Affinity Data by PubMed id=1995876

PubMed code 1995876

Found 9 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydrofolate reductase (Escherichia coli)	BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	MMDB NCI pathway Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Escherichia coli dihydrofolate reductase at 10e8 M				Citation and Details
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50138691 (5-(3,4-Dimethoxy-benzyl)-pyrimidine-2,4-diamine \| ...) Show SMILES COc1ccc(Cc2cnc(N)nc2N)cc1OC Show InChI	MMDB NCI pathway Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Escherichia coli dihydrofolate reductase at 10e8 M				Citation and Details
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Neisseria gonorrhoeae)	BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Neisseria gonorrhoeae dihydrofolate reductase at 10e8 M				Citation and Details
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Neisseria gonorrhoeae)	BDBM50138691 (5-(3,4-Dimethoxy-benzyl)-pyrimidine-2,4-diamine \| ...) Show SMILES COc1ccc(Cc2cnc(N)nc2N)cc1OC Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Neisseria gonorrhoeae dihydrofolate reductase at 10e8 M				Citation and Details
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50406467 (CHEMBL346871) Show SMILES COc1cc2CCC(c2cc1OC)c1cnc(N)nc1N Show InChI	MMDB NCI pathway Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Escherichia coli dihydrofolate reductase at 10e8 M				Citation and Details
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Neisseria gonorrhoeae)	BDBM50406467 (CHEMBL346871) Show SMILES COc1cc2CCC(c2cc1OC)c1cnc(N)nc1N Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Neisseria gonorrhoeae dihydrofolate reductase at 10e8 M				Citation and Details
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50138691 (5-(3,4-Dimethoxy-benzyl)-pyrimidine-2,4-diamine \| ...) Show SMILES COc1ccc(Cc2cnc(N)nc2N)cc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against rat liver dihydrofolate reductase at 10e8 M				Citation and Details
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	3.70E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against rat liver dihydrofolate reductase at 10e8 M				Citation and Details
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50406467 (CHEMBL346871) Show SMILES COc1cc2CCC(c2cc1OC)c1cnc(N)nc1N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against rat liver dihydrofolate reductase at 10e8 M				Citation and Details
Wellcome Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%