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PubMed code 20638290

Compile data set for download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50326793
PNG
((+/-)(1S,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-cyc...)
Show SMILES N[C@@H]([C@H]1[C@H]([C@@H]1C(O)=O)C1CCCCC1)C(O)=O
Show InChI InChI=1S/C12H19NO4/c13-10(12(16)17)8-7(9(8)11(14)15)6-4-2-1-3-5-6/h6-10H,1-5,13H2,(H,14,15)(H,16,17)/t7-,8+,9+,10+/m1/s1
PDB

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UniChem

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Article
PubMed
n/an/a 6.20E+4n/an/an/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Antagonist activity at mGlu2 receptor expressed in CHO cells assessed as increase of cAMP level


Bioorg Med Chem 18: 6089-98 (2010)


Article DOI: 10.1016/j.bmc.2010.06.051
BindingDB Entry DOI: 10.7270/Q2C24WNH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50326794
PNG
((+/-)(1R,2S,3S)-3-[(S)-amino(carboxy)-methyl]-1,10...)
Show SMILES N[C@@H]([C@H]1[C@@H](C2CC2)[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c10-7(9(13)14)5-4(3-1-2-3)6(5)8(11)12/h3-7H,1-2,10H2,(H,11,12)(H,13,14)/t4-,5+,6+,7+/m1/s1
UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Agonist activity at mGlu4 receptor expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP level


Bioorg Med Chem 18: 6089-98 (2010)


Article DOI: 10.1016/j.bmc.2010.06.051
BindingDB Entry DOI: 10.7270/Q2C24WNH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50326794
PNG
((+/-)(1R,2S,3S)-3-[(S)-amino(carboxy)-methyl]-1,10...)
Show SMILES N[C@@H]([C@H]1[C@@H](C2CC2)[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c10-7(9(13)14)5-4(3-1-2-3)6(5)8(11)12/h3-7H,1-2,10H2,(H,11,12)(H,13,14)/t4-,5+,6+,7+/m1/s1
PDB

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PC sid
UniChem

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Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Agonist activity at mGlu1 receptor expressed in CHO cells assessed as myo-[2-3H]Inositol turnover by scintillation counting


Bioorg Med Chem 18: 6089-98 (2010)


Article DOI: 10.1016/j.bmc.2010.06.051
BindingDB Entry DOI: 10.7270/Q2C24WNH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50326794
PNG
((+/-)(1R,2S,3S)-3-[(S)-amino(carboxy)-methyl]-1,10...)
Show SMILES N[C@@H]([C@H]1[C@@H](C2CC2)[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c10-7(9(13)14)5-4(3-1-2-3)6(5)8(11)12/h3-7H,1-2,10H2,(H,11,12)(H,13,14)/t4-,5+,6+,7+/m1/s1
PDB

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Article
PubMed
n/an/an/an/a>50n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Agonist activity at mGlu2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP level


Bioorg Med Chem 18: 6089-98 (2010)


Article DOI: 10.1016/j.bmc.2010.06.051
BindingDB Entry DOI: 10.7270/Q2C24WNH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50138781
PNG
((1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-methyl-c...)
Show SMILES C[C@@H]1[C@H]([C@H](N)C(O)=O)[C@H]1C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-2-3(4(2)6(9)10)5(8)7(11)12/h2-5H,8H2,1H3,(H,9,10)(H,11,12)/t2-,3+,4+,5+/m1/s1
PDB

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Article
PubMed
n/an/an/an/a>10n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Agonist activity at mGlu2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP level


Bioorg Med Chem 18: 6089-98 (2010)


Article DOI: 10.1016/j.bmc.2010.06.051
BindingDB Entry DOI: 10.7270/Q2C24WNH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50138781
PNG
((1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-methyl-c...)
Show SMILES C[C@@H]1[C@H]([C@H](N)C(O)=O)[C@H]1C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-2-3(4(2)6(9)10)5(8)7(11)12/h2-5H,8H2,1H3,(H,9,10)(H,11,12)/t2-,3+,4+,5+/m1/s1
UniProtKB/SwissProt

GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Agonist activity at mGlu4 receptor expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP level


Bioorg Med Chem 18: 6089-98 (2010)


Article DOI: 10.1016/j.bmc.2010.06.051
BindingDB Entry DOI: 10.7270/Q2C24WNH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50326793
PNG
((+/-)(1S,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-cyc...)
Show SMILES N[C@@H]([C@H]1[C@H]([C@@H]1C(O)=O)C1CCCCC1)C(O)=O
Show InChI InChI=1S/C12H19NO4/c13-10(12(16)17)8-7(9(8)11(14)15)6-4-2-1-3-5-6/h6-10H,1-5,13H2,(H,14,15)(H,16,17)/t7-,8+,9+,10+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Agonist activity at mGlu4 receptor expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP level


Bioorg Med Chem 18: 6089-98 (2010)


Article DOI: 10.1016/j.bmc.2010.06.051
BindingDB Entry DOI: 10.7270/Q2C24WNH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50138781
PNG
((1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-methyl-c...)
Show SMILES C[C@@H]1[C@H]([C@H](N)C(O)=O)[C@H]1C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-2-3(4(2)6(9)10)5(8)7(11)12/h2-5H,8H2,1H3,(H,9,10)(H,11,12)/t2-,3+,4+,5+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Agonist activity at mGlu1 receptor expressed in CHO cells assessed as myo-[2-3H]Inositol turnover by scintillation counting


Bioorg Med Chem 18: 6089-98 (2010)


Article DOI: 10.1016/j.bmc.2010.06.051
BindingDB Entry DOI: 10.7270/Q2C24WNH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50326793
PNG
((+/-)(1S,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-cyc...)
Show SMILES N[C@@H]([C@H]1[C@H]([C@@H]1C(O)=O)C1CCCCC1)C(O)=O
Show InChI InChI=1S/C12H19NO4/c13-10(12(16)17)8-7(9(8)11(14)15)6-4-2-1-3-5-6/h6-10H,1-5,13H2,(H,14,15)(H,16,17)/t7-,8+,9+,10+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Agonist activity at mGlu1 receptor expressed in CHO cells assessed as myo-[2-3H]Inositol turnover by scintillation counting


Bioorg Med Chem 18: 6089-98 (2010)


Article DOI: 10.1016/j.bmc.2010.06.051
BindingDB Entry DOI: 10.7270/Q2C24WNH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%