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PubMed code 20634068

Compile data set for download or QSAR
Found 2 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM50343948
PNG
((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)
Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccc(s1)-c1ccccn1)c1cccnc1
Show InChI InChI=1S/C24H18N4O2S/c29-21-9-2-1-7-17(21)20-14-19(16-6-5-12-25-15-16)27-28(20)24(30)23-11-10-22(31-23)18-8-3-4-13-26-18/h1-13,15,20,29H,14H2
PDB
MMDB

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PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf


Bioorg Med Chem Lett 20: 4800-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.113
BindingDB Entry DOI: 10.7270/Q2MP53M9
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50343948
PNG
((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)
Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccc(s1)-c1ccccn1)c1cccnc1
Show InChI InChI=1S/C24H18N4O2S/c29-21-9-2-1-7-17(21)20-14-19(16-6-5-12-25-15-16)27-28(20)24(30)23-11-10-22(31-23)18-8-3-4-13-26-18/h1-13,15,20,29H,14H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of C-Raf


Bioorg Med Chem Lett 20: 4800-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.113
BindingDB Entry DOI: 10.7270/Q2MP53M9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%