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PubMed code 20181486

Compile data set for download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 0.490n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308460
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(thiophen-3-yl)...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccsc2)c1
Show InChI InChI=1/C19H19ClN2O5S2/c20-12-2-1-9(18-17(26)16(25)15(24)13(7-23)27-18)5-11(12)6-14-21-22-19(29-14)10-3-4-28-8-10/h1-5,8,13,15-18,23-26H,6-7H2/t13-,15-,16+,17-,18+/s2
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n/an/a 3.51n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308448
PNG
(2-(2-Chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzylo...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cnccn2)c1
Show InChI InChI=1/C19H19ClN4O5S/c20-11-2-1-9(18-17(28)16(27)15(26)13(8-25)29-18)5-10(11)6-14-23-24-19(30-14)12-7-21-3-4-22-12/h1-5,7,13,15-18,25-28H,6,8H2/t13-,15-,16+,17-,18+/s2
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n/an/a 4.06n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM20878
PNG
((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Show SMILES COc1ccc(Cc2ccccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H24O7/c1-25-14-8-6-12(7-9-14)10-13-4-2-3-5-15(13)26-20-19(24)18(23)17(22)16(11-21)27-20/h2-9,16-24H,10-11H2,1H3/t16-,17-,18+,19-,20-/m1/s1
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n/an/a 6.25n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308450
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)-1,...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccco2)c1
Show InChI InChI=1/C19H19ClN2O6S/c20-11-4-3-9(18-17(26)16(25)15(24)13(8-23)28-18)6-10(11)7-14-21-22-19(29-14)12-2-1-5-27-12/h1-6,13,15-18,23-26H,7-8H2/t13-,15-,16+,17-,18+/s2
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n/an/a 7.03n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308454
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(5-phenylfuran-...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccc(o2)-c2ccccc2)c1
Show InChI InChI=1/C25H23ClN2O6S/c26-16-7-6-14(24-23(32)22(31)21(30)19(12-29)34-24)10-15(16)11-20-27-28-25(35-20)18-9-8-17(33-18)13-4-2-1-3-5-13/h1-10,19,21-24,29-32H,11-12H2/t19-,21-,22+,23-,24+/s2
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n/an/a 10.6n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308436
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(methylthio)-1,...)
Show SMILES CSc1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C16H19ClN2O5S2/c1-25-16-19-18-11(26-16)5-8-4-7(2-3-9(8)17)15-14(23)13(22)12(21)10(6-20)24-15/h2-4,10,12-15,20-23H,5-6H2,1H3/t10-,12-,13+,14-,15+/s2
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n/an/a 10.9n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308459
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(thiophen-2-yl)...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cccs2)c1
Show InChI InChI=1/C19H19ClN2O5S2/c20-11-4-3-9(18-17(26)16(25)15(24)12(8-23)27-18)6-10(11)7-14-21-22-19(29-14)13-2-1-5-28-13/h1-6,12,15-18,23-26H,7-8H2/t12-,15-,16+,17-,18+/s2
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n/an/a 14.4n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308440
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-phenyl-1,3,4-th...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccccc2)c1
Show InChI InChI=1/C21H21ClN2O5S/c22-14-7-6-12(20-19(28)18(27)17(26)15(10-25)29-20)8-13(14)9-16-23-24-21(30-16)11-4-2-1-3-5-11/h1-8,15,17-20,25-28H,9-10H2/t15-,17-,18+,19-,20+/s2
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n/an/a 16.6n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308451
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(furan-3-yl)-1,...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccoc2)c1
Show InChI InChI=1/C19H19ClN2O6S/c20-12-2-1-9(18-17(26)16(25)15(24)13(7-23)28-18)5-11(12)6-14-21-22-19(29-14)10-3-4-27-8-10/h1-5,8,13,15-18,23-26H,6-7H2/t13-,15-,16+,17-,18+/s2
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n/an/a 17.7n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308463
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(5-chlorothioph...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccc(Cl)s2)c1
Show InChI InChI=1/C19H18Cl2N2O5S2/c20-10-2-1-8(18-17(27)16(26)15(25)11(7-24)28-18)5-9(10)6-14-22-23-19(30-14)12-3-4-13(21)29-12/h1-5,11,15-18,24-27H,6-7H2/t11-,15-,16+,17-,18+/s2
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n/an/a 18.2n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308465
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(thiazol-4-yl)-...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cscn2)c1
Show InChI InChI=1/C18H18ClN3O5S2/c19-10-2-1-8(17-16(26)15(25)14(24)12(5-23)27-17)3-9(10)4-13-21-22-18(29-13)11-6-28-7-20-11/h1-3,6-7,12,14-17,23-26H,4-5H2/t12-,14-,15+,16-,17+/s2
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n/an/a 21.8n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308476
PNG
((3R,4R,5S,6R)-2-(4-Chloro-3-((5-(4-propylphenyl)-1...)
Show SMILES CCCc1ccc(cc1)-c1nnc(Cc2cc(ccc2Cl)C2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C24H27ClN2O5S/c1-2-3-13-4-6-14(7-5-13)24-27-26-19(33-24)11-16-10-15(8-9-17(16)25)23-22(31)21(30)20(29)18(12-28)32-23/h4-10,18,20-23,28-31H,2-3,11-12H2,1H3/t18-,20-,21+,22-,23?/s2
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n/an/a 24.9n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308442
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(pyridin-2-yl)-...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccccn2)c1
Show InChI InChI=1/C20H20ClN3O5S/c21-12-5-4-10(19-18(28)17(27)16(26)14(9-25)29-19)7-11(12)8-15-23-24-20(30-15)13-3-1-2-6-22-13/h1-7,14,16-19,25-28H,8-9H2/t14-,16-,17+,18-,19+/s2
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n/an/a 30.3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308445
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(2-methylpyridi...)
Show SMILES Cc1cc(ccn1)-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C21H22ClN3O5S/c1-10-6-12(4-5-23-10)21-25-24-16(31-21)8-13-7-11(2-3-14(13)22)20-19(29)18(28)17(27)15(9-26)30-20/h2-7,15,17-20,26-29H,8-9H2,1H3/t15-,17-,18+,19-,20+/s2
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n/an/a 36.4n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308464
PNG
((2S,3R,4R,5S,6R)-2-(3-((5-(Benzo[b]thiophen-2-yl)-...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cc3ccccc3s2)c1
Show InChI InChI=1/C23H21ClN2O5S2/c24-14-6-5-12(22-21(30)20(29)19(28)15(10-27)31-22)7-13(14)9-18-25-26-23(33-18)17-8-11-3-1-2-4-16(11)32-17/h1-8,15,19-22,27-30H,9-10H2/t15-,19-,20+,21-,22+/s2
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n/an/a 44.5n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308477
PNG
((3R,4R,5S,6R)-2-(4-chloro-3-((5-(pyridin-3-yl)-1,3...)
Show SMILES OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cccnc2)c1
Show InChI InChI=1/C20H20ClN3O5S/c21-13-4-3-10(19-18(28)17(27)16(26)14(9-25)29-19)6-12(13)7-15-23-24-20(30-15)11-2-1-5-22-8-11/h1-6,8,14,16-19,25-28H,7,9H2/t14-,16-,17+,18-,19?/s2
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n/an/a 45.3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308478
PNG
((3R,4R,5S,6R)-2-(4-chloro-3-((5-(pyridin-4-yl)-1,3...)
Show SMILES OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccncc2)c1
Show InChI InChI=1/C20H20ClN3O5S/c21-13-2-1-11(19-18(28)17(27)16(26)14(9-25)29-19)7-12(13)8-15-23-24-20(30-15)10-3-5-22-6-4-10/h1-7,14,16-19,25-28H,8-9H2/t14-,16-,17+,18-,19?/s2
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n/an/a 53n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308453
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(5-methylfuran-...)
Show SMILES Cc1ccc(o1)-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C20H21ClN2O6S/c1-9-2-5-13(28-9)20-23-22-15(30-20)7-11-6-10(3-4-12(11)21)19-18(27)17(26)16(25)14(8-24)29-19/h2-6,14,16-19,24-27H,7-8H2,1H3/t14-,16-,17+,18-,19+/s2
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n/an/a 58.3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308466
PNG
(((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(2-(pyridin-4-...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2csc(n2)-c2ccncc2)c1
Show InChI InChI=1/C23H21ClN4O5S2/c24-14-2-1-12(21-20(32)19(31)18(30)16(9-29)33-21)7-13(14)8-17-27-28-23(35-17)15-10-34-22(26-15)11-3-5-25-6-4-11/h1-7,10,16,18-21,29-32H,8-9H2/t16-,18-,19+,20-,21+/s2
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n/an/a 72.6n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308446
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(isoquinolin-3-...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cc3ccccc3cn2)c1
Show InChI InChI=1/C24H22ClN3O5S/c25-16-6-5-13(23-22(32)21(31)20(30)18(11-29)33-23)7-15(16)9-19-27-28-24(34-19)17-8-12-3-1-2-4-14(12)10-26-17/h1-8,10,18,20-23,29-32H,9,11H2/t18-,20-,21+,22-,23+/s2
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n/an/a 81.6n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308444
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(6-methylpyridi...)
Show SMILES Cc1ccc(cn1)-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C21H22ClN3O5S/c1-10-2-3-12(8-23-10)21-25-24-16(31-21)7-13-6-11(4-5-14(13)22)20-19(29)18(28)17(27)15(9-26)30-20/h2-6,8,15,17-20,26-29H,7,9H2,1H3/t15-,17-,18+,19-,20+/s2
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n/an/a 97.4n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308475
PNG
((3R,4R,5S,6R)-2-(4-Chloro-3-((5-p-tolyl-1,3,4-thia...)
Show SMILES Cc1ccc(cc1)-c1nnc(Cc2cc(ccc2Cl)C2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C22H23ClN2O5S/c1-11-2-4-12(5-3-11)22-25-24-17(31-22)9-14-8-13(6-7-15(14)23)21-20(29)19(28)18(27)16(10-26)30-21/h2-8,16,18-21,26-29H,9-10H2,1H3/t16-,18-,19+,20-,21?/s2
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n/an/a 103n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308452
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(3-methylfuran-...)
Show SMILES Cc1ccoc1-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C20H21ClN2O6S/c1-9-4-5-28-18(9)20-23-22-14(30-20)7-11-6-10(2-3-12(11)21)19-17(27)16(26)15(25)13(8-24)29-19/h2-6,13,15-17,19,24-27H,7-8H2,1H3/t13-,15-,16+,17-,19+/s2
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n/an/a 106n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308457
PNG
(((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(1-methyl-1Hpy...)
Show SMILES Cn1cccc1-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C20H22ClN3O5S/c1-24-6-2-3-13(24)20-23-22-15(30-20)8-11-7-10(4-5-12(11)21)19-18(28)17(27)16(26)14(9-25)29-19/h2-7,14,16-19,25-28H,8-9H2,1H3/t14-,16-,17+,18-,19+/s2
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n/an/a 119n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308484
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-heptyl-1,3,4-th...)
Show SMILES CCCCCCCc1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C22H31ClN2O5S/c1-2-3-4-5-6-7-17-24-25-18(31-17)11-14-10-13(8-9-15(14)23)22-21(29)20(28)19(27)16(12-26)30-22/h8-10,16,19-22,26-29H,2-7,11-12H2,1H3/t16-,19-,20+,21-,22+/s2
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n/an/a 122n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308441
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(4-chlorophenyl...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccc(Cl)cc2)c1
Show InChI InChI=1/C21H20Cl2N2O5S/c22-13-4-1-10(2-5-13)21-25-24-16(31-21)8-12-7-11(3-6-14(12)23)20-19(29)18(28)17(27)15(9-26)30-20/h1-7,15,17-20,26-29H,8-9H2/t15-,17-,18+,19-,20+/s2
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n/an/a 126n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308435
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-methoxy-1,3,4-t...)
Show SMILES COc1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C16H19ClN2O6S/c1-24-16-19-18-11(26-16)5-8-4-7(2-3-9(8)17)15-14(23)13(22)12(21)10(6-20)25-15/h2-4,10,12-15,20-23H,5-6H2,1H3/t10-,12-,13+,14-,15+/s2
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n/an/a 146n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308437
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(trifluoromethy...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)C(F)(F)F)c1
Show InChI InChI=1/C16H16ClF3N2O5S/c17-8-2-1-6(14-13(26)12(25)11(24)9(5-23)27-14)3-7(8)4-10-21-22-15(28-10)16(18,19)20/h1-3,9,11-14,23-26H,4-5H2/t9-,11-,12+,13-,14+/s2
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n/an/a 155n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308449
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(pyridazin-4-yl...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccnnc2)c1
Show InChI InChI=1/C19H19ClN4O5S/c20-12-2-1-9(18-17(28)16(27)15(26)13(8-25)29-18)5-11(12)6-14-23-24-19(30-14)10-3-4-21-22-7-10/h1-5,7,13,15-18,25-28H,6,8H2/t13-,15-,16+,17-,18+/s2
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n/an/a 190n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308481
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-propyl-1,3,4-th...)
Show SMILES CCCc1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C18H23ClN2O5S/c1-2-3-13-20-21-14(27-13)7-10-6-9(4-5-11(10)19)18-17(25)16(24)15(23)12(8-22)26-18/h4-6,12,15-18,22-25H,2-3,7-8H2,1H3/t12-,15-,16+,17-,18+/s2
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n/an/a 214n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308455
PNG
((2S,3R,4R,5S,6R)-2-(3-((5-(Benzofuran-2-yl)-1,3,4-...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cc3ccccc3o2)c1
Show InChI InChI=1/C23H21ClN2O6S/c24-14-6-5-12(22-21(30)20(29)19(28)17(10-27)32-22)7-13(14)9-18-25-26-23(33-18)16-8-11-3-1-2-4-15(11)31-16/h1-8,17,19-22,27-30H,9-10H2/t17-,19-,20+,21-,22+/s2
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n/an/a 249n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308456
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(5-methylisoxaz...)
Show SMILES Cc1cc(no1)-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C19H20ClN3O6S/c1-8-4-12(23-29-8)19-22-21-14(30-19)6-10-5-9(2-3-11(10)20)18-17(27)16(26)15(25)13(7-24)28-18/h2-5,13,15-18,24-27H,6-7H2,1H3/t13-,15-,16+,17-,18+/s2
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n/an/a 257n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308483
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-pentyl-1,3,4-th...)
Show SMILES CCCCCc1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C20H27ClN2O5S/c1-2-3-4-5-15-22-23-16(29-15)9-12-8-11(6-7-13(12)21)20-19(27)18(26)17(25)14(10-24)28-20/h6-8,14,17-20,24-27H,2-5,9-10H2,1H3/t14-,17-,18+,19-,20+/s2
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n/an/a 353n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308482
PNG
((2S,3R,4R,5S,6R)-2-(3-((5-Butyl-1,3,4-thiadiazol-2...)
Show SMILES CCCCc1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C19H25ClN2O5S/c1-2-3-4-14-21-22-15(28-14)8-11-7-10(5-6-12(11)20)19-18(26)17(25)16(24)13(9-23)27-19/h5-7,13,16-19,23-26H,2-4,8-9H2,1H3/t13-,16-,17+,18-,19+/s2
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n/an/a 379n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308439
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-cyclopentyl-1,3...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)C2CCCC2)c1
Show InChI InChI=1/C20H25ClN2O5S/c21-13-6-5-11(19-18(27)17(26)16(25)14(9-24)28-19)7-12(13)8-15-22-23-20(29-15)10-3-1-2-4-10/h5-7,10,14,16-19,24-27H,1-4,8-9H2/t14-,16-,17+,18-,19+/s2
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n/an/a 445n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308474
PNG
((3R,4R,5S,6R)-2-(4-Chloro-3-((5-cyclohexyl-1,3,4-t...)
Show SMILES OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)C2CCCCC2)c1
Show InChI InChI=1/C21H27ClN2O5S/c22-14-7-6-12(20-19(28)18(27)17(26)15(10-25)29-20)8-13(14)9-16-23-24-21(30-16)11-4-2-1-3-5-11/h6-8,11,15,17-20,25-28H,1-5,9-10H2/t15-,17-,18+,19-,20?/s2
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n/an/a 542n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308447
PNG
(((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(quinolin-2-yl...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccc3ccccc3n2)c1
Show InChI InChI=1/C24H22ClN3O5S/c25-15-7-5-13(23-22(32)21(31)20(30)18(11-29)33-23)9-14(15)10-19-27-28-24(34-19)17-8-6-12-3-1-2-4-16(12)26-17/h1-9,18,20-23,29-32H,10-11H2/t18-,20-,21+,22-,23+/s2
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n/an/a 562n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308443
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(6-methylpyridi...)
Show SMILES Cc1cccc(n1)-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C21H22ClN3O5S/c1-10-3-2-4-14(23-10)21-25-24-16(31-21)8-12-7-11(5-6-13(12)22)20-19(29)18(28)17(27)15(9-26)30-20/h2-7,15,17-20,26-29H,8-9H2,1H3/t15-,17-,18+,19-,20+/s2
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n/an/a 638n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308462
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(3-chlorothioph...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2sccc2Cl)c1
Show InChI InChI=1/C19H18Cl2N2O5S2/c20-10-2-1-8(17-16(27)15(26)14(25)12(7-24)28-17)5-9(10)6-13-22-23-19(30-13)18-11(21)3-4-29-18/h1-5,12,14-17,24-27H,6-7H2/t12-,14-,15+,16-,17+/s2
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n/an/a 712n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308438
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(2,2,2-trifluor...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(CC(F)(F)F)s2)c1
Show InChI InChI=1/C17H18ClF3N2O5S/c18-9-2-1-7(16-15(27)14(26)13(25)10(6-24)28-16)3-8(9)4-11-22-23-12(29-11)5-17(19,20)21/h1-3,10,13-16,24-27H,4-6H2/t10-,13-,14+,15-,16+/s2
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n/an/a 758n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308461
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(3-methylthioph...)
Show SMILES Cc1ccsc1-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C20H21ClN2O5S2/c1-9-4-5-29-19(9)20-23-22-14(30-20)7-11-6-10(2-3-12(11)21)18-17(27)16(26)15(25)13(8-24)28-18/h2-6,13,15-18,24-27H,7-8H2,1H3/t13-,15-,16+,17-,18+/s2
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n/an/a 762n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308473
PNG
((2R,3S,4R,5R)-2-(Hydroxymethyl)-6-(3-((5-(pyridin-...)
Show SMILES OC[C@H]1O[C@@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cccc(Cc2nnc(s2)-c2cccnc2)c1
Show InChI InChI=1/C20H21N3O5S/c24-10-14-16(25)17(26)18(27)19(28-14)12-4-1-3-11(7-12)8-15-22-23-20(29-15)13-5-2-6-21-9-13/h1-7,9,14,16-19,24-27H,8,10H2/t14-,16-,17+,18-,19-/s2
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n/an/a 1.23E+3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308472
PNG
((2R,3S,4R,5R)-2-(Hydroxymethyl)-6-(3-((5-phenyl-1,...)
Show SMILES OC[C@H]1O[C@@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cccc(Cc2nnc(s2)-c2ccccc2)c1
Show InChI InChI=1/C21H22N2O5S/c24-11-15-17(25)18(26)19(27)20(28-15)14-8-4-5-12(9-14)10-16-22-23-21(29-16)13-6-2-1-3-7-13/h1-9,15,17-20,24-27H,10-11H2/t15-,17-,18+,19-,20-/s2
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n/an/a 1.42E+3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308479
PNG
((3R,4R,5S,6R)-2-(4-Chloro-3-((5-(4-chlorobenzyl)-1...)
Show SMILES OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(Cc3ccc(Cl)cc3)s2)c1
Show InChI InChI=1/C22H22Cl2N2O5S/c23-14-4-1-11(2-5-14)7-17-25-26-18(32-17)9-13-8-12(3-6-15(13)24)22-21(30)20(29)19(28)16(10-27)31-22/h1-6,8,16,19-22,27-30H,7,9-10H2/t16-,19-,20+,21-,22?/s2
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n/an/a 2.39E+3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308458
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(1-methyl-1Hind...)
Show SMILES Cn1nc(-c2nnc(Cc3cc(ccc3Cl)[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)s2)c2ccccc12
Show InChI InChI=1/C23H23ClN4O5S/c1-28-15-5-3-2-4-13(15)18(27-28)23-26-25-17(34-23)9-12-8-11(6-7-14(12)24)22-21(32)20(31)19(30)16(10-29)33-22/h2-8,16,19-22,29-32H,9-10H2,1H3/t16-,19-,20+,21-,22+/s2
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n/an/a 3.28E+3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308470
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(furan-2-yl)-1,...)
Show SMILES CCCc1nnc(Cc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C18H24N2O5S/c1-2-4-13-19-20-14(26-13)8-10-5-3-6-11(7-10)18-17(24)16(23)15(22)12(9-21)25-18/h3,5-7,12,15-18,21-24H,2,4,8-9H2,1H3/t12-,15-,16+,17-,18+/s2
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n/an/a 6.91E+3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308471
PNG
((3R,4R,5S,6R)-2-(3-((5-tert-Butyl-1,3,4-thiadiazol...)
Show SMILES CC(C)(C)c1nnc(Cc2cccc(c2)C2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C19H26N2O5S/c1-19(2,3)18-21-20-13(27-18)8-10-5-4-6-11(7-10)17-16(25)15(24)14(23)12(9-22)26-17/h4-7,12,14-17,22-25H,8-9H2,1-3H3/t12-,14-,15+,16-,17?/s2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308468
PNG
(((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(3-ethyl-5-met...)
Show SMILES CCc1noc(C)c1-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C21H24ClN3O6S/c1-3-13-16(9(2)31-25-13)21-24-23-15(32-21)7-11-6-10(4-5-12(11)22)20-19(29)18(28)17(27)14(8-26)30-20/h4-6,14,17-20,26-29H,3,7-8H2,1-2H3/t14-,17-,18+,19-,20+/s2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308480
PNG
((3R,4R,5S,6R)-2-(4-Chloro-3-((5-(2-(4-chlorophenyl...)
Show SMILES CC(C)(c1nnc(Cc2cc(ccc2Cl)C2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1)c1ccc(Cl)cc1
Show InChI InChI=1/C24H26Cl2N2O5S/c1-24(2,14-4-6-15(25)7-5-14)23-28-27-18(34-23)10-13-9-12(3-8-16(13)26)22-21(32)20(31)19(30)17(11-29)33-22/h3-9,17,19-22,29-32H,10-11H2,1-2H3/t17-,19-,20+,21-,22?/s2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50308467
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(3,5-dimethylis...)
Show SMILES Cc1noc(C)c1-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1
Show InChI InChI=1/C20H22ClN3O6S/c1-8-15(9(2)30-24-8)20-23-22-14(31-20)6-11-5-10(3-4-12(11)21)19-18(28)17(27)16(26)13(7-25)29-19/h3-5,13,16-19,25-28H,6-7H2,1-2H3/t13-,16-,17+,18-,19+/s2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting


Bioorg Med Chem 18: 2178-94 (2010)


Article DOI: 10.1016/j.bmc.2010.01.073
BindingDB Entry DOI: 10.7270/Q2MG7QF6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%