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PubMed code 1992112

Compile data set for download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452955
PNG
(CHEMBL36271)
Show SMILES Cn1cc(-c2noc(C[N+](C)(C)C)n2)c2ccccc12
Show InChI InChI=1S/C15H19N4O.HI/c1-18-9-12(11-7-5-6-8-13(11)18)15-16-14(20-17-15)10-19(2,3)4;/h5-9H,10H2,1-4H3;1H/q+1;/p-1
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n/an/a 0.708n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452944
PNG
(CHEMBL37444)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2C3)c2ccccc12
Show InChI InChI=1S/C17H18N4O/c1-20-9-14(12-4-2-3-5-15(12)20)16-18-17(22-19-16)13-10-21-7-6-11(13)8-21/h2-5,9,11,13H,6-8,10H2,1H3
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n/an/a 1.10n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50062446
PNG
(3-[3-(1-Methyl-1H-indol-3-yl)-[1,2,4]oxadiazol-5-y...)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2CC3)c2ccccc12
Show InChI InChI=1S/C18H20N4O/c1-21-10-15(13-4-2-3-5-16(13)21)17-19-18(23-20-17)14-11-22-8-6-12(14)7-9-22/h2-5,10,12,14H,6-9,11H2,1H3
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n/an/a 1.40n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM85330
PNG
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
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n/an/a 2n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for the displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 recognition sites in rat brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452961
PNG
(CHEMBL37802)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C17H18N4O/c1-2-4-15-12(3-1)13(9-18-15)16-19-17(22-20-16)14-10-21-7-5-11(14)6-8-21/h1-4,9,11,14,18H,5-8,10H2
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n/an/a 2.70n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452953
PNG
(CHEMBL284101)
Show SMILES Cn1cc(-c2noc(n2)C23CCN(CC2)CC3)c2ccccc12
Show InChI InChI=1S/C18H20N4O/c1-21-12-14(13-4-2-3-5-15(13)21)16-19-17(23-20-16)18-6-9-22(10-7-18)11-8-18/h2-5,12H,6-11H2,1H3
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n/an/a 4.30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452944
PNG
(CHEMBL37444)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2C3)c2ccccc12
Show InChI InChI=1S/C17H18N4O/c1-20-9-14(12-4-2-3-5-15(12)20)16-18-17(22-19-16)13-10-21-7-6-11(13)8-21/h2-5,9,11,13H,6-8,10H2,1H3
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n/an/a 7.60n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452966
PNG
(CHEMBL37500)
Show SMILES COc1cccc(c1)-c1noc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C16H19N3O2/c1-20-13-4-2-3-12(9-13)15-17-16(21-18-15)14-10-19-7-5-11(14)6-8-19/h2-4,9,11,14H,5-8,10H2,1H3
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n/an/a 13n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452959
PNG
(CHEMBL284523)
Show SMILES CN1CCC(CC1)c1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C17H20N4O/c1-20-9-7-12(8-10-20)17-18-16(19-22-17)14-11-21(2)15-6-4-3-5-13(14)15/h3-6,11-12H,7-10H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452945
PNG
(CHEMBL37360)
Show SMILES Cn1cc(-c2noc(n2)C2CC3CCC2NC3)c2ccccc12
Show InChI InChI=1S/C18H20N4O/c1-22-10-14(12-4-2-3-5-16(12)22)17-20-18(23-21-17)13-8-11-6-7-15(13)19-9-11/h2-5,10-11,13,15,19H,6-9H2,1H3
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n/an/a 13n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452952
PNG
(CHEMBL36808)
Show SMILES CN1CCCC(C1)c1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C17H20N4O/c1-20-9-5-6-12(10-20)17-18-16(19-22-17)14-11-21(2)15-8-4-3-7-13(14)15/h3-4,7-8,11-12H,5-6,9-10H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452931
PNG
(CHEMBL35212)
Show SMILES Cn1cc(-c2nsc(n2)C2CC3CCN2C3)c2ccccc12
Show InChI InChI=1S/C17H18N4S/c1-20-10-13(12-4-2-3-5-14(12)20)16-18-17(22-19-16)15-8-11-6-7-21(15)9-11/h2-5,10-11,15H,6-9H2,1H3
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n/an/a 14n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452963
PNG
(CHEMBL38310)
Show SMILES CN(C)CCc1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C15H18N4O/c1-18(2)9-8-14-16-15(17-20-14)12-10-19(3)13-7-5-4-6-11(12)13/h4-7,10H,8-9H2,1-3H3
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n/an/a 14n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452958
PNG
(CHEMBL35722)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1[nH]nc2ccccc12
Show InChI InChI=1S/C16H17N5O/c1-2-4-13-11(3-1)14(19-18-13)15-17-16(22-20-15)12-9-21-7-5-10(12)6-8-21/h1-4,10,12H,5-9H2,(H,18,19)
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n/an/a 18n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452931
PNG
(CHEMBL35212)
Show SMILES Cn1cc(-c2nsc(n2)C2CC3CCN2C3)c2ccccc12
Show InChI InChI=1S/C17H18N4S/c1-20-10-13(12-4-2-3-5-14(12)20)16-18-17(22-19-16)15-8-11-6-7-21(15)9-11/h2-5,10-11,15H,6-9H2,1H3
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n/an/a 20n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452957
PNG
(CHEMBL34435)
Show SMILES C=CCn1cc(-c2noc(n2)C2CN3CCC2CC3)c2ccccc12
Show InChI InChI=1S/C20H22N4O/c1-2-9-24-13-17(15-5-3-4-6-18(15)24)19-21-20(25-22-19)16-12-23-10-7-14(16)8-11-23/h2-6,13-14,16H,1,7-12H2
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n/an/a 22n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM82561
PNG
(CAS_40796-97-2 | TROPANYL 3,5-DICHLOROBENZOATE | T...)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C15H17Cl2NO2/c1-18-12-2-3-13(18)8-14(7-12)20-15(19)9-4-10(16)6-11(17)5-9/h4-6,12-14H,2-3,7-8H2,1H3/t12-,13+,14+
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n/an/a 22n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for the displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor in rat brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452954
PNG
(CHEMBL35775)
Show SMILES Cn1cc(-c2nc(no2)C2CN3CCC2CC3)c2ccccc12
Show InChI InChI=1S/C18H20N4O/c1-21-10-15(13-4-2-3-5-16(13)21)18-19-17(20-23-18)14-11-22-8-6-12(14)7-9-22/h2-5,10,12,14H,6-9,11H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452969
PNG
(CHEMBL287685)
Show SMILES Cn1cc(-c2noc(n2)C2CCC[N+](C)(C)C2)c2ccccc12
Show InChI InChI=1S/C18H23N4O.HI/c1-21-11-15(14-8-4-5-9-16(14)21)17-19-18(23-20-17)13-7-6-10-22(2,3)12-13;/h4-5,8-9,11,13H,6-7,10,12H2,1-3H3;1H/q+1;/p-1
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n/an/a 35n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452932
PNG
(CHEMBL285166)
Show SMILES Cn1cc(-c2noc(n2)C2CC[N+](C)(C)CC2)c2ccccc12
Show InChI InChI=1S/C18H23N4O.HI/c1-21-12-15(14-6-4-5-7-16(14)21)17-19-18(23-20-17)13-8-10-22(2,3)11-9-13;/h4-7,12-13H,8-11H2,1-3H3;1H/q+1;/p-1
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n/an/a 35n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452967
PNG
(CHEMBL284315)
Show SMILES Oc1ccccc1-c1noc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C15H17N3O2/c19-13-4-2-1-3-11(13)14-16-15(20-17-14)12-9-18-7-5-10(12)6-8-18/h1-4,10,12,19H,5-9H2
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n/an/a 42n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452928
PNG
(CHEMBL288898)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2CC3)c2cc(F)ccc12
Show InChI InChI=1S/C18H19FN4O/c1-22-9-15(13-8-12(19)2-3-16(13)22)17-20-18(24-21-17)14-10-23-6-4-11(14)5-7-23/h2-3,8-9,11,14H,4-7,10H2,1H3
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n/an/a 46n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452972
PNG
(CHEMBL37237)
Show SMILES Cn1cc(-c2noc(CC3CN4CCC3CC4)n2)c2ccccc12
Show InChI InChI=1S/C19H22N4O/c1-22-12-16(15-4-2-3-5-17(15)22)19-20-18(24-21-19)10-14-11-23-8-6-13(14)7-9-23/h2-5,12-14H,6-11H2,1H3
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n/an/a 55n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452938
PNG
(CHEMBL288403)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1cccc2ccccc12
Show InChI InChI=1S/C19H19N3O/c1-2-6-15-13(4-1)5-3-7-16(15)18-20-19(23-21-18)17-12-22-10-8-14(17)9-11-22/h1-7,14,17H,8-12H2
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n/an/a 63n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452934
PNG
(CHEMBL286884)
Show SMILES Cn1cc(-c2noc(CCN)n2)c2ccccc12
Show InChI InChI=1S/C13H14N4O/c1-17-8-10(9-4-2-3-5-11(9)17)13-15-12(6-7-14)18-16-13/h2-5,8H,6-7,14H2,1H3
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n/an/a 68n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452965
PNG
(CHEMBL431892)
Show SMILES Oc1cccc(c1)-c1noc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C15H17N3O2/c19-12-3-1-2-11(8-12)14-16-15(20-17-14)13-9-18-6-4-10(13)5-7-18/h1-3,8,10,13,19H,4-7,9H2
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n/an/a 81n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452929
PNG
(CHEMBL287093)
Show SMILES CN1CC2CCC1C(C2)c1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C19H22N4O/c1-22-10-12-7-8-17(22)14(9-12)19-20-18(21-24-19)15-11-23(2)16-6-4-3-5-13(15)16/h3-6,11-12,14,17H,7-10H2,1-2H3
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n/an/a 85n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452933
PNG
(CHEMBL37365)
Show SMILES CNCCc1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C14H16N4O/c1-15-8-7-13-16-14(17-19-13)11-9-18(2)12-6-4-3-5-10(11)12/h3-6,9,15H,7-8H2,1-2H3
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n/an/a 85n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452945
PNG
(CHEMBL37360)
Show SMILES Cn1cc(-c2noc(n2)C2CC3CCC2NC3)c2ccccc12
Show InChI InChI=1S/C18H20N4O/c1-22-10-14(12-4-2-3-5-16(12)22)17-20-18(23-21-17)13-8-11-6-7-15(13)19-9-11/h2-5,10-11,13,15,19H,6-9H2,1H3
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n/an/a 89n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452937
PNG
(CHEMBL35645)
Show SMILES Cc1cccc2c(cn(C)c12)-c1noc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C19H22N4O/c1-12-4-3-5-14-16(10-22(2)17(12)14)18-20-19(24-21-18)15-11-23-8-6-13(15)7-9-23/h3-5,10,13,15H,6-9,11H2,1-2H3
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n/an/a 96n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452949
PNG
(CHEMBL36703)
Show SMILES Cn1cc(-c2noc(n2)C2CC3CCN2CC3)c2ccccc12
Show InChI InChI=1S/C18H20N4O/c1-21-11-14(13-4-2-3-5-15(13)21)17-19-18(23-20-17)16-10-12-6-8-22(16)9-7-12/h2-5,11-12,16H,6-10H2,1H3
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n/an/a 129n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452940
PNG
(CHEMBL36940)
Show SMILES Oc1ccc(cc1)-c1noc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C15H17N3O2/c19-12-3-1-11(2-4-12)14-16-15(20-17-14)13-9-18-7-5-10(13)6-8-18/h1-4,10,13,19H,5-9H2
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n/an/a 148n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452971
PNG
(CHEMBL37890)
Show SMILES COc1ccccc1-c1noc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C16H19N3O2/c1-20-14-5-3-2-4-12(14)15-17-16(21-18-15)13-10-19-8-6-11(13)7-9-19/h2-5,11,13H,6-10H2,1H3
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n/an/a 155n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452951
PNG
(CHEMBL288490)
Show SMILES CN(C)Cc1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C14H16N4O/c1-17(2)9-13-15-14(16-19-13)11-8-18(3)12-7-5-4-6-10(11)12/h4-8H,9H2,1-3H3
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n/an/a 166n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452956
PNG
(CHEMBL35599)
Show SMILES CN(C)CCCc1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C16H20N4O/c1-19(2)10-6-9-15-17-16(18-21-15)13-11-20(3)14-8-5-4-7-12(13)14/h4-5,7-8,11H,6,9-10H2,1-3H3
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n/an/a 191n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452970
PNG
(CHEMBL36478)
Show SMILES CN1C2CCC1CC(C2)c1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C19H22N4O/c1-22-11-16(15-5-3-4-6-17(15)22)18-20-19(24-21-18)12-9-13-7-8-14(10-12)23(13)2/h3-6,11-14H,7-10H2,1-2H3
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n/an/a 191n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452964
PNG
(CHEMBL37309)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1ccccc1
Show InChI InChI=1S/C15H17N3O/c1-2-4-12(5-3-1)14-16-15(19-17-14)13-10-18-8-6-11(13)7-9-18/h1-5,11,13H,6-10H2
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n/an/a 200n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452943
PNG
(CHEMBL413273)
Show SMILES CN1CCC=C(C1)c1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C17H18N4O/c1-20-9-5-6-12(10-20)17-18-16(19-22-17)14-11-21(2)15-8-4-3-7-13(14)15/h3-4,6-8,11H,5,9-10H2,1-2H3
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n/an/a 209n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452929
PNG
(CHEMBL287093)
Show SMILES CN1CC2CCC1C(C2)c1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C19H22N4O/c1-22-10-12-7-8-17(22)14(9-12)19-20-18(21-24-19)15-11-23(2)16-6-4-3-5-13(15)16/h3-6,11-12,14,17H,7-10H2,1-2H3
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n/an/a 224n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452942
PNG
(CHEMBL36315)
Show SMILES Cn1cc(-c2noc(CN)n2)c2ccccc12
Show InChI InChI=1S/C12H12N4O/c1-16-7-9(8-4-2-3-5-10(8)16)12-14-11(6-13)17-15-12/h2-5,7H,6,13H2,1H3
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n/an/a 282n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452960
PNG
(CHEMBL286001)
Show SMILES Cc1ccc2n(C)cc(-c3noc(n3)C3CN4CCC3CC4)c2c1
Show InChI InChI=1S/C19H22N4O/c1-12-3-4-17-14(9-12)16(10-22(17)2)18-20-19(24-21-18)15-11-23-7-5-13(15)6-8-23/h3-4,9-10,13,15H,5-8,11H2,1-2H3
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n/an/a 331n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452941
PNG
(CHEMBL36601)
Show SMILES Cn1cc(-c2noc(CCN3CCCCC3)n2)c2ccccc12
Show InChI InChI=1S/C18H22N4O/c1-21-13-15(14-7-3-4-8-16(14)21)18-19-17(23-20-18)9-12-22-10-5-2-6-11-22/h3-4,7-8,13H,2,5-6,9-12H2,1H3
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n/an/a 372n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452936
PNG
(CHEMBL36330)
Show SMILES Cn1cc(-c2noc(n2)C2=CCCNC2)c2ccccc12
Show InChI InChI=1S/C16H16N4O/c1-20-10-13(12-6-2-3-7-14(12)20)15-18-16(21-19-15)11-5-4-8-17-9-11/h2-3,5-7,10,17H,4,8-9H2,1H3
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n/an/a 468n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452962
PNG
(CHEMBL37359)
Show SMILES CN1CCC(=CC1)c1nnc(o1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C17H18N4O/c1-20-9-7-12(8-10-20)16-18-19-17(22-16)14-11-21(2)15-6-4-3-5-13(14)15/h3-7,11H,8-10H2,1-2H3
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n/an/a 501n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50014406
PNG
(2-Me 5-HT | 2-Methyl-5-hydroxytryptamine | 2-methy...)
Show SMILES Cc1[nH]c2ccc(O)cc2c1CCN
Show InChI InChI=1S/C11H14N2O/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7/h2-3,6,13-14H,4-5,12H2,1H3
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n/an/a 646n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for the displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor in rat brain membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452947
PNG
(CHEMBL36204)
Show SMILES Cn1c(cc2ccccc12)-c1noc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C18H20N4O/c1-21-15-5-3-2-4-13(15)10-16(21)17-19-18(23-20-17)14-11-22-8-6-12(14)7-9-22/h2-5,10,12,14H,6-9,11H2,1H3
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n/an/a 676n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452939
PNG
(CHEMBL287006)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H18N4O/c1-2-4-14-12(3-1)9-15(18-14)16-19-17(22-20-16)13-10-21-7-5-11(13)6-8-21/h1-4,9,11,13,18H,5-8,10H2
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n/an/a 692n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452950
PNG
(CHEMBL288489)
Show SMILES CNCc1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C13H14N4O/c1-14-7-12-15-13(16-18-12)10-8-17(2)11-6-4-3-5-9(10)11/h3-6,8,14H,7H2,1-2H3
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PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452935
PNG
(CHEMBL37093)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H19N3O/c1-2-4-15-11-16(6-5-13(15)3-1)18-20-19(23-21-18)17-12-22-9-7-14(17)8-10-22/h1-6,11,14,17H,7-10,12H2
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PC sid
UniChem

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PubMed
n/an/a 1.48E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452946
PNG
(CHEMBL36854)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1cnc2ccccc2c1
Show InChI InChI=1S/C18H18N4O/c1-2-4-16-13(3-1)9-14(10-19-16)17-20-18(23-21-17)15-11-22-7-5-12(15)6-8-22/h1-4,9-10,12,15H,5-8,11H2
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PC sid
UniChem

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PubMed
n/an/a 1.51E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452968
PNG
(CHEMBL37922)
Show SMILES COc1ccc(cc1)-c1noc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C16H19N3O2/c1-20-13-4-2-12(3-5-13)15-17-16(21-18-15)14-10-19-8-6-11(14)7-9-19/h2-5,11,14H,6-10H2,1H3
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UniChem

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PubMed
n/an/a 1.59E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452930
PNG
(CHEMBL37797)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1cccnc1
Show InChI InChI=1S/C14H16N4O/c1-2-11(8-15-5-1)13-16-14(19-17-13)12-9-18-6-3-10(12)4-7-18/h1-2,5,8,10,12H,3-4,6-7,9H2
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UniChem

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PubMed
n/an/a 2.95E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50452948
PNG
(CHEMBL36093)
Show SMILES CN1CCC=C(C1)c1csc(n1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C18H19N3S/c1-20-9-5-6-13(10-20)16-12-22-18(19-16)15-11-21(2)17-8-4-3-7-14(15)17/h3-4,6-8,11-12H,5,9-10H2,1-2H3
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PC sid
UniChem
PubMed
n/an/a 5.89E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%