Compile Data Set for Download or QSAR
maximum 50k data
Found 28 Enz. Inhib. hit(s) with all data for entry = 50032378
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328080(3-(6-(1H-indazol-4-yl)-1-methyl-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328076(6-(1H-indazol-4-yl)-N-(3-methoxyphenyl)-1-methyl-1...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328082(6-(1H-indazol-4-yl)-1-methyl-N-(4-(methylsulfonyl)...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328079(6-(1H-indazol-4-yl)-1-methyl-N-(3-(methylsulfonyl)...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328078(CHEMBL1257304 | N-(3-methoxyphenyl)-1-methyl-6-(3-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328083(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328084(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328081(6-(1H-indazol-4-yl)-1-methyl-N-(1-methylpiperidin-...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328077(6-(3-amino-1H-indazol-4-yl)-N-(3-methoxyphenyl)-1-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328075(6-(2-aminopyrimidin-5-yl)-N-(3-methoxyphenyl)-1-me...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328074(CHEMBL1258919 | N-(3-methoxyphenyl)-1-methyl-6-(py...)
Affinity DataIC50:  29nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  31nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328070(CHEMBL1255605 | N-(3-methoxyphenyl)-1-methyl-6-(3-...)
Affinity DataIC50:  56nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328071(3-(4-(3-methoxyphenylamino)-1-methyl-1H-pyrazolo[3...)
Affinity DataIC50:  72nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328067(6-(1,1-dioxidothiomorpholin-4-yl)-N-(3-methoxyphen...)
Affinity DataIC50:  75nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328069(CHEMBL1258578 | N,6-bis(3-methoxyphenyl)-1-methyl-...)
Affinity DataIC50:  134nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328064(CHEMBL1258354 | ETP-7382 | N-(3-methoxyphenyl)-1-m...)
Affinity DataIC50:  162nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  187nMAssay Description:Inhibition of PI3Kalpha in human PC3 cells assessed as phosphorylated Akt levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328068(CHEMBL1258577 | N-(3-methoxyphenyl)-1-methyl-6-(pi...)
Affinity DataIC50:  359nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328066(6-(2,6-dimethylmorpholino)-N-(3-methoxyphenyl)-1-m...)
Affinity DataIC50:  370nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328073(CHEMBL1258805 | N-(3-(4-(3-methoxyphenylamino)-1-m...)
Affinity DataIC50:  386nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328065(1-(4-(3-methoxyphenylamino)-1-methyl-1H-pyrazolo[3...)
Affinity DataIC50:  430nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of DNA-PKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328072(3-(4-(3-methoxyphenylamino)-1-methyl-1H-pyrazolo[3...)
Affinity DataIC50:  3.64E+3nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed