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PubMed code 20591669

Compile data set for download or QSAR
Found 81 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348515
PNG
(CHEMBL1233942)
Show SMILES CN1CC2(C1)CNC(=O)c1c3CCc4cnc(cc4-c3[nH]c21)-c1ccccc1F
Show InChI InChI=1S/C23H21FN4O/c1-28-11-23(12-28)10-26-22(29)19-15-7-6-13-9-25-18(14-4-2-3-5-17(14)24)8-16(13)20(15)27-21(19)23/h2-5,8-9,27H,6-7,10-12H2,1H3,(H,26,29)
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PubMed
n/an/a<3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348492
PNG
(CHEMBL1801296)
Show SMILES CN1CCC2(CC1)CNC(=O)c1c3CCc4cnc(cc4-c3[nH]c21)-c1ccccc1F
Show InChI InChI=1S/C25H25FN4O/c1-30-10-8-25(9-11-30)14-28-24(31)21-17-7-6-15-13-27-20(16-4-2-3-5-19(16)26)12-18(15)22(17)29-23(21)25/h2-5,12-13,29H,6-11,14H2,1H3,(H,28,31)
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n/an/a 4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348491
PNG
(CHEMBL1801305)
Show SMILES CN1CC2(C1)CNC(=O)c1c3CCc4cnc(nc4-c3[nH]c21)-c1cccc(F)c1
Show InChI InChI=1S/C22H20FN5O/c1-28-10-22(11-28)9-25-21(29)16-15-6-5-13-8-24-20(12-3-2-4-14(23)7-12)27-17(13)18(15)26-19(16)22/h2-4,7-8,26H,5-6,9-11H2,1H3,(H,25,29)
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n/an/a 6n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348493
PNG
(CHEMBL1801304)
Show SMILES COCCOc1cncc(c1)-c1ncc2CCc3c([nH]c4c3C(=O)NCC43CN(C)C3)-c2n1
Show InChI InChI=1S/C24H26N6O3/c1-30-12-24(13-30)11-27-23(31)18-17-4-3-14-9-26-22(29-19(14)20(17)28-21(18)24)15-7-16(10-25-8-15)33-6-5-32-2/h7-10,28H,3-6,11-13H2,1-2H3,(H,27,31)
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n/an/a 6n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348481
PNG
(CHEMBL1801307)
Show SMILES CN1CC2(C1)CNC(=O)c1c3CCc4cnc(nc4-c3[nH]c21)-c1ccc(F)nc1
Show InChI InChI=1S/C21H19FN6O/c1-28-9-21(10-28)8-25-20(29)15-13-4-2-11-6-24-19(12-3-5-14(22)23-7-12)27-16(11)17(13)26-18(15)21/h3,5-7,26H,2,4,8-10H2,1H3,(H,25,29)
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n/an/a 7n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348494
PNG
(CHEMBL1801274)
Show SMILES Fc1cccc(c1)-c1cc2-c3[nH]c4CCNC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C20H16FN3O/c21-13-3-1-2-11(8-13)17-9-15-12(10-23-17)4-5-14-18-16(24-19(14)15)6-7-22-20(18)25/h1-3,8-10,24H,4-7H2,(H,22,25)
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n/an/a 8n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348495
PNG
(CHEMBL1614995)
Show SMILES COCCOc1cncc(c1)-c1cc2c3[nH]c4CCNC(=O)c4c3ccc2cn1
Show InChI InChI=1S/C22H20N4O3/c1-28-6-7-29-15-8-14(10-23-12-15)19-9-17-13(11-25-19)2-3-16-20-18(26-21(16)17)4-5-24-22(20)27/h2-3,8-12,26H,4-7H2,1H3,(H,24,27)
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n/an/a 10n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348486
PNG
(CHEMBL1801294)
Show SMILES COc1ccc(cc1)-c1cc2-c3[nH]c4CC5(CNC5)NC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C23H22N4O2/c1-29-15-5-2-13(3-6-15)18-8-17-14(10-25-18)4-7-16-20-19(26-21(16)17)9-23(11-24-12-23)27-22(20)28/h2-3,5-6,8,10,24,26H,4,7,9,11-12H2,1H3,(H,27,28)
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n/an/a 12n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348480
PNG
(CHEMBL1801312)
Show SMILES CN1CC2(C1)CNC(=O)c1c3CCc4cnc(cc4-c3n(C)c21)-c1ccccc1F
Show InChI InChI=1S/C24H23FN4O/c1-28-12-24(13-28)11-27-23(30)20-16-8-7-14-10-26-19(15-5-3-4-6-18(15)25)9-17(14)21(16)29(2)22(20)24/h3-6,9-10H,7-8,11-13H2,1-2H3,(H,27,30)
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n/an/a 13n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348496
PNG
(CHEMBL1801284)
Show SMILES Fc1ccccc1-c1cc2-c3[nH]c4c(c3CCc2cn1)C(=O)NCC41CNC1
Show InChI InChI=1S/C22H19FN4O/c23-16-4-2-1-3-13(16)17-7-15-12(8-25-17)5-6-14-18-20(27-19(14)15)22(9-24-10-22)11-26-21(18)28/h1-4,7-8,24,27H,5-6,9-11H2,(H,26,28)
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n/an/a 17n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348497
PNG
(CHEMBL1801311)
Show SMILES Cn1c-2c(CCc3cnc(cc-23)-c2ccccc2F)c2c1C1(CNC1)CNC2=O
Show InChI InChI=1S/C23H21FN4O/c1-28-20-15(19-21(28)23(10-25-11-23)12-27-22(19)29)7-6-13-9-26-18(8-16(13)20)14-4-2-3-5-17(14)24/h2-5,8-9,25H,6-7,10-12H2,1H3,(H,27,29)
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n/an/a 20n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348498
PNG
(CHEMBL1801283)
Show SMILES Fc1ccc(cn1)-c1cc2-c3[nH]c4c(c3CCc2cn1)C(=O)NCC41CC1
Show InChI InChI=1S/C21H17FN4O/c22-16-4-2-12(9-24-16)15-7-14-11(8-23-15)1-3-13-17-19(26-18(13)14)21(5-6-21)10-25-20(17)27/h2,4,7-9,26H,1,3,5-6,10H2,(H,25,27)
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n/an/a 27n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348499
PNG
(CHEMBL1801303)
Show SMILES CN1CC2(C1)CNC(=O)c1c3CCc4cnc(nc4-c3[nH]c21)-c1ccccc1F
Show InChI InChI=1S/C22H20FN5O/c1-28-10-22(11-28)9-25-21(29)16-14-7-6-12-8-24-20(13-4-2-3-5-15(13)23)27-17(12)18(14)26-19(16)22/h2-5,8,26H,6-7,9-11H2,1H3,(H,25,29)
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n/an/a 34n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348483
PNG
(CHEMBL1801194)
Show SMILES Fc1ccccc1-c1cc2-c3[nH]c4CCNC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C20H16FN3O/c21-15-4-2-1-3-12(15)17-9-14-11(10-23-17)5-6-13-18-16(24-19(13)14)7-8-22-20(18)25/h1-4,9-10,24H,5-8H2,(H,22,25)
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n/an/a 37n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348479
PNG
(CHEMBL1801195)
Show SMILES COCCOc1cncc(c1)-c1cc2-c3[nH]c4CCNC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C22H22N4O3/c1-28-6-7-29-15-8-14(10-23-12-15)19-9-17-13(11-25-19)2-3-16-20-18(26-21(16)17)4-5-24-22(20)27/h8-12,26H,2-7H2,1H3,(H,24,27)
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n/an/a 40n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348500
PNG
(CHEMBL1801295)
Show SMILES COc1ccc(cc1)-c1cc2-c3[nH]c4CC5(CN(C)C5)NC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C24H24N4O2/c1-28-12-24(13-28)10-20-21(23(29)27-24)17-8-5-15-11-25-19(9-18(15)22(17)26-20)14-3-6-16(30-2)7-4-14/h3-4,6-7,9,11,26H,5,8,10,12-13H2,1-2H3,(H,27,29)
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n/an/a 45n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348501
PNG
(CHEMBL1801279)
Show SMILES Fc1ccc(cn1)-c1cc2-c3[nH]c4CC5(CC5)NC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C21H17FN4O/c22-17-4-2-12(10-24-17)15-7-14-11(9-23-15)1-3-13-18-16(25-19(13)14)8-21(5-6-21)26-20(18)27/h2,4,7,9-10,25H,1,3,5-6,8H2,(H,26,27)
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n/an/a 50n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348502
PNG
(CHEMBL1801275)
Show SMILES COc1ccc(cc1)-c1cc2-c3[nH]c4CCNC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C21H19N3O2/c1-26-14-5-2-12(3-6-14)18-10-16-13(11-23-18)4-7-15-19-17(24-20(15)16)8-9-22-21(19)25/h2-3,5-6,10-11,24H,4,7-9H2,1H3,(H,22,25)
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n/an/a 80n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348496
PNG
(CHEMBL1801284)
Show SMILES Fc1ccccc1-c1cc2-c3[nH]c4c(c3CCc2cn1)C(=O)NCC41CNC1
Show InChI InChI=1S/C22H19FN4O/c23-16-4-2-1-3-13(16)17-7-15-12(8-25-17)5-6-14-18-20(27-19(14)15)22(9-24-10-22)11-26-21(18)28/h1-4,7-8,24,27H,5-6,9-11H2,(H,26,28)
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n/an/a 100n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348504
PNG
(CHEMBL1801281)
Show SMILES Fc1cccc(c1)-c1cc2-c3[nH]c4c(c3CCc2cn1)C(=O)NCC41CC1
Show InChI InChI=1S/C22H18FN3O/c23-14-3-1-2-12(8-14)17-9-16-13(10-24-17)4-5-15-18-20(26-19(15)16)22(6-7-22)11-25-21(18)27/h1-3,8-10,26H,4-7,11H2,(H,25,27)
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n/an/a 100n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348503
PNG
(CHEMBL1801280)
Show SMILES O=C1NC2(CC2)Cc2[nH]c-3c(CCc4cnc(cc-34)-c3ccc(OCCN4CCOCC4)cc3)c12
Show InChI InChI=1S/C28H30N4O3/c33-27-25-21-6-3-19-17-29-23(15-22(19)26(21)30-24(25)16-28(31-27)7-8-28)18-1-4-20(5-2-18)35-14-11-32-9-12-34-13-10-32/h1-2,4-5,15,17,30H,3,6-14,16H2,(H,31,33)
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n/an/a 100n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348522
PNG
(CHEMBL1801293)
Show SMILES CC(=O)N1CC2(C1)CNC(=O)c1c3CCc4cnc(cc4-c3[nH]c21)-c1ccccc1F
Show InChI InChI=1S/C24H21FN4O2/c1-13(30)29-11-24(12-29)10-27-23(31)20-16-7-6-14-9-26-19(15-4-2-3-5-18(15)25)8-17(14)21(16)28-22(20)24/h2-5,8-9,28H,6-7,10-12H2,1H3,(H,27,31)
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n/an/a 120n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348505
PNG
(CHEMBL1801300)
Show SMILES Fc1ccc(cn1)-c1ncc2CCc3c([nH]c4CC5(CC5)NC(=O)c34)-c2n1
Show InChI InChI=1S/C20H16FN5O/c21-14-4-2-11(9-22-14)18-23-8-10-1-3-12-15-13(24-17(12)16(10)25-18)7-20(5-6-20)26-19(15)27/h2,4,8-9,24H,1,3,5-7H2,(H,26,27)
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n/an/a 120n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348506
PNG
(CHEMBL1801282)
Show SMILES COc1ccc(cc1)-c1cc2-c3[nH]c4c(c3CCc2cn1)C(=O)NCC41CC1
Show InChI InChI=1S/C23H21N3O2/c1-28-15-5-2-13(3-6-15)18-10-17-14(11-24-18)4-7-16-19-21(26-20(16)17)23(8-9-23)12-25-22(19)27/h2-3,5-6,10-11,26H,4,7-9,12H2,1H3,(H,25,27)
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n/an/a 130n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348507
PNG
(CHEMBL1801276)
Show SMILES Fc1ccccc1-c1cc2-c3[nH]c4CC5(CC5)NC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C22H18FN3O/c23-16-4-2-1-3-13(16)17-9-15-12(11-24-17)5-6-14-19-18(25-20(14)15)10-22(7-8-22)26-21(19)27/h1-4,9,11,25H,5-8,10H2,(H,26,27)
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n/an/a 140n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348508
PNG
(CHEMBL1801302)
Show SMILES COc1ccc(cc1)-c1ncc2CCc3c([nH]c4c3C(=O)NCC43CC3)-c2n1
Show InChI InChI=1S/C22H20N4O2/c1-28-14-5-2-12(3-6-14)20-23-10-13-4-7-15-16-19(25-18(15)17(13)26-20)22(8-9-22)11-24-21(16)27/h2-3,5-6,10,25H,4,7-9,11H2,1H3,(H,24,27)
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n/an/a 150n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348509
PNG
(CHEMBL1801278)
Show SMILES COc1ccc(cc1)-c1cc2-c3[nH]c4CC5(CC5)NC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C23H21N3O2/c1-28-15-5-2-13(3-6-15)18-10-17-14(12-24-18)4-7-16-20-19(25-21(16)17)11-23(8-9-23)26-22(20)27/h2-3,5-6,10,12,25H,4,7-9,11H2,1H3,(H,26,27)
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n/an/a 175n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348487
PNG
(CHEMBL1801301)
Show SMILES O=C1NC2(CC2)Cc2[nH]c-3c(CCc4cnc(nc-34)-c3ccc(OCCN4CCOCC4)cc3)c12
Show InChI InChI=1S/C27H29N5O3/c33-26-22-20-6-3-18-16-28-25(30-23(18)24(20)29-21(22)15-27(31-26)7-8-27)17-1-4-19(5-2-17)35-14-11-32-9-12-34-13-10-32/h1-2,4-5,16,29H,3,6-15H2,(H,31,33)
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n/an/a 180n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348489
PNG
(CHEMBL1801196)
Show SMILES COCCOc1cncc(c1)-c1cc2-c3[nH]c4CCNC(=O)c4c3CCCc2cn1
Show InChI InChI=1S/C23H24N4O3/c1-29-7-8-30-16-9-15(11-24-13-16)20-10-18-14(12-26-20)3-2-4-17-21-19(27-22(17)18)5-6-25-23(21)28/h9-13,27H,2-8H2,1H3,(H,25,28)
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n/an/a 180n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348510
PNG
(CHEMBL1801285)
Show SMILES Fc1cccc(c1)-c1cc2-c3[nH]c4c(c3CCc2cn1)C(=O)NCC41CNC1
Show InChI InChI=1S/C22H19FN4O/c23-14-3-1-2-12(6-14)17-7-16-13(8-25-17)4-5-15-18-20(27-19(15)16)22(9-24-10-22)11-26-21(18)28/h1-3,6-8,24,27H,4-5,9-11H2,(H,26,28)
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n/an/a 200n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348512
PNG
(CHEMBL1801309)
Show SMILES Fc1cccc(c1)-c1cc2-c3oc4c(c3CCc2cn1)C(=O)NCC41CNC1
Show InChI InChI=1S/C22H18FN3O2/c23-14-3-1-2-12(6-14)17-7-16-13(8-25-17)4-5-15-18-20(28-19(15)16)22(9-24-10-22)11-26-21(18)27/h1-3,6-8,24H,4-5,9-11H2,(H,26,27)
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n/an/a 200n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348511
PNG
(CHEMBL1801287)
Show SMILES CN1CC2(C1)CNC(=O)c1c3CCc4cnc(cc4-c3[nH]c21)-c1cccc(F)c1
Show InChI InChI=1S/C23H21FN4O/c1-28-11-23(12-28)10-26-22(29)19-16-6-5-14-9-25-18(13-3-2-4-15(24)7-13)8-17(14)20(16)27-21(19)23/h2-4,7-9,27H,5-6,10-12H2,1H3,(H,26,29)
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n/an/a 200n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348514
PNG
(CHEMBL1801277)
Show SMILES Fc1cccc(c1)-c1cc2-c3[nH]c4CC5(CC5)NC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C22H18FN3O/c23-14-3-1-2-12(8-14)17-9-16-13(11-24-17)4-5-15-19-18(25-20(15)16)10-22(6-7-22)26-21(19)27/h1-3,8-9,11,25H,4-7,10H2,(H,26,27)
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n/an/a 230n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348513
PNG
(CHEMBL1801273)
Show SMILES CN1CC2(C1)CNC(=O)c1c3Cc4cnc(cc4-c3[nH]c21)-c1ccccc1F
Show InChI InChI=1S/C22H19FN4O/c1-27-10-22(11-27)9-25-21(28)18-15-6-12-8-24-17(13-4-2-3-5-16(13)23)7-14(12)19(15)26-20(18)22/h2-5,7-8,26H,6,9-11H2,1H3,(H,25,28)
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n/an/a 230n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348521
PNG
(CHEMBL1801292)
Show SMILES FCCN1CC2(C1)CNC(=O)c1c3CCc4cnc(cc4-c3[nH]c21)-c1ccccc1F
Show InChI InChI=1S/C24H22F2N4O/c25-7-8-30-12-24(13-30)11-28-23(31)20-16-6-5-14-10-27-19(15-3-1-2-4-18(15)26)9-17(14)21(16)29-22(20)24/h1-4,9-10,29H,5-8,11-13H2,(H,28,31)
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n/an/a 230n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348490
PNG
(CHEMBL1801297)
Show SMILES COc1ccc(cc1)-c1ncc2CCc3c([nH]c4CCNC(=O)c34)-c2n1
Show InChI InChI=1S/C20H18N4O2/c1-26-13-5-2-11(3-6-13)19-22-10-12-4-7-14-16-15(8-9-21-20(16)25)23-18(14)17(12)24-19/h2-3,5-6,10,23H,4,7-9H2,1H3,(H,21,25)
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n/an/a 270n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348514
PNG
(CHEMBL1801277)
Show SMILES Fc1cccc(c1)-c1cc2-c3[nH]c4CC5(CC5)NC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C22H18FN3O/c23-14-3-1-2-12(8-14)17-9-16-13(11-24-17)4-5-15-19-18(25-20(15)16)10-22(6-7-22)26-21(19)27/h1-3,8-9,11,25H,4-7,10H2,(H,26,27)
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n/an/a 500n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM30192
PNG
(Pyrrolopyridine, 23)
Show SMILES Fc1ccccc1-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1
Show InChI InChI=1S/C18H14FN3O/c19-14-4-2-1-3-12(14)17-9-11(5-7-20-17)16-10-13-15(22-16)6-8-21-18(13)23/h1-5,7,9-10,22H,6,8H2,(H,21,23)
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n/an/a 560n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348492
PNG
(CHEMBL1801296)
Show SMILES CN1CCC2(CC1)CNC(=O)c1c3CCc4cnc(cc4-c3[nH]c21)-c1ccccc1F
Show InChI InChI=1S/C25H25FN4O/c1-30-10-8-25(9-11-30)14-28-24(31)21-17-7-6-15-13-27-20(16-4-2-3-5-19(16)26)12-18(15)22(17)29-23(21)25/h2-5,12-13,29H,6-11,14H2,1H3,(H,28,31)
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n/an/a 700n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348516
PNG
(CHEMBL1801288)
Show SMILES COc1ccc(cc1)-c1cc2-c3[nH]c4c(c3CCc2cn1)C(=O)NCC41CN(C)C1
Show InChI InChI=1S/C24H24N4O2/c1-28-12-24(13-28)11-26-23(29)20-17-8-5-15-10-25-19(9-18(15)21(17)27-22(20)24)14-3-6-16(30-2)7-4-14/h3-4,6-7,9-10,27H,5,8,11-13H2,1-2H3,(H,26,29)
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n/an/a 700n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348509
PNG
(CHEMBL1801278)
Show SMILES COc1ccc(cc1)-c1cc2-c3[nH]c4CC5(CC5)NC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C23H21N3O2/c1-28-15-5-2-13(3-6-15)18-10-17-14(12-24-18)4-7-16-20-19(25-21(16)17)11-23(8-9-23)26-22(20)27/h2-3,5-6,10,12,25H,4,7-9,11H2,1H3,(H,26,27)
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n/an/a 700n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348507
PNG
(CHEMBL1801276)
Show SMILES Fc1ccccc1-c1cc2-c3[nH]c4CC5(CC5)NC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C22H18FN3O/c23-16-4-2-1-3-13(16)17-9-15-12(11-24-17)5-6-14-19-18(25-20(14)15)10-22(7-8-22)26-21(19)27/h1-4,9,11,25H,5-8,10H2,(H,26,27)
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n/an/a 700n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348502
PNG
(CHEMBL1801275)
Show SMILES COc1ccc(cc1)-c1cc2-c3[nH]c4CCNC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C21H19N3O2/c1-26-14-5-2-12(3-6-14)18-10-16-13(11-23-18)4-7-15-19-17(24-20(15)16)8-9-22-21(19)25/h2-3,5-6,10-11,24H,4,7-9H2,1H3,(H,22,25)
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n/an/a 700n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348517
PNG
(CHEMBL1801298)
Show SMILES Fc1ccccc1-c1ncc2CCc3c([nH]c4CC5(CC5)NC(=O)c34)-c2n1
Show InChI InChI=1S/C21H17FN4O/c22-14-4-2-1-3-12(14)19-23-10-11-5-6-13-16-15(24-18(13)17(11)25-19)9-21(7-8-21)26-20(16)27/h1-4,10,24H,5-9H2,(H,26,27)
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n/an/a 860n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348504
PNG
(CHEMBL1801281)
Show SMILES Fc1cccc(c1)-c1cc2-c3[nH]c4c(c3CCc2cn1)C(=O)NCC41CC1
Show InChI InChI=1S/C22H18FN3O/c23-14-3-1-2-12(8-14)17-9-16-13(10-24-17)4-5-15-18-20(26-19(15)16)22(6-7-22)11-25-21(18)27/h1-3,8-10,26H,4-7,11H2,(H,25,27)
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n/an/a 900n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348482
PNG
(CHEMBL1801299)
Show SMILES COc1ccc(cc1)-c1ncc2CCc3c([nH]c4CC5(CC5)NC(=O)c34)-c2n1
Show InChI InChI=1S/C22H20N4O2/c1-28-14-5-2-12(3-6-14)20-23-11-13-4-7-15-17-16(24-19(15)18(13)25-20)10-22(8-9-22)26-21(17)27/h2-3,5-6,11,24H,4,7-10H2,1H3,(H,26,27)
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n/an/a 900n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348501
PNG
(CHEMBL1801279)
Show SMILES Fc1ccc(cn1)-c1cc2-c3[nH]c4CC5(CC5)NC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C21H17FN4O/c22-17-4-2-12(10-24-17)15-7-14-11(9-23-15)1-3-13-18-16(25-19(13)14)8-21(5-6-21)26-20(18)27/h2,4,7,9-10,25H,1,3,5-6,8H2,(H,26,27)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348519
PNG
(CHEMBL1801290)
Show SMILES CN1CC2(C1)CNC(=O)c1c3CCc4cnc(cc4-c3[nH]c21)-c1ccc(OCCN2CCOCC2)cc1
Show InChI InChI=1S/C29H33N5O3/c1-33-17-29(18-33)16-31-28(35)25-22-7-4-20-15-30-24(14-23(20)26(22)32-27(25)29)19-2-5-21(6-3-19)37-13-10-34-8-11-36-12-9-34/h2-3,5-6,14-15,32H,4,7-13,16-18H2,1H3,(H,31,35)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348518
PNG
(CHEMBL1801289)
Show SMILES CN1CC2(C1)CNC(=O)c1c3CCc4cnc(cc4-c3[nH]c21)-c1ccc(F)nc1
Show InChI InChI=1S/C22H20FN5O/c1-28-10-22(11-28)9-26-21(29)18-14-4-2-12-7-24-16(13-3-5-17(23)25-8-13)6-15(12)19(14)27-20(18)22/h3,5-8,27H,2,4,9-11H2,1H3,(H,26,29)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348506
PNG
(CHEMBL1801282)
Show SMILES COc1ccc(cc1)-c1cc2-c3[nH]c4c(c3CCc2cn1)C(=O)NCC41CC1
Show InChI InChI=1S/C23H21N3O2/c1-28-15-5-2-13(3-6-15)18-10-17-14(11-24-18)4-7-16-19-21(26-20(16)17)23(8-9-23)12-25-22(19)27/h2-3,5-6,10-11,26H,4,7-9,12H2,1H3,(H,25,27)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348494
PNG
(CHEMBL1801274)
Show SMILES Fc1cccc(c1)-c1cc2-c3[nH]c4CCNC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C20H16FN3O/c21-13-3-1-2-11(8-13)17-9-15-12(10-23-17)4-5-14-18-16(24-19(14)15)6-7-22-20(18)25/h1-3,8-10,24H,4-7H2,(H,22,25)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348497
PNG
(CHEMBL1801311)
Show SMILES Cn1c-2c(CCc3cnc(cc-23)-c2ccccc2F)c2c1C1(CNC1)CNC2=O
Show InChI InChI=1S/C23H21FN4O/c1-28-20-15(19-21(28)23(10-25-11-23)12-27-22(19)29)7-6-13-9-26-18(8-16(13)20)14-4-2-3-5-17(14)24/h2-5,8-9,25H,6-7,10-12H2,1H3,(H,27,29)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348503
PNG
(CHEMBL1801280)
Show SMILES O=C1NC2(CC2)Cc2[nH]c-3c(CCc4cnc(cc-34)-c3ccc(OCCN4CCOCC4)cc3)c12
Show InChI InChI=1S/C28H30N4O3/c33-27-25-21-6-3-19-17-29-23(15-22(19)26(21)30-24(25)16-28(31-27)7-8-28)18-1-4-20(5-2-18)35-14-11-32-9-12-34-13-10-32/h1-2,4-5,15,17,30H,3,6-14,16H2,(H,31,33)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348520
PNG
(CHEMBL1801286)
Show SMILES COCCCOc1cncc(c1)-c1cc2-c3[nH]c4c(c3CCc2cn1)C(=O)NCC41CN(C)C1
Show InChI InChI=1S/C26H29N5O3/c1-31-14-26(15-31)13-29-25(32)22-19-5-4-16-11-28-21(9-20(16)23(19)30-24(22)26)17-8-18(12-27-10-17)34-7-3-6-33-2/h8-12,30H,3-7,13-15H2,1-2H3,(H,29,32)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348498
PNG
(CHEMBL1801283)
Show SMILES Fc1ccc(cn1)-c1cc2-c3[nH]c4c(c3CCc2cn1)C(=O)NCC41CC1
Show InChI InChI=1S/C21H17FN4O/c22-16-4-2-12(9-24-16)15-7-14-11(8-23-15)1-3-13-17-19(26-18(13)14)21(5-6-21)10-25-20(17)27/h2,4,7-9,26H,1,3,5-6,10H2,(H,25,27)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348495
PNG
(CHEMBL1614995)
Show SMILES COCCOc1cncc(c1)-c1cc2c3[nH]c4CCNC(=O)c4c3ccc2cn1
Show InChI InChI=1S/C22H20N4O3/c1-28-6-7-29-15-8-14(10-23-12-15)19-9-17-13(11-25-19)2-3-16-20-18(26-21(16)17)4-5-24-22(20)27/h2-3,8-12,26H,4-7H2,1H3,(H,24,27)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348523
PNG
(CHEMBL1801291)
Show SMILES CCN1CC2(C1)CNC(=O)c1c3CCc4cnc(cc4-c3[nH]c21)-c1ccccc1F
Show InChI InChI=1S/C24H23FN4O/c1-2-29-12-24(13-29)11-27-23(30)20-16-8-7-14-10-26-19(15-5-3-4-6-18(15)25)9-17(14)21(16)28-22(20)24/h3-6,9-10,28H,2,7-8,11-13H2,1H3,(H,27,30)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348479
PNG
(CHEMBL1801195)
Show SMILES COCCOc1cncc(c1)-c1cc2-c3[nH]c4CCNC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C22H22N4O3/c1-28-6-7-29-15-8-14(10-23-12-15)19-9-17-13(11-25-19)2-3-16-20-18(26-21(16)17)4-5-24-22(20)27/h8-12,26H,2-7H2,1H3,(H,24,27)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348480
PNG
(CHEMBL1801312)
Show SMILES CN1CC2(C1)CNC(=O)c1c3CCc4cnc(cc4-c3n(C)c21)-c1ccccc1F
Show InChI InChI=1S/C24H23FN4O/c1-28-12-24(13-28)11-27-23(30)20-16-8-7-14-10-26-19(15-5-3-4-6-18(15)25)9-17(14)21(16)29(2)22(20)24/h3-6,9-10H,7-8,11-13H2,1-2H3,(H,27,30)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348481
PNG
(CHEMBL1801307)
Show SMILES CN1CC2(C1)CNC(=O)c1c3CCc4cnc(nc4-c3[nH]c21)-c1ccc(F)nc1
Show InChI InChI=1S/C21H19FN6O/c1-28-9-21(10-28)8-25-20(29)15-13-4-2-11-6-24-19(12-3-5-14(22)23-7-12)27-16(11)17(13)26-18(15)21/h3,5-7,26H,2,4,8-10H2,1H3,(H,25,29)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348482
PNG
(CHEMBL1801299)
Show SMILES COc1ccc(cc1)-c1ncc2CCc3c([nH]c4CC5(CC5)NC(=O)c34)-c2n1
Show InChI InChI=1S/C22H20N4O2/c1-28-14-5-2-12(3-6-14)20-23-11-13-4-7-15-17-16(24-19(15)18(13)25-20)10-22(8-9-22)26-21(17)27/h2-3,5-6,11,24H,4,7-10H2,1H3,(H,26,27)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348483
PNG
(CHEMBL1801194)
Show SMILES Fc1ccccc1-c1cc2-c3[nH]c4CCNC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C20H16FN3O/c21-15-4-2-1-3-12(15)17-9-14-11(10-23-17)5-6-13-18-16(24-19(13)14)7-8-22-20(18)25/h1-4,9-10,24H,5-8H2,(H,22,25)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348484
PNG
(CHEMBL1801308)
Show SMILES CN1CC2(C1)CNC(=O)c1c3CCc4cnc(nc4-c3[nH]c21)-c1ccc(OCCN2CCOCC2)cc1
Show InChI InChI=1S/C28H32N6O3/c1-33-16-28(17-33)15-30-27(35)22-21-7-4-19-14-29-26(32-23(19)24(21)31-25(22)28)18-2-5-20(6-3-18)37-13-10-34-8-11-36-12-9-34/h2-3,5-6,14,31H,4,7-13,15-17H2,1H3,(H,30,35)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348485
PNG
(CHEMBL1801306)
Show SMILES COc1ccc(cc1)-c1ncc2CCc3c([nH]c4c3C(=O)NCC43CN(C)C3)-c2n1
Show InChI InChI=1S/C23H23N5O2/c1-28-11-23(12-28)10-25-22(29)17-16-8-5-14-9-24-21(13-3-6-15(30-2)7-4-13)27-18(14)19(16)26-20(17)23/h3-4,6-7,9,26H,5,8,10-12H2,1-2H3,(H,25,29)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348486
PNG
(CHEMBL1801294)
Show SMILES COc1ccc(cc1)-c1cc2-c3[nH]c4CC5(CNC5)NC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C23H22N4O2/c1-29-15-5-2-13(3-6-15)18-8-17-14(10-25-18)4-7-16-20-19(26-21(16)17)9-23(11-24-12-23)27-22(20)28/h2-3,5-6,8,10,24,26H,4,7,9,11-12H2,1H3,(H,27,28)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348487
PNG
(CHEMBL1801301)
Show SMILES O=C1NC2(CC2)Cc2[nH]c-3c(CCc4cnc(nc-34)-c3ccc(OCCN4CCOCC4)cc3)c12
Show InChI InChI=1S/C27H29N5O3/c33-26-22-20-6-3-18-16-28-25(30-23(18)24(20)29-21(22)15-27(31-26)7-8-27)17-1-4-19(5-2-17)35-14-11-32-9-12-34-13-10-32/h1-2,4-5,16,29H,3,6-15H2,(H,31,33)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348488
PNG
(CHEMBL1801310)
Show SMILES CN1CC2(C1)CNC(=O)c1c3CCc4cnc(cc4-c3oc21)-c1cccc(F)c1
Show InChI InChI=1S/C23H20FN3O2/c1-27-11-23(12-27)10-26-22(28)19-16-6-5-14-9-25-18(13-3-2-4-15(24)7-13)8-17(14)20(16)29-21(19)23/h2-4,7-9H,5-6,10-12H2,1H3,(H,26,28)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348489
PNG
(CHEMBL1801196)
Show SMILES COCCOc1cncc(c1)-c1cc2-c3[nH]c4CCNC(=O)c4c3CCCc2cn1
Show InChI InChI=1S/C23H24N4O3/c1-29-7-8-30-16-9-15(11-24-13-16)20-10-18-14(12-26-20)3-2-4-17-21-19(27-22(17)18)5-6-25-23(21)28/h9-13,27H,2-8H2,1H3,(H,25,28)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348490
PNG
(CHEMBL1801297)
Show SMILES COc1ccc(cc1)-c1ncc2CCc3c([nH]c4CCNC(=O)c34)-c2n1
Show InChI InChI=1S/C20H18N4O2/c1-26-13-5-2-11(3-6-13)19-22-10-12-4-7-14-16-15(8-9-21-20(16)25)23-18(14)17(12)24-19/h2-3,5-6,10,23H,4,7-9H2,1H3,(H,21,25)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348491
PNG
(CHEMBL1801305)
Show SMILES CN1CC2(C1)CNC(=O)c1c3CCc4cnc(nc4-c3[nH]c21)-c1cccc(F)c1
Show InChI InChI=1S/C22H20FN5O/c1-28-10-22(11-28)9-25-21(29)16-15-6-5-13-8-24-20(12-3-2-4-14(23)7-12)27-17(13)18(15)26-19(16)22/h2-4,7-8,26H,5-6,9-11H2,1H3,(H,25,29)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348499
PNG
(CHEMBL1801303)
Show SMILES CN1CC2(C1)CNC(=O)c1c3CCc4cnc(nc4-c3[nH]c21)-c1ccccc1F
Show InChI InChI=1S/C22H20FN5O/c1-28-10-22(11-28)9-25-21(29)16-14-7-6-12-8-24-20(13-4-2-3-5-15(13)23)27-17(12)18(14)26-19(16)22/h2-5,8,26H,6-7,9-11H2,1H3,(H,25,29)
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n/an/a 5.60E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348508
PNG
(CHEMBL1801302)
Show SMILES COc1ccc(cc1)-c1ncc2CCc3c([nH]c4c3C(=O)NCC43CC3)-c2n1
Show InChI InChI=1S/C22H20N4O2/c1-28-14-5-2-12(3-6-14)20-23-10-13-4-7-15-16-19(25-18(15)17(13)26-20)22(8-9-22)11-24-21(16)27/h2-3,5-6,10,25H,4,7-9,11H2,1H3,(H,24,27)
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n/an/a 5.60E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348521
PNG
(CHEMBL1801292)
Show SMILES FCCN1CC2(C1)CNC(=O)c1c3CCc4cnc(cc4-c3[nH]c21)-c1ccccc1F
Show InChI InChI=1S/C24H22F2N4O/c25-7-8-30-12-24(13-30)11-28-23(31)20-16-6-5-14-10-27-19(15-3-1-2-4-18(15)26)9-17(14)21(16)29-22(20)24/h1-4,9-10,29H,5-8,11-13H2,(H,28,31)
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n/an/a 6.50E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348493
PNG
(CHEMBL1801304)
Show SMILES COCCOc1cncc(c1)-c1ncc2CCc3c([nH]c4c3C(=O)NCC43CN(C)C3)-c2n1
Show InChI InChI=1S/C24H26N6O3/c1-30-12-24(13-30)11-27-23(31)18-17-4-3-14-9-26-22(29-19(14)20(17)28-21(18)24)15-7-16(10-25-8-15)33-6-5-32-2/h7-10,28H,3-6,11-13H2,1-2H3,(H,27,31)
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n/an/a 6.70E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM30192
PNG
(Pyrrolopyridine, 23)
Show SMILES Fc1ccccc1-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1
Show InChI InChI=1S/C18H14FN3O/c19-14-4-2-1-3-12(14)17-9-11(5-7-20-17)16-10-13-15(22-16)6-8-21-18(13)23/h1-5,7,9-10,22H,6,8H2,(H,21,23)
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n/an/a 8.90E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348513
PNG
(CHEMBL1801273)
Show SMILES CN1CC2(C1)CNC(=O)c1c3Cc4cnc(cc4-c3[nH]c21)-c1ccccc1F
Show InChI InChI=1S/C22H19FN4O/c1-27-10-22(11-27)9-25-21(28)18-15-6-12-8-24-17(13-4-2-3-5-16(13)23)7-14(12)19(15)26-20(18)22/h2-5,7-8,26H,6,9-11H2,1H3,(H,25,28)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348505
PNG
(CHEMBL1801300)
Show SMILES Fc1ccc(cn1)-c1ncc2CCc3c([nH]c4CC5(CC5)NC(=O)c34)-c2n1
Show InChI InChI=1S/C20H16FN5O/c21-14-4-2-11(9-22-14)18-23-8-10-1-3-12-15-13(24-17(12)16(10)25-18)7-20(5-6-20)26-19(15)27/h2,4,8-9,24H,1,3,5-7H2,(H,26,27)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348517
PNG
(CHEMBL1801298)
Show SMILES Fc1ccccc1-c1ncc2CCc3c([nH]c4CC5(CC5)NC(=O)c34)-c2n1
Show InChI InChI=1S/C21H17FN4O/c22-14-4-2-1-3-12(14)19-23-10-11-5-6-13-16-15(24-18(13)17(11)25-19)9-21(7-8-21)26-20(16)27/h1-4,10,24H,5-9H2,(H,26,27)
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n/an/a 1.53E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348512
PNG
(CHEMBL1801309)
Show SMILES Fc1cccc(c1)-c1cc2-c3oc4c(c3CCc2cn1)C(=O)NCC41CNC1
Show InChI InChI=1S/C22H18FN3O2/c23-14-3-1-2-12(6-14)17-7-16-13(8-25-17)4-5-15-18-20(28-19(15)16)22(9-24-10-22)11-26-21(18)27/h1-3,6-8,24H,4-5,9-11H2,(H,26,27)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348500
PNG
(CHEMBL1801295)
Show SMILES COc1ccc(cc1)-c1cc2-c3[nH]c4CC5(CN(C)C5)NC(=O)c4c3CCc2cn1
Show InChI InChI=1S/C24H24N4O2/c1-28-12-24(13-28)10-20-21(23(29)27-24)17-8-5-15-11-25-19(9-18(15)22(17)26-20)14-3-6-16(30-2)7-4-14/h3-4,6-7,9,11,26H,5,8,10,12-13H2,1-2H3,(H,27,29)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (human))
BDBM50348522
PNG
(CHEMBL1801293)
Show SMILES CC(=O)N1CC2(C1)CNC(=O)c1c3CCc4cnc(cc4-c3[nH]c21)-c1ccccc1F
Show InChI InChI=1S/C24H21FN4O2/c1-13(30)29-11-24(12-29)10-27-23(31)20-16-7-6-14-9-26-19(15-4-2-3-5-18(15)25)8-17(14)21(16)28-22(20)24/h2-5,8-9,28H,6-7,10-12H2,1H3,(H,27,31)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis


Bioorg Med Chem Lett 20: 4719-23 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.04.023
BindingDB Entry DOI: 10.7270/Q2BZ66C2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%