Compile Data Set for Download or QSAR
maximum 50k data
Found 16 Enz. Inhib. hit(s) with all data for entry = 50032359
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327695(3-Fluoro-5-(2-(pyridin-2-yl)-7,8-dihydro-4H-oxazol...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]-MPEP from mGluR5 in rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327688(3-Fluoro-5-(2-(pyridin-2-yl)-6,7-dihydrooxazolo[4,...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]-MPEP from mGluR5 in rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327695(3-Fluoro-5-(2-(pyridin-2-yl)-7,8-dihydro-4H-oxazol...)
Affinity DataIC50:  16nMAssay Description:Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327688(3-Fluoro-5-(2-(pyridin-2-yl)-6,7-dihydrooxazolo[4,...)
Affinity DataIC50:  28nMAssay Description:Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327689(3-Fluoro-5-(2-(pyridin-2-yl)-6,7-dihydrooxazolo[5,...)
Affinity DataIC50:  54nMAssay Description:Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327694(3-(2-(Pyridin-2-yl)-7,8-dihydro-4H-oxazolo[4,5-c]a...)
Affinity DataIC50:  57nMAssay Description:Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327686(3-(2-(Pyridin-2-yl)-6,7-dihydrooxazolo[4,5-c]pyrid...)
Affinity DataIC50:  60nMAssay Description:Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327683(2-(2-(Pyridin-2-yl)-6,7-dihydrooxazolo[4,5-c]pyrid...)
Affinity DataIC50:  110nMAssay Description:Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327693(3-(2-(pyridin-2-yl)-3aH-pyrrolo[3,4-d]oxazol-5(4H,...)
Affinity DataIC50:  129nMAssay Description:Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327691(3-fluoro-5-(2-(pyridin-2-yl)-5,6-dihydroimidazo[1,...)
Affinity DataIC50:  153nMAssay Description:Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327687(3-(2-(Pyridin-2-yl)-6,7-dihydrooxazolo[5,4-c]pyrid...)
Affinity DataIC50:  290nMAssay Description:Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327685(5-Phenyl-2-(pyridin-2-yl)-4,5,6,7-tetrahydrooxazol...)
Affinity DataIC50:  330nMAssay Description:Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327692(3-Fluoro-5-(2-(pyridin-2-yl)-5,6-dihydro-[1,2,4]tr...)
Affinity DataIC50:  346nMAssay Description:Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327684(2-(2-(Pyridin-2-yl)-6,7-dihydrooxazolo[5,4-c]pyrid...)
Affinity DataIC50:  640nMAssay Description:Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327682(2-(2-Phenyl-6,7-dihydrooxazolo[4,5-c]pyridin-5(4H)...)
Affinity DataIC50:  1.20E+3nMAssay Description:Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50327690(3-(2-(Pyridin-2-yl)-4,5,6,7-tetrahydrooxazolo[5,4-...)
Affinity DataIC50:  2.60E+3nMAssay Description:Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed