Affinity Data by PubMed id=1995876

PubMed code 1995876

Found 9 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydrofolate reductase (Escherichia coli)	BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	MMDB NCI pathway Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Escherichia coli dihydrofolate reductase at 10e8 M				J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50138691 (5-(3,4-Dimethoxy-benzyl)-pyrimidine-2,4-diamine \| ...) Show SMILES COc1ccc(Cc2cnc(N)nc2N)cc1OC Show InChI	MMDB NCI pathway Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Escherichia coli dihydrofolate reductase at 10e8 M				J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Neisseria gonorrhoeae)	BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Neisseria gonorrhoeae dihydrofolate reductase at 10e8 M				J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Neisseria gonorrhoeae)	BDBM50138691 (5-(3,4-Dimethoxy-benzyl)-pyrimidine-2,4-diamine \| ...) Show SMILES COc1ccc(Cc2cnc(N)nc2N)cc1OC Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Neisseria gonorrhoeae dihydrofolate reductase at 10e8 M				J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50406467 (CHEMBL346871) Show SMILES COc1cc2CCC(c2cc1OC)c1cnc(N)nc1N Show InChI	MMDB NCI pathway Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Escherichia coli dihydrofolate reductase at 10e8 M				J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Neisseria gonorrhoeae)	BDBM50406467 (CHEMBL346871) Show SMILES COc1cc2CCC(c2cc1OC)c1cnc(N)nc1N Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Neisseria gonorrhoeae dihydrofolate reductase at 10e8 M				J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50138691 (5-(3,4-Dimethoxy-benzyl)-pyrimidine-2,4-diamine \| ...) Show SMILES COc1ccc(Cc2cnc(N)nc2N)cc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against rat liver dihydrofolate reductase at 10e8 M				J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.70E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against rat liver dihydrofolate reductase at 10e8 M				J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50406467 (CHEMBL346871) Show SMILES COc1cc2CCC(c2cc1OC)c1cnc(N)nc1N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against rat liver dihydrofolate reductase at 10e8 M				J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%