Compile Data Set for Download or QSAR
maximum 50k data
Found 17 Enz. Inhib. hit(s) with all data for entry = 50031803
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319612((R)-(+)-4-[4,4-Dimethyl-1-(4-methylsulfanyl-benzyl...)
Affinity DataIC50:  28nMAssay Description:Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50:  38nMAssay Description:Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319613((R)-(+)-4-(1-(2-Fluorobenzyl)-4,4-dimethyl-2-oxopy...)
Affinity DataIC50:  44nMAssay Description:Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50248594(4-(2-Fluorophenylthio)-2-(trifluoromethyl)benzonit...)
Affinity DataIC50:  54nMAssay Description:Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319614(4-(2,4-Difluorophenoxy)-2-(trifluoromethyl)benzoni...)
Affinity DataIC50:  60nMAssay Description:Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50:  100nMAssay Description:Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319613((R)-(+)-4-(1-(2-Fluorobenzyl)-4,4-dimethyl-2-oxopy...)
Affinity DataIC50:  174nMAssay Description:Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50248594(4-(2-Fluorophenylthio)-2-(trifluoromethyl)benzonit...)
Affinity DataIC50:  184nMAssay Description:Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319612((R)-(+)-4-[4,4-Dimethyl-1-(4-methylsulfanyl-benzyl...)
Affinity DataIC50:  316nMAssay Description:Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319614(4-(2,4-Difluorophenoxy)-2-(trifluoromethyl)benzoni...)
Affinity DataIC50:  488nMAssay Description:Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50:  4.40E+3nMAssay Description:Binding affinity to progesterone receptor by PRB assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319613((R)-(+)-4-(1-(2-Fluorobenzyl)-4,4-dimethyl-2-oxopy...)
Affinity DataIC50:  4.82E+3nMAssay Description:Binding affinity to progesterone receptor by PRB assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50248594(4-(2-Fluorophenylthio)-2-(trifluoromethyl)benzonit...)
Affinity DataIC50:  6.95E+3nMAssay Description:Binding affinity to progesterone receptor by PRB assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319614(4-(2,4-Difluorophenoxy)-2-(trifluoromethyl)benzoni...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to progesterone receptor by PRB assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319612((R)-(+)-4-[4,4-Dimethyl-1-(4-methylsulfanyl-benzyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to progesterone receptor by PRB assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to estrogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed