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PubMed code 20226658

Compile data set for download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Androgen Receptor


(Homo sapiens (human))
BDBM50131270
PNG
(2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]prop...)
Show SMILES CC(C)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O
Show InChI InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)
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Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Meijo University

Curated by ChEMBL


Assay Description
Antagonist activity at AR in human MDA-kb2 cells cotransfected with MMTV-luc assessed as decrease in DHT-induced luciferase activity by reporter gene...


Bioorg Med Chem Lett 20: 2111-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.059
BindingDB Entry DOI: 10.7270/Q25D8S0V
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50164168
PNG
(1,3,4-Eugenol | 1-Hydroxy-2-methoxy-4-allylbenzene...)
Show SMILES COc1cc(CC=C)ccc1O
Show InChI InChI=1S/C10H12O2/c1-3-4-8-5-6-9(11)10(7-8)12-2/h3,5-7,11H,1,4H2,2H3
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Article
PubMed
n/an/a 1.90E+4n/an/an/an/an/an/a



Meijo University

Curated by ChEMBL


Assay Description
Antagonist activity at AR in human MDA-kb2 cells cotransfected with MMTV-luc assessed as decrease in DHT-induced luciferase activity by reporter gene...


Bioorg Med Chem Lett 20: 2111-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.059
BindingDB Entry DOI: 10.7270/Q25D8S0V
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50304073
PNG
(4-(4-Hydroxy-3-methoxy-phenyl)-butan-2-one | CHEMB...)
Show SMILES COc1cc(CCC(C)=O)ccc1O
Show InChI InChI=1S/C11H14O3/c1-8(12)3-4-9-5-6-10(13)11(7-9)14-2/h5-7,13H,3-4H2,1-2H3
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Article
PubMed
n/an/a 1.53E+5n/an/an/an/an/an/a



Meijo University

Curated by ChEMBL


Assay Description
Antagonist activity at AR in human MDA-kb2 cells cotransfected with MMTV-luc assessed as decrease in DHT-induced luciferase activity by reporter gene...


Bioorg Med Chem Lett 20: 2111-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.059
BindingDB Entry DOI: 10.7270/Q25D8S0V
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50315100
PNG
(4-(4-Hydroxy-phenyl)-butan-2-one | CHEMBL105912 | ...)
Show SMILES CC(=O)CCc1ccc(O)cc1
Show InChI InChI=1S/C10H12O2/c1-8(11)2-3-9-4-6-10(12)7-5-9/h4-7,12H,2-3H2,1H3
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Article
PubMed
n/an/a 2.52E+5n/an/an/an/an/an/a



Meijo University

Curated by ChEMBL


Assay Description
Antagonist activity at AR in human MDA-kb2 cells cotransfected with MMTV-luc assessed as decrease in DHT-induced luciferase activity by reporter gene...


Bioorg Med Chem Lett 20: 2111-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.059
BindingDB Entry DOI: 10.7270/Q25D8S0V
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50315101
PNG
(CHEMBL1090553 | p-hydroxyphenylacetone)
Show SMILES CC(=O)Cc1ccc(O)cc1
Show InChI InChI=1S/C9H10O2/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,11H,6H2,1H3
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Article
PubMed
n/an/a 4.20E+5n/an/an/an/an/an/a



Meijo University

Curated by ChEMBL


Assay Description
Antagonist activity at AR in human MDA-kb2 cells cotransfected with MMTV-luc assessed as decrease in DHT-induced luciferase activity by reporter gene...


Bioorg Med Chem Lett 20: 2111-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.059
BindingDB Entry DOI: 10.7270/Q25D8S0V
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%