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PubMed code 1977909

Compile data set for download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50017674
PNG
((2-Benzhydryloxy-ethyl)-dimethyl-amine | 2-(benzhy...)
Show SMILES CN(C)CCOC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3
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n/an/a 1n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406154
PNG
(CHEMBL100442)
Show SMILES ClN1CCN2Cc3[nH]c4ccccc4c3CC2C1
Show InChI InChI=1S/C14H16ClN3/c15-18-6-5-17-9-14-12(7-10(17)8-18)11-3-1-2-4-13(11)16-14/h1-4,10,16H,5-9H2
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n/an/a 206n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406141
PNG
(CHEMBL321104)
Show SMILES CN1CCN2Cc3[nH]c4ccccc4c3CC2C1
Show InChI InChI=1S/C15H19N3/c1-17-6-7-18-10-15-13(8-11(18)9-17)12-4-2-3-5-14(12)16-15/h2-5,11,16H,6-10H2,1H3
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n/an/a 283n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406166
PNG
(CHEMBL100858)
Show SMILES Ic1ccccc1C(=O)NCCN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H24IN3O/c21-19-9-5-4-8-18(19)20(25)22-10-11-23-12-14-24(15-13-23)16-17-6-2-1-3-7-17/h1-9H,10-16H2,(H,22,25)
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n/an/a 345n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406167
PNG
(CHEMBL101490)
Show SMILES CON1CCN2Cc3[nH]c4ccccc4c3CC2C1
Show InChI InChI=1S/C15H19N3O/c1-19-18-7-6-17-10-15-13(8-11(17)9-18)12-4-2-3-5-14(12)16-15/h2-5,11,16H,6-10H2,1H3
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n/an/a 364n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406161
PNG
(CHEMBL97938)
Show SMILES [O-][N+](=O)N1CCN2Cc3[nH]c4ccccc4c3CC2C1
Show InChI InChI=1S/C14H16N4O2/c19-18(20)17-6-5-16-9-14-12(7-10(16)8-17)11-3-1-2-4-13(11)15-14/h1-4,10,15H,5-9H2
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n/an/a 375n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406147
PNG
(CHEMBL319123)
Show SMILES Brc1ccccc1C(=O)NCCN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H24BrN3O/c21-19-9-5-4-8-18(19)20(25)22-10-11-23-12-14-24(15-13-23)16-17-6-2-1-3-7-17/h1-9H,10-16H2,(H,22,25)
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n/an/a 421n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406156
PNG
(CHEMBL101973)
Show SMILES CCc1ccccc1NC(=O)CCN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H30N2O/c1-2-21-10-6-7-11-22(21)24-23(26)14-17-25-15-12-20(13-16-25)18-19-8-4-3-5-9-19/h3-11,20H,2,12-18H2,1H3,(H,24,26)
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n/an/a 477n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406164
PNG
(CHEMBL421393)
Show SMILES CCc1ccccc1NC(=O)CCN1CCN2Cc3ccccc3CC2C1
Show InChI InChI=1S/C23H29N3O/c1-2-18-7-5-6-10-22(18)24-23(27)11-12-25-13-14-26-16-20-9-4-3-8-19(20)15-21(26)17-25/h3-10,21H,2,11-17H2,1H3,(H,24,27)
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n/an/a 525n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406149
PNG
(CHEMBL101491)
Show SMILES C1CN2Cc3[nH]c4ccccc4c3CC2CN1
Show InChI InChI=1S/C14H17N3/c1-2-4-13-11(3-1)12-7-10-8-15-5-6-17(10)9-14(12)16-13/h1-4,10,15-16H,5-9H2
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n/an/a 535n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406140
PNG
(CHEMBL100276)
Show SMILES Clc1ccccc1NC(=O)CCN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H25ClN2O/c22-19-8-4-5-9-20(19)23-21(25)12-15-24-13-10-18(11-14-24)16-17-6-2-1-3-7-17/h1-9,18H,10-16H2,(H,23,25)
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n/an/a 561n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406153
PNG
(CHEMBL101625)
Show SMILES CCc1ccccc1NC(=O)CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1
Show InChI InChI=1S/C25H30N4O/c1-2-18-7-3-5-9-22(18)27-25(30)11-12-28-13-14-29-17-24-21(15-19(29)16-28)20-8-4-6-10-23(20)26-24/h3-10,19,26H,2,11-17H2,1H3,(H,27,30)
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n/an/a 634n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406142
PNG
(CHEMBL100125)
Show SMILES Brc1ccccc1C(=O)NCCN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H25BrN2O/c22-20-9-5-4-8-19(20)21(25)23-12-15-24-13-10-18(11-14-24)16-17-6-2-1-3-7-17/h1-9,18H,10-16H2,(H,23,25)
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n/an/a 661n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406148
PNG
(CHEMBL319817)
Show SMILES Clc1ccccc1NC(=O)CCN1CCN2Cc3ccccc3CC2C1
Show InChI InChI=1S/C21H24ClN3O/c22-19-7-3-4-8-20(19)23-21(26)9-10-24-11-12-25-14-17-6-2-1-5-16(17)13-18(25)15-24/h1-8,18H,9-15H2,(H,23,26)
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n/an/a 677n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406152
PNG
(CHEMBL321738)
Show SMILES Clc1ccccc1C(=O)NCCN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H24ClN3O/c21-19-9-5-4-8-18(19)20(25)22-10-11-23-12-14-24(15-13-23)16-17-6-2-1-3-7-17/h1-9H,10-16H2,(H,22,25)
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n/an/a 696n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406145
PNG
(CHEMBL101088)
Show SMILES CCc1ccccc1NC(=O)CCN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H29N3O/c1-2-20-10-6-7-11-21(20)23-22(26)12-13-24-14-16-25(17-15-24)18-19-8-4-3-5-9-19/h3-11H,2,12-18H2,1H3,(H,23,26)
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n/an/a 778n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406139
PNG
(CHEMBL101758)
Show SMILES Clc1ccccc1C(=O)NCCN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H25ClN2O/c22-20-9-5-4-8-19(20)21(25)23-12-15-24-13-10-18(11-14-24)16-17-6-2-1-3-7-17/h1-9,18H,10-16H2,(H,23,25)
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n/an/a 799n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406146
PNG
(CHEMBL101133)
Show SMILES Fc1ccccc1NC(=O)CCN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H25FN2O/c22-19-8-4-5-9-20(19)23-21(25)12-15-24-13-10-18(11-14-24)16-17-6-2-1-3-7-17/h1-9,18H,10-16H2,(H,23,25)
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n/an/a 832n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406143
PNG
(CHEMBL101387)
Show SMILES Clc1ccccc1NC(=O)CCN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H24ClN3O/c21-18-8-4-5-9-19(18)22-20(25)10-11-23-12-14-24(15-13-23)16-17-6-2-1-3-7-17/h1-9H,10-16H2,(H,22,25)
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n/an/a 836n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406150
PNG
(CHEMBL327724)
Show SMILES NN1CCN2Cc3[nH]c4ccccc4c3CC2C1
Show InChI InChI=1S/C14H18N4/c15-18-6-5-17-9-14-12(7-10(17)8-18)11-3-1-2-4-13(11)16-14/h1-4,10,16H,5-9,15H2
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n/an/a 925n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406169
PNG
(CHEMBL327517)
Show SMILES COc1ccccc1NC(=O)CCN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H28N2O2/c1-26-21-10-6-5-9-20(21)23-22(25)13-16-24-14-11-19(12-15-24)17-18-7-3-2-4-8-18/h2-10,19H,11-17H2,1H3,(H,23,25)
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n/an/a 963n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406155
PNG
(CHEMBL101217)
Show SMILES Clc1ccccc1NC(=O)CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1
Show InChI InChI=1S/C23H25ClN4O/c24-19-6-2-4-8-21(19)26-23(29)9-10-27-11-12-28-15-22-18(13-16(28)14-27)17-5-1-3-7-20(17)25-22/h1-8,16,25H,9-15H2,(H,26,29)
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n/an/a 979n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406158
PNG
(CHEMBL101790)
Show SMILES Cc1ccccc1C(=O)NCCN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H28N2O/c1-18-7-5-6-10-21(18)22(25)23-13-16-24-14-11-20(12-15-24)17-19-8-3-2-4-9-19/h2-10,20H,11-17H2,1H3,(H,23,25)
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n/an/a 1.07E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406162
PNG
(CHEMBL101029)
Show SMILES Fc1ccccc1NC(=O)CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1
Show InChI InChI=1S/C23H25FN4O/c24-19-6-2-4-8-21(19)26-23(29)9-10-27-11-12-28-15-22-18(13-16(28)14-27)17-5-1-3-7-20(17)25-22/h1-8,16,25H,9-15H2,(H,26,29)
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n/an/a 1.28E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406159
PNG
(CHEMBL100169)
Show SMILES [O-][N+](=O)c1ccccc1NC(=O)CCN1CCN2Cc3ccccc3CC2C1
Show InChI InChI=1S/C21H24N4O3/c26-21(22-19-7-3-4-8-20(19)25(27)28)9-10-23-11-12-24-14-17-6-2-1-5-16(17)13-18(24)15-23/h1-8,18H,9-15H2,(H,22,26)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406170
PNG
(CHEMBL101312)
Show SMILES Fc1ccccc1NC(=O)CCN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H24FN3O/c21-18-8-4-5-9-19(18)22-20(25)10-11-23-12-14-24(15-13-23)16-17-6-2-1-3-7-17/h1-9H,10-16H2,(H,22,25)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406163
PNG
(CHEMBL100695)
Show SMILES [O-][N+](=O)c1ccccc1C(=O)NCCN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H24N4O3/c25-20(18-8-4-5-9-19(18)24(26)27)21-10-11-22-12-14-23(15-13-22)16-17-6-2-1-3-7-17/h1-9H,10-16H2,(H,21,25)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406144
PNG
(CHEMBL100064)
Show SMILES O=C(CCN1CCN2Cc3ccccc3CC2C1)Nc1ccccc1
Show InChI InChI=1S/C21H25N3O/c25-21(22-19-8-2-1-3-9-19)10-11-23-12-13-24-15-18-7-5-4-6-17(18)14-20(24)16-23/h1-9,20H,10-16H2,(H,22,25)
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n/an/a 1.34E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406168
PNG
(CHEMBL103303)
Show SMILES O=C(CCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1
Show InChI InChI=1S/C21H26N2O/c24-21(22-20-9-5-2-6-10-20)13-16-23-14-11-19(12-15-23)17-18-7-3-1-4-8-18/h1-10,19H,11-17H2,(H,22,24)
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n/an/a 1.51E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406151
PNG
(CHEMBL101388)
Show SMILES O=C(NCCN1CCC(Cc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C21H26N2O/c24-21(20-9-5-2-6-10-20)22-13-16-23-14-11-19(12-15-23)17-18-7-3-1-4-8-18/h1-10,19H,11-17H2,(H,22,24)
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n/an/a 1.55E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406165
PNG
(CHEMBL100865)
Show SMILES O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1
Show InChI InChI=1S/C23H26N4O/c28-23(24-17-6-2-1-3-7-17)10-11-26-12-13-27-16-22-20(14-18(27)15-26)19-8-4-5-9-21(19)25-22/h1-9,18,25H,10-16H2,(H,24,28)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406160
PNG
(CHEMBL101122)
Show SMILES [O-][N+](=O)c1ccccc1NC(=O)CCN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H24N4O3/c25-20(21-18-8-4-5-9-19(18)24(26)27)10-11-22-12-14-23(15-13-22)16-17-6-2-1-3-7-17/h1-9H,10-16H2,(H,21,25)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406138
PNG
(CHEMBL100170)
Show SMILES [O-][N+](=O)c1ccccc1NC(=O)CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1
Show InChI InChI=1S/C23H25N5O3/c29-23(25-20-7-3-4-8-22(20)28(30)31)9-10-26-11-12-27-15-21-18(13-16(27)14-26)17-5-1-2-6-19(17)24-21/h1-8,16,24H,9-15H2,(H,25,29)
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n/an/a 1.74E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406157
PNG
(CHEMBL316616)
Show SMILES O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1
Show InChI InChI=1S/C20H25N3O/c24-20(21-19-9-5-2-6-10-19)11-12-22-13-15-23(16-14-22)17-18-7-3-1-4-8-18/h1-10H,11-17H2,(H,21,24)
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n/an/a 2.17E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406171
PNG
(CHEMBL101927)
Show SMILES O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C20H25N3O/c24-20(19-9-5-2-6-10-19)21-11-12-22-13-15-23(16-14-22)17-18-7-3-1-4-8-18/h1-10H,11-17H2,(H,21,24)
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n/an/a 6.94E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406137
PNG
(CHEMBL328170)
Show SMILES Cc1ccccc1C(=O)NCCN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H27N3O/c1-18-7-5-6-10-20(18)21(25)22-11-12-23-13-15-24(16-14-23)17-19-8-3-2-4-9-19/h2-10H,11-17H2,1H3,(H,22,25)
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n/an/a 7.12E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%