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PubMed code 20673717

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416599
PNG
(CHEMBL1222821)
Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C15H16ClF3N2O2/c1-2-21-11(6-7-12(21)22)14(23)20-8-9-4-3-5-10(13(9)16)15(17,18)19/h3-5,11H,2,6-8H2,1H3,(H,20,23)/t11-/m0/s1
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n/an/a 1.58n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416603
PNG
(CHEMBL1222883)
Show SMILES CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C14H14ClF3N2O2/c1-20-10(5-6-11(20)21)13(22)19-7-8-3-2-4-9(12(8)15)14(16,17)18/h2-4,10H,5-7H2,1H3,(H,19,22)/t10-/m0/s1
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n/an/a 3.16n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416598
PNG
(CHEMBL1222820)
Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H16Cl2N2O2/c1-2-18-12(5-6-13(18)19)14(20)17-8-9-3-4-10(15)7-11(9)16/h3-4,7,12H,2,5-6,8H2,1H3,(H,17,20)/t12-/m0/s1
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n/an/a 6.31n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416383
PNG
(CHEMBL1210558)
Show SMILES Cc1n[nH]c(C)c1CC(=O)NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H15Cl2N3O/c1-8-12(9(2)19-18-8)6-14(20)17-7-10-3-4-11(15)5-13(10)16/h3-5H,6-7H2,1-2H3,(H,17,20)(H,18,19)
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n/an/a 7.94n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416618
PNG
(CHEMBL1222819)
Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCc1cccc(Cl)c1Cl
Show InChI InChI=1S/C14H16Cl2N2O2/c1-2-18-11(6-7-12(18)19)14(20)17-8-9-4-3-5-10(15)13(9)16/h3-5,11H,2,6-8H2,1H3,(H,17,20)/t11-/m0/s1
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n/an/a 12.6n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416610
PNG
(CHEMBL1222673)
Show SMILES Fc1ccc(CNC(=O)[C@@H]2CCC(=O)N2C2CCC2)c(Cl)c1
Show InChI InChI=1S/C16H18ClFN2O2/c17-13-8-11(18)5-4-10(13)9-19-16(22)14-6-7-15(21)20(14)12-2-1-3-12/h4-5,8,12,14H,1-3,6-7,9H2,(H,19,22)/t14-/m0/s1
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n/an/a 25.1n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416602
PNG
(CHEMBL1222882)
Show SMILES CCN1[C@@H](CCCC1=O)C(=O)NCc1ccc(F)cc1Cl
Show InChI InChI=1S/C15H18ClFN2O2/c1-2-19-13(4-3-5-14(19)20)15(21)18-9-10-6-7-11(17)8-12(10)16/h6-8,13H,2-5,9H2,1H3,(H,18,21)/t13-/m0/s1
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n/an/a 31.6n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416607
PNG
(CHEMBL1222669)
Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCc1ccc(F)cc1Cl
Show InChI InChI=1S/C14H16ClFN2O2/c1-2-18-12(5-6-13(18)19)14(20)17-8-9-3-4-10(16)7-11(9)15/h3-4,7,12H,2,5-6,8H2,1H3,(H,17,20)/t12-/m0/s1
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n/an/a 31.6n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50415883
PNG
(CHEMBL1095454)
Show SMILES Cc1nn(c(C)c1CC(=O)NCc1ccc(F)cc1Cl)-c1ccccc1
Show InChI InChI=1S/C20H19ClFN3O/c1-13-18(14(2)25(24-13)17-6-4-3-5-7-17)11-20(26)23-12-15-8-9-16(22)10-19(15)21/h3-10H,11-12H2,1-2H3,(H,23,26)
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n/an/a 39.8n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM50416383
PNG
(CHEMBL1210558)
Show SMILES Cc1n[nH]c(C)c1CC(=O)NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H15Cl2N3O/c1-8-12(9(2)19-18-8)6-14(20)17-7-10-3-4-11(15)5-13(10)16/h3-5H,6-7H2,1-2H3,(H,17,20)(H,18,19)
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n/an/a 79.4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of rat P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416613
PNG
(CHEMBL1222739)
Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C18H28N2O2/c1-2-20-15(3-4-16(20)21)17(22)19-11-18-8-12-5-13(9-18)7-14(6-12)10-18/h12-15H,2-11H2,1H3,(H,19,22)/t12?,13?,14?,15-,18?/m0/s1
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n/an/a 79.4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416600
PNG
(CHEMBL1222823)
Show SMILES CC(=O)N1CCC[C@H]1C(=O)NCc1ccc(F)cc1Cl
Show InChI InChI=1S/C14H16ClFN2O2/c1-9(19)18-6-2-3-13(18)14(20)17-8-10-4-5-11(16)7-12(10)15/h4-5,7,13H,2-3,6,8H2,1H3,(H,17,20)/t13-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM50415883
PNG
(CHEMBL1095454)
Show SMILES Cc1nn(c(C)c1CC(=O)NCc1ccc(F)cc1Cl)-c1ccccc1
Show InChI InChI=1S/C20H19ClFN3O/c1-13-18(14(2)25(24-13)17-6-4-3-5-7-17)11-20(26)23-12-15-8-9-16(22)10-19(15)21/h3-10H,11-12H2,1-2H3,(H,23,26)
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of rat P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416617
PNG
(CHEMBL1222743)
Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C15H17F3N2O2/c1-2-20-12(6-7-13(20)21)14(22)19-9-10-4-3-5-11(8-10)15(16,17)18/h3-5,8,12H,2,6-7,9H2,1H3,(H,19,22)/t12-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416604
PNG
(CHEMBL1222604)
Show SMILES CC(C)N1[C@@H](CCC1=O)C(=O)NCc1ccc(F)cc1Cl
Show InChI InChI=1S/C15H18ClFN2O2/c1-9(2)19-13(5-6-14(19)20)15(21)18-8-10-3-4-11(17)7-12(10)16/h3-4,7,9,13H,5-6,8H2,1-2H3,(H,18,21)/t13-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416606
PNG
(CHEMBL1222606)
Show SMILES CN1[C@@H](CCC1=O)C(=O)NCc1ccc(F)cc1Cl
Show InChI InChI=1S/C13H14ClFN2O2/c1-17-11(4-5-12(17)18)13(19)16-7-8-2-3-9(15)6-10(8)14/h2-3,6,11H,4-5,7H2,1H3,(H,16,19)/t11-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416605
PNG
(CHEMBL1222602)
Show SMILES CN(C(=O)c1cc(Cl)c(=O)n(Cc2c(Cl)cccc2Cl)c1)c1ccccc1
Show InChI InChI=1S/C20H15Cl3N2O2/c1-24(14-6-3-2-4-7-14)19(26)13-10-18(23)20(27)25(11-13)12-15-16(21)8-5-9-17(15)22/h2-11H,12H2,1H3
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n/an/a 126n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416608
PNG
(CHEMBL1222670)
Show SMILES CCCN1[C@@H](CCC1=O)C(=O)NCc1ccc(F)cc1Cl
Show InChI InChI=1S/C15H18ClFN2O2/c1-2-7-19-13(5-6-14(19)20)15(21)18-9-10-3-4-11(17)8-12(10)16/h3-4,8,13H,2,5-7,9H2,1H3,(H,18,21)/t13-/m0/s1
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n/an/a 158n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416601
PNG
(CHEMBL1222881)
Show SMILES CCN1[C@H](CCC1=O)C(=O)NCc1ccc(F)cc1Cl
Show InChI InChI=1S/C14H16ClFN2O2/c1-2-18-12(5-6-13(18)19)14(20)17-8-9-3-4-10(16)7-11(9)15/h3-4,7,12H,2,5-6,8H2,1H3,(H,17,20)/t12-/m1/s1
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n/an/a 158n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM50416603
PNG
(CHEMBL1222883)
Show SMILES CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C14H14ClF3N2O2/c1-20-10(5-6-11(20)21)13(22)19-7-8-3-2-4-9(12(8)15)14(16,17)18/h2-4,10H,5-7H2,1H3,(H,19,22)/t10-/m0/s1
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n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of rat P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM50416605
PNG
(CHEMBL1222602)
Show SMILES CN(C(=O)c1cc(Cl)c(=O)n(Cc2c(Cl)cccc2Cl)c1)c1ccccc1
Show InChI InChI=1S/C20H15Cl3N2O2/c1-24(14-6-3-2-4-7-14)19(26)13-10-18(23)20(27)25(11-13)12-15-16(21)8-5-9-17(15)22/h2-11H,12H2,1H3
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n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of rat P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416604
PNG
(CHEMBL1222604)
Show SMILES CC(C)N1[C@@H](CCC1=O)C(=O)NCc1ccc(F)cc1Cl
Show InChI InChI=1S/C15H18ClFN2O2/c1-9(2)19-13(5-6-14(19)20)15(21)18-8-10-3-4-11(17)7-12(10)16/h3-4,7,9,13H,5-6,8H2,1-2H3,(H,18,21)/t13-/m0/s1
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n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416609
PNG
(CHEMBL1222671)
Show SMILES CC(C)CN1[C@@H](CCC1=O)C(=O)NCc1ccc(F)cc1Cl
Show InChI InChI=1S/C16H20ClFN2O2/c1-10(2)9-20-14(5-6-15(20)21)16(22)19-8-11-3-4-12(18)7-13(11)17/h3-4,7,10,14H,5-6,8-9H2,1-2H3,(H,19,22)/t14-/m0/s1
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n/an/a 398n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416611
PNG
(CHEMBL1222519)
Show SMILES Fc1ccc(CNC(=O)[C@@H]2CCC(=O)N2C2CCCC2)c(Cl)c1
Show InChI InChI=1S/C17H20ClFN2O2/c18-14-9-12(19)6-5-11(14)10-20-17(23)15-7-8-16(22)21(15)13-3-1-2-4-13/h5-6,9,13,15H,1-4,7-8,10H2,(H,20,23)/t15-/m0/s1
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n/an/a 501n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416615
PNG
(CHEMBL1222744)
Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCc1ccccc1C(F)(F)F
Show InChI InChI=1S/C15H17F3N2O2/c1-2-20-12(7-8-13(20)21)14(22)19-9-10-5-3-4-6-11(10)15(16,17)18/h3-6,12H,2,7-9H2,1H3,(H,19,22)/t12-/m0/s1
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n/an/a 631n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416616
PNG
(CHEMBL1222740)
Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCc1ccccc1Cl
Show InChI InChI=1S/C14H17ClN2O2/c1-2-17-12(7-8-13(17)18)14(19)16-9-10-5-3-4-6-11(10)15/h3-6,12H,2,7-9H2,1H3,(H,16,19)/t12-/m0/s1
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n/an/a 631n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416614
PNG
(CHEMBL1222742)
Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C14H17ClN2O2/c1-2-17-12(7-8-13(17)18)14(19)16-9-10-3-5-11(15)6-4-10/h3-6,12H,2,7-9H2,1H3,(H,16,19)/t12-/m0/s1
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n/an/a 631n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416612
PNG
(CHEMBL1222601)
Show SMILES Fc1ccc(CNC(=O)[C@@H]2CCC(=O)N2c2ccccc2)c(Cl)c1
Show InChI InChI=1S/C18H16ClFN2O2/c19-15-10-13(20)7-6-12(15)11-21-18(24)16-8-9-17(23)22(16)14-4-2-1-3-5-14/h1-7,10,16H,8-9,11H2,(H,21,24)/t16-/m0/s1
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n/an/a 794n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM50416604
PNG
(CHEMBL1222604)
Show SMILES CC(C)N1[C@@H](CCC1=O)C(=O)NCc1ccc(F)cc1Cl
Show InChI InChI=1S/C15H18ClFN2O2/c1-9(2)19-13(5-6-14(19)20)15(21)18-8-10-3-4-11(17)7-12(10)16/h3-4,7,9,13H,5-6,8H2,1-2H3,(H,18,21)/t13-/m0/s1
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n/an/a 1.58E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of rat P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM50416604
PNG
(CHEMBL1222604)
Show SMILES CC(C)N1[C@@H](CCC1=O)C(=O)NCc1ccc(F)cc1Cl
Show InChI InChI=1S/C15H18ClFN2O2/c1-9(2)19-13(5-6-14(19)20)15(21)18-8-10-3-4-11(17)7-12(10)16/h3-4,7,9,13H,5-6,8H2,1-2H3,(H,18,21)/t13-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of rat P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%