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PubMed code 20575553

Compile data set for download or QSAR
Found 7 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dynamin-1


(Rattus norvegicus)
BDBM50318675
PNG
(4-Chloro-2-{[2-(3-nitrophenyl)-1,3-dioxo-2,3-dihyd...)
Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C22H12ClN3O7/c23-12-5-7-16(22(30)31)18(9-12)24-19(27)11-4-6-15-17(8-11)21(29)25(20(15)28)13-2-1-3-14(10-13)26(32)33/h1-10H,(H,24,27)(H,30,31)
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PubMed
n/an/a 1.29E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dynamin 1-mediated synaptic vesicle endocytosis in Sprague-Dawley rat synaptosomes assessed as uptake of FM 4-64 dye after 30 mins by a...


J Med Chem 53: 5267-80 (2010)


Article DOI: 10.1021/jm100442u
BindingDB Entry DOI: 10.7270/Q2PV6MBN
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50318676
PNG
(4-Chloro-2-{[2-(4-hydroxymethylphenyl)-1,3-dioxo-2...)
Show SMILES OCc1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(=O)Nc1cc(Cl)ccc1C(O)=O
Show InChI InChI=1S/C23H15ClN2O6/c24-14-4-8-17(23(31)32)19(10-14)25-20(28)13-3-7-16-18(9-13)22(30)26(21(16)29)15-5-1-12(11-27)2-6-15/h1-10,27H,11H2,(H,25,28)(H,31,32)
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n/an/a 4.00E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of recombinant dynamin 2 expressed in Sf9 cells after 30 mins by malachite green method


J Med Chem 53: 5267-80 (2010)


Article DOI: 10.1021/jm100442u
BindingDB Entry DOI: 10.7270/Q2PV6MBN
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50318675
PNG
(4-Chloro-2-{[2-(3-nitrophenyl)-1,3-dioxo-2,3-dihyd...)
Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C22H12ClN3O7/c23-12-5-7-16(22(30)31)18(9-12)24-19(27)11-4-6-15-17(8-11)21(29)25(20(15)28)13-2-1-3-14(10-13)26(32)33/h1-10H,(H,24,27)(H,30,31)
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n/an/a 6.30E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of recombinant dynamin 2 expressed in Sf9 cells after 30 mins by malachite green method


J Med Chem 53: 5267-80 (2010)


Article DOI: 10.1021/jm100442u
BindingDB Entry DOI: 10.7270/Q2PV6MBN
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50318674
PNG
(4-Chloro-2-{[2-(2-hydroxyphenyl)-1,3-dioxo-2,3-dih...)
Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccccc1O
Show InChI InChI=1S/C22H13ClN2O6/c23-12-6-8-14(22(30)31)16(10-12)24-19(27)11-5-7-13-15(9-11)21(29)25(20(13)28)17-3-1-2-4-18(17)26/h1-10,26H,(H,24,27)(H,30,31)
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n/an/a 7.10E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of recombinant dynamin 2 expressed in Sf9 cells after 30 mins by malachite green method


J Med Chem 53: 5267-80 (2010)


Article DOI: 10.1021/jm100442u
BindingDB Entry DOI: 10.7270/Q2PV6MBN
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50318677
PNG
(4-Chloro-2-{[2-(4-hydroxyphenyl)-1,3-dioxo-2,3-dih...)
Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccc(O)cc1
Show InChI InChI=1S/C22H13ClN2O6/c23-12-2-8-16(22(30)31)18(10-12)24-19(27)11-1-7-15-17(9-11)21(29)25(20(15)28)13-3-5-14(26)6-4-13/h1-10,26H,(H,24,27)(H,30,31)
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n/an/a 1.14E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of recombinant dynamin 2 expressed in Sf9 cells after 30 mins by malachite green method


J Med Chem 53: 5267-80 (2010)


Article DOI: 10.1021/jm100442u
BindingDB Entry DOI: 10.7270/Q2PV6MBN
More data for this
Ligand-Target Pair
Dynamin-1


(Rattus norvegicus)
BDBM50318674
PNG
(4-Chloro-2-{[2-(2-hydroxyphenyl)-1,3-dioxo-2,3-dih...)
Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccccc1O
Show InChI InChI=1S/C22H13ClN2O6/c23-12-6-8-14(22(30)31)16(10-12)24-19(27)11-5-7-13-15(9-11)21(29)25(20(13)28)17-3-1-2-4-18(17)26/h1-10,26H,(H,24,27)(H,30,31)
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n/an/a 1.19E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dynamin 1-mediated synaptic vesicle endocytosis in Sprague-Dawley rat synaptosomes assessed as uptake of FM 4-64 dye after 30 mins by a...


J Med Chem 53: 5267-80 (2010)


Article DOI: 10.1021/jm100442u
BindingDB Entry DOI: 10.7270/Q2PV6MBN
More data for this
Ligand-Target Pair
Dynamin-1


(Rattus norvegicus)
BDBM50318676
PNG
(4-Chloro-2-{[2-(4-hydroxymethylphenyl)-1,3-dioxo-2...)
Show SMILES OCc1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(=O)Nc1cc(Cl)ccc1C(O)=O
Show InChI InChI=1S/C23H15ClN2O6/c24-14-4-8-17(23(31)32)19(10-14)25-20(28)13-3-7-16-18(9-13)22(30)26(21(16)29)15-5-1-12(11-27)2-6-15/h1-10,27H,11H2,(H,25,28)(H,31,32)
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n/an/a 6.90E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dynamin 1-mediated synaptic vesicle endocytosis in Sprague-Dawley rat synaptosomes assessed as uptake of FM 4-64 dye after 30 mins by a...


J Med Chem 53: 5267-80 (2010)


Article DOI: 10.1021/jm100442u
BindingDB Entry DOI: 10.7270/Q2PV6MBN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%