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Found 33 Enz. Inhib. hit(s) with all data for entry = 50032342
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327416(1-(2-(2-(2-(dimethylamino)ethylamino)-6-(2-(isopro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327391(CHEMBL1258976 | N1-(4-(2-chlorophenyl)-6-(2-(isopr...)
Affinity DataIC50:  3.05nMAssay Description:Inhibition of LIMK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327390(5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327391(CHEMBL1258976 | N1-(4-(2-chlorophenyl)-6-(2-(isopr...)
Affinity DataIC50:  4.01nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327391(CHEMBL1258976 | N1-(4-(2-chlorophenyl)-6-(2-(isopr...)
Affinity DataIC50:  5nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327410((R)-N-sec-butyl-5-(6-(2-chlorophenyl)-2-(pyridin-2...)
Affinity DataIC50:  5nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327415(3-(4-(2-chlorophenyl)-6-(2-(isopropylamino)thiazol...)
Affinity DataIC50:  6nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327417(1-(2-(2-(2-(dimethylamino)ethylamino)-6-(2-(isopro...)
Affinity DataIC50:  7nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327414(2-(4-(2-chlorophenyl)-6-(2-(isopropylamino)thiazol...)
Affinity DataIC50:  8nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327409((S)-N-sec-butyl-5-(6-(2-chlorophenyl)-2-(pyridin-2...)
Affinity DataIC50:  8nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327408(5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327418(1-cyclopropyl-3-(2-(2-(2-(dimethylamino)ethylamino...)
Affinity DataIC50:  16nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327412(5-(2-amino-6-(2-chlorophenyl)pyrimidin-4-yl)-N-iso...)
Affinity DataIC50:  16nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327406(5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  17nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327407(5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  17nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327401(5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327403(5-(6-(2-chloro-4-fluorophenyl)-2-(pyridin-2-yl)pyr...)
Affinity DataIC50:  42nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327411(5-(6-(2-chlorophenyl)pyrimidin-4-yl)-N-isopropylth...)
Affinity DataIC50:  46nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327399(5-(6-(4-fluorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  52nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327400(5-(6-(2-fluorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  52nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327405(5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  114nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327392(5-(2-(2-chlorophenyl)pyrimidin-4-yl)-N-isopropylth...)
Affinity DataIC50:  223nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327393(5-(2-amino-6-(2-fluorophenyl)pyrimidin-4-yl)-N-pro...)
Affinity DataIC50:  225nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327390(5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  252nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327398(CHEMBL1258065 | N-propyl-5-(2-(pyridin-2-yl)pyrimi...)
Affinity DataIC50:  314nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327390(5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  362nMAssay Description:Inhibition of LIMK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327394(5-(6-(2-fluorophenyl)-2-methylpyrimidin-4-yl)-N-pr...)
Affinity DataIC50:  520nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327413(5-(6-(2-chlorophenyl)-2-(dimethylamino)pyrimidin-4...)
Affinity DataIC50:  573nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327402(5-(6-(2-ethoxyphenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  859nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327397(5-(2-cyclopropylpyrimidin-4-yl)-N-propylthiazol-2-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327395(5-(2-cyclopropyl-6-(2-fluorophenyl)pyrimidin-4-yl)...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327404(5-(6-(2-chloro-4-ethoxyphenyl)-2-(pyridin-2-yl)pyr...)
Affinity DataIC50:  3.94E+3nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327396(5-(2-(2-fluorophenyl)pyrimidin-4-yl)-N-propylthiaz...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed