BindingDB logo
myBDB logout

PubMed code 19807124

Compile data set for download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tryrosine-Protein Kinase (HCK) + Protein Nef (NEF)


(Homo sapiens (Human)-Human immunodeficiency virus ...)
BDBM36545
PNG
(DFP-4APF | diphenylfuropyrimidine-4-aminopropylfur...)
Show SMILES C(CNc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1)Cc1ccco1
Show InChI InChI=1S/C25H21N3O2/c1-3-9-18(10-4-1)21-22-24(26-15-7-13-20-14-8-16-29-20)27-17-28-25(22)30-23(21)19-11-5-2-6-12-19/h1-6,8-12,14,16-17H,7,13,15H2,(H,26,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/a25



University of Pittsburgh School of Medicine



Assay Description
In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.


ACS Chem Biol 4: 939-47 (2009)


Article DOI: 10.1021/cb900195c
BindingDB Entry DOI: 10.7270/Q2PG1Q32
More data for this
Ligand-Target Pair
Tryrosine-Protein Kinase (HCK) + Protein Nef (NEF)


(Homo sapiens (Human)-Human immunodeficiency virus ...)
BDBM14807
PNG
(3-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-pr...)
Show SMILES OCCCNc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C21H19N3O2/c25-13-7-12-22-20-18-17(15-8-3-1-4-9-15)19(16-10-5-2-6-11-16)26-21(18)24-14-23-20/h1-6,8-11,14,25H,7,12-13H2,(H,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5.10E+3n/an/an/an/an/a25



University of Pittsburgh School of Medicine



Assay Description
In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.


ACS Chem Biol 4: 939-47 (2009)


Article DOI: 10.1021/cb900195c
BindingDB Entry DOI: 10.7270/Q2PG1Q32
More data for this
Ligand-Target Pair
Tyrosine-protein kinase HCK


(Homo sapiens (Human))
BDBM14807
PNG
(3-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-pr...)
Show SMILES OCCCNc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C21H19N3O2/c25-13-7-12-22-20-18-17(15-8-3-1-4-9-15)19(16-10-5-2-6-11-16)26-21(18)24-14-23-20/h1-6,8-11,14,25H,7,12-13H2,(H,22,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.28E+4n/an/an/an/an/a25



University of Pittsburgh School of Medicine



Assay Description
In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.


ACS Chem Biol 4: 939-47 (2009)


Article DOI: 10.1021/cb900195c
BindingDB Entry DOI: 10.7270/Q2PG1Q32
More data for this
Ligand-Target Pair
Tryrosine-Protein Kinase (HCK) + Protein Nef (NEF)


(Homo sapiens (Human)-Human immunodeficiency virus ...)
BDBM36544
PNG
(DFP-4AB | Diphenylfuropyrimidine-4-aminobutanol)
Show SMILES OCCCCNc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C22H21N3O2/c26-14-8-7-13-23-21-19-18(16-9-3-1-4-10-16)20(17-11-5-2-6-12-17)27-22(19)25-15-24-21/h1-6,9-12,15,26H,7-8,13-14H2,(H,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.60E+4n/an/an/an/an/a25



University of Pittsburgh School of Medicine



Assay Description
In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.


ACS Chem Biol 4: 939-47 (2009)


Article DOI: 10.1021/cb900195c
BindingDB Entry DOI: 10.7270/Q2PG1Q32
More data for this
Ligand-Target Pair
Tyrosine-protein kinase HCK


(Homo sapiens (Human))
BDBM14806
PNG
(5,6-Diphenyl-furo[2,3-d]pyrimidin-4 -ylamine | 5,6...)
Show SMILES Nc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C18H13N3O/c19-17-15-14(12-7-3-1-4-8-12)16(13-9-5-2-6-10-13)22-18(15)21-11-20-17/h1-11H,(H2,19,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/a25



University of Pittsburgh School of Medicine



Assay Description
In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.


ACS Chem Biol 4: 939-47 (2009)


Article DOI: 10.1021/cb900195c
BindingDB Entry DOI: 10.7270/Q2PG1Q32
More data for this
Ligand-Target Pair
Tyrosine-protein kinase HCK


(Homo sapiens (Human))
BDBM36544
PNG
(DFP-4AB | Diphenylfuropyrimidine-4-aminobutanol)
Show SMILES OCCCCNc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C22H21N3O2/c26-14-8-7-13-23-21-19-18(16-9-3-1-4-10-16)20(17-11-5-2-6-12-17)27-22(19)25-15-24-21/h1-6,9-12,15,26H,7-8,13-14H2,(H,23,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/a25



University of Pittsburgh School of Medicine



Assay Description
In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.


ACS Chem Biol 4: 939-47 (2009)


Article DOI: 10.1021/cb900195c
BindingDB Entry DOI: 10.7270/Q2PG1Q32
More data for this
Ligand-Target Pair
Tyrosine-protein kinase HCK


(Homo sapiens (Human))
BDBM36545
PNG
(DFP-4APF | diphenylfuropyrimidine-4-aminopropylfur...)
Show SMILES C(CNc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1)Cc1ccco1
Show InChI InChI=1S/C25H21N3O2/c1-3-9-18(10-4-1)21-22-24(26-15-7-13-20-14-8-16-29-20)27-17-28-25(22)30-23(21)19-11-5-2-6-12-19/h1-6,8-12,14,16-17H,7,13,15H2,(H,26,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/a25



University of Pittsburgh School of Medicine



Assay Description
In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.


ACS Chem Biol 4: 939-47 (2009)


Article DOI: 10.1021/cb900195c
BindingDB Entry DOI: 10.7270/Q2PG1Q32
More data for this
Ligand-Target Pair
Tryrosine-Protein Kinase (HCK) + Protein Nef (NEF)


(Homo sapiens (Human)-Human immunodeficiency virus ...)
BDBM14806
PNG
(5,6-Diphenyl-furo[2,3-d]pyrimidin-4 -ylamine | 5,6...)
Show SMILES Nc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C18H13N3O/c19-17-15-14(12-7-3-1-4-8-12)16(13-9-5-2-6-10-13)22-18(15)21-11-20-17/h1-11H,(H2,19,20,21)
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/a25



University of Pittsburgh School of Medicine



Assay Description
In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.


ACS Chem Biol 4: 939-47 (2009)


Article DOI: 10.1021/cb900195c
BindingDB Entry DOI: 10.7270/Q2PG1Q32
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%