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PubMed code 20192242

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50316419
PNG
(CHEMBL1097908 | Gneyulin B)
Show SMILES Oc1ccc([C@@H]2Oc3cc(O)c(cc3[C@H]2c2cc(O)cc(O)c2)[C@@H]2Oc3cc(cc(O)c3[C@H]2c2cc(O)cc(O)c2)-c2cc3ccc(O)cc3o2)c(O)c1
Show InChI InChI=1S/C42H30O12/c43-22-3-4-28(31(49)14-22)41-38(20-5-24(45)12-25(46)6-20)30-16-29(32(50)17-36(30)53-41)42-39(21-7-26(47)13-27(48)8-21)40-33(51)9-19(11-37(40)54-42)34-10-18-1-2-23(44)15-35(18)52-34/h1-17,38-39,41-51H/t38-,39-,41+,42+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.80E+4n/an/an/an/an/an/a



Hoshi University

Curated by ChEMBL


Assay Description
Inhibition of SGLT2 transfected in african green monkey COS1 cells assessed as alpha-D-[U-14C]glucopyranoside uptake after 30 mins by scintillation c...


J Nat Prod 73: 763-7 (2010)


Article DOI: 10.1021/np9007987
BindingDB Entry DOI: 10.7270/Q2BP02XJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50316418
PNG
(CHEMBL1097907 | Gneyulin A)
Show SMILES Oc1ccc(\C=C\c2cc3O[C@H]([C@@H](c3c(O)c2)c2cc(O)cc(O)c2)c2cc3[C@H]([C@@H](Oc3cc2O)c2ccc(O)cc2O)c2cc(O)cc(O)c2)c(O)c1
Show InChI InChI=1S/C42H32O12/c43-23-4-3-20(32(49)15-23)2-1-19-7-35(52)40-37(8-19)54-42(39(40)22-11-27(47)14-28(48)12-22)30-17-31-36(18-34(30)51)53-41(29-6-5-24(44)16-33(29)50)38(31)21-9-25(45)13-26(46)10-21/h1-18,38-39,41-52H/b2-1+/t38-,39-,41+,42+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



Hoshi University

Curated by ChEMBL


Assay Description
Inhibition of SGLT2 transfected in african green monkey COS1 cells assessed as alpha-D-[U-14C]glucopyranoside uptake after 30 mins by scintillation c...


J Nat Prod 73: 763-7 (2010)


Article DOI: 10.1021/np9007987
BindingDB Entry DOI: 10.7270/Q2BP02XJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50316418
PNG
(CHEMBL1097907 | Gneyulin A)
Show SMILES Oc1ccc(\C=C\c2cc3O[C@H]([C@@H](c3c(O)c2)c2cc(O)cc(O)c2)c2cc3[C@H]([C@@H](Oc3cc2O)c2ccc(O)cc2O)c2cc(O)cc(O)c2)c(O)c1
Show InChI InChI=1S/C42H32O12/c43-23-4-3-20(32(49)15-23)2-1-19-7-35(52)40-37(8-19)54-42(39(40)22-11-27(47)14-28(48)12-22)30-17-31-36(18-34(30)51)53-41(29-6-5-24(44)16-33(29)50)38(31)21-9-25(45)13-26(46)10-21/h1-18,38-39,41-52H/b2-1+/t38-,39-,41+,42+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.70E+4n/an/an/an/an/an/a



Hoshi University

Curated by ChEMBL


Assay Description
Inhibition of SGLT1 transfected in african green monkey COS1 cells assessed as alpha-D-[U-14C]glucopyranoside uptake after 30 mins by scintillation c...


J Nat Prod 73: 763-7 (2010)


Article DOI: 10.1021/np9007987
BindingDB Entry DOI: 10.7270/Q2BP02XJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50316419
PNG
(CHEMBL1097908 | Gneyulin B)
Show SMILES Oc1ccc([C@@H]2Oc3cc(O)c(cc3[C@H]2c2cc(O)cc(O)c2)[C@@H]2Oc3cc(cc(O)c3[C@H]2c2cc(O)cc(O)c2)-c2cc3ccc(O)cc3o2)c(O)c1
Show InChI InChI=1S/C42H30O12/c43-22-3-4-28(31(49)14-22)41-38(20-5-24(45)12-25(46)6-20)30-16-29(32(50)17-36(30)53-41)42-39(21-7-26(47)13-27(48)8-21)40-33(51)9-19(11-37(40)54-42)34-10-18-1-2-23(44)15-35(18)52-34/h1-17,38-39,41-51H/t38-,39-,41+,42+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.70E+4n/an/an/an/an/an/a



Hoshi University

Curated by ChEMBL


Assay Description
Inhibition of SGLT1 transfected in african green monkey COS1 cells assessed as alpha-D-[U-14C]glucopyranoside uptake after 30 mins by scintillation c...


J Nat Prod 73: 763-7 (2010)


Article DOI: 10.1021/np9007987
BindingDB Entry DOI: 10.7270/Q2BP02XJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%