Compile Data Set for Download or QSAR
maximum 50k data
Found 79 Enz. Inhib. hit(s) with all data for entry = 50032645
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of JAK2 by solution phase kinase assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332622(CHEMBL1630782 | N-Methyl-N-((1S,2R,5S)-2-methyl-5-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of JAK3 by solution phase kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332622(CHEMBL1630782 | N-Methyl-N-((1S,2R,5S)-2-methyl-5-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of JAK1 by solution phase kinase assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332623(CHEMBL1630786 | N-Benzyl-2-((R)-2-((1S,3S,4R)-4-me...)
Affinity DataIC50:  13nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332620(2-Methyl-3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]py...)
Affinity DataIC50:  13nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332604(CHEMBL1630788 | cis-N-Methyl-N-(4-methyl-1-(2,2,2-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332597(CHEMBL1630801 | cis-3,3,3-Trifluoro-1-(4-methyl-3-...)
Affinity DataIC50:  19nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332624(CHEMBL1630774 | N-(2,5-Dimethylcyclohexyl)-N-methy...)
Affinity DataIC50:  20nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332625((R)-2-((1S,3S,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,...)
Affinity DataIC50:  20nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332601(CHEMBL1630800 | cis-2-Cyclopropyl-1-(4-methyl-3-(m...)
Affinity DataIC50:  20nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332593(CHEMBL1630789 | cis-4-Methyl-3-(methyl(7H-pyrrolo[...)
Affinity DataIC50:  26nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332598(3-(4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4...)
Affinity DataIC50:  29nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332626(CHEMBL1630784 | N,N-Diethyl-2-((R)-2-((1S,3S,4R)-4...)
Affinity DataIC50:  32nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332592(CHEMBL1630791 | D3RKN_90 | cis-2-Hydroxy-1-(4-meth...)
Affinity DataIC50:  32nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  34nMAssay Description:Inhibition of Tyk2 by solution phase kinase assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332627(CHEMBL1630785 | N-Methyl-2-((R)-2-((1S,3S,4R)-4-me...)
Affinity DataIC50:  38nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332628(CHEMBL1630798 | cis-Cyclopentyl(4-methyl-3-(methyl...)
Affinity DataIC50:  39nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332611((4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-y...)
Affinity DataIC50:  40nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332596(CHEMBL1630790 | cis-N-(1-(2,3-Difluorobenzyl)-4-me...)
Affinity DataIC50:  42nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50273930(3-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  43nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332603(CHEMBL1630771 | N-Cyclooctyl-N-methyl-7H-pyrrolo[2...)
Affinity DataIC50:  58nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332629(CHEMBL1630775 | N-(2-Isopropyl-5-methylcyclohexyl)...)
Affinity DataIC50:  61nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332630(CHEMBL1630773 | N-Methyl-N-(2-methylcyclohexyl)-7H...)
Affinity DataIC50:  65nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332595(CHEMBL1630764 | N-Cycloheptyl-N-methyl-7H-pyrrolo[...)
Affinity DataIC50:  110nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  110nMAssay Description:Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332606(2,2-Dimethyl-3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-...)
Affinity DataIC50:  113nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332605(1-Benzyl-3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]py...)
Affinity DataIC50:  117nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332613(CHEMBL1630765 | N-Methyl-N-(3-methylcyclohexyl)-7H...)
Affinity DataIC50:  138nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332610((4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-y...)
Affinity DataIC50:  143nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332612(1-(4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4...)
Affinity DataIC50:  147nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332614((R)-2-((1S,3S,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,...)
Affinity DataIC50:  150nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332599(CHEMBL1630770 | N-Cyclohexyl-N-methyl-7H-pyrrolo[2...)
Affinity DataIC50:  160nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332607(9-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3,4,4a,9,9a-...)
Affinity DataIC50:  210nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332608(4-(Piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine | C...)
Affinity DataIC50:  210nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332616(CHEMBL1630794 | cis-2-Cyclopentyl-1-(4-methyl-3-(m...)
Affinity DataIC50:  230nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332615(CHEMBL1630778 | N-(2,2-dimethylcyclohexyl)-N-methy...)
Affinity DataIC50:  230nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332609(4-(2,5-Dimethylpyrrolidin-1-yl)-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50:  270nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332600(4-(Octahydro-1H-indol-1-yl)-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  350nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332617(CHEMBL1630772 | N-Methyl-N-(4-methylcyclohexyl)-7H...)
Affinity DataIC50:  370nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332618(CHEMBL1630769 | N-Cyclopentyl-N-methyl-7H-pyrrolo[...)
Affinity DataIC50:  390nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332619(CHEMBL1630792 | cis-(5-Chloro-2,3-dihydrobenzofura...)
Affinity DataIC50:  480nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332592(CHEMBL1630791 | D3RKN_90 | cis-2-Hydroxy-1-(4-meth...)
Affinity DataIC50:  480nMAssay Description:Inhibition of GST-tagged human JAK2 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332620(2-Methyl-3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]py...)
Affinity DataIC50:  490nMAssay Description:Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332593(CHEMBL1630789 | cis-4-Methyl-3-(methyl(7H-pyrrolo[...)
Affinity DataIC50:  510nMAssay Description:Inhibition of GST-tagged human JAK2 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332621(CHEMBL1630779 | N-(2-methoxycyclohexyl)-N-methyl-7...)
Affinity DataIC50:  540nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332618(CHEMBL1630769 | N-Cyclopentyl-N-methyl-7H-pyrrolo[...)
Affinity DataIC50:  670nMAssay Description:Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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