEMBL78356 | N-(4-Amino-2-methyl-phenyl)-N'-(3-hy...)
Show SMILES Cc1cc(N)ccc1N=C(N)Nc1cccc(O)c1
Show InChI InChI=1S/C14H16N4O/c1-9-7-10(15)5-6-13(9)18-14(16)17-11-3-2-4-12(19)8-11/h2-8,19H,15H2,1H3,(H3,16,17,18)
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n/an/a 962n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010772
PNG
(CHEMBL557002 | N-(3,5-Dimethyl-adamantan-1-yl)-N'-...)
Show SMILES CC12CC3CC(C)(C1)CC(C3)(C2)NC(N)=Nc1ccccc1C=Cc1ccccc1
Show InChI InChI=1S/C27H33N3/c1-25-14-21-15-26(2,17-25)19-27(16-21,18-25)30-24(28)29-23-11-7-6-10-22(23)13-12-20-8-4-3-5-9-20/h3-13,21H,14-19H2,1-2H3,(H3,28,29,30)
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n/an/a 970n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010809
PNG
(CHEMBL78928 | N-(2-Iodo-phenyl)-N'-(2-styryl-pheny...)
Show SMILES NC(Nc1ccccc1C=Cc1ccccc1)=Nc1ccccc1I
Show InChI InChI=1S/C21H18IN3/c22-18-11-5-7-13-20(18)25-21(23)24-19-12-6-4-10-17(19)15-14-16-8-2-1-3-9-16/h1-15H,(H3,23,24,25)
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010745
PNG
(CHEMBL310729 | N,N'-Bis-(2-methoxy-phenyl)-guanidi...)
Show SMILES COc1ccccc1NC(N)=Nc1ccccc1OC
Show InChI InChI=1S/C15H17N3O2/c1-19-13-9-5-3-7-11(13)17-15(16)18-12-8-4-6-10-14(12)20-2/h3-10H,1-2H3,(H3,16,17,18)
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010741
PNG
(1-Phenyl-imidazolidin-2-ylideneamine; hydrobromide...)
Show SMILES NC1=NCCN1c1ccccc1
Show InChI InChI=1S/C9H11N3/c10-9-11-6-7-12(9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H2,10,11)
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n/an/a 3.50E+3n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010745
PNG
(CHEMBL310729 | N,N'-Bis-(2-methoxy-phenyl)-guanidi...)
Show SMILES COc1ccccc1NC(N)=Nc1ccccc1OC
Show InChI InChI=1S/C15H17N3O2/c1-19-13-9-5-3-7-11(13)17-15(16)18-12-8-4-6-10-14(12)20-2/h3-10H,1-2H3,(H3,16,17,18)
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n/an/a 3.80E+3n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010777
PNG
(3-Phenyl-3,4-dihydro-quinazolin-2-ylamine | CHEMBL...)
Show SMILES NC1=Nc2ccccc2CN1c1ccccc1
Show InChI InChI=1S/C14H13N3/c15-14-16-13-9-5-4-6-11(13)10-17(14)12-7-2-1-3-8-12/h1-9H,10H2,(H2,15,16)
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n/an/a 4.10E+3n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010770
PNG
(CHEMBL79165 | N,N'-Bis-(4-amino-2-methyl-phenyl)-g...)
Show SMILES Cc1cc(N)ccc1NC(N)=Nc1ccc(N)cc1C
Show InChI InChI=1S/C15H19N5/c1-9-7-11(16)3-5-13(9)19-15(18)20-14-6-4-12(17)8-10(14)2/h3-8H,16-17H2,1-2H3,(H3,18,19,20)
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n/an/a 5.10E+3n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


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More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010770
PNG
(CHEMBL79165 | N,N'-Bis-(4-amino-2-methyl-phenyl)-g...)
Show SMILES Cc1cc(N)ccc1NC(N)=Nc1ccc(N)cc1C
Show InChI InChI=1S/C15H19N5/c1-9-7-11(16)3-5-13(9)19-15(18)20-14-6-4-12(17)8-10(14)2/h3-8H,16-17H2,1-2H3,(H3,18,19,20)
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n/an/a 7.15E+3n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


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More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010792
PNG
(CHEMBL81594 | N,N'-Bis-biphenyl-2-yl-guanidine)
Show SMILES NC(Nc1ccccc1-c1ccccc1)=Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C25H21N3/c26-25(27-23-17-9-7-15-21(23)19-11-3-1-4-12-19)28-24-18-10-8-16-22(24)20-13-5-2-6-14-20/h1-18H,(H3,26,27,28)
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n/an/a 8.11E+3n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010805
PNG
(5,7-Dihydro-dibenzo[d,f][1,3]diazepin-6-ylideneami...)
Show SMILES NC1=Nc2ccccc2-c2ccccc2N1
Show InChI InChI=1S/C13H11N3/c14-13-15-11-7-3-1-5-9(11)10-6-2-4-8-12(10)16-13/h1-8H,(H3,14,15,16)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010788
PNG
(CHEMBL545471 | N,N'-Dimethyl-guanidine; hydrobromi...)
Show SMILES CNC(=N)NC
Show InChI InChI=1S/C3H9N3/c1-5-3(4)6-2/h1-2H3,(H3,4,5,6)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


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More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010788
PNG
(CHEMBL545471 | N,N'-Dimethyl-guanidine; hydrobromi...)
Show SMILES CNC(=N)NC
Show InChI InChI=1S/C3H9N3/c1-5-3(4)6-2/h1-2H3,(H3,4,5,6)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


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More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010808
PNG
(CHEMBL544537 | N-[17-(1,5-Dimethyl-hexyl)-10,13-di...)
Show SMILES CC(C)CCCC(C)[C@H]1CCC2C3CC=C4CC(CC[C@]4(C)C3CC[C@]12C)NC(N)=Nc1ccccc1C
Show InChI InChI=1S/C35H55N3/c1-23(2)10-9-12-24(3)29-16-17-30-28-15-14-26-22-27(37-33(36)38-32-13-8-7-11-25(32)4)18-20-34(26,5)31(28)19-21-35(29,30)6/h7-8,11,13-14,23-24,27-31H,9-10,12,15-22H2,1-6H3,(H3,36,37,38)/t24?,27?,28?,29-,30?,31?,34+,35-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010751
PNG
(1H,3H-Perimidin-2-ylideneamine | 2-aminoperimidine...)
Show SMILES Nc1nc2cccc3cccc([nH]1)c23
Show InChI InChI=1S/C11H9N3/c12-11-13-8-5-1-3-7-4-2-6-9(14-11)10(7)8/h1-6H,(H3,12,13,14)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50010737
PNG
(CHEMBL79616 | N,N-Diphenyl-guanidine)
Show SMILES NC(=N)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C13H13N3/c14-13(15)16(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H3,14,15)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenates


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%