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PubMed code 19856955

Compile data set for download or QSAR
Found 2 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50312003
PNG
(CHEMBL1079947 | Lorneic acid A)
Show SMILES CCCC\C=C\c1cc(C)ccc1\C=C\CC(O)=O
Show InChI InChI=1S/C17H22O2/c1-3-4-5-6-8-16-13-14(2)11-12-15(16)9-7-10-17(18)19/h6-9,11-13H,3-5,10H2,1-2H3,(H,18,19)/b8-6+,9-7+
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.26E+4n/an/an/an/an/an/a



Nippon Suisan Kaisha, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as [3H]cGMP to [3H]GMP conversion pretreated 15 mins before substrate addition measured after 20 mins


J Nat Prod 72: 2046-8 (2009)


Article DOI: 10.1021/np900353y
BindingDB Entry DOI: 10.7270/Q22F7NM9
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50312004
PNG
(CHEMBL1079948 | Lorneic acid B)
Show SMILES CCCCCC(O)c1cc(C)ccc1\C=C\CC(O)=O
Show InChI InChI=1S/C17H24O3/c1-3-4-5-8-16(18)15-12-13(2)10-11-14(15)7-6-9-17(19)20/h6-7,10-12,16,18H,3-5,8-9H2,1-2H3,(H,19,20)/b7-6+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.71E+4n/an/an/an/an/an/a



Nippon Suisan Kaisha, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as [3H]cGMP to [3H]GMP conversion pretreated 15 mins before substrate addition measured after 20 mins


J Nat Prod 72: 2046-8 (2009)


Article DOI: 10.1021/np900353y
BindingDB Entry DOI: 10.7270/Q22F7NM9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%