BindingDB logo
myBDB logout

PubMed code 20561787

Compile data set for download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50321650
PNG
((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Show SMILES NCc1ccc(cc1)-c1cn2c(cnc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C16H14N6/c17-5-11-1-3-12(4-2-11)14-10-22-15(13-6-20-21-7-13)8-19-16(22)9-18-14/h1-4,6-10H,5,17H2,(H,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK2 by DELFIA assay


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50321650
PNG
((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Show SMILES NCc1ccc(cc1)-c1cn2c(cnc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C16H14N6/c17-5-11-1-3-12(4-2-11)14-10-22-15(13-6-20-21-7-13)8-19-16(22)9-18-14/h1-4,6-10H,5,17H2,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 240n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of ABL1 by Z-lite assay


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50321651
PNG
((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Show SMILES OCc1ccc(cc1)-c1cn2c(cnc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C16H13N5O/c22-10-11-1-3-12(4-2-11)14-9-21-15(13-5-19-20-6-13)7-18-16(21)8-17-14/h1-9,22H,10H2,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of ABL1 by Z-lite assay


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50321649
PNG
(3,6-di(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidine | ...)
Show SMILES c1n[nH]cc1-c1cnc2ncc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C12H9N7/c1-10(8-2-15-16-3-8)7-19-11(6-14-12(19)13-1)9-4-17-18-5-9/h1-7H,(H,15,16)(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 440n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of ABL1 by Z-lite assay


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50321654
PNG
(3-(1H-pyrazol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2...)
Show SMILES c1cc(n[nH]1)-c1cnc2ncc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C12H9N7/c1-2-15-18-10(1)11-6-14-12-13-3-9(7-19(11)12)8-4-16-17-5-8/h1-7H,(H,15,18)(H,16,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 480n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK2 by DELFIA assay


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50321655
PNG
(3-(1H-indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a...)
Show SMILES c1n[nH]cc1-c1cn2c(cnc2cn1)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C17H12N6/c1-2-4-14-12(3-1)13(7-18-14)16-8-20-17-9-19-15(10-23(16)17)11-5-21-22-6-11/h1-10,18H,(H,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK2 by DELFIA assay


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321654
PNG
(3-(1H-pyrazol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2...)
Show SMILES c1cc(n[nH]1)-c1cnc2ncc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C12H9N7/c1-2-15-18-10(1)11-6-14-12-13-3-9(7-19(11)12)8-4-16-17-5-8/h1-7H,(H,15,18)(H,16,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50321656
PNG
((3-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Show SMILES OCc1cccc(c1)-c1cn2c(cnc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C16H13N5O/c22-10-11-2-1-3-12(4-11)14-9-21-15(13-5-19-20-6-13)7-18-16(21)8-17-14/h1-9,22H,10H2,(H,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK2 by DELFIA assay


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321650
PNG
((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Show SMILES NCc1ccc(cc1)-c1cn2c(cnc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C16H14N6/c17-5-11-1-3-12(4-2-11)14-10-22-15(13-6-20-21-7-13)8-19-16(22)9-18-14/h1-4,6-10H,5,17H2,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50321651
PNG
((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Show SMILES OCc1ccc(cc1)-c1cn2c(cnc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C16H13N5O/c22-10-11-1-3-12(4-2-11)14-9-21-15(13-5-19-20-6-13)7-18-16(21)8-17-14/h1-9,22H,10H2,(H,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK2 by DELFIA assay


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50321657
PNG
(3-phenyl-6-(pyridin-4-yl)imidazo[1,2-a]pyrazine | ...)
Show SMILES c1nc2cnc(cn2c1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C17H12N4/c1-2-4-14(5-3-1)16-10-20-17-11-19-15(12-21(16)17)13-6-8-18-9-7-13/h1-12H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of GSK3-beta at 10 uM by mobility shift assay


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321681
PNG
((3-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Show SMILES NCc1cccc(c1)-c1cn2c(cnc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C16H14N6/c17-5-11-2-1-3-12(4-11)14-10-22-15(13-6-20-21-7-13)8-19-16(22)9-18-14/h1-4,6-10H,5,17H2,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.50E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321649
PNG
(3,6-di(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidine | ...)
Show SMILES c1n[nH]cc1-c1cnc2ncc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C12H9N7/c1-10(8-2-15-16-3-8)7-19-11(6-14-12(19)13-1)9-4-17-18-5-9/h1-7H,(H,15,16)(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50321655
PNG
(3-(1H-indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a...)
Show SMILES c1n[nH]cc1-c1cn2c(cnc2cn1)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C17H12N6/c1-2-4-14-12(3-1)13(7-18-14)16-8-20-17-9-19-15(10-23(16)17)11-5-21-22-6-11/h1-10,18H,(H,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 5.90E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of GSK3-beta at 10 uM by mobility shift assay


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50321652
PNG
(3-PHENYL-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE...)
Show SMILES c1n[nH]cc1-c1cn2c(cnc2cn1)-c1ccccc1
Show InChI InChI=1S/C15H11N5/c1-2-4-11(5-3-1)14-8-17-15-9-16-13(10-20(14)15)12-6-18-19-7-12/h1-10H,(H,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK2 by DELFIA assay


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321655
PNG
(3-(1H-indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a...)
Show SMILES c1n[nH]cc1-c1cn2c(cnc2cn1)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C17H12N6/c1-2-4-14-12(3-1)13(7-18-14)16-8-20-17-9-19-15(10-23(16)17)11-5-21-22-6-11/h1-10,18H,(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 6.50E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50321649
PNG
(3,6-di(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidine | ...)
Show SMILES c1n[nH]cc1-c1cnc2ncc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C12H9N7/c1-10(8-2-15-16-3-8)7-19-11(6-14-12(19)13-1)9-4-17-18-5-9/h1-7H,(H,15,16)(H,17,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.80E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK2 by DELFIA assay


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321678
PNG
(6-(5-methyl-1H-pyrazol-4-yl)-3-(1H-pyrazol-4-yl)im...)
Show SMILES Cc1[nH]ncc1-c1cn2c(cnc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C13H11N7/c1-8-10(4-18-19-8)11-7-20-12(9-2-16-17-3-9)5-15-13(20)6-14-11/h2-7H,1H3,(H,16,17)(H,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.50E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50321653
PNG
(3-(1-methyl-1H-pyrazol-4-yl)-6-(1H-pyrazol-4-yl)im...)
Show SMILES Cn1cc(cn1)-c1cnc2ncc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C13H11N7/c1-19-7-11(5-18-19)12-6-15-13-14-2-10(8-20(12)13)9-3-16-17-4-9/h2-8H,1H3,(H,16,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.50E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK2 by DELFIA assay


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321679
PNG
(4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)a...)
Show SMILES Nc1ccc(cc1)-c1cn2c(cnc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C15H12N6/c16-12-3-1-10(2-4-12)13-9-21-14(11-5-19-20-6-11)7-18-15(21)8-17-13/h1-9H,16H2,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.50E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321677
PNG
(6-phenyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine...)
Show SMILES c1n[nH]cc1-c1cnc2cnc(cn12)-c1ccccc1
Show InChI InChI=1S/C15H11N5/c1-2-4-11(5-3-1)13-10-20-14(12-6-18-19-7-12)8-17-15(20)9-16-13/h1-10H,(H,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321653
PNG
(3-(1-methyl-1H-pyrazol-4-yl)-6-(1H-pyrazol-4-yl)im...)
Show SMILES Cn1cc(cn1)-c1cnc2ncc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C13H11N7/c1-19-7-11(5-18-19)12-6-15-13-14-2-10(8-20(12)13)9-3-16-17-4-9/h2-8H,1H3,(H,16,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321669
PNG
(4-(4-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidin-3...)
Show SMILES C(N1CCOCC1)c1ccc(cc1)-c1cnc2ncc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C20H20N6O/c1-3-16(4-2-15(1)13-25-5-7-27-8-6-25)19-12-22-20-21-9-18(14-26(19)20)17-10-23-24-11-17/h1-4,9-12,14H,5-8,13H2,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321668
PNG
(4-(3-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidin-3...)
Show SMILES C(N1CCOCC1)c1cccc(c1)-c1cnc2ncc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C20H20N6O/c1-2-15(13-25-4-6-27-7-5-25)8-16(3-1)19-12-22-20-21-9-18(14-26(19)20)17-10-23-24-11-17/h1-3,8-12,14H,4-7,13H2,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.30E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321676
PNG
(3-(1H-pyrazol-4-yl)-6-(pyridin-4-yl)imidazo[1,2-a]...)
Show SMILES c1n[nH]cc1-c1cnc2cnc(cn12)-c1ccncc1
Show InChI InChI=1S/C14H10N6/c1-3-15-4-2-10(1)12-9-20-13(11-5-18-19-6-11)7-17-14(20)8-16-12/h1-9H,(H,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321673
PNG
(4-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)a...)
Show SMILES Nc1ccc(cc1)-c1cnc2cnc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C15H12N6/c16-12-3-1-10(2-4-12)14-7-18-15-8-17-13(9-21(14)15)11-5-19-20-6-11/h1-9H,16H2,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.60E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321680
PNG
(3-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)a...)
Show SMILES Nc1cccc(c1)-c1cn2c(cnc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C15H12N6/c16-12-3-1-2-10(4-12)13-9-21-14(11-5-19-20-6-11)7-18-15(21)8-17-13/h1-9H,16H2,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.80E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321656
PNG
((3-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Show SMILES OCc1cccc(c1)-c1cn2c(cnc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C16H13N5O/c22-10-11-2-1-3-12(4-11)14-9-21-15(13-5-19-20-6-13)7-18-16(21)8-17-14/h1-9,22H,10H2,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.90E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321652
PNG
(3-PHENYL-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE...)
Show SMILES c1n[nH]cc1-c1cn2c(cnc2cn1)-c1ccccc1
Show InChI InChI=1S/C15H11N5/c1-2-4-11(5-3-1)14-8-17-15-9-16-13(10-20(14)15)12-6-18-19-7-12/h1-10H,(H,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321651
PNG
((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Show SMILES OCc1ccc(cc1)-c1cn2c(cnc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C16H13N5O/c22-10-11-1-3-12(4-2-11)14-9-21-15(13-5-19-20-6-13)7-18-16(21)8-17-14/h1-9,22H,10H2,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.90E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321675
PNG
(6-(1H-pyrazol-4-yl)-3-(1H-pyrrol-2-yl)imidazo[1,2-...)
Show SMILES c1c[nH]c(c1)-c1cnc2cnc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C13H10N6/c1-2-10(14-3-1)12-6-16-13-7-15-11(8-19(12)13)9-4-17-18-5-9/h1-8,14H,(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.30E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321667
PNG
((3-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidin-3-y...)
Show SMILES OCc1cccc(c1)-c1cnc2ncc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C16H13N5O/c22-10-11-2-1-3-12(4-11)15-8-18-16-17-5-14(9-21(15)16)13-6-19-20-7-13/h1-9,22H,10H2,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.60E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321657
PNG
(3-phenyl-6-(pyridin-4-yl)imidazo[1,2-a]pyrazine | ...)
Show SMILES c1nc2cnc(cn2c1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C17H12N4/c1-2-4-14(5-3-1)16-10-20-17-11-19-15(12-21(16)17)13-6-8-18-9-7-13/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.20E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321659
PNG
(6-(1-methyl-1H-pyrazol-4-yl)-3-phenylimidazo[1,2-a...)
Show SMILES Cn1cc(cn1)-c1cn2c(cnc2cn1)-c1ccccc1
Show InChI InChI=1S/C16H13N5/c1-20-10-13(7-19-20)14-11-21-15(8-18-16(21)9-17-14)12-5-3-2-4-6-12/h2-11H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.20E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321674
PNG
((4-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)...)
Show SMILES OCc1ccc(cc1)-c1cnc2cnc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C16H13N5O/c22-10-11-1-3-12(4-2-11)15-7-18-16-8-17-14(9-21(15)16)13-5-19-20-6-13/h1-9,22H,10H2,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.60E+4n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321661
PNG
(3-phenyl-6-(1H-pyrrol-2-yl)imidazo[1,2-a]pyrazine ...)
Show SMILES c1c[nH]c(c1)-c1cn2c(cnc2cn1)-c1ccccc1
Show InChI InChI=1S/C16H12N4/c1-2-5-12(6-3-1)15-9-19-16-10-18-14(11-20(15)16)13-7-4-8-17-13/h1-11,17H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321665
PNG
(6-(1H-pyrazol-4-yl)-3-(pyridin-3-yl)imidazo[1,2-a]...)
Show SMILES c1n[nH]cc1-c1cnc2ncc(-c3cccnc3)n2c1
Show InChI InChI=1S/C14H10N6/c1-2-10(4-15-3-1)13-8-17-14-16-5-12(9-20(13)14)11-6-18-19-7-11/h1-9H,(H,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321666
PNG
(3-(4-phenoxyphenyl)-6-(1H-pyrazol-4-yl)imidazo[1,2...)
Show SMILES O(c1ccccc1)c1ccc(cc1)-c1cnc2ncc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C21H15N5O/c1-2-4-18(5-3-1)27-19-8-6-15(7-9-19)20-13-23-21-22-10-17(14-26(20)21)16-11-24-25-12-16/h1-14H,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321670
PNG
(4-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)b...)
Show SMILES NC(=O)c1ccc(cc1)-c1cnc2cnc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C16H12N6O/c17-16(23)11-3-1-10(2-4-11)14-7-19-15-8-18-13(9-22(14)15)12-5-20-21-6-12/h1-9H,(H2,17,23)(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321662
PNG
(6-(1H-indol-3-yl)-3-phenylimidazo[1,2-a]pyrazine |...)
Show SMILES c1nc2cnc(cn2c1-c1ccccc1)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H14N4/c1-2-6-14(7-3-1)19-11-23-20-12-22-18(13-24(19)20)16-10-21-17-9-5-4-8-15(16)17/h1-13,21H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321671
PNG
(3-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)b...)
Show SMILES NC(=O)c1cccc(c1)-c1cnc2cnc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C16H12N6O/c17-16(23)11-3-1-2-10(4-11)14-7-19-15-8-18-13(9-22(14)15)12-5-20-21-6-12/h1-9H,(H2,17,23)(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321672
PNG
(3-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)a...)
Show SMILES Nc1cccc(c1)-c1cnc2cnc(cn12)-c1cn[nH]c1
Show InChI InChI=1S/C15H12N6/c16-12-3-1-2-10(4-12)14-7-18-15-8-17-13(9-21(14)15)11-5-19-20-6-11/h1-9H,16H2,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321658
PNG
(3-phenyl-6-(1H-pyrazol-3-yl)imidazo[1,2-a]pyrazine...)
Show SMILES c1cc(n[nH]1)-c1cn2c(cnc2cn1)-c1ccccc1
Show InChI InChI=1S/C15H11N5/c1-2-4-11(5-3-1)14-8-17-15-9-16-13(10-20(14)15)12-6-7-18-19-12/h1-10H,(H,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321663
PNG
(3-phenyl-6-(pyridin-2-yl)imidazo[1,2-a]pyrazine | ...)
Show SMILES c1nc2cnc(cn2c1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C17H12N4/c1-2-6-13(7-3-1)16-10-20-17-11-19-15(12-21(16)17)14-8-4-5-9-18-14/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321664
PNG
(3-phenyl-6-(pyridin-3-yl)imidazo[1,2-a]pyrazine | ...)
Show SMILES c1nc2cnc(cn2c1-c1ccccc1)-c1cccnc1
Show InChI InChI=1S/C17H12N4/c1-2-5-13(6-3-1)16-10-20-17-11-19-15(12-21(16)17)14-7-4-8-18-9-14/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.39E+5n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50321660
PNG
(6-(1-benzyl-1H-pyrazol-4-yl)-3-phenylimidazo[1,2-a...)
Show SMILES C(c1ccccc1)n1cc(cn1)-c1cn2c(cnc2cn1)-c1ccccc1
Show InChI InChI=1S/C22H17N5/c1-3-7-17(8-4-1)14-26-15-19(11-25-26)20-16-27-21(12-24-22(27)13-23-20)18-9-5-2-6-10-18/h1-13,15-16H,14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.08E+5n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA


Bioorg Med Chem Lett 20: 4045-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.096
BindingDB Entry DOI: 10.7270/Q2MP5487
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%