Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydrofolate reductase (Escherichia coli) | BDBM18069![]() (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Wellcome Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against Escherichia coli dihydrofolate reductase at 10e8 M | J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50138691![]() (5-(3,4-Dimethoxy-benzyl)-pyrimidine-2,4-diamine | ...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar | Purchase CHEBI CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Wellcome Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against Escherichia coli dihydrofolate reductase at 10e8 M | J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Neisseria gonorrhoeae) | BDBM18069![]() (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) | UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Wellcome Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against Neisseria gonorrhoeae dihydrofolate reductase at 10e8 M | J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Neisseria gonorrhoeae) | BDBM50138691![]() (5-(3,4-Dimethoxy-benzyl)-pyrimidine-2,4-diamine | ...) | UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Wellcome Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against Neisseria gonorrhoeae dihydrofolate reductase at 10e8 M | J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50406467![]() (CHEMBL346871) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wellcome Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against Escherichia coli dihydrofolate reductase at 10e8 M | J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Neisseria gonorrhoeae) | BDBM50406467![]() (CHEMBL346871) | UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wellcome Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against Neisseria gonorrhoeae dihydrofolate reductase at 10e8 M | J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Rattus norvegicus (rat)) | BDBM50138691![]() (5-(3,4-Dimethoxy-benzyl)-pyrimidine-2,4-diamine | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar | Purchase CHEBI CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wellcome Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against rat liver dihydrofolate reductase at 10e8 M | J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Rattus norvegicus (rat)) | BDBM18069![]() (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wellcome Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against rat liver dihydrofolate reductase at 10e8 M | J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Dihydrofolate reductase (Rattus norvegicus (rat)) | BDBM50406467![]() (CHEMBL346871) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wellcome Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against rat liver dihydrofolate reductase at 10e8 M | J Med Chem 34: 550-5 (1991) Article DOI: 10.1021/jm00106a011 BindingDB Entry DOI: 10.7270/Q2J104B2 | |||||||||||
More data for this Ligand-Target Pair |