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PubMed code 1976813

Compile data set for download or QSAR
Found 80 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010859
PNG
(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Show SMILES CN(C)CCCN1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
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n/an/a 1.70n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010870
PNG
(1-[1-(3,4-Dichloro-phenyl)-2-dimethylamino-ethyl]-...)
Show SMILES CN(C)CC(c1ccc(Cl)c(Cl)c1)C1(O)CCCCC1
Show InChI InChI=1S/C16H23Cl2NO/c1-19(2)11-13(16(20)8-4-3-5-9-16)12-6-7-14(17)15(18)10-12/h6-7,10,13,20H,3-5,8-9,11H2,1-2H3
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n/an/a 37n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010867
PNG
(1-[1-(3-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1cccc(Br)c1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24BrNO/c1-18(2)12-15(13-7-6-8-14(17)11-13)16(19)9-4-3-5-10-16/h6-8,11,15,19H,3-5,9-10,12H2,1-2H3
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n/an/a 52n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM86748
PNG
(CAS_386750-22-7 | DESVENLAFAXINE | Desvenlafaxine ...)
Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3
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n/an/a 60n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010872
PNG
(1-[1-(4-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1ccc(Br)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24BrNO/c1-18(2)12-15(13-6-8-14(17)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,19H,3-5,10-12H2,1-2H3
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n/an/a 62n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010870
PNG
(1-[1-(3,4-Dichloro-phenyl)-2-dimethylamino-ethyl]-...)
Show SMILES CN(C)CC(c1ccc(Cl)c(Cl)c1)C1(O)CCCCC1
Show InChI InChI=1S/C16H23Cl2NO/c1-19(2)11-13(16(20)8-4-3-5-9-16)12-6-7-14(17)15(18)10-12/h6-7,10,13,20H,3-5,8-9,11H2,1-2H3
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n/an/a 70n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010870
PNG
(1-[1-(3,4-Dichloro-phenyl)-2-dimethylamino-ethyl]-...)
Show SMILES CN(C)CC(c1ccc(Cl)c(Cl)c1)C1(O)CCCCC1
Show InChI InChI=1S/C16H23Cl2NO/c1-19(2)11-13(16(20)8-4-3-5-9-16)12-6-7-14(17)15(18)10-12/h6-7,10,13,20H,3-5,8-9,11H2,1-2H3
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n/an/a 80n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010877
PNG
(1-[2-Dimethylamino-1-(4-trifluoromethyl-phenyl)-et...)
Show SMILES CN(C)CC(c1ccc(cc1)C(F)(F)F)C1(O)CCCCC1
Show InChI InChI=1S/C17H24F3NO/c1-21(2)12-15(16(22)10-4-3-5-11-16)13-6-8-14(9-7-13)17(18,19)20/h6-9,15,22H,3-5,10-12H2,1-2H3
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n/an/a 88n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM82071
PNG
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
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n/an/a 90n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM82071
PNG
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
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n/an/a 90n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010866
PNG
(1-[2-Dimethylamino-1-(3-methoxy-phenyl)-ethyl]-cyc...)
Show SMILES COc1cccc(c1)C(CN(C)C)C1(O)CCCC1
Show InChI InChI=1S/C16H25NO2/c1-17(2)12-15(16(18)9-4-5-10-16)13-7-6-8-14(11-13)19-3/h6-8,11,15,18H,4-5,9-10,12H2,1-3H3
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n/an/a 95n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM82071
PNG
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
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n/an/a 100n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010874
PNG
(1-(1-(4-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...)
Show SMILES CN(C)CC(c1ccc(Cl)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24ClNO/c1-18(2)12-15(13-6-8-14(17)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,19H,3-5,10-12H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM82071
PNG
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
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n/an/a 100n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010867
PNG
(1-[1-(3-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1cccc(Br)c1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24BrNO/c1-18(2)12-15(13-7-6-8-14(17)11-13)16(19)9-4-3-5-10-16/h6-8,11,15,19H,3-5,9-10,12H2,1-2H3
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n/an/a 110n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010872
PNG
(1-[1-(4-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1ccc(Br)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24BrNO/c1-18(2)12-15(13-6-8-14(17)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,19H,3-5,10-12H2,1-2H3
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n/an/a 110n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010859
PNG
(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Show SMILES CN(C)CCCN1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
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n/an/a 120n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010862
PNG
(1-[2-Dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyc...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCC1
Show InChI InChI=1S/C16H25NO2/c1-17(2)12-15(16(18)10-4-5-11-16)13-6-8-14(19-3)9-7-13/h6-9,15,18H,4-5,10-12H2,1-3H3
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n/an/a 126n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010878
PNG
(1-[1-(3,4-Dimethoxy-phenyl)-2-dimethylamino-ethyl]...)
Show SMILES COc1ccc(cc1OC)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C18H29NO3/c1-19(2)13-15(18(20)10-6-5-7-11-18)14-8-9-16(21-3)17(12-14)22-4/h8-9,12,15,20H,5-7,10-11,13H2,1-4H3
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n/an/a 130n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM35229
PNG
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Show SMILES CNCCCN1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
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n/an/a 130n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010858
PNG
(1-(1-(3-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...)
Show SMILES CN(C)CC(c1cccc(Cl)c1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24ClNO/c1-18(2)12-15(13-7-6-8-14(17)11-13)16(19)9-4-3-5-10-16/h6-8,11,15,19H,3-5,9-10,12H2,1-2H3
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n/an/a 130n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010873
PNG
(1-[1-(3-Bromo-4-methoxy-phenyl)-2-dimethylamino-et...)
Show SMILES COc1ccc(cc1Br)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H26BrNO2/c1-19(2)12-14(17(20)9-5-4-6-10-17)13-7-8-16(21-3)15(18)11-13/h7-8,11,14,20H,4-6,9-10,12H2,1-3H3
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n/an/a 140n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM35229
PNG
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Show SMILES CNCCCN1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
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n/an/a 150n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010879
PNG
(1-(2-(dimethylamino)-1-(3-methoxyphenyl)ethyl)cycl...)
Show SMILES COc1cccc(c1)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)10-5-4-6-11-17)14-8-7-9-15(12-14)20-3/h7-9,12,16,19H,4-6,10-11,13H2,1-3H3
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n/an/a 150n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010858
PNG
(1-(1-(3-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...)
Show SMILES CN(C)CC(c1cccc(Cl)c1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24ClNO/c1-18(2)12-15(13-7-6-8-14(17)11-13)16(19)9-4-3-5-10-16/h6-8,11,15,19H,3-5,9-10,12H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010874
PNG
(1-(1-(4-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...)
Show SMILES CN(C)CC(c1ccc(Cl)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24ClNO/c1-18(2)12-15(13-6-8-14(17)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,19H,3-5,10-12H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM86748
PNG
(CAS_386750-22-7 | DESVENLAFAXINE | Desvenlafaxine ...)
Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010879
PNG
(1-(2-(dimethylamino)-1-(3-methoxyphenyl)ethyl)cycl...)
Show SMILES COc1cccc(c1)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)10-5-4-6-11-17)14-8-7-9-15(12-14)20-3/h7-9,12,16,19H,4-6,10-11,13H2,1-3H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010873
PNG
(1-[1-(3-Bromo-4-methoxy-phenyl)-2-dimethylamino-et...)
Show SMILES COc1ccc(cc1Br)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H26BrNO2/c1-19(2)12-14(17(20)9-5-4-6-10-17)13-7-8-16(21-3)15(18)11-13/h7-8,11,14,20H,4-6,9-10,12H2,1-3H3
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n/an/a 190n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010873
PNG
(1-[1-(3-Bromo-4-methoxy-phenyl)-2-dimethylamino-et...)
Show SMILES COc1ccc(cc1Br)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H26BrNO2/c1-19(2)12-14(17(20)9-5-4-6-10-17)13-7-8-16(21-3)15(18)11-13/h7-8,11,14,20H,4-6,9-10,12H2,1-3H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010880
PNG
(1-(2-Dimethylamino-1-p-tolyl-ethyl)-cyclohexanol (...)
Show SMILES CN(C)CC(c1ccc(C)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO/c1-14-7-9-15(10-8-14)16(13-18(2)3)17(19)11-5-4-6-12-17/h7-10,16,19H,4-6,11-13H2,1-3H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010872
PNG
(1-[1-(4-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1ccc(Br)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24BrNO/c1-18(2)12-15(13-6-8-14(17)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,19H,3-5,10-12H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010867
PNG
(1-[1-(3-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1cccc(Br)c1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24BrNO/c1-18(2)12-15(13-7-6-8-14(17)11-13)16(19)9-4-3-5-10-16/h6-8,11,15,19H,3-5,9-10,12H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010864
PNG
(1-[2-Dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyc...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCCC1
Show InChI InChI=1S/C18H29NO2/c1-19(2)14-17(15-8-10-16(21-3)11-9-15)18(20)12-6-4-5-7-13-18/h8-11,17,20H,4-7,12-14H2,1-3H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010887
PNG
(1-[1-(2-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1ccccc1Br)C1(O)CCCCC1
Show InChI InChI=1S/C16H24BrNO/c1-18(2)12-14(13-8-4-5-9-15(13)17)16(19)10-6-3-7-11-16/h4-5,8-9,14,19H,3,6-7,10-12H2,1-2H3
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n/an/a 260n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010859
PNG
(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Show SMILES CN(C)CCCN1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010863
PNG
(1-(2-Dimethylamino-1-phenyl-ethyl)-cyclohexanol (H...)
Show SMILES CN(C)CC(c1ccccc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H25NO/c1-17(2)13-15(14-9-5-3-6-10-14)16(18)11-7-4-8-12-16/h3,5-6,9-10,15,18H,4,7-8,11-13H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010864
PNG
(1-[2-Dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyc...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCCC1
Show InChI InChI=1S/C18H29NO2/c1-19(2)14-17(15-8-10-16(21-3)11-9-15)18(20)12-6-4-5-7-13-18/h8-11,17,20H,4-7,12-14H2,1-3H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010874
PNG
(1-(1-(4-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...)
Show SMILES CN(C)CC(c1ccc(Cl)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24ClNO/c1-18(2)12-15(13-6-8-14(17)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,19H,3-5,10-12H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50367952
PNG
(CHEMBL1628258 | N-Desmethylvenlafaxine)
Show SMILES CNCC(c1ccc(OC)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H25NO2/c1-17-12-15(16(18)10-4-3-5-11-16)13-6-8-14(19-2)9-7-13/h6-9,15,17-18H,3-5,10-12H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010858
PNG
(1-(1-(3-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...)
Show SMILES CN(C)CC(c1cccc(Cl)c1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24ClNO/c1-18(2)12-15(13-7-6-8-14(17)11-13)16(19)9-4-3-5-10-16/h6-8,11,15,19H,3-5,9-10,12H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010884
PNG
(1-(2-(dimethylamino)-1-(3-(trifluoromethyl)phenyl)...)
Show SMILES CN(C)CC(c1cccc(c1)C(F)(F)F)C1(O)CCCCC1
Show InChI InChI=1S/C17H24F3NO/c1-21(2)12-15(16(22)9-4-3-5-10-16)13-7-6-8-14(11-13)17(18,19)20/h6-8,11,15,22H,3-5,9-10,12H2,1-2H3
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n/an/a 360n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010884
PNG
(1-(2-(dimethylamino)-1-(3-(trifluoromethyl)phenyl)...)
Show SMILES CN(C)CC(c1cccc(c1)C(F)(F)F)C1(O)CCCCC1
Show InChI InChI=1S/C17H24F3NO/c1-21(2)12-15(16(22)9-4-3-5-10-16)13-7-6-8-14(11-13)17(18,19)20/h6-8,11,15,22H,3-5,9-10,12H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010862
PNG
(1-[2-Dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyc...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCC1
Show InChI InChI=1S/C16H25NO2/c1-17(2)12-15(16(18)10-4-5-11-16)13-6-8-14(19-3)9-7-13/h6-9,15,18H,4-5,10-12H2,1-3H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010877
PNG
(1-[2-Dimethylamino-1-(4-trifluoromethyl-phenyl)-et...)
Show SMILES CN(C)CC(c1ccc(cc1)C(F)(F)F)C1(O)CCCCC1
Show InChI InChI=1S/C17H24F3NO/c1-21(2)12-15(16(22)10-4-3-5-11-16)13-6-8-14(9-7-13)17(18,19)20/h6-9,15,22H,3-5,10-12H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010876
PNG
(1-[1-(4-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1ccc(Br)cc1)C1(O)CCC1
Show InChI InChI=1S/C14H20BrNO/c1-16(2)10-13(14(17)8-3-9-14)11-4-6-12(15)7-5-11/h4-7,13,17H,3,8-10H2,1-2H3
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n/an/a 435n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010881
PNG
(1-[2-Dimethylamino-1-(4-trifluoromethyl-phenyl)-et...)
Show SMILES CN(C)CC(c1ccc(cc1)C(F)(F)F)C1(O)CCCC1
Show InChI InChI=1S/C16H22F3NO/c1-20(2)11-14(15(21)9-3-4-10-15)12-5-7-13(8-6-12)16(17,18)19/h5-8,14,21H,3-4,9-11H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010871
PNG
(1-[2-Dimethylamino-1-(4-trifluoromethyl-phenyl)-et...)
Show SMILES CN(C)CC(c1ccc(cc1)C(F)(F)F)C1(O)CCCCCC1
Show InChI InChI=1S/C18H26F3NO/c1-22(2)13-16(17(23)11-5-3-4-6-12-17)14-7-9-15(10-8-14)18(19,20)21/h7-10,16,23H,3-6,11-13H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010860
PNG
(1-(1-(2-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...)
Show SMILES CN(C)CC(c1ccccc1Cl)C1(O)CCCCC1
Show InChI InChI=1S/C16H24ClNO/c1-18(2)12-14(13-8-4-5-9-15(13)17)16(19)10-6-3-7-11-16/h4-5,8-9,14,19H,3,6-7,10-12H2,1-2H3
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010880
PNG
(1-(2-Dimethylamino-1-p-tolyl-ethyl)-cyclohexanol (...)
Show SMILES CN(C)CC(c1ccc(C)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO/c1-14-7-9-15(10-8-14)16(13-18(2)3)17(19)11-5-4-6-12-17/h7-10,16,19H,4-6,11-13H2,1-3H3
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n/an/a 530n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010876
PNG
(1-[1-(4-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1ccc(Br)cc1)C1(O)CCC1
Show InChI InChI=1S/C14H20BrNO/c1-16(2)10-13(14(17)8-3-9-14)11-4-6-12(15)7-5-11/h4-7,13,17H,3,8-10H2,1-2H3
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n/an/a 580n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010879
PNG
(1-(2-(dimethylamino)-1-(3-methoxyphenyl)ethyl)cycl...)
Show SMILES COc1cccc(c1)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)10-5-4-6-11-17)14-8-7-9-15(12-14)20-3/h7-9,12,16,19H,4-6,10-11,13H2,1-3H3
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n/an/a 620n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM82071
PNG
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
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n/an/a 640n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010866
PNG
(1-[2-Dimethylamino-1-(3-methoxy-phenyl)-ethyl]-cyc...)
Show SMILES COc1cccc(c1)C(CN(C)C)C1(O)CCCC1
Show InChI InChI=1S/C16H25NO2/c1-17(2)12-15(16(18)9-4-5-10-16)13-7-6-8-14(11-13)19-3/h6-8,11,15,18H,4-5,9-10,12H2,1-3H3
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n/an/a 680n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010878
PNG
(1-[1-(3,4-Dimethoxy-phenyl)-2-dimethylamino-ethyl]...)
Show SMILES COc1ccc(cc1OC)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C18H29NO3/c1-19(2)13-15(18(20)10-6-5-7-11-18)14-8-9-16(21-3)17(12-14)22-4/h8-9,12,15,20H,5-7,10-11,13H2,1-4H3
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n/an/a 700n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM82071
PNG
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
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n/an/a 760n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010876
PNG
(1-[1-(4-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1ccc(Br)cc1)C1(O)CCC1
Show InChI InChI=1S/C14H20BrNO/c1-16(2)10-13(14(17)8-3-9-14)11-4-6-12(15)7-5-11/h4-7,13,17H,3,8-10H2,1-2H3
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n/an/a 890n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010888
PNG
(1-[2-Amino-1-(4-methoxy-phenyl)-ethyl]-cyclohexano...)
Show SMILES COc1ccc(cc1)C(CN)C1(O)CCCCC1
Show InChI InChI=1S/C15H23NO2/c1-18-13-7-5-12(6-8-13)14(11-16)15(17)9-3-2-4-10-15/h5-8,14,17H,2-4,9-11,16H2,1H3
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n/an/a 900n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM86748
PNG
(CAS_386750-22-7 | DESVENLAFAXINE | Desvenlafaxine ...)
Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3
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n/an/a 1.16E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010878
PNG
(1-[1-(3,4-Dimethoxy-phenyl)-2-dimethylamino-ethyl]...)
Show SMILES COc1ccc(cc1OC)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C18H29NO3/c1-19(2)13-15(18(20)10-6-5-7-11-18)14-8-9-16(21-3)17(12-14)22-4/h8-9,12,15,20H,5-7,10-11,13H2,1-4H3
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n/an/a 1.38E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010884
PNG
(1-(2-(dimethylamino)-1-(3-(trifluoromethyl)phenyl)...)
Show SMILES CN(C)CC(c1cccc(c1)C(F)(F)F)C1(O)CCCCC1
Show InChI InChI=1S/C17H24F3NO/c1-21(2)12-15(16(22)9-4-3-5-10-16)13-7-6-8-14(11-13)17(18,19)20/h6-8,11,15,22H,3-5,9-10,12H2,1-2H3
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n/an/a 1.44E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010880
PNG
(1-(2-Dimethylamino-1-p-tolyl-ethyl)-cyclohexanol (...)
Show SMILES CN(C)CC(c1ccc(C)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO/c1-14-7-9-15(10-8-14)16(13-18(2)3)17(19)11-5-4-6-12-17/h7-10,16,19H,4-6,11-13H2,1-3H3
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n/an/a 1.54E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50367952
PNG
(CHEMBL1628258 | N-Desmethylvenlafaxine)
Show SMILES CNCC(c1ccc(OC)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H25NO2/c1-17-12-15(16(18)10-4-3-5-11-16)13-6-8-14(19-2)9-7-13/h6-9,15,17-18H,3-5,10-12H2,1-2H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010863
PNG
(1-(2-Dimethylamino-1-phenyl-ethyl)-cyclohexanol (H...)
Show SMILES CN(C)CC(c1ccccc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H25NO/c1-17(2)13-15(14-9-5-3-6-10-14)16(18)11-7-4-8-12-16/h3,5-6,9-10,15,18H,4,7-8,11-13H2,1-2H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010864
PNG
(1-[2-Dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyc...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCCC1
Show InChI InChI=1S/C18H29NO2/c1-19(2)14-17(15-8-10-16(21-3)11-9-15)18(20)12-6-4-5-7-13-18/h8-11,17,20H,4-7,12-14H2,1-3H3
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n/an/a 2.07E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010871
PNG
(1-[2-Dimethylamino-1-(4-trifluoromethyl-phenyl)-et...)
Show SMILES CN(C)CC(c1ccc(cc1)C(F)(F)F)C1(O)CCCCCC1
Show InChI InChI=1S/C18H26F3NO/c1-22(2)13-16(17(23)11-5-3-4-6-12-17)14-7-9-15(10-8-14)18(19,20)21/h7-10,16,23H,3-6,11-13H2,1-2H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010863
PNG
(1-(2-Dimethylamino-1-phenyl-ethyl)-cyclohexanol (H...)
Show SMILES CN(C)CC(c1ccccc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H25NO/c1-17(2)13-15(14-9-5-3-6-10-14)16(18)11-7-4-8-12-16/h3,5-6,9-10,15,18H,4,7-8,11-13H2,1-2H3
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n/an/a 2.58E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010877
PNG
(1-[2-Dimethylamino-1-(4-trifluoromethyl-phenyl)-et...)
Show SMILES CN(C)CC(c1ccc(cc1)C(F)(F)F)C1(O)CCCCC1
Show InChI InChI=1S/C17H24F3NO/c1-21(2)12-15(16(22)10-4-3-5-11-16)13-6-8-14(9-7-13)17(18,19)20/h6-9,15,22H,3-5,10-12H2,1-2H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM35229
PNG
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Show SMILES CNCCCN1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50367952
PNG
(CHEMBL1628258 | N-Desmethylvenlafaxine)
Show SMILES CNCC(c1ccc(OC)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H25NO2/c1-17-12-15(16(18)10-4-3-5-11-16)13-6-8-14(19-2)9-7-13/h6-9,15,17-18H,3-5,10-12H2,1-2H3
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n/an/a 4.70E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010862
PNG
(1-[2-Dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyc...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCC1
Show InChI InChI=1S/C16H25NO2/c1-17(2)12-15(16(18)10-4-5-11-16)13-6-8-14(19-3)9-7-13/h6-9,15,18H,4-5,10-12H2,1-3H3
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n/an/a 5.80E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010885
PNG
(1-[1-(4-Methoxy-phenyl)-2-morpholin-4-yl-ethyl]-cy...)
Show SMILES COc1ccc(cc1)C(CN1CCOCC1)C1(O)CCCCC1
Show InChI InChI=1S/C19H29NO3/c1-22-17-7-5-16(6-8-17)18(15-20-11-13-23-14-12-20)19(21)9-3-2-4-10-19/h5-8,18,21H,2-4,9-15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010889
PNG
(1-[2-Dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyc...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCCCC1
Show InChI InChI=1S/C19H31NO2/c1-20(2)15-18(16-9-11-17(22-3)12-10-16)19(21)13-7-5-4-6-8-14-19/h9-12,18,21H,4-8,13-15H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010883
PNG
(1-[1-(4-Amino-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1ccc(N)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H26N2O/c1-18(2)12-15(13-6-8-14(17)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,19H,3-5,10-12,17H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010866
PNG
(1-[2-Dimethylamino-1-(3-methoxy-phenyl)-ethyl]-cyc...)
Show SMILES COc1cccc(c1)C(CN(C)C)C1(O)CCCC1
Show InChI InChI=1S/C16H25NO2/c1-17(2)12-15(16(18)9-4-5-10-16)13-7-6-8-14(11-13)19-3/h6-8,11,15,18H,4-5,9-10,12H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010890
PNG
(1-[1-(4-Methoxy-phenyl)-2-piperidin-1-yl-ethyl]-cy...)
Show SMILES COc1ccc(cc1)C(CN1CCCCC1)C1(O)CCCCC1
Show InChI InChI=1S/C20H31NO2/c1-23-18-10-8-17(9-11-18)19(16-21-14-6-3-7-15-21)20(22)12-4-2-5-13-20/h8-11,19,22H,2-7,12-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010861
PNG
(2-[2-Dimethylamino-1-(1-hydroxy-cyclohexyl)-ethyl]...)
Show SMILES CN(C)CC(c1ccccc1O)C1(O)CCCCC1
Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14(13-8-4-5-9-15(13)18)16(19)10-6-3-7-11-16/h4-5,8-9,14,18-19H,3,6-7,10-12H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010886
PNG
(1-[1-(4-Methoxy-phenyl)-2-pyrrolidin-1-yl-ethyl]-c...)
Show SMILES COc1ccc(cc1)C(CN1CCCC1)C1(O)CCCCC1
Show InChI InChI=1S/C19H29NO2/c1-22-17-9-7-16(8-10-17)18(15-20-13-5-6-14-20)19(21)11-3-2-4-12-19/h7-10,18,21H,2-6,11-15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010881
PNG
(1-[2-Dimethylamino-1-(4-trifluoromethyl-phenyl)-et...)
Show SMILES CN(C)CC(c1ccc(cc1)C(F)(F)F)C1(O)CCCC1
Show InChI InChI=1S/C16H22F3NO/c1-20(2)11-14(15(21)9-3-4-10-15)12-5-7-13(8-6-12)16(17,18)19/h5-8,14,21H,3-4,9-11H2,1-2H3
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n/an/a 1.04E+4n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010865
PNG
(1-[2-Dimethylamino-1-(4-nitro-phenyl)-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1ccc(cc1)[N+]([O-])=O)C1(O)CCCCC1
Show InChI InChI=1S/C16H24N2O3/c1-17(2)12-15(16(19)10-4-3-5-11-16)13-6-8-14(9-7-13)18(20)21/h6-9,15,19H,3-5,10-12H2,1-2H3
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n/an/a 2.50E+5n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%