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Found 21 Enz. Inhib. hit(s) with all data for entry = 50031616
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50316295(CHEMBL1099284 | N-(3-Fluorophenyl)-2-methyl-2,3,4,...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to human recombinant 5HT6 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50316296(2,5-Dimethyl-8-(phenylsulfonyl)-2,3,4,5-tetrahydro...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to human recombinant 5HT6 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50316295(CHEMBL1099284 | N-(3-Fluorophenyl)-2-methyl-2,3,4,...)
Affinity DataKi:  7nMAssay Description:Binding affinity to 5HT1A receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(CHEMBL589390 | Dimebolin)
Affinity DataKi:  8nMAssay Description:Binding affinity to 5HT7 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(CHEMBL589390 | Dimebolin)
Affinity DataKi:  26nMAssay Description:Binding affinity to human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(CHEMBL589390 | Dimebolin)
Affinity DataKi:  34nMAssay Description:Binding affinity to human recombinant 5HT6 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50316295(CHEMBL1099284 | N-(3-Fluorophenyl)-2-methyl-2,3,4,...)
Affinity DataKi:  39nMAssay Description:Binding affinity to 5HT2C receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50316295(CHEMBL1099284 | N-(3-Fluorophenyl)-2-methyl-2,3,4,...)
Affinity DataKi:  42nMAssay Description:Binding affinity to 5HT7 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(CHEMBL589390 | Dimebolin)
Affinity DataKi:  76nMAssay Description:Binding affinity to 5HT2C receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(CHEMBL589390 | Dimebolin)
Affinity DataKi: >100nMAssay Description:Binding affinity to 5HT1A receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(CHEMBL589390 | Dimebolin)
Affinity DataKi:  119nMAssay Description:Binding affinity to rat recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50316295(CHEMBL1099284 | N-(3-Fluorophenyl)-2-methyl-2,3,4,...)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production by LANCE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50316296(2,5-Dimethyl-8-(phenylsulfonyl)-2,3,4,5-tetrahydro...)
Affinity DataIC50:  78nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production by LANCE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50316300(8-[(3-Fluorophenyl)sulfonyl]-2-methyl-2,3,4,5-tetr...)
Affinity DataIC50:  85nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production by LANCE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50316293(2-Methyl-8-(phenylsulfonyl)-5-(2-pyridin-2-ylethyl...)
Affinity DataIC50:  620nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production by LANCE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(CHEMBL589390 | Dimebolin)
Affinity DataIC50:  890nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production by LANCE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50316301(2-Methyl-8-(pyridin-3-ylsulfonyl)-2,3,4,5-tetrahyd...)
Affinity DataIC50:  3.40E+3nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production by LANCE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50316299(2-Benzyl-N-(3-fluorophenyl)-2,3,4,5-tetrahydro-1H-...)
Affinity DataIC50:  3.90E+3nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production by LANCE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50316297(CHEMBL1099282 | N,N,2-Trimethyl-2,3,4,5-tetrahydro...)
Affinity DataIC50:  2.60E+4nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production by LANCE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50316294(2-Methyl-5-[(4-methylphenyl)sulfonyl]-8-(phenylsul...)
Affinity DataIC50:  2.80E+4nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production by LANCE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50316298(2-Methyl-8-[(4-methylpiperazin-1-yl)sulfonyl]-2,3,...)
Affinity DataIC50:  6.20E+4nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production by LANCE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed