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PubMed code 20430619

Compile data set for download or QSAR
Found 73 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318946
PNG
(CHEMBL1085293 | rac-9-(2-hydroxyethyl)-5-methyl-12...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c3n(CCO)c3ccc(cc23)C2CCCCO2)n1
Show InChI InChI=1S/C27H28N4O3/c1-30-14-19-20(29-30)7-6-16-23(19)25-18(13-28-27(25)33)24-17-12-15(22-4-2-3-11-34-22)5-8-21(17)31(9-10-32)26(16)24/h5,8,12,14,22,32H,2-4,6-7,9-11,13H2,1H3,(H,28,33)
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n/an/a 3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318963
PNG
(CHEMBL1084061 | rac-5-methyl-9-propyl-12-(tetrahyd...)
Show SMILES CCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C28H30N4O2/c1-3-11-32-22-10-7-16(23-6-4-5-12-34-23)13-18(22)25-19-14-29-28(33)26(19)24-17(27(25)32)8-9-21-20(24)15-31(2)30-21/h7,10,13,15,23H,3-6,8-9,11-12,14H2,1-2H3,(H,29,33)
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n/an/a 3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318959
PNG
(CHEMBL1084337 | rac-9-isobutyl-5-methyl-12-(tetrah...)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-16(2)14-33-23-10-7-17(24-6-4-5-11-35-24)12-19(23)26-20-13-30-29(34)27(20)25-18(28(26)33)8-9-22-21(25)15-32(3)31-22/h7,10,12,15-16,24H,4-6,8-9,11,13-14H2,1-3H3,(H,30,34)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50318958
PNG
(CHEMBL1082829 | rac-9-butyl-5-methyl-12-(tetrahydr...)
Show SMILES CCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-3-4-12-33-23-11-8-17(24-7-5-6-13-35-24)14-19(23)26-20-15-30-29(34)27(20)25-18(28(26)33)9-10-22-21(25)16-32(2)31-22/h8,11,14,16,24H,3-7,9-10,12-13,15H2,1-2H3,(H,30,34)
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n/an/a 5n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 at 3 uM


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318960
PNG
(CHEMBL1082503 | rac-5-methyl-12-(tetrahydro-2H-pyr...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4[nH]c32)C2CCCCO2)n1
Show InChI InChI=1S/C25H24N4O2/c1-29-12-17-19(28-29)8-6-14-21(17)23-16(11-26-25(23)30)22-15-10-13(20-4-2-3-9-31-20)5-7-18(15)27-24(14)22/h5,7,10,12,20,27H,2-4,6,8-9,11H2,1H3,(H,26,30)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318962
PNG
(CHEMBL1083757 | rac-9-ethyl-5-methyl-12-(tetrahydr...)
Show SMILES CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C27H28N4O2/c1-3-31-21-10-7-15(22-6-4-5-11-33-22)12-17(21)24-18-13-28-27(32)25(18)23-16(26(24)31)8-9-20-19(23)14-30(2)29-20/h7,10,12,14,22H,3-6,8-9,11,13H2,1-2H3,(H,28,32)
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n/an/a 6n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318957
PNG
(9-(2-hydroxyethyl)-6-methyl-12-(tetrahydro-2H-pyra...)
Show SMILES Cn1ncc-2c1CCc1c-2c2C(=O)NCc2c2c1n(CCO)c1ccc(cc21)C1CCCCO1
Show InChI InChI=1S/C27H28N4O3/c1-30-20-8-6-16-23(18(20)14-29-30)25-19(13-28-27(25)33)24-17-12-15(22-4-2-3-11-34-22)5-7-21(17)31(9-10-32)26(16)24/h5,7,12,14,22,32H,2-4,6,8-11,13H2,1H3,(H,28,33)
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n/an/a 7n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318949
PNG
(6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9-tet...)
Show SMILES Cn1ncc-2c1CCc1c-2c2C(=O)NCc2c2c3cc(ccc3[nH]c12)C1CCCCO1
Show InChI InChI=1S/C25H24N4O2/c1-29-19-8-6-14-21(16(19)12-27-29)23-17(11-26-25(23)30)22-15-10-13(20-4-2-3-9-31-20)5-7-18(15)28-24(14)22/h5,7,10,12,20,28H,2-4,6,8-9,11H2,1H3,(H,26,30)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318963
PNG
(CHEMBL1084061 | rac-5-methyl-9-propyl-12-(tetrahyd...)
Show SMILES CCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C28H30N4O2/c1-3-11-32-22-10-7-16(23-6-4-5-12-34-23)13-18(22)25-19-14-29-28(33)26(19)24-17(27(25)32)8-9-21-20(24)15-31(2)30-21/h7,10,13,15,23H,3-6,8-9,11-12,14H2,1-2H3,(H,29,33)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50318959
PNG
(CHEMBL1084337 | rac-9-isobutyl-5-methyl-12-(tetrah...)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-16(2)14-33-23-10-7-17(24-6-4-5-11-35-24)12-19(23)26-20-13-30-29(34)27(20)25-18(28(26)33)8-9-22-21(25)15-32(3)31-22/h7,10,12,15-16,24H,4-6,8-9,11,13-14H2,1-3H3,(H,30,34)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 at 3 uM


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318951
PNG
(9-ethyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7...)
Show SMILES CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cnn(C)c4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C27H28N4O2/c1-3-31-21-9-7-15(22-6-4-5-11-33-22)12-17(21)24-19-13-28-27(32)25(19)23-16(26(24)31)8-10-20-18(23)14-29-30(20)2/h7,9,12,14,22H,3-6,8,10-11,13H2,1-2H3,(H,28,32)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318970
PNG
(CHEMBL1082755 | rac-9-allyl-5-methyl-12-(tetrahydr...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4n(CC=C)c32)C2CCCCO2)n1
Show InChI InChI=1S/C28H28N4O2/c1-3-11-32-22-10-7-16(23-6-4-5-12-34-23)13-18(22)25-19-14-29-28(33)26(19)24-17(27(25)32)8-9-21-20(24)15-31(2)30-21/h3,7,10,13,15,23H,1,4-6,8-9,11-12,14H2,2H3,(H,29,33)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318959
PNG
(CHEMBL1084337 | rac-9-isobutyl-5-methyl-12-(tetrah...)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-16(2)14-33-23-10-7-17(24-6-4-5-11-35-24)12-19(23)26-20-13-30-29(34)27(20)25-18(28(26)33)8-9-22-21(25)15-32(3)31-22/h7,10,12,15-16,24H,4-6,8-9,11,13-14H2,1-3H3,(H,30,34)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318964
PNG
(CHEMBL1084062 | rac-9-isopropyl-5-methyl-12-(tetra...)
Show SMILES CC(C)n1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C28H30N4O2/c1-15(2)32-22-10-7-16(23-6-4-5-11-34-23)12-18(22)25-19-13-29-28(33)26(19)24-17(27(25)32)8-9-21-20(24)14-31(3)30-21/h7,10,12,14-15,23H,4-6,8-9,11,13H2,1-3H3,(H,29,33)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318962
PNG
(CHEMBL1083757 | rac-9-ethyl-5-methyl-12-(tetrahydr...)
Show SMILES CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C27H28N4O2/c1-3-31-21-10-7-15(22-6-4-5-11-33-22)12-17(21)24-18-13-28-27(32)25(18)23-16(26(24)31)8-9-20-19(23)14-30(2)29-20/h7,10,12,14,22H,3-6,8-9,11,13H2,1-2H3,(H,28,32)
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n/an/a<10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318961
PNG
(CHEMBL1082826 | rac-5,9-dimethyl-12-(tetrahydro-2H...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4n(C)c32)C2CCCCO2)n1
Show InChI InChI=1S/C26H26N4O2/c1-29-13-18-19(28-29)8-7-15-22(18)24-17(12-27-26(24)31)23-16-11-14(21-5-3-4-10-32-21)6-9-20(16)30(2)25(15)23/h6,9,11,13,21H,3-5,7-8,10,12H2,1-2H3,(H,27,31)
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n/an/a<10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318963
PNG
(CHEMBL1084061 | rac-5-methyl-9-propyl-12-(tetrahyd...)
Show SMILES CCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C28H30N4O2/c1-3-11-32-22-10-7-16(23-6-4-5-12-34-23)13-18(22)25-19-14-29-28(33)26(19)24-17(27(25)32)8-9-21-20(24)15-31(2)30-21/h7,10,13,15,23H,3-6,8-9,11-12,14H2,1-2H3,(H,29,33)
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n/an/a<10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318958
PNG
(CHEMBL1082829 | rac-9-butyl-5-methyl-12-(tetrahydr...)
Show SMILES CCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-3-4-12-33-23-11-8-17(24-7-5-6-13-35-24)14-19(23)26-20-15-30-29(34)27(20)25-18(28(26)33)9-10-22-21(25)16-32(2)31-22/h8,11,14,16,24H,3-7,9-10,12-13,15H2,1-2H3,(H,30,34)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318960
PNG
(CHEMBL1082503 | rac-5-methyl-12-(tetrahydro-2H-pyr...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4[nH]c32)C2CCCCO2)n1
Show InChI InChI=1S/C25H24N4O2/c1-29-12-17-19(28-29)8-6-14-21(17)23-16(11-26-25(23)30)22-15-10-13(20-4-2-3-9-31-20)5-7-18(15)27-24(14)22/h5,7,10,12,20,27H,2-4,6,8-9,11H2,1H3,(H,26,30)
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n/an/a<10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318964
PNG
(CHEMBL1084062 | rac-9-isopropyl-5-methyl-12-(tetra...)
Show SMILES CC(C)n1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C28H30N4O2/c1-15(2)32-22-10-7-16(23-6-4-5-11-34-23)12-18(22)25-19-13-29-28(33)26(19)24-17(27(25)32)8-9-21-20(24)14-31(3)30-21/h7,10,12,14-15,23H,4-6,8-9,11,13H2,1-3H3,(H,29,33)
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n/an/a<10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318958
PNG
(CHEMBL1082829 | rac-9-butyl-5-methyl-12-(tetrahydr...)
Show SMILES CCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-3-4-12-33-23-11-8-17(24-7-5-6-13-35-24)14-19(23)26-20-15-30-29(34)27(20)25-18(28(26)33)9-10-22-21(25)16-32(2)31-22/h8,11,14,16,24H,3-7,9-10,12-13,15H2,1-2H3,(H,30,34)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318959
PNG
(CHEMBL1084337 | rac-9-isobutyl-5-methyl-12-(tetrah...)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-16(2)14-33-23-10-7-17(24-6-4-5-11-35-24)12-19(23)26-20-13-30-29(34)27(20)25-18(28(26)33)8-9-22-21(25)15-32(3)31-22/h7,10,12,15-16,24H,4-6,8-9,11,13-14H2,1-3H3,(H,30,34)
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n/an/a 11n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318962
PNG
(CHEMBL1083757 | rac-9-ethyl-5-methyl-12-(tetrahydr...)
Show SMILES CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C27H28N4O2/c1-3-31-21-10-7-15(22-6-4-5-11-33-22)12-17(21)24-18-13-28-27(32)25(18)23-16(26(24)31)8-9-20-19(23)14-30(2)29-20/h7,10,12,14,22H,3-6,8-9,11,13H2,1-2H3,(H,28,32)
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n/an/a 14n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318961
PNG
(CHEMBL1082826 | rac-5,9-dimethyl-12-(tetrahydro-2H...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4n(C)c32)C2CCCCO2)n1
Show InChI InChI=1S/C26H26N4O2/c1-29-13-18-19(28-29)8-7-15-22(18)24-17(12-27-26(24)31)23-16-11-14(21-5-3-4-10-32-21)6-9-20(16)30(2)25(15)23/h6,9,11,13,21H,3-5,7-8,10,12H2,1-2H3,(H,27,31)
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n/an/a 15n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318947
PNG
(CHEMBL1085540 | rac-9-(3-hydroxypropyl)-5-methyl-1...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c3n(CCCO)c3ccc(cc23)C2CCCCO2)n1
Show InChI InChI=1S/C28H30N4O3/c1-31-15-20-21(30-31)8-7-17-24(20)26-19(14-29-28(26)34)25-18-13-16(23-5-2-3-12-35-23)6-9-22(18)32(27(17)25)10-4-11-33/h6,9,13,15,23,33H,2-5,7-8,10-12,14H2,1H3,(H,29,34)
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n/an/a 16n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318947
PNG
(CHEMBL1085540 | rac-9-(3-hydroxypropyl)-5-methyl-1...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c3n(CCCO)c3ccc(cc23)C2CCCCO2)n1
Show InChI InChI=1S/C28H30N4O3/c1-31-15-20-21(30-31)8-7-17-24(20)26-19(14-29-28(26)34)25-18-13-16(23-5-2-3-12-35-23)6-9-22(18)32(27(17)25)10-4-11-33/h6,9,13,15,23,33H,2-5,7-8,10-12,14H2,1H3,(H,29,34)
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n/an/a 16n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318948
PNG
(CHEMBL1085541 | rac-9-(2-(diethylamino)ethyl)-5-me...)
Show SMILES CCN(CC)CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C31H37N5O2/c1-4-35(5-2)13-14-36-25-12-9-19(26-8-6-7-15-38-26)16-21(25)28-22-17-32-31(37)29(22)27-20(30(28)36)10-11-24-23(27)18-34(3)33-24/h9,12,16,18,26H,4-8,10-11,13-15,17H2,1-3H3,(H,32,37)
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n/an/a 16n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50318959
PNG
(CHEMBL1084337 | rac-9-isobutyl-5-methyl-12-(tetrah...)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-16(2)14-33-23-10-7-17(24-6-4-5-11-35-24)12-19(23)26-20-13-30-29(34)27(20)25-18(28(26)33)8-9-22-21(25)15-32(3)31-22/h7,10,12,15-16,24H,4-6,8-9,11,13-14H2,1-3H3,(H,30,34)
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n/an/a 16n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 at 3 uM


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318945
PNG
(CHEMBL1082756 | rac-9-(2-ethoxyethyl)-5-methyl-12-...)
Show SMILES CCOCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O3/c1-3-35-13-11-33-23-10-7-17(24-6-4-5-12-36-24)14-19(23)26-20-15-30-29(34)27(20)25-18(28(26)33)8-9-22-21(25)16-32(2)31-22/h7,10,14,16,24H,3-6,8-9,11-13,15H2,1-2H3,(H,30,34)
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n/an/a 17n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318955
PNG
(9-isobutyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-...)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cnn(C)c4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-16(2)15-33-23-9-7-17(24-6-4-5-11-35-24)12-19(23)26-21-13-30-29(34)27(21)25-18(28(26)33)8-10-22-20(25)14-31-32(22)3/h7,9,12,14,16,24H,4-6,8,10-11,13,15H2,1-3H3,(H,30,34)
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n/an/a 18n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318970
PNG
(CHEMBL1082755 | rac-9-allyl-5-methyl-12-(tetrahydr...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4n(CC=C)c32)C2CCCCO2)n1
Show InChI InChI=1S/C28H28N4O2/c1-3-11-32-22-10-7-16(23-6-4-5-12-34-23)13-18(22)25-19-14-29-28(33)26(19)24-17(27(25)32)8-9-21-20(24)15-31(2)30-21/h3,7,10,13,15,23H,1,4-6,8-9,11-12,14H2,2H3,(H,29,33)
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n/an/a 18n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318952
PNG
(6-methyl-9-propyl-12-(tetrahydro-2H-pyran-2-yl)-6,...)
Show SMILES CCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cnn(C)c4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C28H30N4O2/c1-3-11-32-22-9-7-16(23-6-4-5-12-34-23)13-18(22)25-20-14-29-28(33)26(20)24-17(27(25)32)8-10-21-19(24)15-30-31(21)2/h7,9,13,15,23H,3-6,8,10-12,14H2,1-2H3,(H,29,33)
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n/an/a 20n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318965
PNG
(CHEMBL1084338 | rac-9-isopentyl-5-methyl-12-(tetra...)
Show SMILES CC(C)CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C30H34N4O2/c1-17(2)11-12-34-24-10-7-18(25-6-4-5-13-36-25)14-20(24)27-21-15-31-30(35)28(21)26-19(29(27)34)8-9-23-22(26)16-33(3)32-23/h7,10,14,16-17,25H,4-6,8-9,11-13,15H2,1-3H3,(H,31,35)
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n/an/a 21n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318964
PNG
(CHEMBL1084062 | rac-9-isopropyl-5-methyl-12-(tetra...)
Show SMILES CC(C)n1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C28H30N4O2/c1-15(2)32-22-10-7-16(23-6-4-5-11-34-23)12-18(22)25-19-13-29-28(33)26(19)24-17(27(25)32)8-9-21-20(24)14-31(3)30-21/h7,10,12,14-15,23H,4-6,8-9,11,13H2,1-3H3,(H,29,33)
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n/an/a 21n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318950
PNG
(6,9-dimethyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9...)
Show SMILES Cn1ncc-2c1CCc1c-2c2C(=O)NCc2c2c3cc(ccc3n(C)c12)C1CCCCO1
Show InChI InChI=1S/C26H26N4O2/c1-29-19-8-6-14(21-5-3-4-10-32-21)11-16(19)23-18-12-27-26(31)24(18)22-15(25(23)29)7-9-20-17(22)13-28-30(20)2/h6,8,11,13,21H,3-5,7,9-10,12H2,1-2H3,(H,27,31)
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n/an/a 22n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318945
PNG
(CHEMBL1082756 | rac-9-(2-ethoxyethyl)-5-methyl-12-...)
Show SMILES CCOCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O3/c1-3-35-13-11-33-23-10-7-17(24-6-4-5-12-36-24)14-19(23)26-20-15-30-29(34)27(20)25-18(28(26)33)8-9-22-21(25)16-32(2)31-22/h7,10,14,16,24H,3-6,8-9,11-13,15H2,1-2H3,(H,30,34)
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n/an/a 22n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318958
PNG
(CHEMBL1082829 | rac-9-butyl-5-methyl-12-(tetrahydr...)
Show SMILES CCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-3-4-12-33-23-11-8-17(24-7-5-6-13-35-24)14-19(23)26-20-15-30-29(34)27(20)25-18(28(26)33)9-10-22-21(25)16-32(2)31-22/h8,11,14,16,24H,3-7,9-10,12-13,15H2,1-2H3,(H,30,34)
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n/an/a 24n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318952
PNG
(6-methyl-9-propyl-12-(tetrahydro-2H-pyran-2-yl)-6,...)
Show SMILES CCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cnn(C)c4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C28H30N4O2/c1-3-11-32-22-9-7-16(23-6-4-5-12-34-23)13-18(22)25-20-14-29-28(33)26(20)24-17(27(25)32)8-10-21-19(24)15-30-31(21)2/h7,9,13,15,23H,3-6,8,10-12,14H2,1-2H3,(H,29,33)
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n/an/a 24n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318946
PNG
(CHEMBL1085293 | rac-9-(2-hydroxyethyl)-5-methyl-12...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c3n(CCO)c3ccc(cc23)C2CCCCO2)n1
Show InChI InChI=1S/C27H28N4O3/c1-30-14-19-20(29-30)7-6-16-23(19)25-18(13-28-27(25)33)24-17-12-15(22-4-2-3-11-34-22)5-8-21(17)31(9-10-32)26(16)24/h5,8,12,14,22,32H,2-4,6-7,9-11,13H2,1H3,(H,28,33)
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n/an/a 27n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50318958
PNG
(CHEMBL1082829 | rac-9-butyl-5-methyl-12-(tetrahydr...)
Show SMILES CCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-3-4-12-33-23-11-8-17(24-7-5-6-13-35-24)14-19(23)26-20-15-30-29(34)27(20)25-18(28(26)33)9-10-22-21(25)16-32(2)31-22/h8,11,14,16,24H,3-7,9-10,12-13,15H2,1-2H3,(H,30,34)
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n/an/a 28n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 at 3 uM


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318955
PNG
(9-isobutyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-...)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cnn(C)c4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-16(2)15-33-23-9-7-17(24-6-4-5-11-35-24)12-19(23)26-21-13-30-29(34)27(21)25-18(28(26)33)8-10-22-20(25)14-31-32(22)3/h7,9,12,14,16,24H,4-6,8,10-11,13,15H2,1-3H3,(H,30,34)
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n/an/a 36n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318954
PNG
(9-butyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7...)
Show SMILES CCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cnn(C)c4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-3-4-12-33-23-10-8-17(24-7-5-6-13-35-24)14-19(23)26-21-15-30-29(34)27(21)25-18(28(26)33)9-11-22-20(25)16-31-32(22)2/h8,10,14,16,24H,3-7,9,11-13,15H2,1-2H3,(H,30,34)
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n/an/a 37n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318961
PNG
(CHEMBL1082826 | rac-5,9-dimethyl-12-(tetrahydro-2H...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4n(C)c32)C2CCCCO2)n1
Show InChI InChI=1S/C26H26N4O2/c1-29-13-18-19(28-29)8-7-15-22(18)24-17(12-27-26(24)31)23-16-11-14(21-5-3-4-10-32-21)6-9-20(16)30(2)25(15)23/h6,9,11,13,21H,3-5,7-8,10,12H2,1-2H3,(H,27,31)
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n/an/a 41n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318967
PNG
(CHEMBL1083454 | rac-9-cyclopentyl-5-methyl-12-(tet...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4n(C4CCCC4)c32)C2CCCCO2)n1
Show InChI InChI=1S/C30H32N4O2/c1-33-16-22-23(32-33)11-10-19-26(22)28-21(15-31-30(28)35)27-20-14-17(25-8-4-5-13-36-25)9-12-24(20)34(29(19)27)18-6-2-3-7-18/h9,12,14,16,18,25H,2-8,10-11,13,15H2,1H3,(H,31,35)
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n/an/a 41n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318953
PNG
(9-isopropyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)...)
Show SMILES CC(C)n1c2ccc(cc2c2c3CNC(=O)c3c3-c4cnn(C)c4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C28H30N4O2/c1-15(2)32-22-9-7-16(23-6-4-5-11-34-23)12-18(22)25-20-13-29-28(33)26(20)24-17(27(25)32)8-10-21-19(24)14-30-31(21)3/h7,9,12,14-15,23H,4-6,8,10-11,13H2,1-3H3,(H,29,33)
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n/an/a 44n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318960
PNG
(CHEMBL1082503 | rac-5-methyl-12-(tetrahydro-2H-pyr...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4[nH]c32)C2CCCCO2)n1
Show InChI InChI=1S/C25H24N4O2/c1-29-12-17-19(28-29)8-6-14-21(17)23-16(11-26-25(23)30)22-15-10-13(20-4-2-3-9-31-20)5-7-18(15)27-24(14)22/h5,7,10,12,20,27H,2-4,6,8-9,11H2,1H3,(H,26,30)
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n/an/a 44n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318968
PNG
(CHEMBL1085291 | rac-9-cyclohexyl-5-methyl-12-(tetr...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4n(C4CCCCC4)c32)C2CCCCO2)n1
Show InChI InChI=1S/C31H34N4O2/c1-34-17-23-24(33-34)12-11-20-27(23)29-22(16-32-31(29)36)28-21-15-18(26-9-5-6-14-37-26)10-13-25(21)35(30(20)28)19-7-3-2-4-8-19/h10,13,15,17,19,26H,2-9,11-12,14,16H2,1H3,(H,32,36)
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n/an/a 44n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318945
PNG
(CHEMBL1082756 | rac-9-(2-ethoxyethyl)-5-methyl-12-...)
Show SMILES CCOCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O3/c1-3-35-13-11-33-23-10-7-17(24-6-4-5-12-36-24)14-19(23)26-20-15-30-29(34)27(20)25-18(28(26)33)8-9-22-21(25)16-32(2)31-22/h7,10,14,16,24H,3-6,8-9,11-13,15H2,1-2H3,(H,30,34)
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n/an/a<50n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318948
PNG
(CHEMBL1085541 | rac-9-(2-(diethylamino)ethyl)-5-me...)
Show SMILES CCN(CC)CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C31H37N5O2/c1-4-35(5-2)13-14-36-25-12-9-19(26-8-6-7-15-38-26)16-21(25)28-22-17-32-31(37)29(22)27-20(30(28)36)10-11-24-23(27)18-34(3)33-24/h9,12,16,18,26H,4-8,10-11,13-15,17H2,1-3H3,(H,32,37)
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n/an/a<50n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318946
PNG
(CHEMBL1085293 | rac-9-(2-hydroxyethyl)-5-methyl-12...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c3n(CCO)c3ccc(cc23)C2CCCCO2)n1
Show InChI InChI=1S/C27H28N4O3/c1-30-14-19-20(29-30)7-6-16-23(19)25-18(13-28-27(25)33)24-17-12-15(22-4-2-3-11-34-22)5-8-21(17)31(9-10-32)26(16)24/h5,8,12,14,22,32H,2-4,6-7,9-11,13H2,1H3,(H,28,33)
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n/an/a<50n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318970
PNG
(CHEMBL1082755 | rac-9-allyl-5-methyl-12-(tetrahydr...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4n(CC=C)c32)C2CCCCO2)n1
Show InChI InChI=1S/C28H28N4O2/c1-3-11-32-22-10-7-16(23-6-4-5-12-34-23)13-18(22)25-19-14-29-28(33)26(19)24-17(27(25)32)8-9-21-20(24)15-31(2)30-21/h3,7,10,13,15,23H,1,4-6,8-9,11-12,14H2,2H3,(H,29,33)
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n/an/a<50n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318967
PNG
(CHEMBL1083454 | rac-9-cyclopentyl-5-methyl-12-(tet...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4n(C4CCCC4)c32)C2CCCCO2)n1
Show InChI InChI=1S/C30H32N4O2/c1-33-16-22-23(32-33)11-10-19-26(22)28-21(15-31-30(28)35)27-20-14-17(25-8-4-5-13-36-25)9-12-24(20)34(29(19)27)18-6-2-3-7-18/h9,12,14,16,18,25H,2-8,10-11,13,15H2,1H3,(H,31,35)
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n/an/a<50n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318947
PNG
(CHEMBL1085540 | rac-9-(3-hydroxypropyl)-5-methyl-1...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c3n(CCCO)c3ccc(cc23)C2CCCCO2)n1
Show InChI InChI=1S/C28H30N4O3/c1-31-15-20-21(30-31)8-7-17-24(20)26-19(14-29-28(26)34)25-18-13-16(23-5-2-3-12-35-23)6-9-22(18)32(27(17)25)10-4-11-33/h6,9,13,15,23,33H,2-5,7-8,10-12,14H2,1H3,(H,29,34)
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n/an/a<50n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318966
PNG
(CHEMBL1083144 | rac-5-methyl-9-pentyl-12-(tetrahyd...)
Show SMILES CCCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C30H34N4O2/c1-3-4-6-13-34-24-12-9-18(25-8-5-7-14-36-25)15-20(24)27-21-16-31-30(35)28(21)26-19(29(27)34)10-11-23-22(26)17-33(2)32-23/h9,12,15,17,25H,3-8,10-11,13-14,16H2,1-2H3,(H,31,35)
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n/an/a 52n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318954
PNG
(9-butyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7...)
Show SMILES CCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cnn(C)c4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-3-4-12-33-23-10-8-17(24-7-5-6-13-35-24)14-19(23)26-21-15-30-29(34)27(21)25-18(28(26)33)9-11-22-20(25)16-31-32(22)2/h8,10,14,16,24H,3-7,9,11-13,15H2,1-2H3,(H,30,34)
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n/an/a 53n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318967
PNG
(CHEMBL1083454 | rac-9-cyclopentyl-5-methyl-12-(tet...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4n(C4CCCC4)c32)C2CCCCO2)n1
Show InChI InChI=1S/C30H32N4O2/c1-33-16-22-23(32-33)11-10-19-26(22)28-21(15-31-30(28)35)27-20-14-17(25-8-4-5-13-36-25)9-12-24(20)34(29(19)27)18-6-2-3-7-18/h9,12,14,16,18,25H,2-8,10-11,13,15H2,1H3,(H,31,35)
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n/an/a 55n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318956
PNG
(9-cyclopentyl-6-methyl-12-(tetrahydro-2H-pyran-2-y...)
Show SMILES Cn1ncc-2c1CCc1c-2c2C(=O)NCc2c2c3cc(ccc3n(C3CCCC3)c12)C1CCCCO1
Show InChI InChI=1S/C30H32N4O2/c1-33-23-12-10-19-26(21(23)16-32-33)28-22(15-31-30(28)35)27-20-14-17(25-8-4-5-13-36-25)9-11-24(20)34(29(19)27)18-6-2-3-7-18/h9,11,14,16,18,25H,2-8,10,12-13,15H2,1H3,(H,31,35)
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n/an/a 65n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318965
PNG
(CHEMBL1084338 | rac-9-isopentyl-5-methyl-12-(tetra...)
Show SMILES CC(C)CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C30H34N4O2/c1-17(2)11-12-34-24-10-7-18(25-6-4-5-13-36-25)14-20(24)27-21-15-31-30(35)28(21)26-19(29(27)34)8-9-23-22(26)16-33(3)32-23/h7,10,14,16-17,25H,4-6,8-9,11-13,15H2,1-3H3,(H,31,35)
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n/an/a 77n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318966
PNG
(CHEMBL1083144 | rac-5-methyl-9-pentyl-12-(tetrahyd...)
Show SMILES CCCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C30H34N4O2/c1-3-4-6-13-34-24-12-9-18(25-8-5-7-14-36-25)15-20(24)27-21-16-31-30(35)28(21)26-19(29(27)34)10-11-23-22(26)17-33(2)32-23/h9,12,15,17,25H,3-8,10-11,13-14,16H2,1-2H3,(H,31,35)
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n/an/a 78n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318951
PNG
(9-ethyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7...)
Show SMILES CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cnn(C)c4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C27H28N4O2/c1-3-31-21-9-7-15(22-6-4-5-11-33-22)12-17(21)24-19-13-28-27(32)25(19)23-16(26(24)31)8-10-20-18(23)14-29-30(20)2/h7,9,12,14,22H,3-6,8,10-11,13H2,1-2H3,(H,28,32)
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n/an/a 88n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318968
PNG
(CHEMBL1085291 | rac-9-cyclohexyl-5-methyl-12-(tetr...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4n(C4CCCCC4)c32)C2CCCCO2)n1
Show InChI InChI=1S/C31H34N4O2/c1-34-17-23-24(33-34)12-11-20-27(23)29-22(16-32-31(29)36)28-21-15-18(26-9-5-6-14-37-26)10-13-25(21)35(30(20)28)19-7-3-2-4-8-19/h10,13,15,17,19,26H,2-9,11-12,14,16H2,1H3,(H,32,36)
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n/an/a 102n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318953
PNG
(9-isopropyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)...)
Show SMILES CC(C)n1c2ccc(cc2c2c3CNC(=O)c3c3-c4cnn(C)c4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C28H30N4O2/c1-15(2)32-22-9-7-16(23-6-4-5-11-34-23)12-18(22)25-20-13-29-28(33)26(20)24-17(27(25)32)8-10-21-19(24)14-30-31(21)3/h7,9,12,14-15,23H,4-6,8,10-11,13H2,1-3H3,(H,29,33)
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n/an/a 103n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318948
PNG
(CHEMBL1085541 | rac-9-(2-(diethylamino)ethyl)-5-me...)
Show SMILES CCN(CC)CCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C31H37N5O2/c1-4-35(5-2)13-14-36-25-12-9-19(26-8-6-7-15-38-26)16-21(25)28-22-17-32-31(37)29(22)27-20(30(28)36)10-11-24-23(27)18-34(3)33-24/h9,12,16,18,26H,4-8,10-11,13-15,17H2,1-3H3,(H,32,37)
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n/an/a 142n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50318969
PNG
(CHEMBL1085292 | rac-9-(cyclohexylmethyl)-5-methyl-...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4n(CC4CCCCC4)c32)C2CCCCO2)n1
Show InChI InChI=1S/C32H36N4O2/c1-35-18-24-25(34-35)12-11-21-28(24)30-23(16-33-32(30)37)29-22-15-20(27-9-5-6-14-38-27)10-13-26(22)36(31(21)29)17-19-7-3-2-4-8-19/h10,13,15,18-19,27H,2-9,11-12,14,16-17H2,1H3,(H,33,37)
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n/an/a 149n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318956
PNG
(9-cyclopentyl-6-methyl-12-(tetrahydro-2H-pyran-2-y...)
Show SMILES Cn1ncc-2c1CCc1c-2c2C(=O)NCc2c2c3cc(ccc3n(C3CCCC3)c12)C1CCCCO1
Show InChI InChI=1S/C30H32N4O2/c1-33-23-12-10-19-26(21(23)16-32-33)28-22(15-31-30(28)35)27-20-14-17(25-8-4-5-13-36-25)9-11-24(20)34(29(19)27)18-6-2-3-7-18/h9,11,14,16,18,25H,2-8,10,12-13,15H2,1H3,(H,31,35)
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n/an/a 300n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318957
PNG
(9-(2-hydroxyethyl)-6-methyl-12-(tetrahydro-2H-pyra...)
Show SMILES Cn1ncc-2c1CCc1c-2c2C(=O)NCc2c2c1n(CCO)c1ccc(cc21)C1CCCCO1
Show InChI InChI=1S/C27H28N4O3/c1-30-20-8-6-16-23(18(20)14-29-30)25-19(13-28-27(25)33)24-17-12-15(22-4-2-3-11-34-22)5-7-21(17)31(9-10-32)26(16)24/h5,7,12,14,22,32H,2-4,6,8-11,13H2,1H3,(H,28,33)
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n/an/a 350n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318969
PNG
(CHEMBL1085292 | rac-9-(cyclohexylmethyl)-5-methyl-...)
Show SMILES Cn1cc-2c(CCc3c-2c2C(=O)NCc2c2c4cc(ccc4n(CC4CCCCC4)c32)C2CCCCO2)n1
Show InChI InChI=1S/C32H36N4O2/c1-35-18-24-25(34-35)12-11-21-28(24)30-23(16-33-32(30)37)29-22-15-20(27-9-5-6-14-38-27)10-13-26(22)36(31(21)29)17-19-7-3-2-4-8-19/h10,13,15,18-19,27H,2-9,11-12,14,16-17H2,1H3,(H,33,37)
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n/an/a 469n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318950
PNG
(6,9-dimethyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9...)
Show SMILES Cn1ncc-2c1CCc1c-2c2C(=O)NCc2c2c3cc(ccc3n(C)c12)C1CCCCO1
Show InChI InChI=1S/C26H26N4O2/c1-29-19-8-6-14(21-5-3-4-10-32-21)11-16(19)23-18-12-27-26(31)24(18)22-15(25(23)29)7-9-20-17(22)13-28-30(20)2/h6,8,11,13,21H,3-5,7,9-10,12H2,1-2H3,(H,27,31)
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n/an/a 554n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50318949
PNG
(6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9-tet...)
Show SMILES Cn1ncc-2c1CCc1c-2c2C(=O)NCc2c2c3cc(ccc3[nH]c12)C1CCCCO1
Show InChI InChI=1S/C25H24N4O2/c1-29-19-8-6-14-21(16(19)12-27-29)23-17(11-26-25(23)30)22-15-10-13(20-4-2-3-9-31-20)5-7-18(15)28-24(14)22/h5,7,10,12,20,28H,2-4,6,8-9,11H2,1H3,(H,26,30)
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n/an/a 715n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TIE-2 by time resolved fluorescence measurements


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50318958
PNG
(CHEMBL1082829 | rac-9-butyl-5-methyl-12-(tetrahydr...)
Show SMILES CCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-3-4-12-33-23-11-8-17(24-7-5-6-13-35-24)14-19(23)26-20-15-30-29(34)27(20)25-18(28(26)33)9-10-22-21(25)16-32(2)31-22/h8,11,14,16,24H,3-7,9-10,12-13,15H2,1-2H3,(H,30,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50318959
PNG
(CHEMBL1084337 | rac-9-isobutyl-5-methyl-12-(tetrah...)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-16(2)14-33-23-10-7-17(24-6-4-5-11-35-24)12-19(23)26-20-13-30-29(34)27(20)25-18(28(26)33)8-9-22-21(25)15-32(3)31-22/h7,10,12,15-16,24H,4-6,8-9,11,13-14H2,1-3H3,(H,30,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50318959
PNG
(CHEMBL1084337 | rac-9-isobutyl-5-methyl-12-(tetrah...)
Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-16(2)14-33-23-10-7-17(24-6-4-5-11-35-24)12-19(23)26-20-13-30-29(34)27(20)25-18(28(26)33)8-9-22-21(25)15-32(3)31-22/h7,10,12,15-16,24H,4-6,8-9,11,13-14H2,1-3H3,(H,30,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50318958
PNG
(CHEMBL1082829 | rac-9-butyl-5-methyl-12-(tetrahydr...)
Show SMILES CCCCn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C1CCCCO1
Show InChI InChI=1S/C29H32N4O2/c1-3-4-12-33-23-11-8-17(24-7-5-6-13-35-24)14-19(23)26-20-15-30-29(34)27(20)25-18(28(26)33)9-10-22-21(25)16-32(2)31-22/h8,11,14,16,24H,3-7,9-10,12-13,15H2,1-2H3,(H,30,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Bioorg Med Chem Lett 20: 3356-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.021
BindingDB Entry DOI: 10.7270/Q2HT2PH9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%