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PubMed code 20722422

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50326432
PNG
(CHEMBL1242995 | N-ethyl-4-methyl-5-(2-(4-(piperazi...)
Show SMILES CCNc1nc(C)c(s1)-c1ccnc(Nc2ccc(cc2)N2CCNCC2)n1
Show InChI InChI=1S/C20H25N7S/c1-3-22-20-24-14(2)18(28-20)17-8-9-23-19(26-17)25-15-4-6-16(7-5-15)27-12-10-21-11-13-27/h4-9,21H,3,10-13H2,1-2H3,(H,22,24)(H,23,25,26)
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PubMed
n/an/a 16n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of FLT3


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326421
PNG
(2,6-Dibromo-4-(6,7-dimethoxy-quinazolin-4-ylamino)...)
Show SMILES COc1cc2ncnc(Nc3cc(Br)c(O)c(Br)c3)c2cc1OC
Show InChI InChI=1S/C16H13Br2N3O3/c1-23-13-5-9-12(6-14(13)24-2)19-7-20-16(9)21-8-3-10(17)15(22)11(18)4-8/h3-7,22H,1-2H3,(H,19,20,21)
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n/an/a 120n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326413
PNG
(4-(9H-purin-6-ylamino)benzamide | CHEMBL1241463)
Show SMILES NC(=O)c1ccc(Nc2ncnc3nc[nH]c23)cc1
Show InChI InChI=1S/C12H10N6O/c13-10(19)7-1-3-8(4-2-7)18-12-9-11(15-5-14-9)16-6-17-12/h1-6H,(H2,13,19)(H2,14,15,16,17,18)
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n/an/a 160n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM27344
PNG
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)
Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccncc1
Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16)
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n/an/a 171n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK2


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM3532
PNG
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
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n/an/a 530n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50326412
PNG
(4-(3-(piperidin-4-yl)-1H-pyrazol-5-yl)pyridine | C...)
Show SMILES C1CC(CCN1)c1cc(n[nH]1)-c1ccncc1
Show InChI InChI=1S/C13H16N4/c1-5-14-6-2-10(1)12-9-13(17-16-12)11-3-7-15-8-4-11/h1-2,5-6,9,11,15H,3-4,7-8H2,(H,16,17)
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n/an/a 575n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK2


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326429
PNG
(CHEMBL1240786 | N-(4-chlorophenyl)-1H-pyrazolo[3,4...)
Show SMILES Clc1ccc(Nc2ncnc3n[nH]cc23)cc1
Show InChI InChI=1S/C11H8ClN5/c12-7-1-3-8(4-2-7)16-10-9-5-15-17-11(9)14-6-13-10/h1-6H,(H2,13,14,15,16,17)
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n/an/a 580n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM3032
PNG
(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Show SMILES COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC
Show InChI InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
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n/an/a 630n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326412
PNG
(4-(3-(piperidin-4-yl)-1H-pyrazol-5-yl)pyridine | C...)
Show SMILES C1CC(CCN1)c1cc(n[nH]1)-c1ccncc1
Show InChI InChI=1S/C13H16N4/c1-5-14-6-2-10(1)12-9-13(17-16-12)11-3-7-15-8-4-11/h1-2,5-6,9,11,15H,3-4,7-8H2,(H,16,17)
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n/an/a 646n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326428
PNG
(4-(9H-Purin-6-ylamino)-benzoic acid methyl ester |...)
Show SMILES COC(=O)c1ccc(Nc2ncnc3nc[nH]c23)cc1
Show InChI InChI=1S/C13H11N5O2/c1-20-13(19)8-2-4-9(5-3-8)18-12-10-11(15-6-14-10)16-7-17-12/h2-7H,1H3,(H2,14,15,16,17,18)
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n/an/a 850n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50298223
PNG
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)
Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
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n/an/a 870n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326427
PNG
((4-Fluoro-phenyl)-(9H-purin-6-yl)-amine | CHEMBL36...)
Show SMILES Fc1ccc(Nc2ncnc3nc[nH]c23)cc1
Show InChI InChI=1S/C11H8FN5/c12-7-1-3-8(4-2-7)17-11-9-10(14-5-13-9)15-6-16-11/h1-6H,(H2,13,14,15,16,17)
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n/an/a 1.03E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50321929
PNG
(3-((1-Cyclohexyl-3-hydroxypropan-2-ylamino)methyl)...)
Show SMILES OCC(CC1CCCCC1)NCc1coc2cccc(OCC3CCCCC3)c2c1=O
Show InChI InChI=1S/C26H37NO4/c28-16-22(14-19-8-3-1-4-9-19)27-15-21-18-31-24-13-7-12-23(25(24)26(21)29)30-17-20-10-5-2-6-11-20/h7,12-13,18-20,22,27-28H,1-6,8-11,14-17H2
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n/an/a 1.09E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326430
PNG
(CHEMBL1240884 | N-(naphthalen-2-yl)-1H-pyrazolo[3,...)
Show SMILES N(c1ccc2ccccc2c1)c1ncnc2n[nH]cc12
Show InChI InChI=1S/C15H11N5/c1-2-4-11-7-12(6-5-10(11)3-1)19-14-13-8-18-20-15(13)17-9-16-14/h1-9H,(H2,16,17,18,19,20)
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n/an/a 1.35E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326422
PNG
(3-(6-(methylamino)imidazo[1,2-b]pyridazin-3-yl)phe...)
Show SMILES CNc1ccc2ncc(-c3cccc(O)c3)n2n1
Show InChI InChI=1S/C13H12N4O/c1-14-12-5-6-13-15-8-11(17(13)16-12)9-3-2-4-10(18)7-9/h2-8,18H,1H3,(H,14,16)
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n/an/a 1.53E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM53334
PNG
(2-methoxy-N-[2-[1-(1-methylsulfanylpropan-2-yl)pip...)
Show SMILES COc1ccccc1C(=O)Nc1ccnn1C1CCN(CC1)C(C)CSC
Show InChI InChI=1S/C20H28N4O2S/c1-15(14-27-3)23-12-9-16(10-13-23)24-19(8-11-21-24)22-20(25)17-6-4-5-7-18(17)26-2/h4-8,11,15-16H,9-10,12-14H2,1-3H3,(H,22,25)
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n/an/a 1.56E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50298223
PNG
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)
Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK2


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326416
PNG
(3-(4-chlorophenyl)-N-(2-methoxyethyl)imidazo[1,2-b...)
Show SMILES COCCNc1ccc2ncc(-c3ccc(Cl)cc3)n2n1
Show InChI InChI=1S/C15H15ClN4O/c1-21-9-8-17-14-6-7-15-18-10-13(20(15)19-14)11-2-4-12(16)5-3-11/h2-7,10H,8-9H2,1H3,(H,17,19)
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n/an/a 1.62E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM3603
PNG
(4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimid...)
Show SMILES CNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C14H12BrN5/c1-16-13-6-11-12(7-17-13)18-8-19-14(11)20-10-4-2-3-9(15)5-10/h2-8H,1H3,(H,16,17)(H,18,19,20)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326425
PNG
(CHEMBL1240674 | N-(cyclopropylmethyl)-5-(pyridin-4...)
Show SMILES C(Nc1nn2c(cnc2s1)-c1ccncc1)C1CC1
Show InChI InChI=1S/C13H13N5S/c1-2-9(1)7-15-12-17-18-11(8-16-13(18)19-12)10-3-5-14-6-4-10/h3-6,8-9H,1-2,7H2,(H,15,17)
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n/an/a 1.71E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326418
PNG
(3-(3-(4-fluorophenyl)imidazo[1,2-b]pyridazin-6-yla...)
Show SMILES OCCCNc1ccc2ncc(-c3ccc(F)cc3)n2n1
Show InChI InChI=1S/C15H15FN4O/c16-12-4-2-11(3-5-12)13-10-18-15-7-6-14(19-20(13)15)17-8-1-9-21/h2-7,10,21H,1,8-9H2,(H,17,19)
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n/an/a 2.41E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM27344
PNG
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)
Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccncc1
Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16)
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n/an/a 2.67E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM50298223
PNG
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)
Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of SGK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM3570
PNG
(8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]quinazol...)
Show SMILES Brc1cccc(Nc2ncnc3cc4nc[nH]c4cc23)c1
Show InChI InChI=1S/C15H10BrN5/c16-9-2-1-3-10(4-9)21-15-11-5-13-14(19-7-18-13)6-12(11)17-8-20-15/h1-8H,(H,18,19)(H,17,20,21)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326415
PNG
(2-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yla...)
Show SMILES OCCNc1ccc2ncc(-c3ccc(Cl)cc3)n2n1
Show InChI InChI=1S/C14H13ClN4O/c15-11-3-1-10(2-4-11)12-9-17-14-6-5-13(16-7-8-20)18-19(12)14/h1-6,9,20H,7-8H2,(H,16,18)
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n/an/a 2.93E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326419
PNG
(3-(3-(2-fluorophenyl)imidazo[1,2-b]pyridazin-6-yla...)
Show SMILES OCCCNc1ccc2ncc(-c3ccccc3F)n2n1
Show InChI InChI=1S/C15H15FN4O/c16-12-5-2-1-4-11(12)13-10-18-15-7-6-14(19-20(13)15)17-8-3-9-21/h1-2,4-7,10,21H,3,8-9H2,(H,17,19)
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n/an/a 3.24E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326424
PNG
(3-(pyridin-4-yl)imidazo[1,2-b]pyridazine | CHEMBL1...)
Show SMILES c1nc2cccnn2c1-c1ccncc1
Show InChI InChI=1S/C11H8N4/c1-2-11-13-8-10(15(11)14-5-1)9-3-6-12-7-4-9/h1-8H
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n/an/a 3.80E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326423
PNG
(3-(4-fluorophenyl)-N-methylimidazo[1,2-b]pyridazin...)
Show SMILES CNc1ccc2ncc(-c3ccc(F)cc3)n2n1
Show InChI InChI=1S/C13H11FN4/c1-15-12-6-7-13-16-8-11(18(13)17-12)9-2-4-10(14)5-3-9/h2-8H,1H3,(H,15,17)
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n/an/a 4.05E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326417
PNG
(3-(4-fluorophenyl)-N-(2-methoxyethyl)imidazo[1,2-b...)
Show SMILES COCCNc1ccc2ncc(-c3ccc(F)cc3)n2n1
Show InChI InChI=1S/C15H15FN4O/c1-21-9-8-17-14-6-7-15-18-10-13(20(15)19-14)11-2-4-12(16)5-3-11/h2-7,10H,8-9H2,1H3,(H,17,19)
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n/an/a 4.09E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326420
PNG
(3-phenyl-N-(2-(pyridin-2-yl)ethyl)imidazo[1,2-b]py...)
Show SMILES C(Cc1ccccn1)Nc1ccc2ncc(-c3ccccc3)n2n1
Show InChI InChI=1S/C19H17N5/c1-2-6-15(7-3-1)17-14-22-19-10-9-18(23-24(17)19)21-13-11-16-8-4-5-12-20-16/h1-10,12,14H,11,13H2,(H,21,23)
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n/an/a 4.28E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50309189
PNG
(4-(2-amino-5-phenylpyridin-3-yl)benzamide | CHEMBL...)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(cnc1N)-c1ccccc1
Show InChI InChI=1S/C18H15N3O/c19-17-16(13-6-8-14(9-7-13)18(20)22)10-15(11-21-17)12-4-2-1-3-5-12/h1-11H,(H2,19,21)(H2,20,22)
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n/an/a 5.15E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326426
PNG
(CHEMBL1240675 | N-isobutyl-5-(pyridin-4-yl)imidazo...)
Show SMILES CC(C)CNc1nn2c(cnc2s1)-c1ccncc1
Show InChI InChI=1S/C13H15N5S/c1-9(2)7-15-12-17-18-11(8-16-13(18)19-12)10-3-5-14-6-4-10/h3-6,8-9H,7H2,1-2H3,(H,15,17)
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n/an/a 6.18E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50326414
PNG
(1H-pyrazolo[4,3-g]quinazolin-5(6H)-one | CHEMBL124...)
Show SMILES O=c1[nH]cnc2cc3n[nH]cc3cc12
Show InChI InChI=1S/C9H6N4O/c14-9-6-1-5-3-12-13-7(5)2-8(6)10-4-11-9/h1-4H,(H,12,13)(H,10,11,14)
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n/an/a 8.17E+3n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of MNK1


J Med Chem 53: 6618-28 (2010)


Article DOI: 10.1021/jm1005513
BindingDB Entry DOI: 10.7270/Q2Z038CP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%