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PubMed code 20675134

Compile data set for download or QSAR
Found 88 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325416
PNG
((S)-4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyr...)
Show SMILES O=C(NC[C@@H]1CCCCN1)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C23H28N6O/c30-23(27-14-19-3-1-2-12-24-19)18-8-6-17(7-9-18)20-15-26-22-11-10-21(28-29(20)22)25-13-16-4-5-16/h6-11,15-16,19,24H,1-5,12-14H2,(H,25,28)(H,27,30)/t19-/m0/s1
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n/an/a 47n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325375
PNG
((S)-4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyr...)
Show SMILES O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C22H26N6O/c29-22(26-13-18-2-1-11-23-18)17-7-5-16(6-8-17)19-14-25-21-10-9-20(27-28(19)21)24-12-15-3-4-15/h5-10,14-15,18,23H,1-4,11-13H2,(H,24,27)(H,26,29)/t18-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325371
PNG
(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridaz...)
Show SMILES CC(CN(C)C)NC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C22H28N6O/c1-15(14-27(2)3)25-22(29)18-8-6-17(7-9-18)19-13-24-21-11-10-20(26-28(19)21)23-12-16-4-5-16/h6-11,13,15-16H,4-5,12,14H2,1-3H3,(H,23,26)(H,25,29)
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n/an/a 73n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325370
PNG
(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridaz...)
Show SMILES CCN(CC)CCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C23H30N6O/c1-3-28(4-2)14-13-24-23(30)19-9-7-18(8-10-19)20-16-26-22-12-11-21(27-29(20)22)25-15-17-5-6-17/h7-12,16-17H,3-6,13-15H2,1-2H3,(H,24,30)(H,25,27)
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n/an/a 79n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325415
PNG
((R)-4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyr...)
Show SMILES O=C(NC[C@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C22H26N6O/c29-22(26-13-18-2-1-11-23-18)17-7-5-16(6-8-17)19-14-25-21-10-9-20(27-28(19)21)24-12-15-3-4-15/h5-10,14-15,18,23H,1-4,11-13H2,(H,24,27)(H,26,29)/t18-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325418
PNG
((S)-4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyr...)
Show SMILES CN1CCC[C@H]1CNC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C23H28N6O/c1-28-12-2-3-19(28)14-26-23(30)18-8-6-17(7-9-18)20-15-25-22-11-10-21(27-29(20)22)24-13-16-4-5-16/h6-11,15-16,19H,2-5,12-14H2,1H3,(H,24,27)(H,26,30)/t19-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325417
PNG
((S)-4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyr...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C24H30N6O/c1-2-29-13-3-4-20(29)15-27-24(31)19-9-7-18(8-10-19)21-16-26-23-12-11-22(28-30(21)23)25-14-17-5-6-17/h7-12,16-17,20H,2-6,13-15H2,1H3,(H,25,28)(H,27,31)/t20-/m0/s1
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n/an/a 140n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325414
PNG
((R)-(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]py...)
Show SMILES O=C(N1CCC[C@@H]1CN1CCCC1)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C26H32N6O/c33-26(31-15-3-4-22(31)18-30-13-1-2-14-30)21-9-7-20(8-10-21)23-17-28-25-12-11-24(29-32(23)25)27-16-19-5-6-19/h7-12,17,19,22H,1-6,13-16,18H2,(H,27,29)/t22-/m1/s1
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n/an/a 160n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325368
PNG
((S)-4-(6-(3-chlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1cccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)c1
Show InChI InChI=1S/C25H25ClN6O/c26-20-4-1-3-17(13-20)14-28-23-10-11-24-29-16-22(32(24)31-23)18-6-8-19(9-7-18)25(33)30-15-21-5-2-12-27-21/h1,3-4,6-11,13,16,21,27H,2,5,12,14-15H2,(H,28,31)(H,30,33)/t21-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325403
PNG
((S)-4-(6-(cyclopropylamino)imidazo[1,2-b]pyridazin...)
Show SMILES O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NC3CC3)nn12
Show InChI InChI=1S/C21H24N6O/c28-21(24-12-17-2-1-11-22-17)15-5-3-14(4-6-15)18-13-23-20-10-9-19(26-27(18)20)25-16-7-8-16/h3-6,9-10,13,16-17,22H,1-2,7-8,11-12H2,(H,24,28)(H,25,26)/t17-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325369
PNG
(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridaz...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C21H26N6O/c1-26(2)12-11-22-21(28)17-7-5-16(6-8-17)18-14-24-20-10-9-19(25-27(18)20)23-13-15-3-4-15/h5-10,14-15H,3-4,11-13H2,1-2H3,(H,22,28)(H,23,25)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325402
PNG
((S)-4-(6-(isopropylamino)imidazo[1,2-b]pyridazin-3...)
Show SMILES CC(C)Nc1ccc2ncc(-c3ccc(cc3)C(=O)NC[C@@H]3CCCN3)n2n1
Show InChI InChI=1S/C21H26N6O/c1-14(2)25-19-9-10-20-23-13-18(27(20)26-19)15-5-7-16(8-6-15)21(28)24-12-17-4-3-11-22-17/h5-10,13-14,17,22H,3-4,11-12H2,1-2H3,(H,24,28)(H,25,26)/t17-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325412
PNG
(CHEMBL1223206 | N-(2-aminopropyl)-4-(6-(cyclopropy...)
Show SMILES CC(N)CNC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C20H24N6O/c1-13(21)10-24-20(27)16-6-4-15(5-7-16)17-12-23-19-9-8-18(25-26(17)19)22-11-14-2-3-14/h4-9,12-14H,2-3,10-11,21H2,1H3,(H,22,25)(H,24,27)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325374
PNG
((S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)cc1Cl
Show InChI InChI=1S/C25H24Cl2N6O/c26-20-8-3-16(12-21(20)27)13-29-23-9-10-24-30-15-22(33(24)32-23)17-4-6-18(7-5-17)25(34)31-14-19-2-1-11-28-19/h3-10,12,15,19,28H,1-2,11,13-14H2,(H,29,32)(H,31,34)/t19-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325404
PNG
((S)-4-(6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl...)
Show SMILES O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NCc3ccccc3)nn12
Show InChI InChI=1S/C25H26N6O/c32-25(29-16-21-7-4-14-26-21)20-10-8-19(9-11-20)22-17-28-24-13-12-23(30-31(22)24)27-15-18-5-2-1-3-6-18/h1-3,5-6,8-13,17,21,26H,4,7,14-16H2,(H,27,30)(H,29,32)/t21-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325411
PNG
(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridaz...)
Show SMILES CN(C)CCN(C)C(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C22H28N6O/c1-26(2)12-13-27(3)22(29)18-8-6-17(7-9-18)19-15-24-21-11-10-20(25-28(19)21)23-14-16-4-5-16/h6-11,15-16H,4-5,12-14H2,1-3H3,(H,23,25)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325366
PNG
((S)-4-(6-(3-(1H-imidazol-1-yl)propylamino)imidazo[...)
Show SMILES O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NCCCn3ccnc3)nn12
Show InChI InChI=1S/C24H28N8O/c33-24(29-15-20-3-1-10-26-20)19-6-4-18(5-7-19)21-16-28-23-9-8-22(30-32(21)23)27-11-2-13-31-14-12-25-17-31/h4-9,12,14,16-17,20,26H,1-3,10-11,13,15H2,(H,27,30)(H,29,33)/t20-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325367
PNG
(CHEMBL1223136 | trans-4-(6-(4-hydroxycyclohexylami...)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3ccc(cc3)C(=O)NC[C@@H]3CCCN3)n2n1
Show InChI InChI=1S/C24H30N6O2/c31-20-9-7-18(8-10-20)28-22-11-12-23-26-15-21(30(23)29-22)16-3-5-17(6-4-16)24(32)27-14-19-2-1-13-25-19/h3-6,11-12,15,18-20,25,31H,1-2,7-10,13-14H2,(H,27,32)(H,28,29)/t18-,19-,20-/m0/s1
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n/an/a 530n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325406
PNG
((S)-4-(6-(3-hydroxypropylamino)imidazo[1,2-b]pyrid...)
Show SMILES OCCCNc1ccc2ncc(-c3ccc(cc3)C(=O)NC[C@@H]3CCCN3)n2n1
Show InChI InChI=1S/C21H26N6O2/c28-12-2-11-23-19-8-9-20-24-14-18(27(20)26-19)15-4-6-16(7-5-15)21(29)25-13-17-3-1-10-22-17/h4-9,14,17,22,28H,1-3,10-13H2,(H,23,26)(H,25,29)/t17-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325373
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCCN4CCCC4)n3n2)cc1Cl
Show InChI InChI=1S/C26H26Cl2N6O/c27-21-8-3-18(15-22(21)28)16-30-24-9-10-25-31-17-23(34(25)32-24)19-4-6-20(7-5-19)26(35)29-11-14-33-12-1-2-13-33/h3-10,15,17H,1-2,11-14,16H2,(H,29,35)(H,30,32)
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n/an/a 590n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325372
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C24H24Cl2N6O/c1-31(2)12-11-27-24(33)18-6-4-17(5-7-18)21-15-29-23-10-9-22(30-32(21)23)28-14-16-3-8-19(25)20(26)13-16/h3-10,13,15H,11-12,14H2,1-2H3,(H,27,33)(H,28,30)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325401
PNG
((S)-4-(6-(methylamino)imidazo[1,2-b]pyridazin-3-yl...)
Show SMILES CNc1ccc2ncc(-c3ccc(cc3)C(=O)NC[C@@H]3CCCN3)n2n1
Show InChI InChI=1S/C19H22N6O/c1-20-17-8-9-18-22-12-16(25(18)24-17)13-4-6-14(7-5-13)19(26)23-11-15-3-2-10-21-15/h4-9,12,15,21H,2-3,10-11H2,1H3,(H,20,24)(H,23,26)/t15-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325393
PNG
((4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrid...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)N4CCC(CC4)N4CCCC4)n3n2)cc1Cl
Show InChI InChI=1S/C29H30Cl2N6O/c30-24-8-3-20(17-25(24)31)18-32-27-9-10-28-33-19-26(37(28)34-27)21-4-6-22(7-5-21)29(38)36-15-11-23(12-16-36)35-13-1-2-14-35/h3-10,17,19,23H,1-2,11-16,18H2,(H,32,34)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325391
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES CN(C)CCN(C)C(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C25H26Cl2N6O/c1-31(2)12-13-32(3)25(34)19-7-5-18(6-8-19)22-16-29-24-11-10-23(30-33(22)24)28-15-17-4-9-20(26)21(27)14-17/h4-11,14,16H,12-13,15H2,1-3H3,(H,28,30)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50325374
PNG
((S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)cc1Cl
Show InChI InChI=1S/C25H24Cl2N6O/c26-20-8-3-16(12-21(20)27)13-29-23-9-10-24-30-15-22(33(24)32-23)17-4-6-18(7-5-17)25(34)31-14-19-2-1-11-28-19/h3-10,12,15,19,28H,1-2,11,13-14H2,(H,29,32)(H,31,34)/t19-/m0/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant IKKalpha after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325377
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCCN4CCCCC4)n3n2)cc1Cl
Show InChI InChI=1S/C27H28Cl2N6O/c28-22-9-4-19(16-23(22)29)17-31-25-10-11-26-32-18-24(35(26)33-25)20-5-7-21(8-6-20)27(36)30-12-15-34-13-2-1-3-14-34/h4-11,16,18H,1-3,12-15,17H2,(H,30,36)(H,31,33)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325380
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES CN(C)CCCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C25H26Cl2N6O/c1-32(2)13-3-12-28-25(34)19-7-5-18(6-8-19)22-16-30-24-11-10-23(31-33(22)24)29-15-17-4-9-20(26)21(27)14-17/h4-11,14,16H,3,12-13,15H2,1-2H3,(H,28,34)(H,29,31)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325376
PNG
(CHEMBL1223564 | N-(2-aminoethyl)-4-(6-(3,4-dichlor...)
Show SMILES NCCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C22H20Cl2N6O/c23-17-6-1-14(11-18(17)24)12-27-20-7-8-21-28-13-19(30(21)29-20)15-2-4-16(5-3-15)22(31)26-10-9-25/h1-8,11,13H,9-10,12,25H2,(H,26,31)(H,27,29)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325365
PNG
((S)-4-(6-(2-(1H-imidazol-5-yl)ethylamino)imidazo[1...)
Show SMILES O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NCCc3cnc[nH]3)nn12
Show InChI InChI=1S/C23H26N8O/c32-23(28-13-18-2-1-10-25-18)17-5-3-16(4-6-17)20-14-27-22-8-7-21(30-31(20)22)26-11-9-19-12-24-15-29-19/h3-8,12,14-15,18,25H,1-2,9-11,13H2,(H,24,29)(H,26,30)(H,28,32)/t18-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325405
PNG
((S)-4-(6-(2-hydroxyethylamino)imidazo[1,2-b]pyrida...)
Show SMILES OCCNc1ccc2ncc(-c3ccc(cc3)C(=O)NC[C@@H]3CCCN3)n2n1
Show InChI InChI=1S/C20H24N6O2/c27-11-10-22-18-7-8-19-23-13-17(26(19)25-18)14-3-5-15(6-4-14)20(28)24-12-16-2-1-9-21-16/h3-8,13,16,21,27H,1-2,9-12H2,(H,22,25)(H,24,28)/t16-/m0/s1
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n/an/a 3.70E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50325368
PNG
((S)-4-(6-(3-chlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1cccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)c1
Show InChI InChI=1S/C25H25ClN6O/c26-20-4-1-3-17(13-20)14-28-23-10-11-24-29-16-22(32(24)31-23)18-6-8-19(9-7-18)25(33)30-15-21-5-2-12-27-21/h1,3-4,6-11,13,16,21,27H,2,5,12,14-15H2,(H,28,31)(H,30,33)/t21-/m0/s1
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n/an/a>4.00E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant IKKalpha after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325379
PNG
(CHEMBL1222477 | N-(3-aminopropyl)-4-(6-(3,4-dichlo...)
Show SMILES NCCCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C23H22Cl2N6O/c24-18-7-2-15(12-19(18)25)13-28-21-8-9-22-29-14-20(31(22)30-21)16-3-5-17(6-4-16)23(32)27-11-1-10-26/h2-9,12,14H,1,10-11,13,26H2,(H,27,32)(H,28,30)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50325373
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCCN4CCCC4)n3n2)cc1Cl
Show InChI InChI=1S/C26H26Cl2N6O/c27-21-8-3-18(15-22(21)28)16-30-24-9-10-25-31-17-23(34(25)32-24)19-4-6-20(7-5-19)26(35)29-11-14-33-12-1-2-13-33/h3-10,15,17H,1-2,11-14,16H2,(H,29,35)(H,30,32)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant IKKalpha after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325413
PNG
((S)-(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]py...)
Show SMILES O=C(N1CCC[C@H]1CN1CCCC1)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C26H32N6O/c33-26(31-15-3-4-22(31)18-30-13-1-2-14-30)21-9-7-20(8-10-21)23-17-28-25-12-11-24(29-32(23)25)27-16-19-5-6-19/h7-12,17,19,22H,1-6,13-16,18H2,(H,27,29)/t22-/m0/s1
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n/an/a 5.10E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325385
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC4CCNC4)n3n2)cc1Cl
Show InChI InChI=1S/C24H22Cl2N6O/c25-19-6-1-15(11-20(19)26)12-28-22-7-8-23-29-14-21(32(23)31-22)16-2-4-17(5-3-16)24(33)30-18-9-10-27-13-18/h1-8,11,14,18,27H,9-10,12-13H2,(H,28,31)(H,30,33)
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n/an/a 5.60E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325408
PNG
((S)-4-(6-(dimethylamino)imidazo[1,2-b]pyridazin-3-...)
Show SMILES CN(C)c1ccc2ncc(-c3ccc(cc3)C(=O)NC[C@@H]3CCCN3)n2n1
Show InChI InChI=1S/C20H24N6O/c1-25(2)19-10-9-18-22-13-17(26(18)24-19)14-5-7-15(8-6-14)20(27)23-12-16-4-3-11-21-16/h5-10,13,16,21H,3-4,11-12H2,1-2H3,(H,23,27)/t16-/m0/s1
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n/an/a 7.10E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325392
PNG
((3-aminoazetidin-1-yl)(4-(6-(3,4-dichlorobenzylami...)
Show SMILES NC1CN(C1)C(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C23H20Cl2N6O/c24-18-6-1-14(9-19(18)25)10-27-21-7-8-22-28-11-20(31(22)29-21)15-2-4-16(5-3-15)23(32)30-12-17(26)13-30/h1-9,11,17H,10,12-13,26H2,(H,27,29)
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n/an/a 8.90E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325383
PNG
((R)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCNC4)n3n2)cc1Cl
Show InChI InChI=1S/C25H24Cl2N6O/c26-20-6-1-16(11-21(20)27)13-29-23-7-8-24-30-15-22(33(24)32-23)18-2-4-19(5-3-18)25(34)31-14-17-9-10-28-12-17/h1-8,11,15,17,28H,9-10,12-14H2,(H,29,32)(H,31,34)/t17-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325381
PNG
(CHEMBL1222563 | N-(2-amino-2-methylpropyl)-4-(6-(3...)
Show SMILES CC(C)(N)CNC(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C24H24Cl2N6O/c1-24(2,27)14-30-23(33)17-6-4-16(5-7-17)20-13-29-22-10-9-21(31-32(20)22)28-12-15-3-8-18(25)19(26)11-15/h3-11,13H,12,14,27H2,1-2H3,(H,28,31)(H,30,33)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325407
PNG
((S)-4-(6-(2-acetamidoethylamino)imidazo[1,2-b]pyri...)
Show SMILES CC(=O)NCCNc1ccc2ncc(-c3ccc(cc3)C(=O)NC[C@@H]3CCCN3)n2n1
Show InChI InChI=1S/C22H27N7O2/c1-15(30)23-11-12-25-20-8-9-21-26-14-19(29(21)28-20)16-4-6-17(7-5-16)22(31)27-13-18-3-2-10-24-18/h4-9,14,18,24H,2-3,10-13H2,1H3,(H,23,30)(H,25,28)(H,27,31)/t18-/m0/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325400
PNG
((S)-4-(6-aminoimidazo[1,2-b]pyridazin-3-yl)-N-(pyr...)
Show SMILES Nc1ccc2ncc(-c3ccc(cc3)C(=O)NC[C@@H]3CCCN3)n2n1
Show InChI InChI=1S/C18H20N6O/c19-16-7-8-17-21-11-15(24(17)23-16)12-3-5-13(6-4-12)18(25)22-10-14-2-1-9-20-14/h3-8,11,14,20H,1-2,9-10H2,(H2,19,23)(H,22,25)/t14-/m0/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325384
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCC4CCNCC4)n3n2)cc1Cl
Show InChI InChI=1S/C26H26Cl2N6O/c27-21-6-1-18(13-22(21)28)15-30-24-7-8-25-31-16-23(34(25)33-24)19-2-4-20(5-3-19)26(35)32-14-17-9-11-29-12-10-17/h1-8,13,16-17,29H,9-12,14-15H2,(H,30,33)(H,32,35)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325386
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC4CCNCC4)n3n2)cc1Cl
Show InChI InChI=1S/C25H24Cl2N6O/c26-20-6-1-16(13-21(20)27)14-29-23-7-8-24-30-15-22(33(24)32-23)17-2-4-18(5-3-17)25(34)31-19-9-11-28-12-10-19/h1-8,13,15,19,28H,9-12,14H2,(H,29,32)(H,31,34)
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n/an/a 1.80E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325398
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES CCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C22H19Cl2N5O/c1-2-25-22(30)16-6-4-15(5-7-16)19-13-27-21-10-9-20(28-29(19)21)26-12-14-3-8-17(23)18(24)11-14/h3-11,13H,2,12H2,1H3,(H,25,30)(H,26,28)
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n/an/a 2.70E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325409
PNG
((S)-4-(6-morpholinoimidazo[1,2-b]pyridazin-3-yl)-N...)
Show SMILES O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(nn12)N1CCOCC1
Show InChI InChI=1S/C22H26N6O2/c29-22(25-14-18-2-1-9-23-18)17-5-3-16(4-6-17)19-15-24-20-7-8-21(26-28(19)20)27-10-12-30-13-11-27/h3-8,15,18,23H,1-2,9-14H2,(H,25,29)/t18-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325387
PNG
((S)-N-(1-benzylpyrrolidin-3-yl)-4-(6-(3,4-dichloro...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)N[C@H]4CCN(Cc5ccccc5)C4)n3n2)cc1Cl
Show InChI InChI=1S/C31H28Cl2N6O/c32-26-11-6-22(16-27(26)33)17-34-29-12-13-30-35-18-28(39(30)37-29)23-7-9-24(10-8-23)31(40)36-25-14-15-38(20-25)19-21-4-2-1-3-5-21/h1-13,16,18,25H,14-15,17,19-20H2,(H,34,37)(H,36,40)/t25-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325397
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES OCCCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C23H21Cl2N5O2/c24-18-7-2-15(12-19(18)25)13-27-21-8-9-22-28-14-20(30(22)29-21)16-3-5-17(6-4-16)23(32)26-10-1-11-31/h2-9,12,14,31H,1,10-11,13H2,(H,26,32)(H,27,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325410
PNG
((S)-4-(6-(4-hydroxypiperidin-1-yl)imidazo[1,2-b]py...)
Show SMILES OC1CCN(CC1)c1ccc2ncc(-c3ccc(cc3)C(=O)NC[C@@H]3CCCN3)n2n1
Show InChI InChI=1S/C23H28N6O2/c30-19-9-12-28(13-10-19)22-8-7-21-25-15-20(29(21)27-22)16-3-5-17(6-4-16)23(31)26-14-18-2-1-11-24-18/h3-8,15,18-19,24,30H,1-2,9-14H2,(H,26,31)/t18-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325396
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES COCCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C23H21Cl2N5O2/c1-32-11-10-26-23(31)17-5-3-16(4-6-17)20-14-28-22-9-8-21(29-30(20)22)27-13-15-2-7-18(24)19(25)12-15/h2-9,12,14H,10-11,13H2,1H3,(H,26,31)(H,27,29)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325394
PNG
((4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrid...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C25H24Cl2N6O/c1-31-10-12-32(13-11-31)25(34)19-5-3-18(4-6-19)22-16-29-24-9-8-23(30-33(22)24)28-15-17-2-7-20(26)21(27)14-17/h2-9,14,16H,10-13,15H2,1H3,(H,28,30)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325378
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCCN4CCOCC4)n3n2)cc1Cl
Show InChI InChI=1S/C26H26Cl2N6O2/c27-21-6-1-18(15-22(21)28)16-30-24-7-8-25-31-17-23(34(25)32-24)19-2-4-20(5-3-19)26(35)29-9-10-33-11-13-36-14-12-33/h1-8,15,17H,9-14,16H2,(H,29,35)(H,30,32)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325388
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCc4ccccn4)n3n2)cc1Cl
Show InChI InChI=1S/C26H20Cl2N6O/c27-21-9-4-17(13-22(21)28)14-30-24-10-11-25-31-16-23(34(25)33-24)18-5-7-19(8-6-18)26(35)32-15-20-3-1-2-12-29-20/h1-13,16H,14-15H2,(H,30,33)(H,32,35)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325389
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCc4cccnc4)n3n2)cc1Cl
Show InChI InChI=1S/C26H20Cl2N6O/c27-21-8-3-17(12-22(21)28)14-30-24-9-10-25-31-16-23(34(25)33-24)19-4-6-20(7-5-19)26(35)32-15-18-2-1-11-29-13-18/h1-13,16H,14-15H2,(H,30,33)(H,32,35)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325395
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES OCCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C22H19Cl2N5O2/c23-17-6-1-14(11-18(17)24)12-26-20-7-8-21-27-13-19(29(21)28-20)15-2-4-16(5-3-15)22(31)25-9-10-30/h1-8,11,13,30H,9-10,12H2,(H,25,31)(H,26,28)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325390
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCc4ccncc4)n3n2)cc1Cl
Show InChI InChI=1S/C26H20Cl2N6O/c27-21-6-1-18(13-22(21)28)15-30-24-7-8-25-31-16-23(34(25)33-24)19-2-4-20(5-3-19)26(35)32-14-17-9-11-29-12-10-17/h1-13,16H,14-15H2,(H,30,33)(H,32,35)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325399
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES NC(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C20H15Cl2N5O/c21-15-6-1-12(9-16(15)22)10-24-18-7-8-19-25-11-17(27(19)26-18)13-2-4-14(5-3-13)20(23)28/h1-9,11H,10H2,(H2,23,28)(H,24,26)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (human))
BDBM50325382
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCCNc4ccccc4)n3n2)cc1Cl
Show InChI InChI=1S/C28H24Cl2N6O/c29-23-11-6-19(16-24(23)30)17-33-26-12-13-27-34-18-25(36(27)35-26)20-7-9-21(10-8-20)28(37)32-15-14-31-22-4-2-1-3-5-22/h1-13,16,18,31H,14-15,17H2,(H,32,37)(H,33,35)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50325375
PNG
((S)-4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyr...)
Show SMILES O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C22H26N6O/c29-22(26-13-18-2-1-11-23-18)17-7-5-16(6-8-17)19-14-25-21-10-9-20(27-28(19)21)24-12-15-3-4-15/h5-10,14-15,18,23H,1-4,11-13H2,(H,24,27)(H,26,29)/t18-/m0/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant IKKalpha after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50325368
PNG
((S)-4-(6-(3-chlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1cccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)c1
Show InChI InChI=1S/C25H25ClN6O/c26-20-4-1-3-17(13-20)14-28-23-10-11-24-29-16-22(32(24)31-23)18-6-8-19(9-7-18)25(33)30-15-21-5-2-12-27-21/h1,3-4,6-11,13,16,21,27H,2,5,12,14-15H2,(H,28,31)(H,30,33)/t21-/m0/s1
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n/an/a 7.80E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50325373
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCCN4CCCC4)n3n2)cc1Cl
Show InChI InChI=1S/C26H26Cl2N6O/c27-21-8-3-18(15-22(21)28)16-30-24-9-10-25-31-17-23(34(25)32-24)19-4-6-20(7-5-19)26(35)29-11-14-33-12-1-2-13-33/h3-10,15,17H,1-2,11-14,16H2,(H,29,35)(H,30,32)
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n/an/a 9.00E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (human))
BDBM50325374
PNG
((S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)cc1Cl
Show InChI InChI=1S/C25H24Cl2N6O/c26-20-8-3-16(12-21(20)27)13-29-23-9-10-24-30-15-22(33(24)32-23)17-4-6-18(7-5-17)25(34)31-14-19-2-1-11-28-19/h3-10,12,15,19,28H,1-2,11,13-14H2,(H,29,32)(H,31,34)/t19-/m0/s1
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n/an/a 9.50E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant CDK2 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (human))
BDBM50325369
PNG
(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridaz...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C21H26N6O/c1-26(2)12-11-22-21(28)17-7-5-16(6-8-17)18-14-24-20-10-9-19(25-27(18)20)23-13-15-3-4-15/h5-10,14-15H,3-4,11-13H2,1-2H3,(H,22,28)(H,23,25)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant CDK2 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1)


(Homo sapiens (human))
BDBM50325368
PNG
((S)-4-(6-(3-chlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1cccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)c1
Show InChI InChI=1S/C25H25ClN6O/c26-20-4-1-3-17(13-20)14-28-23-10-11-24-29-16-22(32(24)31-23)18-6-8-19(9-7-18)25(33)30-15-21-5-2-12-27-21/h1,3-4,6-11,13,16,21,27H,2,5,12,14-15H2,(H,28,31)(H,30,33)/t21-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDK1 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50325374
PNG
((S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)cc1Cl
Show InChI InChI=1S/C25H24Cl2N6O/c26-20-8-3-16(12-21(20)27)13-29-23-9-10-24-30-15-22(33(24)32-23)17-4-6-18(7-5-17)25(34)31-14-19-2-1-11-28-19/h3-10,12,15,19,28H,1-2,11,13-14H2,(H,29,32)(H,31,34)/t19-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (human))
BDBM50325368
PNG
((S)-4-(6-(3-chlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1cccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)c1
Show InChI InChI=1S/C25H25ClN6O/c26-20-4-1-3-17(13-20)14-28-23-10-11-24-29-16-22(32(24)31-23)18-6-8-19(9-7-18)25(33)30-15-21-5-2-12-27-21/h1,3-4,6-11,13,16,21,27H,2,5,12,14-15H2,(H,28,31)(H,30,33)/t21-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant CDK2 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50325371
PNG
(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridaz...)
Show SMILES CC(CN(C)C)NC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C22H28N6O/c1-15(14-27(2)3)25-22(29)18-8-6-17(7-9-18)19-13-24-21-11-10-20(26-28(19)21)23-12-16-4-5-16/h6-11,13,15-16H,4-5,12,14H2,1-3H3,(H,23,26)(H,25,29)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant IKKalpha after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50325369
PNG
(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridaz...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C21H26N6O/c1-26(2)12-11-22-21(28)17-7-5-16(6-8-17)18-14-24-20-10-9-19(25-27(18)20)23-13-15-3-4-15/h5-10,14-15H,3-4,11-13H2,1-2H3,(H,22,28)(H,23,25)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant IKKalpha after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50325372
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C24H24Cl2N6O/c1-31(2)12-11-27-24(33)18-6-4-17(5-7-18)21-15-29-23-10-9-22(30-32(21)23)28-14-16-3-8-19(25)20(26)13-16/h3-10,13,15H,11-12,14H2,1-2H3,(H,27,33)(H,28,30)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50325369
PNG
(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridaz...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C21H26N6O/c1-26(2)12-11-22-21(28)17-7-5-16(6-8-17)18-14-24-20-10-9-19(25-27(18)20)23-13-15-3-4-15/h5-10,14-15H,3-4,11-13H2,1-2H3,(H,22,28)(H,23,25)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50325375
PNG
((S)-4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyr...)
Show SMILES O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C22H26N6O/c29-22(26-13-18-2-1-11-23-18)17-7-5-16(6-8-17)19-14-25-21-10-9-20(27-28(19)21)24-12-15-3-4-15/h5-10,14-15,18,23H,1-4,11-13H2,(H,24,27)(H,26,29)/t18-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50325369
PNG
(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridaz...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C21H26N6O/c1-26(2)12-11-22-21(28)17-7-5-16(6-8-17)18-14-24-20-10-9-19(25-27(18)20)23-13-15-3-4-15/h5-10,14-15H,3-4,11-13H2,1-2H3,(H,22,28)(H,23,25)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50325369
PNG
(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridaz...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C21H26N6O/c1-26(2)12-11-22-21(28)17-7-5-16(6-8-17)18-14-24-20-10-9-19(25-27(18)20)23-13-15-3-4-15/h5-10,14-15H,3-4,11-13H2,1-2H3,(H,22,28)(H,23,25)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50325370
PNG
(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridaz...)
Show SMILES CCN(CC)CCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C23H30N6O/c1-3-28(4-2)14-13-24-23(30)19-9-7-18(8-10-19)20-16-26-22-12-11-21(27-29(20)22)25-15-17-5-6-17/h7-12,16-17H,3-6,13-15H2,1-2H3,(H,24,30)(H,25,27)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant IKKalpha after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1)


(Homo sapiens (human))
BDBM50325374
PNG
((S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)cc1Cl
Show InChI InChI=1S/C25H24Cl2N6O/c26-20-8-3-16(12-21(20)27)13-29-23-9-10-24-30-15-22(33(24)32-23)17-4-6-18(7-5-17)25(34)31-14-19-2-1-11-28-19/h3-10,12,15,19,28H,1-2,11,13-14H2,(H,29,32)(H,31,34)/t19-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDK1 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1)


(Homo sapiens (human))
BDBM50325375
PNG
((S)-4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyr...)
Show SMILES O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C22H26N6O/c29-22(26-13-18-2-1-11-23-18)17-7-5-16(6-8-17)19-14-25-21-10-9-20(27-28(19)21)24-12-15-3-4-15/h5-10,14-15,18,23H,1-4,11-13H2,(H,24,27)(H,26,29)/t18-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDK1 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50325374
PNG
((S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)cc1Cl
Show InChI InChI=1S/C25H24Cl2N6O/c26-20-8-3-16(12-21(20)27)13-29-23-9-10-24-30-15-22(33(24)32-23)17-4-6-18(7-5-17)25(34)31-14-19-2-1-11-28-19/h3-10,12,15,19,28H,1-2,11,13-14H2,(H,29,32)(H,31,34)/t19-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50325374
PNG
((S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]py...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)cc1Cl
Show InChI InChI=1S/C25H24Cl2N6O/c26-20-8-3-16(12-21(20)27)13-29-23-9-10-24-30-15-22(33(24)32-23)17-4-6-18(7-5-17)25(34)31-14-19-2-1-11-28-19/h3-10,12,15,19,28H,1-2,11,13-14H2,(H,29,32)(H,31,34)/t19-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50325368
PNG
((S)-4-(6-(3-chlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1cccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)c1
Show InChI InChI=1S/C25H25ClN6O/c26-20-4-1-3-17(13-20)14-28-23-10-11-24-29-16-22(32(24)31-23)18-6-8-19(9-7-18)25(33)30-15-21-5-2-12-27-21/h1,3-4,6-11,13,16,21,27H,2,5,12,14-15H2,(H,28,31)(H,30,33)/t21-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50325375
PNG
((S)-4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyr...)
Show SMILES O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C22H26N6O/c29-22(26-13-18-2-1-11-23-18)17-7-5-16(6-8-17)19-14-25-21-10-9-20(27-28(19)21)24-12-15-3-4-15/h5-10,14-15,18,23H,1-4,11-13H2,(H,24,27)(H,26,29)/t18-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50325373
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCCN4CCCC4)n3n2)cc1Cl
Show InChI InChI=1S/C26H26Cl2N6O/c27-21-8-3-18(15-22(21)28)16-30-24-9-10-25-31-17-23(34(25)32-24)19-4-6-20(7-5-19)26(35)29-11-14-33-12-1-2-13-33/h3-10,15,17H,1-2,11-14,16H2,(H,29,35)(H,30,32)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1)


(Homo sapiens (human))
BDBM50325369
PNG
(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridaz...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C21H26N6O/c1-26(2)12-11-22-21(28)17-7-5-16(6-8-17)18-14-24-20-10-9-19(25-27(18)20)23-13-15-3-4-15/h5-10,14-15H,3-4,11-13H2,1-2H3,(H,22,28)(H,23,25)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDK1 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (human))
BDBM50325372
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCc3ccc(Cl)c(Cl)c3)nn12
Show InChI InChI=1S/C24H24Cl2N6O/c1-31(2)12-11-27-24(33)18-6-4-17(5-7-18)21-15-29-23-10-9-22(30-32(21)23)28-14-16-3-8-19(25)20(26)13-16/h3-10,13,15H,11-12,14H2,1-2H3,(H,27,33)(H,28,30)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant CDK2 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1)


(Homo sapiens (human))
BDBM50325373
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCCN4CCCC4)n3n2)cc1Cl
Show InChI InChI=1S/C26H26Cl2N6O/c27-21-8-3-18(15-22(21)28)16-30-24-9-10-25-31-17-23(34(25)32-24)19-4-6-20(7-5-19)26(35)29-11-14-33-12-1-2-13-33/h3-10,15,17H,1-2,11-14,16H2,(H,29,35)(H,30,32)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDK1 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50325368
PNG
((S)-4-(6-(3-chlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1cccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)c1
Show InChI InChI=1S/C25H25ClN6O/c26-20-4-1-3-17(13-20)14-28-23-10-11-24-29-16-22(32(24)31-23)18-6-8-19(9-7-18)25(33)30-15-21-5-2-12-27-21/h1,3-4,6-11,13,16,21,27H,2,5,12,14-15H2,(H,28,31)(H,30,33)/t21-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50325375
PNG
((S)-4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyr...)
Show SMILES O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C22H26N6O/c29-22(26-13-18-2-1-11-23-18)17-7-5-16(6-8-17)19-14-25-21-10-9-20(27-28(19)21)24-12-15-3-4-15/h5-10,14-15,18,23H,1-4,11-13H2,(H,24,27)(H,26,29)/t18-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50325373
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCCN4CCCC4)n3n2)cc1Cl
Show InChI InChI=1S/C26H26Cl2N6O/c27-21-8-3-18(15-22(21)28)16-30-24-9-10-25-31-17-23(34(25)32-24)19-4-6-20(7-5-19)26(35)29-11-14-33-12-1-2-13-33/h3-10,15,17H,1-2,11-14,16H2,(H,29,35)(H,30,32)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (human))
BDBM50325373
PNG
(4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyrida...)
Show SMILES Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCCN4CCCC4)n3n2)cc1Cl
Show InChI InChI=1S/C26H26Cl2N6O/c27-21-8-3-18(15-22(21)28)16-30-24-9-10-25-31-17-23(34(25)32-24)19-4-6-20(7-5-19)26(35)29-11-14-33-12-1-2-13-33/h3-10,15,17H,1-2,11-14,16H2,(H,29,35)(H,30,32)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant CDK2 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (human))
BDBM50325375
PNG
((S)-4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyr...)
Show SMILES O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C22H26N6O/c29-22(26-13-18-2-1-11-23-18)17-7-5-16(6-8-17)19-14-25-21-10-9-20(27-28(19)21)24-12-15-3-4-15/h5-10,14-15,18,23H,1-4,11-13H2,(H,24,27)(H,26,29)/t18-/m0/s1
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant CDK2 after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%