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PubMed code 21036612

Compile data set for download or QSAR
Found 10 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50331744
PNG
((S)-1-(2-amino-2-carboxyethyl)-1H-1,2,3-triazole-4...)
Show SMILES N[C@@H](Cn1cc(nn1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H8N4O4/c7-3(5(11)12)1-10-2-4(6(13)14)8-9-10/h2-3H,1,7H2,(H,11,12)(H,13,14)/t3-/m0/s1
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PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Binding affinity at mGluR4 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 mins


Bioorg Med Chem Lett 20: 7512-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.139
BindingDB Entry DOI: 10.7270/Q2K64J94
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50331744
PNG
((S)-1-(2-amino-2-carboxyethyl)-1H-1,2,3-triazole-4...)
Show SMILES N[C@@H](Cn1cc(nn1)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H8N4O4/c7-3(5(11)12)1-10-2-4(6(13)14)8-9-10/h2-3H,1,7H2,(H,11,12)(H,13,14)/t3-/m0/s1
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PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Binding affinity at mGluR2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 mins


Bioorg Med Chem Lett 20: 7512-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.139
BindingDB Entry DOI: 10.7270/Q2K64J94
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50331745
PNG
((S)-2-amino-3-(1-((S)-1-carboxy-2-phenylethyl)-1H-...)
Show SMILES N[C@@H](Cc1cnnn1[C@@H](Cc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16N4O4/c15-11(13(19)20)7-10-8-16-17-18(10)12(14(21)22)6-9-4-2-1-3-5-9/h1-5,8,11-12H,6-7,15H2,(H,19,20)(H,21,22)/t11-,12-/m0/s1
PDB

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n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Binding affinity at mGluR2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 mins


Bioorg Med Chem Lett 20: 7512-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.139
BindingDB Entry DOI: 10.7270/Q2K64J94
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50331745
PNG
((S)-2-amino-3-(1-((S)-1-carboxy-2-phenylethyl)-1H-...)
Show SMILES N[C@@H](Cc1cnnn1[C@@H](Cc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16N4O4/c15-11(13(19)20)7-10-8-16-17-18(10)12(14(21)22)6-9-4-2-1-3-5-9/h1-5,8,11-12H,6-7,15H2,(H,19,20)(H,21,22)/t11-,12-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Binding affinity at mGluR4 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 mins


Bioorg Med Chem Lett 20: 7512-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.139
BindingDB Entry DOI: 10.7270/Q2K64J94
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50331747
PNG
((S)-2-amino-3-(1-((S)-1-carboxy-2-phenylethyl)-1H-...)
Show SMILES N[C@@H](Cc1cn(nn1)[C@@H](Cc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16N4O4/c15-11(13(19)20)7-10-8-18(17-16-10)12(14(21)22)6-9-4-2-1-3-5-9/h1-5,8,11-12H,6-7,15H2,(H,19,20)(H,21,22)/t11-,12-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Binding affinity at mGluR4 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 mins


Bioorg Med Chem Lett 20: 7512-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.139
BindingDB Entry DOI: 10.7270/Q2K64J94
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50331746
PNG
((S)-2-amino-3-(1-(carboxymethyl)-1H-1,2,3-triazol-...)
Show SMILES N[C@@H](Cc1cnnn1CC(O)=O)C(O)=O
Show InChI InChI=1S/C7H10N4O4/c8-5(7(14)15)1-4-2-9-10-11(4)3-6(12)13/h2,5H,1,3,8H2,(H,12,13)(H,14,15)/t5-/m0/s1
PDB

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CHEMBL
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n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Binding affinity at mGluR2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 mins


Bioorg Med Chem Lett 20: 7512-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.139
BindingDB Entry DOI: 10.7270/Q2K64J94
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50331748
PNG
((S)-2-amino-3-(1-(carboxymethyl)-1H-1,2,3-triazol-...)
Show SMILES N[C@@H](Cc1cn(CC(O)=O)nn1)C(O)=O
Show InChI InChI=1S/C7H10N4O4/c8-5(7(14)15)1-4-2-11(10-9-4)3-6(12)13/h2,5H,1,3,8H2,(H,12,13)(H,14,15)/t5-/m0/s1
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Binding affinity at mGluR2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 mins


Bioorg Med Chem Lett 20: 7512-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.139
BindingDB Entry DOI: 10.7270/Q2K64J94
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50331747
PNG
((S)-2-amino-3-(1-((S)-1-carboxy-2-phenylethyl)-1H-...)
Show SMILES N[C@@H](Cc1cn(nn1)[C@@H](Cc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16N4O4/c15-11(13(19)20)7-10-8-18(17-16-10)12(14(21)22)6-9-4-2-1-3-5-9/h1-5,8,11-12H,6-7,15H2,(H,19,20)(H,21,22)/t11-,12-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Binding affinity at mGluR2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 mins


Bioorg Med Chem Lett 20: 7512-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.139
BindingDB Entry DOI: 10.7270/Q2K64J94
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50331746
PNG
((S)-2-amino-3-(1-(carboxymethyl)-1H-1,2,3-triazol-...)
Show SMILES N[C@@H](Cc1cnnn1CC(O)=O)C(O)=O
Show InChI InChI=1S/C7H10N4O4/c8-5(7(14)15)1-4-2-9-10-11(4)3-6(12)13/h2,5H,1,3,8H2,(H,12,13)(H,14,15)/t5-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Binding affinity at mGluR4 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 mins


Bioorg Med Chem Lett 20: 7512-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.139
BindingDB Entry DOI: 10.7270/Q2K64J94
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50331748
PNG
((S)-2-amino-3-(1-(carboxymethyl)-1H-1,2,3-triazol-...)
Show SMILES N[C@@H](Cc1cn(CC(O)=O)nn1)C(O)=O
Show InChI InChI=1S/C7H10N4O4/c8-5(7(14)15)1-4-2-11(10-9-4)3-6(12)13/h2,5H,1,3,8H2,(H,12,13)(H,14,15)/t5-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Binding affinity at mGluR4 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 mins


Bioorg Med Chem Lett 20: 7512-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.139
BindingDB Entry DOI: 10.7270/Q2K64J94
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%