BindingDB logo
myBDB logout

PubMed code 20974532

Compile data set for download or QSAR
Found 57 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 3A


(Homo sapiens (human))
BDBM50332373
PNG
((S)-(5-chloroisoindolin-2-yl)(5-(methylsulfonyl)-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(Cl)cc2C1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C19H17ClF3NO4S/c1-11(19(21,22)23)28-17-6-5-15(29(2,26)27)8-16(17)18(25)24-9-12-3-4-14(20)7-13(12)10-24/h3-8,11H,9-10H2,1-2H3/t11-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.80E+4n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50332373
PNG
((S)-(5-chloroisoindolin-2-yl)(5-(methylsulfonyl)-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(Cl)cc2C1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C19H17ClF3NO4S/c1-11(19(21,22)23)28-17-6-5-15(29(2,26)27)8-16(17)18(25)24-9-12-3-4-14(20)7-13(12)10-24/h3-8,11H,9-10H2,1-2H3/t11-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.80E+4n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50332373
PNG
((S)-(5-chloroisoindolin-2-yl)(5-(methylsulfonyl)-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(Cl)cc2C1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C19H17ClF3NO4S/c1-11(19(21,22)23)28-17-6-5-15(29(2,26)27)8-16(17)18(25)24-9-12-3-4-14(20)7-13(12)10-24/h3-8,11H,9-10H2,1-2H3/t11-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.80E+4n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332348
PNG
((S)-(5-methoxyisoindolin-2-yl)(5-(methylsulfonyl)-...)
Show SMILES COc1ccc2CN(Cc2c1)C(=O)c1cc(ccc1O[C@@H](C)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C20H20F3NO5S/c1-12(20(21,22)23)29-18-7-6-16(30(3,26)27)9-17(18)19(25)24-10-13-4-5-15(28-2)8-14(13)11-24/h4-9,12H,10-11H2,1-3H3/t12-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 180n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332372
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)N1CCOCC1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C23H25F3N2O5S/c1-15(23(24,25)26)33-21-6-5-19(34(2,30)31)12-20(21)22(29)28-13-16-3-4-18(11-17(16)14-28)27-7-9-32-10-8-27/h3-6,11-12,15H,7-10,13-14H2,1-2H3/t15-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 275n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332351
PNG
((S)-isoindolin-2-yl(5-(methylsulfonyl)-2-(1,1,1-tr...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccccc2C1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C19H18F3NO4S/c1-12(19(20,21)22)27-17-8-7-15(28(2,25)26)9-16(17)18(24)23-10-13-5-3-4-6-14(13)11-23/h3-9,12H,10-11H2,1-2H3/t12-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332360
PNG
((2-isopropoxy-5-(methylsulfonyl)phenyl)(3-(trifluo...)
Show SMILES CC(C)Oc1ccc(cc1C(=O)N1Cc2cc(cnc2C1)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C19H19F3N2O4S/c1-11(2)28-17-5-4-14(29(3,26)27)7-15(17)18(25)24-9-12-6-13(19(20,21)22)8-23-16(12)10-24/h4-8,11H,9-10H2,1-3H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 70n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332373
PNG
((S)-(5-chloroisoindolin-2-yl)(5-(methylsulfonyl)-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(Cl)cc2C1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C19H17ClF3NO4S/c1-11(19(21,22)23)28-17-6-5-15(29(2,26)27)8-16(17)18(25)24-9-12-3-4-14(20)7-13(12)10-24/h3-8,11H,9-10H2,1-2H3/t11-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332349
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)-c1ccccc1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C25H22F3NO4S/c1-16(25(26,27)28)33-23-11-10-21(34(2,31)32)13-22(23)24(30)29-14-19-9-8-18(12-20(19)15-29)17-6-4-3-5-7-17/h3-13,16H,14-15H2,1-2H3/t16-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 13n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332364
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)-c1ccccn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C24H21F3N2O4S/c1-15(24(25,26)27)33-22-9-8-19(34(2,31)32)12-20(22)23(30)29-13-17-7-6-16(11-18(17)14-29)21-5-3-4-10-28-21/h3-12,15H,13-14H2,1-2H3/t15-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332363
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)-c1ccncc1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C24H21F3N2O4S/c1-15(24(25,26)27)33-22-6-5-20(34(2,31)32)12-21(22)23(30)29-13-18-4-3-17(11-19(18)14-29)16-7-9-28-10-8-16/h3-12,15H,13-14H2,1-2H3/t15-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332358
PNG
((2-isobutoxy-5-(methylsulfonyl)phenyl)(3-(trifluor...)
Show SMILES CC(C)COc1ccc(cc1C(=O)N1Cc2cc(cnc2C1)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C20H21F3N2O4S/c1-12(2)11-29-18-5-4-15(30(3,27)28)7-16(18)19(26)25-9-13-6-14(20(21,22)23)8-24-17(13)10-25/h4-8,12H,9-11H2,1-3H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 30n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332348
PNG
((S)-(5-methoxyisoindolin-2-yl)(5-(methylsulfonyl)-...)
Show SMILES COc1ccc2CN(Cc2c1)C(=O)c1cc(ccc1O[C@@H](C)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C20H20F3NO5S/c1-12(20(21,22)23)29-18-7-6-16(30(3,26)27)9-17(18)19(25)24-10-13-4-5-15(28-2)8-14(13)11-24/h4-9,12H,10-11H2,1-3H3/t12-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332357
PNG
((5-(methylsulfonyl)-2-(3,3,3-trifluoropropoxy)phen...)
Show SMILES CS(=O)(=O)c1ccc(OCCC(F)(F)F)c(c1)C(=O)N1Cc2cc(cnc2C1)C(F)(F)F
Show InChI InChI=1S/C19H16F6N2O4S/c1-32(29,30)13-2-3-16(31-5-4-18(20,21)22)14(7-13)17(28)27-9-11-6-12(19(23,24)25)8-26-15(11)10-27/h2-3,6-8H,4-5,9-10H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332366
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2cnc(cc2C1)C(F)(F)F)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C19H16F6N2O4S/c1-10(18(20,21)22)31-15-4-3-13(32(2,29)30)6-14(15)17(28)27-8-11-5-16(19(23,24)25)26-7-12(11)9-27/h3-7,10H,8-9H2,1-2H3/t10-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 132n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332363
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)-c1ccncc1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C24H21F3N2O4S/c1-15(24(25,26)27)33-22-6-5-20(34(2,31)32)12-21(22)23(30)29-13-18-4-3-17(11-19(18)14-29)16-7-9-28-10-8-16/h3-12,15H,13-14H2,1-2H3/t15-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 17n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332361
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)C1CCOCC1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C24H26F3NO5S/c1-15(24(25,26)27)33-22-6-5-20(34(2,30)31)12-21(22)23(29)28-13-18-4-3-17(11-19(18)14-28)16-7-9-32-10-8-16/h3-6,11-12,15-16H,7-10,13-14H2,1-2H3/t15-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332360
PNG
((2-isopropoxy-5-(methylsulfonyl)phenyl)(3-(trifluo...)
Show SMILES CC(C)Oc1ccc(cc1C(=O)N1Cc2cc(cnc2C1)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C19H19F3N2O4S/c1-11(2)28-17-5-4-14(29(3,26)27)7-15(17)18(25)24-9-12-6-13(19(20,21)22)8-23-16(12)10-24/h4-8,11H,9-10H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332373
PNG
((S)-(5-chloroisoindolin-2-yl)(5-(methylsulfonyl)-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(Cl)cc2C1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C19H17ClF3NO4S/c1-11(19(21,22)23)28-17-6-5-15(29(2,26)27)8-16(17)18(25)24-9-12-3-4-14(20)7-13(12)10-24/h3-8,11H,9-10H2,1-2H3/t11-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 135n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332347
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)N1CCCC1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C23H25F3N2O4S/c1-15(23(24,25)26)32-21-8-7-19(33(2,30)31)12-20(21)22(29)28-13-16-5-6-18(11-17(16)14-28)27-9-3-4-10-27/h5-8,11-12,15H,3-4,9-10,13-14H2,1-2H3/t15-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.43E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332355
PNG
((2-(benzyloxy)-5-(methylsulfonyl)phenyl)(3-(triflu...)
Show SMILES CS(=O)(=O)c1ccc(OCc2ccccc2)c(c1)C(=O)N1Cc2cc(cnc2C1)C(F)(F)F
Show InChI InChI=1S/C23H19F3N2O4S/c1-33(30,31)18-7-8-21(32-14-15-5-3-2-4-6-15)19(10-18)22(29)28-12-16-9-17(23(24,25)26)11-27-20(16)13-28/h2-11H,12-14H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332356
PNG
((5-(methylsulfonyl)-2-(3,3,3-trifluoropropoxy)phen...)
Show SMILES CS(=O)(=O)c1ccc(OCCC(F)(F)F)c(c1)C(=O)N1Cc2ccc(cc2C1)C1CCOCC1
Show InChI InChI=1S/C24H26F3NO5S/c1-34(30,31)20-4-5-22(33-11-8-24(25,26)27)21(13-20)23(29)28-14-18-3-2-17(12-19(18)15-28)16-6-9-32-10-7-16/h2-5,12-13,16H,6-11,14-15H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332371
PNG
((S)-(5-(4-methylpiperazin-1-yl)isoindolin-2-yl)(5-...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)N1CCN(C)CC1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C24H28F3N3O4S/c1-16(24(25,26)27)34-22-7-6-20(35(3,32)33)13-21(22)23(31)30-14-17-4-5-19(12-18(17)15-30)29-10-8-28(2)9-11-29/h4-7,12-13,16H,8-11,14-15H2,1-3H3/t16-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 2.08E+3n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332359
PNG
((2-isopropoxy-5-(methylsulfonyl)phenyl)(5-(tetrahy...)
Show SMILES CC(C)Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)C1CCOCC1)S(C)(=O)=O
Show InChI InChI=1S/C24H29NO5S/c1-16(2)30-23-7-6-21(31(3,27)28)13-22(23)24(26)25-14-19-5-4-18(12-20(19)15-25)17-8-10-29-11-9-17/h4-7,12-13,16-17H,8-11,14-15H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332351
PNG
((S)-isoindolin-2-yl(5-(methylsulfonyl)-2-(1,1,1-tr...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccccc2C1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C19H18F3NO4S/c1-12(19(20,21)22)27-17-8-7-15(28(2,25)26)9-16(17)18(24)23-10-13-5-3-4-6-14(13)11-23/h3-9,12H,10-11H2,1-2H3/t12-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.54E+3n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332350
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)C(F)(F)F)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H17F6NO4S/c1-11(19(21,22)23)31-17-6-5-15(32(2,29)30)8-16(17)18(28)27-9-12-3-4-14(20(24,25)26)7-13(12)10-27/h3-8,11H,9-10H2,1-2H3/t11-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 21n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332358
PNG
((2-isobutoxy-5-(methylsulfonyl)phenyl)(3-(trifluor...)
Show SMILES CC(C)COc1ccc(cc1C(=O)N1Cc2cc(cnc2C1)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C20H21F3N2O4S/c1-12(2)11-29-18-5-4-15(30(3,27)28)7-16(18)19(26)25-9-13-6-14(20(21,22)23)8-24-17(13)10-25/h4-8,12H,9-11H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332366
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2cnc(cc2C1)C(F)(F)F)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C19H16F6N2O4S/c1-10(18(20,21)22)31-15-4-3-13(32(2,29)30)6-14(15)17(28)27-8-11-5-16(19(23,24)25)26-7-12(11)9-27/h3-7,10H,8-9H2,1-2H3/t10-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332367
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2cc(cnc2C1)C(F)(F)F)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C19H16F6N2O4S/c1-10(18(20,21)22)31-16-4-3-13(32(2,29)30)6-14(16)17(28)27-8-11-5-12(19(23,24)25)7-26-15(11)9-27/h3-7,10H,8-9H2,1-2H3/t10-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332371
PNG
((S)-(5-(4-methylpiperazin-1-yl)isoindolin-2-yl)(5-...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)N1CCN(C)CC1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C24H28F3N3O4S/c1-16(24(25,26)27)34-22-7-6-20(35(3,32)33)13-21(22)23(31)30-14-17-4-5-19(12-18(17)15-30)29-10-8-28(2)9-11-29/h4-7,12-13,16H,8-11,14-15H2,1-3H3/t16-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332369
PNG
((S)-(4-methoxyisoindolin-2-yl)(5-(methylsulfonyl)-...)
Show SMILES COc1cccc2CN(Cc12)C(=O)c1cc(ccc1O[C@@H](C)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C20H20F3NO5S/c1-12(20(21,22)23)29-18-8-7-14(30(3,26)27)9-15(18)19(25)24-10-13-5-4-6-17(28-2)16(13)11-24/h4-9,12H,10-11H2,1-3H3/t12-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.94E+3n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332356
PNG
((5-(methylsulfonyl)-2-(3,3,3-trifluoropropoxy)phen...)
Show SMILES CS(=O)(=O)c1ccc(OCCC(F)(F)F)c(c1)C(=O)N1Cc2ccc(cc2C1)C1CCOCC1
Show InChI InChI=1S/C24H26F3NO5S/c1-34(30,31)20-4-5-22(33-11-8-24(25,26)27)21(13-20)23(29)28-14-18-3-2-17(12-19(18)15-28)16-6-9-32-10-7-16/h2-5,12-13,16H,6-11,14-15H2,1H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 137n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332355
PNG
((2-(benzyloxy)-5-(methylsulfonyl)phenyl)(3-(triflu...)
Show SMILES CS(=O)(=O)c1ccc(OCc2ccccc2)c(c1)C(=O)N1Cc2cc(cnc2C1)C(F)(F)F
Show InChI InChI=1S/C23H19F3N2O4S/c1-33(30,31)18-7-8-21(32-14-15-5-3-2-4-6-15)19(10-18)22(29)28-12-16-9-17(23(24,25)26)11-27-20(16)13-28/h2-11H,12-14H2,1H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 805n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332350
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)C(F)(F)F)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H17F6NO4S/c1-11(19(21,22)23)31-17-6-5-15(32(2,29)30)8-16(17)18(28)27-9-12-3-4-14(20(24,25)26)7-13(12)10-27/h3-8,11H,9-10H2,1-2H3/t11-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332362
PNG
((5-(methylsulfonyl)-2-((S)-1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)C1CCCCO1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C24H26F3NO5S/c1-15(24(25,26)27)33-22-9-8-19(34(2,30)31)12-20(22)23(29)28-13-17-7-6-16(11-18(17)14-28)21-5-3-4-10-32-21/h6-9,11-12,15,21H,3-5,10,13-14H2,1-2H3/t15-,21?/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 205n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332354
PNG
((4'-fluoro-4-(methylsulfonyl)biphenyl-2-yl)(5-(tet...)
Show SMILES CS(=O)(=O)c1ccc(-c2ccc(F)cc2)c(c1)C(=O)N1Cc2ccc(cc2C1)C1CCOCC1
Show InChI InChI=1S/C27H26FNO4S/c1-34(31,32)24-8-9-25(19-4-6-23(28)7-5-19)26(15-24)27(30)29-16-21-3-2-20(14-22(21)17-29)18-10-12-33-13-11-18/h2-9,14-15,18H,10-13,16-17H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332367
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2cc(cnc2C1)C(F)(F)F)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C19H16F6N2O4S/c1-10(18(20,21)22)31-16-4-3-13(32(2,29)30)6-14(16)17(28)27-8-11-5-12(19(23,24)25)7-26-15(11)9-27/h3-7,10H,8-9H2,1-2H3/t10-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 50n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332364
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)-c1ccccn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C24H21F3N2O4S/c1-15(24(25,26)27)33-22-9-8-19(34(2,31)32)12-20(22)23(30)29-13-17-7-6-16(11-18(17)14-29)21-5-3-4-10-28-21/h3-12,15H,13-14H2,1-2H3/t15-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 84n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332357
PNG
((5-(methylsulfonyl)-2-(3,3,3-trifluoropropoxy)phen...)
Show SMILES CS(=O)(=O)c1ccc(OCCC(F)(F)F)c(c1)C(=O)N1Cc2cc(cnc2C1)C(F)(F)F
Show InChI InChI=1S/C19H16F6N2O4S/c1-32(29,30)13-2-3-16(31-5-4-18(20,21)22)14(7-13)17(28)27-9-11-6-12(19(23,24)25)8-26-15(11)10-27/h2-3,6-8H,4-5,9-10H2,1H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 111n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332354
PNG
((4'-fluoro-4-(methylsulfonyl)biphenyl-2-yl)(5-(tet...)
Show SMILES CS(=O)(=O)c1ccc(-c2ccc(F)cc2)c(c1)C(=O)N1Cc2ccc(cc2C1)C1CCOCC1
Show InChI InChI=1S/C27H26FNO4S/c1-34(31,32)24-8-9-25(19-4-6-23(28)7-5-19)26(15-24)27(30)29-16-21-3-2-20(14-22(21)17-29)18-10-12-33-13-11-18/h2-9,14-15,18H,10-13,16-17H2,1H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a 16n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332353
PNG
((3',4'-difluoro-4-(methylsulfonyl)biphenyl-2-yl)(3...)
Show SMILES CS(=O)(=O)c1ccc(-c2ccc(F)c(F)c2)c(c1)C(=O)N1Cc2cc(cnc2C1)C(F)(F)F
Show InChI InChI=1S/C22H15F5N2O3S/c1-33(31,32)15-3-4-16(12-2-5-18(23)19(24)7-12)17(8-15)21(30)29-10-13-6-14(22(25,26)27)9-28-20(13)11-29/h2-9H,10-11H2,1H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a 30n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332352
PNG
((5-(methylsulfonyl)-2-morpholinophenyl)(3-(trifluo...)
Show SMILES CS(=O)(=O)c1ccc(N2CCOCC2)c(c1)C(=O)N1Cc2cc(cnc2C1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N3O4S/c1-31(28,29)15-2-3-18(25-4-6-30-7-5-25)16(9-15)19(27)26-11-13-8-14(20(21,22)23)10-24-17(13)12-26/h2-3,8-10H,4-7,11-12H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332370
PNG
((S)-(4-methylisoindolin-2-yl)(5-(methylsulfonyl)-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2cccc(C)c2C1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H20F3NO4S/c1-12-5-4-6-14-10-24(11-17(12)14)19(25)16-9-15(29(3,26)27)7-8-18(16)28-13(2)20(21,22)23/h4-9,13H,10-11H2,1-3H3/t13-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332369
PNG
((S)-(4-methoxyisoindolin-2-yl)(5-(methylsulfonyl)-...)
Show SMILES COc1cccc2CN(Cc12)C(=O)c1cc(ccc1O[C@@H](C)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C20H20F3NO5S/c1-12(20(21,22)23)29-18-8-7-14(30(3,26)27)9-15(18)19(25)24-10-13-5-4-6-17(28-2)16(13)11-24/h4-9,12H,10-11H2,1-3H3/t12-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332359
PNG
((2-isopropoxy-5-(methylsulfonyl)phenyl)(5-(tetrahy...)
Show SMILES CC(C)Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)C1CCOCC1)S(C)(=O)=O
Show InChI InChI=1S/C24H29NO5S/c1-16(2)30-23-7-6-21(31(3,27)28)13-22(23)24(26)25-14-19-5-4-18(12-20(19)15-25)17-8-10-29-11-9-17/h4-7,12-13,16-17H,8-11,14-15H2,1-3H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 28n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332349
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)-c1ccccc1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C25H22F3NO4S/c1-16(25(26,27)28)33-23-11-10-21(34(2,31)32)13-22(23)24(30)29-14-19-9-8-18(12-20(19)15-29)17-6-4-3-5-7-17/h3-13,16H,14-15H2,1-2H3/t16-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.20E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332361
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)C1CCOCC1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C24H26F3NO5S/c1-15(24(25,26)27)33-22-6-5-20(34(2,30)31)12-21(22)23(29)28-13-18-4-3-17(11-19(18)14-28)16-7-9-32-10-8-16/h3-6,11-12,15-16H,7-10,13-14H2,1-2H3/t15-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 14n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332352
PNG
((5-(methylsulfonyl)-2-morpholinophenyl)(3-(trifluo...)
Show SMILES CS(=O)(=O)c1ccc(N2CCOCC2)c(c1)C(=O)N1Cc2cc(cnc2C1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N3O4S/c1-31(28,29)15-2-3-18(25-4-6-30-7-5-25)16(9-15)19(27)26-11-13-8-14(20(21,22)23)10-24-17(13)12-26/h2-3,8-10H,4-7,11-12H2,1H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a 3.00E+3n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332347
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)N1CCCC1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C23H25F3N2O4S/c1-15(23(24,25)26)32-21-8-7-19(33(2,30)31)12-20(21)22(29)28-13-16-5-6-18(11-17(16)14-28)27-9-3-4-10-27/h5-8,11-12,15H,3-4,9-10,13-14H2,1-2H3/t15-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 180n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332372
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)N1CCOCC1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C23H25F3N2O5S/c1-15(23(24,25)26)33-21-6-5-19(34(2,30)31)12-20(21)22(29)28-13-16-3-4-18(11-17(16)14-28)27-7-9-32-10-8-27/h3-6,11-12,15H,7-10,13-14H2,1-2H3/t15-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332365
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(nc2C1)C(F)(F)F)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C19H16F6N2O4S/c1-10(18(20,21)22)31-15-5-4-12(32(2,29)30)7-13(15)17(28)27-8-11-3-6-16(19(23,24)25)26-14(11)9-27/h3-7,10H,8-9H2,1-2H3/t10-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 250n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332362
PNG
((5-(methylsulfonyl)-2-((S)-1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)C1CCCCO1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C24H26F3NO5S/c1-15(24(25,26)27)33-22-9-8-19(34(2,30)31)12-20(22)23(29)28-13-17-7-6-16(11-18(17)14-28)21-5-3-4-10-32-21/h6-9,11-12,15,21H,3-5,10,13-14H2,1-2H3/t15-,21?/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332368
PNG
((S)-2-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2cccc(C#N)c2C1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H17F3N2O4S/c1-12(20(21,22)23)29-18-7-6-15(30(2,27)28)8-16(18)19(26)25-10-14-5-3-4-13(9-24)17(14)11-25/h3-8,12H,10-11H2,1-2H3/t12-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332368
PNG
((S)-2-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2cccc(C#N)c2C1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H17F3N2O4S/c1-12(20(21,22)23)29-18-7-6-15(30(2,27)28)8-16(18)19(26)25-10-14-5-3-4-13(9-24)17(14)11-25/h3-8,12H,10-11H2,1-2H3/t12-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 770n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50332370
PNG
((S)-(4-methylisoindolin-2-yl)(5-(methylsulfonyl)-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2cccc(C)c2C1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H20F3NO4S/c1-12-5-4-6-14-10-24(11-17(12)14)19(25)16-9-15(29(3,26)27)7-8-18(16)28-13(2)20(21,22)23/h4-9,13H,10-11H2,1-3H3/t13-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 3.36E+3n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332365
PNG
((S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2...)
Show SMILES C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(nc2C1)C(F)(F)F)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C19H16F6N2O4S/c1-10(18(20,21)22)31-15-5-4-12(32(2,29)30)7-13(15)17(28)27-8-11-3-6-16(19(23,24)25)26-14(11)9-27/h3-7,10H,8-9H2,1-2H3/t10-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
Glycine transporter 2


(HUMAN)
BDBM50332353
PNG
((3',4'-difluoro-4-(methylsulfonyl)biphenyl-2-yl)(3...)
Show SMILES CS(=O)(=O)c1ccc(-c2ccc(F)c(F)c2)c(c1)C(=O)N1Cc2cc(cnc2C1)C(F)(F)F
Show InChI InChI=1S/C22H15F5N2O3S/c1-33(31,32)15-3-4-16(12-2-5-18(23)19(24)7-12)17(8-15)21(30)29-10-13-6-14(22(25,26)27)9-28-20(13)11-29/h2-9H,10-11H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycine uptake by liquid scintillation counting


Bioorg Med Chem Lett 20: 6960-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.124
BindingDB Entry DOI: 10.7270/Q2K35TXV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%