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PubMed code 20724156

Compile data set for download or QSAR
Found 71 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325971
PNG
(CHEMBL1224229 | N-(3-(1-(4-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCCc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H33FN4O/c1-22(36)32-26-8-6-7-24(21-26)23-16-19-34(20-17-23)18-5-4-11-30-33-28-9-2-3-10-29(28)35(30)27-14-12-25(31)13-15-27/h2-3,6-10,12-15,21,23H,4-5,11,16-20H2,1H3,(H,32,36)
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n/an/a 0.600n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325950
PNG
(CHEMBL1223770 | N-(3-(1-(3-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C29H32FN5O/c1-21(36)32-25-7-4-6-23(20-25)22-14-18-34(19-15-22)17-5-16-31-29-33-27-8-2-3-9-28(27)35(29)26-12-10-24(30)11-13-26/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,31,33)(H,32,36)
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n/an/a 2n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325971
PNG
(CHEMBL1224229 | N-(3-(1-(4-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCCc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H33FN4O/c1-22(36)32-26-8-6-7-24(21-26)23-16-19-34(20-17-23)18-5-4-11-30-33-28-9-2-3-10-29(28)35(30)27-14-12-25(31)13-15-27/h2-3,6-10,12-15,21,23H,4-5,11,16-20H2,1H3,(H,32,36)
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n/an/a 3n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325976
PNG
(CHEMBL1224306 | N-(3-(1-(4,4-difluoro-4-(1-(4-fluo...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCC(F)(F)c2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H31F3N4O/c1-21(38)34-25-7-4-6-23(20-25)22-14-18-36(19-15-22)17-5-16-30(32,33)29-35-27-8-2-3-9-28(27)37(29)26-12-10-24(31)11-13-26/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,34,38)
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n/an/a 4n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325952
PNG
(CHEMBL1223829 | N-(3-(1-(3-(1-(4-chlorobenzyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C30H34ClN5O/c1-22(37)33-27-7-4-6-25(20-27)24-14-18-35(19-15-24)17-5-16-32-30-34-28-8-2-3-9-29(28)36(30)21-23-10-12-26(31)13-11-23/h2-4,6-13,20,24H,5,14-19,21H2,1H3,(H,32,34)(H,33,37)
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n/an/a 8n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325979
PNG
(6-(1-(4-(1-(4-fluorophenyl)-1H-benzo[d]imidazol-2-...)
Show SMILES Fc1ccc(cc1)-n1c(CCCCN2CCC(CC2)c2ccc3CC(=O)Nc3c2)nc2ccccc12
Show InChI InChI=1S/C30H31FN4O/c31-24-10-12-25(13-11-24)35-28-6-2-1-5-26(28)32-29(35)7-3-4-16-34-17-14-21(15-18-34)22-8-9-23-20-30(36)33-27(23)19-22/h1-2,5-6,8-13,19,21H,3-4,7,14-18,20H2,(H,33,36)
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n/an/a 9n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325979
PNG
(6-(1-(4-(1-(4-fluorophenyl)-1H-benzo[d]imidazol-2-...)
Show SMILES Fc1ccc(cc1)-n1c(CCCCN2CCC(CC2)c2ccc3CC(=O)Nc3c2)nc2ccccc12
Show InChI InChI=1S/C30H31FN4O/c31-24-10-12-25(13-11-24)35-28-6-2-1-5-26(28)32-29(35)7-3-4-16-34-17-14-21(15-18-34)22-8-9-23-20-30(36)33-27(23)19-22/h1-2,5-6,8-13,19,21H,3-4,7,14-18,20H2,(H,33,36)
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n/an/a 9n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325967
PNG
(CHEMBL1224152 | N-(3-(1-(3-(1-(4-fluorophenyl)-1H-...)
Show SMILES Fc1ccc(cc1)-n1c(NCCCN2CCC(CC2)c2cccc(NC(=O)C3CC3)c2)nc2ccccc12
Show InChI InChI=1S/C31H34FN5O/c32-25-11-13-27(14-12-25)37-29-8-2-1-7-28(29)35-31(37)33-17-4-18-36-19-15-22(16-20-36)24-5-3-6-26(21-24)34-30(38)23-9-10-23/h1-3,5-8,11-14,21-23H,4,9-10,15-20H2,(H,33,35)(H,34,38)
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n/an/a 10n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325944
PNG
(CHEMBL1223708 | N-(3-(1-(3-(1-(4-chlorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C29H32ClN5O/c1-21(36)32-25-7-4-6-23(20-25)22-14-18-34(19-15-22)17-5-16-31-29-33-27-8-2-3-9-28(27)35(29)26-12-10-24(30)11-13-26/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,31,33)(H,32,36)
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n/an/a 11n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325975
PNG
(CHEMBL1224305 | N-(3-(1-(4-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCC(=O)c2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H31FN4O2/c1-21(36)32-25-7-4-6-23(20-25)22-15-18-34(19-16-22)17-5-10-29(37)30-33-27-8-2-3-9-28(27)35(30)26-13-11-24(31)12-14-26/h2-4,6-9,11-14,20,22H,5,10,15-19H2,1H3,(H,32,36)
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n/an/a 13n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325968
PNG
(CHEMBL1224153 | N-(3-(1-(3-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(C)C(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C31H36FN5O/c1-22(2)30(38)34-26-8-5-7-24(21-26)23-15-19-36(20-16-23)18-6-17-33-31-35-28-9-3-4-10-29(28)37(31)27-13-11-25(32)12-14-27/h3-5,7-14,21-23H,6,15-20H2,1-2H3,(H,33,35)(H,34,38)
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n/an/a 15n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325950
PNG
(CHEMBL1223770 | N-(3-(1-(3-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C29H32FN5O/c1-21(36)32-25-7-4-6-23(20-25)22-14-18-34(19-15-22)17-5-16-31-29-33-27-8-2-3-9-28(27)35(29)26-12-10-24(30)11-13-26/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,31,33)(H,32,36)
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n/an/a 18n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325946
PNG
(CHEMBL1223710 | N-(3-(1-(3-(1-phenyl-1H-benzo[d]im...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccccc2)CC1
Show InChI InChI=1S/C29H33N5O/c1-22(35)31-25-10-7-9-24(21-25)23-15-19-33(20-16-23)18-8-17-30-29-32-27-13-5-6-14-28(27)34(29)26-11-3-2-4-12-26/h2-7,9-14,21,23H,8,15-20H2,1H3,(H,30,32)(H,31,35)
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n/an/a 21n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325953
PNG
(CHEMBL1223830 | N-(3-(1-(3-(1-(4-fluorobenzyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H34FN5O/c1-22(37)33-27-7-4-6-25(20-27)24-14-18-35(19-15-24)17-5-16-32-30-34-28-8-2-3-9-29(28)36(30)21-23-10-12-26(31)13-11-23/h2-4,6-13,20,24H,5,14-19,21H2,1H3,(H,32,34)(H,33,37)
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n/an/a 22n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325948
PNG
(CHEMBL1223768 | N-(3-(1-(3-(1-(4-cyanophenyl)-1H-b...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C30H32N6O/c1-22(37)33-26-7-4-6-25(20-26)24-14-18-35(19-15-24)17-5-16-32-30-34-28-8-2-3-9-29(28)36(30)27-12-10-23(21-31)11-13-27/h2-4,6-13,20,24H,5,14-19H2,1H3,(H,32,34)(H,33,37)
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n/an/a 24n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325961
PNG
(CHEMBL1223968 | N-(3-(1-(3-(1-(3-chlorobenzyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2cccc(Cl)c2)CC1
Show InChI InChI=1S/C30H34ClN5O/c1-22(37)33-27-10-5-8-25(20-27)24-13-17-35(18-14-24)16-6-15-32-30-34-28-11-2-3-12-29(28)36(30)21-23-7-4-9-26(31)19-23/h2-5,7-12,19-20,24H,6,13-18,21H2,1H3,(H,32,34)(H,33,37)
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n/an/a 29n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325949
PNG
(CHEMBL1223769 | N-(3-(1-(3-(1-p-tolyl-1H-benzo[d]i...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(C)cc2)CC1
Show InChI InChI=1S/C30H35N5O/c1-22-11-13-27(14-12-22)35-29-10-4-3-9-28(29)33-30(35)31-17-6-18-34-19-15-24(16-20-34)25-7-5-8-26(21-25)32-23(2)36/h3-5,7-14,21,24H,6,15-20H2,1-2H3,(H,31,33)(H,32,36)
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n/an/a 35n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325955
PNG
(CHEMBL1223885 | N-(3-(1-(3-(1-(4-(trifluoromethoxy...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2ccc(OC(F)(F)F)cc2)CC1
Show InChI InChI=1S/C31H34F3N5O2/c1-22(40)36-26-7-4-6-25(20-26)24-14-18-38(19-15-24)17-5-16-35-30-37-28-8-2-3-9-29(28)39(30)21-23-10-12-27(13-11-23)41-31(32,33)34/h2-4,6-13,20,24H,5,14-19,21H2,1H3,(H,35,37)(H,36,40)
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n/an/a 35n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325976
PNG
(CHEMBL1224306 | N-(3-(1-(4,4-difluoro-4-(1-(4-fluo...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCC(F)(F)c2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H31F3N4O/c1-21(38)34-25-7-4-6-23(20-25)22-14-18-36(19-15-22)17-5-16-30(32,33)29-35-27-8-2-3-9-28(27)37(29)26-12-10-24(31)11-13-26/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,34,38)
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n/an/a 37n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325959
PNG
(CHEMBL1223966 | N-(3-(1-(3-(1-(4-cyanobenzyl)-1H-b...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C31H34N6O/c1-23(38)34-28-7-4-6-27(20-28)26-14-18-36(19-15-26)17-5-16-33-31-35-29-8-2-3-9-30(29)37(31)22-25-12-10-24(21-32)11-13-25/h2-4,6-13,20,26H,5,14-19,22H2,1H3,(H,33,35)(H,34,38)
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n/an/a 38n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325945
PNG
(CHEMBL1223709 | N-(3-(1-(3-(1-(3-chlorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2cccc(Cl)c2)CC1
Show InChI InChI=1S/C29H32ClN5O/c1-21(36)32-25-9-4-7-23(19-25)22-13-17-34(18-14-22)16-6-15-31-29-33-27-11-2-3-12-28(27)35(29)26-10-5-8-24(30)20-26/h2-5,7-12,19-20,22H,6,13-18H2,1H3,(H,31,33)(H,32,36)
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n/an/a 45n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325953
PNG
(CHEMBL1223830 | N-(3-(1-(3-(1-(4-fluorobenzyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H34FN5O/c1-22(37)33-27-7-4-6-25(20-27)24-14-18-35(19-15-24)17-5-16-32-30-34-28-8-2-3-9-29(28)36(30)21-23-10-12-26(31)13-11-23/h2-4,6-13,20,24H,5,14-19,21H2,1H3,(H,32,34)(H,33,37)
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n/an/a 45n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325944
PNG
(CHEMBL1223708 | N-(3-(1-(3-(1-(4-chlorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C29H32ClN5O/c1-21(36)32-25-7-4-6-23(20-25)22-14-18-34(19-15-22)17-5-16-31-29-33-27-8-2-3-9-28(27)35(29)26-12-10-24(30)11-13-26/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,31,33)(H,32,36)
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n/an/a 49n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325956
PNG
(CHEMBL1223886 | N-(3-(1-(3-(1-(3-methoxybenzyl)-1H...)
Show SMILES COc1cccc(Cn2c(NCCCN3CCC(CC3)c3cccc(NC(C)=O)c3)nc3ccccc23)c1
Show InChI InChI=1S/C31H37N5O2/c1-23(37)33-27-10-6-9-26(21-27)25-14-18-35(19-15-25)17-7-16-32-31-34-29-12-3-4-13-30(29)36(31)22-24-8-5-11-28(20-24)38-2/h3-6,8-13,20-21,25H,7,14-19,22H2,1-2H3,(H,32,34)(H,33,37)
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n/an/a 54n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325952
PNG
(CHEMBL1223829 | N-(3-(1-(3-(1-(4-chlorobenzyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C30H34ClN5O/c1-22(37)33-27-7-4-6-25(20-27)24-14-18-35(19-15-24)17-5-16-32-30-34-28-8-2-3-9-29(28)36(30)21-23-10-12-26(31)13-11-23/h2-4,6-13,20,24H,5,14-19,21H2,1H3,(H,32,34)(H,33,37)
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n/an/a 65n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325947
PNG
(CHEMBL1223767 | N-(3-(1-(3-(1-(4-methoxyphenyl)-1H...)
Show SMILES COc1ccc(cc1)-n1c(NCCCN2CCC(CC2)c2cccc(NC(C)=O)c2)nc2ccccc12
Show InChI InChI=1S/C30H35N5O2/c1-22(36)32-25-8-5-7-24(21-25)23-15-19-34(20-16-23)18-6-17-31-30-33-28-9-3-4-10-29(28)35(30)26-11-13-27(37-2)14-12-26/h3-5,7-14,21,23H,6,15-20H2,1-2H3,(H,31,33)(H,32,36)
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n/an/a 68n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325948
PNG
(CHEMBL1223768 | N-(3-(1-(3-(1-(4-cyanophenyl)-1H-b...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C30H32N6O/c1-22(37)33-26-7-4-6-25(20-26)24-14-18-35(19-15-24)17-5-16-32-30-34-28-8-2-3-9-29(28)36(30)27-12-10-23(21-31)11-13-27/h2-4,6-13,20,24H,5,14-19H2,1H3,(H,32,34)(H,33,37)
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n/an/a 71n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325955
PNG
(CHEMBL1223885 | N-(3-(1-(3-(1-(4-(trifluoromethoxy...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2ccc(OC(F)(F)F)cc2)CC1
Show InChI InChI=1S/C31H34F3N5O2/c1-22(40)36-26-7-4-6-25(20-26)24-14-18-38(19-15-24)17-5-16-35-30-37-28-8-2-3-9-29(28)39(30)21-23-10-12-27(13-11-23)41-31(32,33)34/h2-4,6-13,20,24H,5,14-19,21H2,1H3,(H,35,37)(H,36,40)
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n/an/a 85n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325949
PNG
(CHEMBL1223769 | N-(3-(1-(3-(1-p-tolyl-1H-benzo[d]i...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(C)cc2)CC1
Show InChI InChI=1S/C30H35N5O/c1-22-11-13-27(14-12-22)35-29-10-4-3-9-28(29)33-30(35)31-17-6-18-34-19-15-24(16-20-34)25-7-5-8-26(21-25)32-23(2)36/h3-5,7-14,21,24H,6,15-20H2,1-2H3,(H,31,33)(H,32,36)
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n/an/a 85n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325966
PNG
(CHEMBL1224082 | N-(3-(4-(3-(ethylamino)phenyl)pipe...)
Show SMILES CCNc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C29H34FN5/c1-2-31-25-8-5-7-23(21-25)22-15-19-34(20-16-22)18-6-17-32-29-33-27-9-3-4-10-28(27)35(29)26-13-11-24(30)12-14-26/h3-5,7-14,21-22,31H,2,6,15-20H2,1H3,(H,32,33)
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n/an/a 87n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325972
PNG
(CHEMBL1224230 | N-(3-(1-(3-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C29H31FN4O/c1-21(35)31-25-7-4-6-23(20-25)22-15-18-33(19-16-22)17-5-10-29-32-27-8-2-3-9-28(27)34(29)26-13-11-24(30)12-14-26/h2-4,6-9,11-14,20,22H,5,10,15-19H2,1H3,(H,31,35)
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n/an/a 88n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325957
PNG
(CHEMBL1223887 | N-(3-(1-(3-(1-(3-(trifluoromethoxy...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C31H34F3N5O2/c1-22(40)36-26-9-5-8-25(20-26)24-13-17-38(18-14-24)16-6-15-35-30-37-28-11-2-3-12-29(28)39(30)21-23-7-4-10-27(19-23)41-31(32,33)34/h2-5,7-12,19-20,24H,6,13-18,21H2,1H3,(H,35,37)(H,36,40)
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n/an/a 88n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325958
PNG
(CHEMBL1223888 | N-(3-(1-(3-(1-(3-(trifluoromethyl)...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2cccc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C31H34F3N5O/c1-22(40)36-27-10-5-8-25(20-27)24-13-17-38(18-14-24)16-6-15-35-30-37-28-11-2-3-12-29(28)39(30)21-23-7-4-9-26(19-23)31(32,33)34/h2-5,7-12,19-20,24H,6,13-18,21H2,1H3,(H,35,37)(H,36,40)
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n/an/a 93n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325967
PNG
(CHEMBL1224152 | N-(3-(1-(3-(1-(4-fluorophenyl)-1H-...)
Show SMILES Fc1ccc(cc1)-n1c(NCCCN2CCC(CC2)c2cccc(NC(=O)C3CC3)c2)nc2ccccc12
Show InChI InChI=1S/C31H34FN5O/c32-25-11-13-27(14-12-25)37-29-8-2-1-7-28(29)35-31(37)33-17-4-18-36-19-15-22(16-20-36)24-5-3-6-26(21-24)34-30(38)23-9-10-23/h1-3,5-8,11-14,21-23H,4,9-10,15-20H2,(H,33,35)(H,34,38)
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n/an/a 96n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325980
PNG
(1-(4-fluorophenyl)-2-(4-(4-(2-methyl-1H-benzo[d]im...)
Show SMILES Cc1nc2ccc(cc2[nH]1)C1CCN(CCCCc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H32FN5/c1-21-32-26-14-9-23(20-28(26)33-21)22-15-18-35(19-16-22)17-5-4-8-30-34-27-6-2-3-7-29(27)36(30)25-12-10-24(31)11-13-25/h2-3,6-7,9-14,20,22H,4-5,8,15-19H2,1H3,(H,32,33)
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n/an/a 106n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325980
PNG
(1-(4-fluorophenyl)-2-(4-(4-(2-methyl-1H-benzo[d]im...)
Show SMILES Cc1nc2ccc(cc2[nH]1)C1CCN(CCCCc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H32FN5/c1-21-32-26-14-9-23(20-28(26)33-21)22-15-18-35(19-16-22)17-5-4-8-30-34-27-6-2-3-7-29(27)36(30)25-12-10-24(31)11-13-25/h2-3,6-7,9-14,20,22H,4-5,8,15-19H2,1H3,(H,32,33)
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n/an/a 106n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325957
PNG
(CHEMBL1223887 | N-(3-(1-(3-(1-(3-(trifluoromethoxy...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C31H34F3N5O2/c1-22(40)36-26-9-5-8-25(20-26)24-13-17-38(18-14-24)16-6-15-35-30-37-28-11-2-3-12-29(28)39(30)21-23-7-4-10-27(19-23)41-31(32,33)34/h2-5,7-12,19-20,24H,6,13-18,21H2,1H3,(H,35,37)(H,36,40)
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n/an/a 110n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325963
PNG
(3-(1-(3-(1-(4-chlorophenyl)-1H-benzo[d]imidazol-2-...)
Show SMILES Oc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C27H29ClN4O/c28-22-9-11-23(12-10-22)32-26-8-2-1-7-25(26)30-27(32)29-15-4-16-31-17-13-20(14-18-31)21-5-3-6-24(33)19-21/h1-3,5-12,19-20,33H,4,13-18H2,(H,29,30)
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n/an/a 110n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325947
PNG
(CHEMBL1223767 | N-(3-(1-(3-(1-(4-methoxyphenyl)-1H...)
Show SMILES COc1ccc(cc1)-n1c(NCCCN2CCC(CC2)c2cccc(NC(C)=O)c2)nc2ccccc12
Show InChI InChI=1S/C30H35N5O2/c1-22(36)32-25-8-5-7-24(21-25)23-15-19-34(20-16-23)18-6-17-31-30-33-28-9-3-4-10-29(28)35(30)26-11-13-27(37-2)14-12-26/h3-5,7-14,21,23H,6,15-20H2,1-2H3,(H,31,33)(H,32,36)
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n/an/a 110n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325945
PNG
(CHEMBL1223709 | N-(3-(1-(3-(1-(3-chlorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2cccc(Cl)c2)CC1
Show InChI InChI=1S/C29H32ClN5O/c1-21(36)32-25-9-4-7-23(19-25)22-13-17-34(18-14-22)16-6-15-31-29-33-27-11-2-3-12-28(27)35(29)26-10-5-8-24(30)20-26/h2-5,7-12,19-20,22H,6,13-18H2,1H3,(H,31,33)(H,32,36)
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n/an/a 110n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325969
PNG
(CHEMBL1224154 | N-(3-(4-(3-(1-(4-chlorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCNc2nc3ccccc3n2-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C28H31ClN6O/c1-21(36)31-23-6-4-7-25(20-23)34-18-16-33(17-19-34)15-5-14-30-28-32-26-8-2-3-9-27(26)35(28)24-12-10-22(29)11-13-24/h2-4,6-13,20H,5,14-19H2,1H3,(H,30,32)(H,31,36)
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n/an/a 112n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325975
PNG
(CHEMBL1224305 | N-(3-(1-(4-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCC(=O)c2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H31FN4O2/c1-21(36)32-25-7-4-6-23(20-25)22-15-18-34(19-16-22)17-5-10-29(37)30-33-27-8-2-3-9-28(27)35(30)26-13-11-24(31)12-14-26/h2-4,6-9,11-14,20,22H,5,10,15-19H2,1H3,(H,32,36)
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n/an/a 112n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325960
PNG
(CHEMBL1223967 | N-(3-(1-(3-(1-(3-cyanobenzyl)-1H-b...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2cccc(c2)C#N)CC1
Show InChI InChI=1S/C31H34N6O/c1-23(38)34-28-10-5-9-27(20-28)26-13-17-36(18-14-26)16-6-15-33-31-35-29-11-2-3-12-30(29)37(31)22-25-8-4-7-24(19-25)21-32/h2-5,7-12,19-20,26H,6,13-18,22H2,1H3,(H,33,35)(H,34,38)
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n/an/a 140n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325958
PNG
(CHEMBL1223888 | N-(3-(1-(3-(1-(3-(trifluoromethyl)...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2cccc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C31H34F3N5O/c1-22(40)36-27-10-5-8-25(20-27)24-13-17-38(18-14-24)16-6-15-35-30-37-28-11-2-3-12-29(28)39(30)21-23-7-4-9-26(19-23)31(32,33)34/h2-5,7-12,19-20,24H,6,13-18,21H2,1H3,(H,35,37)(H,36,40)
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n/an/a 150n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325946
PNG
(CHEMBL1223710 | N-(3-(1-(3-(1-phenyl-1H-benzo[d]im...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccccc2)CC1
Show InChI InChI=1S/C29H33N5O/c1-22(35)31-25-10-7-9-24(21-25)23-15-19-33(20-16-23)18-8-17-30-29-32-27-13-5-6-14-28(27)34(29)26-11-3-2-4-12-26/h2-7,9-14,21,23H,8,15-20H2,1H3,(H,30,32)(H,31,35)
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n/an/a 153n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325956
PNG
(CHEMBL1223886 | N-(3-(1-(3-(1-(3-methoxybenzyl)-1H...)
Show SMILES COc1cccc(Cn2c(NCCCN3CCC(CC3)c3cccc(NC(C)=O)c3)nc3ccccc23)c1
Show InChI InChI=1S/C31H37N5O2/c1-23(37)33-27-10-6-9-26(21-27)25-14-18-35(19-15-25)17-7-16-32-31-34-29-12-3-4-13-30(29)36(31)22-24-8-5-11-28(20-24)38-2/h3-6,8-13,20-21,25H,7,14-19,22H2,1-2H3,(H,32,34)(H,33,37)
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n/an/a 180n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325968
PNG
(CHEMBL1224153 | N-(3-(1-(3-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(C)C(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C31H36FN5O/c1-22(2)30(38)34-26-8-5-7-24(21-26)23-15-19-36(20-16-23)18-6-17-33-31-35-28-9-3-4-10-29(28)37(31)27-13-11-25(32)12-14-27/h3-5,7-14,21-23H,6,15-20H2,1-2H3,(H,33,35)(H,34,38)
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n/an/a 183n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325962
PNG
(1-(4-chlorophenyl)-N-(3-(4-(3-fluorophenyl)piperid...)
Show SMILES Fc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C27H28ClFN4/c28-22-9-11-24(12-10-22)33-26-8-2-1-7-25(26)31-27(33)30-15-4-16-32-17-13-20(14-18-32)21-5-3-6-23(29)19-21/h1-3,5-12,19-20H,4,13-18H2,(H,30,31)
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n/an/a 261n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325951
PNG
(CHEMBL1223828 | N-(3-(1-(3-(1-(4-(methylsulfonyl)p...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(cc2)S(C)(=O)=O)CC1
Show InChI InChI=1S/C30H35N5O3S/c1-22(36)32-25-8-5-7-24(21-25)23-15-19-34(20-16-23)18-6-17-31-30-33-28-9-3-4-10-29(28)35(30)26-11-13-27(14-12-26)39(2,37)38/h3-5,7-14,21,23H,6,15-20H2,1-2H3,(H,31,33)(H,32,36)
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n/an/a 269n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325972
PNG
(CHEMBL1224230 | N-(3-(1-(3-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C29H31FN4O/c1-21(35)31-25-7-4-6-23(20-25)22-15-18-33(19-16-22)17-5-10-29-32-27-8-2-3-9-28(27)34(29)26-13-11-24(30)12-14-26/h2-4,6-9,11-14,20,22H,5,10,15-19H2,1H3,(H,31,35)
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n/an/a 280n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325954
PNG
(CHEMBL1223884 | N-(3-(1-(3-(1-(4-tert-butylbenzyl)...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2ccc(cc2)C(C)(C)C)CC1
Show InChI InChI=1S/C34H43N5O/c1-25(40)36-30-10-7-9-28(23-30)27-17-21-38(22-18-27)20-8-19-35-33-37-31-11-5-6-12-32(31)39(33)24-26-13-15-29(16-14-26)34(2,3)4/h5-7,9-16,23,27H,8,17-22,24H2,1-4H3,(H,35,37)(H,36,40)
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n/an/a 320n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325973
PNG
(CHEMBL1224231 | N-(3-(1-(2-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C28H29FN4O/c1-20(34)30-24-6-4-5-22(19-24)21-13-16-32(17-14-21)18-15-28-31-26-7-2-3-8-27(26)33(28)25-11-9-23(29)10-12-25/h2-12,19,21H,13-18H2,1H3,(H,30,34)
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n/an/a 336n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325964
PNG
(1-(4-chlorophenyl)-N-(3-(4-(3-(trifluoromethoxy)ph...)
Show SMILES FC(F)(F)Oc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C28H28ClF3N4O/c29-22-9-11-23(12-10-22)36-26-8-2-1-7-25(26)34-27(36)33-15-4-16-35-17-13-20(14-18-35)21-5-3-6-24(19-21)37-28(30,31)32/h1-3,5-12,19-20H,4,13-18H2,(H,33,34)
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n/an/a 528n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325978
PNG
(CHEMBL1224387 | ethyl 4-(1-(4-(1-(4-fluorophenyl)-...)
Show SMILES CCOC(=O)c1ccc(cc1O)C1CCN(CCCCc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C31H34FN3O3/c1-2-38-31(37)26-15-10-23(21-29(26)36)22-16-19-34(20-17-22)18-6-5-9-30-33-27-7-3-4-8-28(27)35(30)25-13-11-24(32)12-14-25/h3-4,7-8,10-15,21-22,36H,2,5-6,9,16-20H2,1H3
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n/an/a 566n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325978
PNG
(CHEMBL1224387 | ethyl 4-(1-(4-(1-(4-fluorophenyl)-...)
Show SMILES CCOC(=O)c1ccc(cc1O)C1CCN(CCCCc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C31H34FN3O3/c1-2-38-31(37)26-15-10-23(21-29(26)36)22-16-19-34(20-17-22)18-6-5-9-30-33-27-7-3-4-8-28(27)35(30)25-13-11-24(32)12-14-25/h3-4,7-8,10-15,21-22,36H,2,5-6,9,16-20H2,1H3
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n/an/a 566n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325954
PNG
(CHEMBL1223884 | N-(3-(1-(3-(1-(4-tert-butylbenzyl)...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2ccc(cc2)C(C)(C)C)CC1
Show InChI InChI=1S/C34H43N5O/c1-25(40)36-30-10-7-9-28(23-30)27-17-21-38(22-18-27)20-8-19-35-33-37-31-11-5-6-12-32(31)39(33)24-26-13-15-29(16-14-26)34(2,3)4/h5-7,9-16,23,27H,8,17-22,24H2,1-4H3,(H,35,37)(H,36,40)
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n/an/a 600n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325970
PNG
(CHEMBL1224228 | N-(3-(4-(3-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCNc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C28H31FN6O/c1-21(36)31-23-6-4-7-25(20-23)34-18-16-33(17-19-34)15-5-14-30-28-32-26-8-2-3-9-27(26)35(28)24-12-10-22(29)11-13-24/h2-4,6-13,20H,5,14-19H2,1H3,(H,30,32)(H,31,36)
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n/an/a 646n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325969
PNG
(CHEMBL1224154 | N-(3-(4-(3-(1-(4-chlorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCNc2nc3ccccc3n2-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C28H31ClN6O/c1-21(36)31-23-6-4-7-25(20-23)34-18-16-33(17-19-34)15-5-14-30-28-32-26-8-2-3-9-27(26)35(28)24-12-10-22(29)11-13-24/h2-4,6-13,20H,5,14-19H2,1H3,(H,30,32)(H,31,36)
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n/an/a 648n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325977
PNG
(CHEMBL1224386 | N-(2-(4-(3-acetamidophenyl)piperid...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCNC(=O)c2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C29H30FN5O2/c1-20(36)32-24-6-4-5-22(19-24)21-13-16-34(17-14-21)18-15-31-29(37)28-33-26-7-2-3-8-27(26)35(28)25-11-9-23(30)10-12-25/h2-12,19,21H,13-18H2,1H3,(H,31,37)(H,32,36)
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n/an/a 678n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325951
PNG
(CHEMBL1223828 | N-(3-(1-(3-(1-(4-(methylsulfonyl)p...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(cc2)S(C)(=O)=O)CC1
Show InChI InChI=1S/C30H35N5O3S/c1-22(36)32-25-8-5-7-24(21-25)23-15-19-34(20-16-23)18-6-17-31-30-33-28-9-3-4-10-29(28)35(30)26-11-13-27(14-12-26)39(2,37)38/h3-5,7-14,21,23H,6,15-20H2,1-2H3,(H,31,33)(H,32,36)
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n/an/a 798n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325966
PNG
(CHEMBL1224082 | N-(3-(4-(3-(ethylamino)phenyl)pipe...)
Show SMILES CCNc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C29H34FN5/c1-2-31-25-8-5-7-23(21-25)22-15-19-34(20-16-22)18-6-17-32-29-33-27-9-3-4-10-28(27)35(29)26-13-11-24(30)12-14-26/h3-5,7-14,21-22,31H,2,6,15-20H2,1H3,(H,32,33)
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n/an/a 970n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325977
PNG
(CHEMBL1224386 | N-(2-(4-(3-acetamidophenyl)piperid...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCNC(=O)c2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C29H30FN5O2/c1-20(36)32-24-6-4-5-22(19-24)21-13-16-34(17-14-21)18-15-31-29(37)28-33-26-7-2-3-8-27(26)35(28)25-11-9-23(30)10-12-25/h2-12,19,21H,13-18H2,1H3,(H,31,37)(H,32,36)
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n/an/a 973n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325963
PNG
(3-(1-(3-(1-(4-chlorophenyl)-1H-benzo[d]imidazol-2-...)
Show SMILES Oc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C27H29ClN4O/c28-22-9-11-23(12-10-22)32-26-8-2-1-7-25(26)30-27(32)29-15-4-16-31-17-13-20(14-18-31)21-5-3-6-24(33)19-21/h1-3,5-12,19-20,33H,4,13-18H2,(H,29,30)
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n/an/a 1.44E+3n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325974
PNG
(CHEMBL1224304 | N-(3-(1-(4-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CC1)C(=O)CCCc1nc2ccccc2n1-c1ccc(F)cc1
Show InChI InChI=1S/C30H31FN4O2/c1-21(36)32-25-7-4-6-23(20-25)22-16-18-34(19-17-22)30(37)11-5-10-29-33-27-8-2-3-9-28(27)35(29)26-14-12-24(31)13-15-26/h2-4,6-9,12-15,20,22H,5,10-11,16-19H2,1H3,(H,32,36)
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n/an/a 1.45E+3n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325973
PNG
(CHEMBL1224231 | N-(3-(1-(2-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C28H29FN4O/c1-20(34)30-24-6-4-5-22(19-24)21-13-16-32(17-14-21)18-15-28-31-26-7-2-3-8-27(26)33(28)25-11-9-23(29)10-12-25/h2-12,19,21H,13-18H2,1H3,(H,30,34)
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n/an/a 1.47E+3n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325965
PNG
(CHEMBL1224081 | N-(3-(1-(3-(1-(4-chlorophenyl)-1H-...)
Show SMILES CN(C(C)=O)c1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C30H34ClN5O/c1-22(37)34(2)27-8-5-7-24(21-27)23-15-19-35(20-16-23)18-6-17-32-30-33-28-9-3-4-10-29(28)36(30)26-13-11-25(31)12-14-26/h3-5,7-14,21,23H,6,15-20H2,1-2H3,(H,32,33)
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n/an/a 1.62E+3n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325970
PNG
(CHEMBL1224228 | N-(3-(4-(3-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCNc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C28H31FN6O/c1-21(36)31-23-6-4-7-25(20-23)34-18-16-33(17-19-34)15-5-14-30-28-32-26-8-2-3-9-27(26)35(28)24-12-10-22(29)11-13-24/h2-4,6-13,20H,5,14-19H2,1H3,(H,30,32)(H,31,36)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325962
PNG
(1-(4-chlorophenyl)-N-(3-(4-(3-fluorophenyl)piperid...)
Show SMILES Fc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C27H28ClFN4/c28-22-9-11-24(12-10-22)33-26-8-2-1-7-25(26)31-27(33)30-15-4-16-32-17-13-20(14-18-32)21-5-3-6-23(29)19-21/h1-3,5-12,19-20H,4,13-18H2,(H,30,31)
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n/an/a 6.32E+3n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325964
PNG
(1-(4-chlorophenyl)-N-(3-(4-(3-(trifluoromethoxy)ph...)
Show SMILES FC(F)(F)Oc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C28H28ClF3N4O/c29-22-9-11-23(12-10-22)36-26-8-2-1-7-25(26)34-27(36)33-15-4-16-35-17-13-20(14-18-35)21-5-3-6-24(19-21)37-28(30,31)32/h1-3,5-12,19-20H,4,13-18H2,(H,33,34)
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n/an/a 7.58E+3n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325965
PNG
(CHEMBL1224081 | N-(3-(1-(3-(1-(4-chlorophenyl)-1H-...)
Show SMILES CN(C(C)=O)c1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C30H34ClN5O/c1-22(37)34(2)27-8-5-7-24(21-27)23-15-19-35(20-16-23)18-6-17-32-30-33-28-9-3-4-10-29(28)36(30)26-13-11-25(31)12-14-26/h3-5,7-14,21,23H,6,15-20H2,1-2H3,(H,32,33)
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UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325974
PNG
(CHEMBL1224304 | N-(3-(1-(4-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CC1)C(=O)CCCc1nc2ccccc2n1-c1ccc(F)cc1
Show InChI InChI=1S/C30H31FN4O2/c1-21(36)32-25-7-4-6-23(20-25)22-16-18-34(19-17-22)30(37)11-5-10-29-33-27-8-2-3-9-28(27)35(29)26-14-12-24(31)13-15-26/h2-4,6-9,12-15,20,22H,5,10-11,16-19H2,1H3,(H,32,36)
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%