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PubMed code 20207151

Compile data set for download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314754
PNG
(CHEMBL1088784 | N-(5-benzyl-4-phenyl-1,3-thiazol-2...)
Show SMILES CCOc1cc(C)c(cc1OCC)C(=O)CCC(=O)Nc1nc(c(Cc2ccccc2)s1)-c1ccccc1
Show InChI InChI=1S/C31H32N2O4S/c1-4-36-26-18-21(3)24(20-27(26)37-5-2)25(34)16-17-29(35)32-31-33-30(23-14-10-7-11-15-23)28(38-31)19-22-12-8-6-9-13-22/h6-15,18,20H,4-5,16-17,19H2,1-3H3,(H,32,33,35)
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n/an/a 8.5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314752
PNG
(CHEMBL1092385 | N-[2-({[1-Phenyl-3-(trifluoromethy...)
Show SMILES FC(F)(F)COc1ccc(cn1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C21H17F6N5O3/c22-20(23,24)12-35-16-7-6-13(10-30-16)18(33)28-8-9-29-19(34)15-11-32(14-4-2-1-3-5-14)31-17(15)21(25,26)27/h1-7,10-11H,8-9,12H2,(H,28,33)(H,29,34)
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n/an/a 22n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314753
PNG
(6-Ethoxy-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Show SMILES CCOc1ccc(cn1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C21H20F3N5O3/c1-2-32-17-9-8-14(12-27-17)19(30)25-10-11-26-20(31)16-13-29(15-6-4-3-5-7-15)28-18(16)21(22,23)24/h3-9,12-13H,2,10-11H2,1H3,(H,25,30)(H,26,31)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314738
PNG
(CHEMBL1089182 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccn1
Show InChI InChI=1S/C21H20F3N5O3/c1-2-32-15-8-6-14(7-9-15)19(30)26-11-12-27-20(31)16-13-29(17-5-3-4-10-25-17)28-18(16)21(22,23)24/h3-10,13H,2,11-12H2,1H3,(H,26,30)(H,27,31)
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n/an/a 28n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314730
PNG
(CHEMBL1089874 | N-(2-(4-ethoxybenzamido)ethyl)-1-p...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C22H21F3N4O3/c1-2-32-17-10-8-15(9-11-17)20(30)26-12-13-27-21(31)18-14-29(16-6-4-3-5-7-16)28-19(18)22(23,24)25/h3-11,14H,2,12-13H2,1H3,(H,26,30)(H,27,31)
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n/an/a 33n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314752
PNG
(CHEMBL1092385 | N-[2-({[1-Phenyl-3-(trifluoromethy...)
Show SMILES FC(F)(F)COc1ccc(cn1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C21H17F6N5O3/c22-20(23,24)12-35-16-7-6-13(10-30-16)18(33)28-8-9-29-19(34)15-11-32(14-4-2-1-3-5-14)31-17(15)21(25,26)27/h1-7,10-11H,8-9,12H2,(H,28,33)(H,29,34)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314737
PNG
(1-(3-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1cccc(OCC)c1
Show InChI InChI=1S/C24H25F3N4O4/c1-3-34-18-10-8-16(9-11-18)22(32)28-12-13-29-23(33)20-15-31(30-21(20)24(25,26)27)17-6-5-7-19(14-17)35-4-2/h5-11,14-15H,3-4,12-13H2,1-2H3,(H,28,32)(H,29,33)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314751
PNG
(6-Chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Show SMILES FC(F)(F)c1nn(cc1C(=O)NCCNC(=O)c1ccc(Cl)nc1)-c1ccccc1
Show InChI InChI=1S/C19H15ClF3N5O2/c20-15-7-6-12(10-26-15)17(29)24-8-9-25-18(30)14-11-28(13-4-2-1-3-5-13)27-16(14)19(21,22)23/h1-7,10-11H,8-9H2,(H,24,29)(H,25,30)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314730
PNG
(CHEMBL1089874 | N-(2-(4-ethoxybenzamido)ethyl)-1-p...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C22H21F3N4O3/c1-2-32-17-10-8-15(9-11-17)20(30)26-12-13-27-21(31)18-14-29(16-6-4-3-5-7-16)28-19(18)22(23,24)25/h3-11,14H,2,12-13H2,1H3,(H,26,30)(H,27,31)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314749
PNG
(1-Phenyl-N-[2-({[4-(1H-pyrazol-1-yl)phenyl]carbony...)
Show SMILES FC(F)(F)c1nn(cc1C(=O)NCCNC(=O)c1ccc(cc1)-n1cccn1)-c1ccccc1
Show InChI InChI=1S/C23H19F3N6O2/c24-23(25,26)20-19(15-32(30-20)17-5-2-1-3-6-17)22(34)28-13-12-27-21(33)16-7-9-18(10-8-16)31-14-4-11-29-31/h1-11,14-15H,12-13H2,(H,27,33)(H,28,34)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314753
PNG
(6-Ethoxy-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Show SMILES CCOc1ccc(cn1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C21H20F3N5O3/c1-2-32-17-9-8-14(12-27-17)19(30)25-10-11-26-20(31)16-13-29(15-6-4-3-5-7-15)28-18(16)21(22,23)24/h3-9,12-13H,2,10-11H2,1H3,(H,25,30)(H,26,31)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314738
PNG
(CHEMBL1089182 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccn1
Show InChI InChI=1S/C21H20F3N5O3/c1-2-32-15-8-6-14(7-9-15)19(30)26-11-12-27-20(31)16-13-29(17-5-3-4-10-25-17)28-18(16)21(22,23)24/h3-10,13H,2,11-12H2,1H3,(H,26,30)(H,27,31)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314734
PNG
(1-(4-Chlorophenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H20ClF3N4O3/c1-2-33-17-9-3-14(4-10-17)20(31)27-11-12-28-21(32)18-13-30(29-19(18)22(24,25)26)16-7-5-15(23)6-8-16/h3-10,13H,2,11-12H2,1H3,(H,27,31)(H,28,32)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314741
PNG
(CHEMBL1089208 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1O
Show InChI InChI=1S/C22H21F3N4O4/c1-2-33-15-9-7-14(8-10-15)20(31)26-11-12-27-21(32)16-13-29(28-19(16)22(23,24)25)17-5-3-4-6-18(17)30/h3-10,13,30H,2,11-12H2,1H3,(H,26,31)(H,27,32)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314736
PNG
(1-(4-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccc(OCC)cc1
Show InChI InChI=1S/C24H25F3N4O4/c1-3-34-18-9-5-16(6-10-18)22(32)28-13-14-29-23(33)20-15-31(30-21(20)24(25,26)27)17-7-11-19(12-8-17)35-4-2/h5-12,15H,3-4,13-14H2,1-2H3,(H,28,32)(H,29,33)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314733
PNG
(1-Cyclohexyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)C1CCCCC1
Show InChI InChI=1S/C22H27F3N4O3/c1-2-32-17-10-8-15(9-11-17)20(30)26-12-13-27-21(31)18-14-29(16-6-4-3-5-7-16)28-19(18)22(23,24)25/h8-11,14,16H,2-7,12-13H2,1H3,(H,26,30)(H,27,31)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314732
PNG
(CHEMBL1089875 | N-(2-(4-Ethoxybenzamido)ethyl)-3-m...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C)-c1ccccc1
Show InChI InChI=1S/C22H24N4O3/c1-3-29-19-11-9-17(10-12-19)21(27)23-13-14-24-22(28)20-15-26(25-16(20)2)18-7-5-4-6-8-18/h4-12,15H,3,13-14H2,1-2H3,(H,23,27)(H,24,28)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314751
PNG
(6-Chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Show SMILES FC(F)(F)c1nn(cc1C(=O)NCCNC(=O)c1ccc(Cl)nc1)-c1ccccc1
Show InChI InChI=1S/C19H15ClF3N5O2/c20-15-7-6-12(10-26-15)17(29)24-8-9-25-18(30)14-11-28(13-4-2-1-3-5-13)27-16(14)19(21,22)23/h1-7,10-11H,8-9H2,(H,24,29)(H,25,30)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314736
PNG
(1-(4-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccc(OCC)cc1
Show InChI InChI=1S/C24H25F3N4O4/c1-3-34-18-9-5-16(6-10-18)22(32)28-13-14-29-23(33)20-15-31(30-21(20)24(25,26)27)17-7-11-19(12-8-17)35-4-2/h5-12,15H,3-4,13-14H2,1-2H3,(H,28,32)(H,29,33)
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n/an/a 380n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314749
PNG
(1-Phenyl-N-[2-({[4-(1H-pyrazol-1-yl)phenyl]carbony...)
Show SMILES FC(F)(F)c1nn(cc1C(=O)NCCNC(=O)c1ccc(cc1)-n1cccn1)-c1ccccc1
Show InChI InChI=1S/C23H19F3N6O2/c24-23(25,26)20-19(15-32(30-20)17-5-2-1-3-6-17)22(34)28-13-12-27-21(33)16-7-9-18(10-8-16)31-14-4-11-29-31/h1-11,14-15H,12-13H2,(H,27,33)(H,28,34)
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n/an/a 400n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314737
PNG
(1-(3-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1cccc(OCC)c1
Show InChI InChI=1S/C24H25F3N4O4/c1-3-34-18-10-8-16(9-11-18)22(32)28-12-13-29-23(33)20-15-31(30-21(20)24(25,26)27)17-6-5-7-19(14-17)35-4-2/h5-11,14-15H,3-4,12-13H2,1-2H3,(H,28,32)(H,29,33)
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n/an/a 600n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314741
PNG
(CHEMBL1089208 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1O
Show InChI InChI=1S/C22H21F3N4O4/c1-2-33-15-9-7-14(8-10-15)20(31)26-11-12-27-21(32)16-13-29(28-19(16)22(23,24)25)17-5-3-4-6-18(17)30/h3-10,13,30H,2,11-12H2,1H3,(H,26,31)(H,27,32)
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n/an/a 610n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314732
PNG
(CHEMBL1089875 | N-(2-(4-Ethoxybenzamido)ethyl)-3-m...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C)-c1ccccc1
Show InChI InChI=1S/C22H24N4O3/c1-3-29-19-11-9-17(10-12-19)21(27)23-13-14-24-22(28)20-15-26(25-16(20)2)18-7-5-4-6-8-18/h4-12,15H,3,13-14H2,1-2H3,(H,23,27)(H,24,28)
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n/an/a 650n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314733
PNG
(1-Cyclohexyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)C1CCCCC1
Show InChI InChI=1S/C22H27F3N4O3/c1-2-32-17-10-8-15(9-11-17)20(30)26-12-13-27-21(31)18-14-29(16-6-4-3-5-7-16)28-19(18)22(23,24)25/h8-11,14,16H,2-7,12-13H2,1H3,(H,26,30)(H,27,31)
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n/an/a 650n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314755
PNG
(5-benzyl-N-(2-(4-ethoxybenzamido)ethyl)-4-phenylth...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1nc(c(Cc2ccccc2)s1)-c1ccccc1
Show InChI InChI=1S/C28H27N3O3S/c1-2-34-23-15-13-22(14-16-23)26(32)29-17-18-30-27(33)28-31-25(21-11-7-4-8-12-21)24(35-28)19-20-9-5-3-6-10-20/h3-16H,2,17-19H2,1H3,(H,29,32)(H,30,33)
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n/an/a 700n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314735
PNG
(1-Benzyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino}-et...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(Cc2ccccc2)nc1C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O3/c1-2-33-18-10-8-17(9-11-18)21(31)27-12-13-28-22(32)19-15-30(29-20(19)23(24,25)26)14-16-6-4-3-5-7-16/h3-11,15H,2,12-14H2,1H3,(H,27,31)(H,28,32)
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n/an/a 770n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314735
PNG
(1-Benzyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino}-et...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(Cc2ccccc2)nc1C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O3/c1-2-33-18-10-8-17(9-11-18)21(31)27-12-13-28-22(32)19-15-30(29-20(19)23(24,25)26)14-16-6-4-3-5-7-16/h3-11,15H,2,12-14H2,1H3,(H,27,31)(H,28,32)
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n/an/a 790n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314731
PNG
(CHEMBL1089304 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1nn(cc1C)-c1ccccc1
Show InChI InChI=1S/C22H24N4O3/c1-3-29-19-11-9-17(10-12-19)21(27)23-13-14-24-22(28)20-16(2)15-26(25-20)18-7-5-4-6-8-18/h4-12,15H,3,13-14H2,1-2H3,(H,23,27)(H,24,28)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314750
PNG
(5-Chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Show SMILES FC(F)(F)c1nn(cc1C(=O)NCCNC(=O)c1ccc(Cl)cn1)-c1ccccc1
Show InChI InChI=1S/C19H15ClF3N5O2/c20-12-6-7-15(26-10-12)18(30)25-9-8-24-17(29)14-11-28(13-4-2-1-3-5-13)27-16(14)19(21,22)23/h1-7,10-11H,8-9H2,(H,24,29)(H,25,30)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314750
PNG
(5-Chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Show SMILES FC(F)(F)c1nn(cc1C(=O)NCCNC(=O)c1ccc(Cl)cn1)-c1ccccc1
Show InChI InChI=1S/C19H15ClF3N5O2/c20-12-6-7-15(26-10-12)18(30)25-9-8-24-17(29)14-11-28(13-4-2-1-3-5-13)27-16(14)19(21,22)23/h1-7,10-11H,8-9H2,(H,24,29)(H,25,30)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314734
PNG
(1-(4-Chlorophenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H20ClF3N4O3/c1-2-33-17-9-3-14(4-10-17)20(31)27-11-12-28-21(32)18-13-30(29-19(18)22(24,25)26)16-7-5-15(23)6-8-16/h3-10,13H,2,11-12H2,1H3,(H,27,31)(H,28,32)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314740
PNG
(CHEMBL1089507 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1cccnc1
Show InChI InChI=1S/C21H20F3N5O3/c1-2-32-16-7-5-14(6-8-16)19(30)26-10-11-27-20(31)17-13-29(15-4-3-9-25-12-15)28-18(17)21(22,23)24/h3-9,12-13H,2,10-11H2,1H3,(H,26,30)(H,27,31)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314731
PNG
(CHEMBL1089304 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1nn(cc1C)-c1ccccc1
Show InChI InChI=1S/C22H24N4O3/c1-3-29-19-11-9-17(10-12-19)21(27)23-13-14-24-22(28)20-16(2)15-26(25-20)18-7-5-4-6-8-18/h4-12,15H,3,13-14H2,1-2H3,(H,23,27)(H,24,28)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314746
PNG
(CHEMBL1091906 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCC(C)NC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C23H23F3N4O3/c1-3-33-18-11-9-16(10-12-18)21(31)27-13-15(2)28-22(32)19-14-30(17-7-5-4-6-8-17)29-20(19)23(24,25)26/h4-12,14-15H,3,13H2,1-2H3,(H,27,31)(H,28,32)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314740
PNG
(CHEMBL1089507 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1cccnc1
Show InChI InChI=1S/C21H20F3N5O3/c1-2-32-16-7-5-14(6-8-16)19(30)26-10-11-27-20(31)17-13-29(15-4-3-9-25-12-15)28-18(17)21(22,23)24/h3-9,12-13H,2,10-11H2,1H3,(H,26,30)(H,27,31)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314748
PNG
(CHEMBL1091721 | N-(2-{[(3-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1cccc(c1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C22H21F3N4O3/c1-2-32-17-10-6-7-15(13-17)20(30)26-11-12-27-21(31)18-14-29(16-8-4-3-5-9-16)28-19(18)22(23,24)25/h3-10,13-14H,2,11-12H2,1H3,(H,26,30)(H,27,31)
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n/an/a 3.60E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314748
PNG
(CHEMBL1091721 | N-(2-{[(3-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1cccc(c1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C22H21F3N4O3/c1-2-32-17-10-6-7-15(13-17)20(30)26-11-12-27-21(31)18-14-29(16-8-4-3-5-9-16)28-19(18)22(23,24)25/h3-10,13-14H,2,11-12H2,1H3,(H,26,30)(H,27,31)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314747
PNG
(CHEMBL1091905 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NC(C)CNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C23H23F3N4O3/c1-3-33-18-11-9-16(10-12-18)21(31)28-15(2)13-27-22(32)19-14-30(17-7-5-4-6-8-17)29-20(19)23(24,25)26/h4-12,14-15H,3,13H2,1-2H3,(H,27,32)(H,28,31)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314739
PNG
(CHEMBL1089508 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccncc1
Show InChI InChI=1S/C21H20F3N5O3/c1-2-32-16-5-3-14(4-6-16)19(30)26-11-12-27-20(31)17-13-29(15-7-9-25-10-8-15)28-18(17)21(22,23)24/h3-10,13H,2,11-12H2,1H3,(H,26,30)(H,27,31)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314742
PNG
((R)-N-(2-{[(4-Ethoxyphenyl)carbonyl]amino}-3-hydro...)
Show SMILES CCOc1ccc(cc1)C(=O)N[C@@H](CO)CNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C23H23F3N4O4/c1-2-34-18-10-8-15(9-11-18)21(32)28-16(14-31)12-27-22(33)19-13-30(17-6-4-3-5-7-17)29-20(19)23(24,25)26/h3-11,13,16,31H,2,12,14H2,1H3,(H,27,33)(H,28,32)/t16-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314745
PNG
((R)-N-[2-{[(4-Ethoxyphenyl)carbonyl]amino}-1-(hydr...)
Show SMILES CCOc1ccc(cc1)C(=O)NC[C@H](CO)NC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C23H23F3N4O4/c1-2-34-18-10-8-15(9-11-18)21(32)27-12-16(14-31)28-22(33)19-13-30(17-6-4-3-5-7-17)29-20(19)23(24,25)26/h3-11,13,16,31H,2,12,14H2,1H3,(H,27,32)(H,28,33)/t16-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314743
PNG
((S)-N-(2-{[(4-Ethoxyphenyl)carbonyl]amino}-3-hydro...)
Show SMILES CCOc1ccc(cc1)C(=O)N[C@H](CO)CNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C23H23F3N4O4/c1-2-34-18-10-8-15(9-11-18)21(32)28-16(14-31)12-27-22(33)19-13-30(17-6-4-3-5-7-17)29-20(19)23(24,25)26/h3-11,13,16,31H,2,12,14H2,1H3,(H,27,33)(H,28,32)/t16-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314739
PNG
(CHEMBL1089508 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccncc1
Show InChI InChI=1S/C21H20F3N5O3/c1-2-32-16-5-3-14(4-6-16)19(30)26-11-12-27-20(31)17-13-29(15-7-9-25-10-8-15)28-18(17)21(22,23)24/h3-10,13H,2,11-12H2,1H3,(H,26,30)(H,27,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314744
PNG
((S)-N-[2-{[(4-Ethoxyphenyl)carbonyl]amino}-1-(hydr...)
Show SMILES CCOc1ccc(cc1)C(=O)NC[C@@H](CO)NC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C23H23F3N4O4/c1-2-34-18-10-8-15(9-11-18)21(32)27-12-16(14-31)28-22(33)19-13-30(17-6-4-3-5-7-17)29-20(19)23(24,25)26/h3-11,13,16,31H,2,12,14H2,1H3,(H,27,32)(H,28,33)/t16-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%